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UniProtKB - P46379 (BAG6_HUMAN)
Protein
Large proline-rich protein BAG6
Gene
BAG6
Organism
Homo sapiens (Human)
Status
Functioni
ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins (PubMed:21636303).
Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20516149, PubMed:21636303, PubMed:21743475, PubMed:28104892).
The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20516149, PubMed:20676083, PubMed:28104892, PubMed:25535373).
Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome (PubMed:24981174, PubMed:28104892, PubMed:27193484).
SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins (PubMed:23129660, PubMed:25179605, PubMed:27193484).
Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475).
The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).
BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity).
BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress (PubMed:26565908).
By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity).
Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).
By similarity11 PublicationsInvolved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity (PubMed:17403783).
When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) (PubMed:18765639).
2 PublicationsReleased extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
2 PublicationsMediates ricin-induced apoptosis.
1 PublicationGO - Molecular functioni
- Hsp70 protein binding Source: Ensembl
- identical protein binding Source: IntAct
- misfolded protein binding Source: ParkinsonsUK-UCL
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- proteasome binding Source: UniProtKB
- ribosome binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: ParkinsonsUK-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB
- brain development Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- endoplasmic reticulum stress-induced pre-emptive quality control Source: UniProtKB
- ER-associated misfolded protein catabolic process Source: UniProtKB
- immune response-activating cell surface receptor signaling pathway Source: UniProtKB
- internal peptidyl-lysine acetylation Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
- kidney development Source: UniProtKB
- lung development Source: UniProtKB
- maintenance of unfolded protein involved in ERAD pathway Source: ParkinsonsUK-UCL
- natural killer cell activation Source: UniProtKB
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- negative regulation of proteolysis Source: UniProtKB
- positive regulation of ERAD pathway Source: ParkinsonsUK-UCL
- posttranslational protein targeting to endoplasmic reticulum membrane Source: ComplexPortal
- proteasomal protein catabolic process Source: UniProtKB
- protein localization to cytosolic proteasome complex involved in ERAD pathway Source: ParkinsonsUK-UCL
- protein stabilization Source: UniProtKB
- regulation of embryonic development Source: UniProtKB
- regulation of protein stability Source: ComplexPortal
- spermatogenesis Source: UniProtKB
- synaptonemal complex assembly Source: UniProtKB
- tail-anchored membrane protein insertion into ER membrane Source: UniProtKB
- ubiquitin-dependent ERAD pathway Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: ComplexPortal
Keywordsi
| Molecular function | Chaperone, Chromatin regulator |
| Biological process | Apoptosis, Differentiation, Immunity, Spermatogenesis, Transport |
Enzyme and pathway databases
| PathwayCommonsi | P46379 |
| Reactomei | R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| SignaLinki | P46379 |
Names & Taxonomyi
| Protein namesi | Recommended name: Large proline-rich protein BAG6CuratedAlternative name(s): BAG family molecular chaperone regulator 6 BCL2-associated athanogene 6Imported Short name: BAG-6 HLA-B-associated transcript 31 Publication Protein G3 Protein Scythe1 Publication |
| Gene namesi | |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:13919, BAG6 |
| MIMi | 142590, gene |
| neXtProti | NX_P46379 |
| VEuPathDBi | HostDB:ENSG00000204463 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome 2 Publications
Cytoplasm and Cytosol
- cytosol 4 Publications
Nucleus
- Nucleus 4 Publications
Note: Normally localized in cytosol and nucleus, it can also be released extracellularly, in exosomes, by tumor and myeloid dendritic cells (PubMed:18055229, PubMed:18852879). Cytoplasmic retention is due to interaction with GET4 (PubMed:29042515).3 Publications
Cytosol
- BAT3 complex Source: UniProtKB
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: ParkinsonsUK-UCL
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 1001 | D → A: Abolishes cleavage by the caspase CASP3. 1 Publication | 1 | |
| Mutagenesisi | 1010 | W → A: Decreases interaction with GET4. Localizes in the nucleus and cytoplasm. Decreases interaction with GET4, localizes in the nucleus and increases GET4 ubiquitination; when associated with A-1042. 1 Publication | 1 | |
| Mutagenesisi | 1018 | W → A: Decreases interaction with GET4. Localizes in the nucleus. Decreases interaction with GET4, localizes in the nucleus and increases GET4 ubiquitination; when associated with A-1042. 1 Publication | 1 | |
| Mutagenesisi | 1030 – 1031 | RK → SL: No effect on interaction with GET4 and KPNA2. 1 Publication | 2 | |
| Mutagenesisi | 1042 | Y → A: Decreases interaction with GET4. Localizes in the nucleus. Decreases interaction with GET4, localizes in the nucleus and increases GET4 ubiquitination; when associated with A-1010 or A-1018. 1 Publication | 1 | |
| Mutagenesisi | 1049 – 1050 | KR → SL: No effect on interaction with GET4. Inhibits interaction with KPNA2. 1 Publication | 2 | |
| Mutagenesisi | 1067 | V → R: No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with A-1078. Abolishes on interaction with UBL4A; when associated with R-1085. 1 Publication | 1 | |
| Mutagenesisi | 1078 | P → A: No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with R-1067 or R-1085. 1 Publication | 1 | |
| Mutagenesisi | 1085 | L → R: No effect on interaction with UBL4A. No effect on interaction with UBL4A; when associated with R-1078. Abolishes on interaction with UBL4A; when associated with R-1067. 1 Publication | 1 | |
| Mutagenesisi | 1088 | D → H: No effect on interaction with UBL4A. 1 Publication | 1 |
Organism-specific databases
| DisGeNETi | 7917 |
| OpenTargetsi | ENSG00000204463 |
| PharmGKBi | PA25264 |
Miscellaneous databases
| Pharosi | P46379, Tbio |
Genetic variation databases
| BioMutai | BAG6 |
| DMDMi | 76800648 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000114897 | 1 – 1132 | Large proline-rich protein BAG6Add BLAST | 1132 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
|---|---|---|---|---|---|
| Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | ||
| Modified residuei | 96 | PhosphoserineCombined sources | 1 | ||
| Modified residuei | 113 | PhosphoserineCombined sources | 1 | ||
| Modified residuei | 117 | PhosphothreonineCombined sources | 1 | ||
| Modified residuei | 350 | PhosphothreonineCombined sources | 1 | ||
| Modified residuei | 964 | PhosphoserineCombined sources | 1 | ||
| Modified residuei | 973 | PhosphoserineCombined sources | 1 | ||
| Modified residuei | 1053 | PhosphothreonineCombined sources | 1 | ||
| Modified residuei | 1081 | PhosphoserineCombined sources | 1 | ||
| Modified residuei | 1117 | PhosphoserineCombined sources | 1 | ||
| Isoform 4 (identifier: P46379-4) | |||||
| Modified residuei | 832 | PhosphoserineCombined sources | 1 | ||
Post-translational modificationi
Ricin can induce a cleavage by the caspase CASP3. The released C-terminal peptide induces apoptosis.1 Publication
(Microbial infection) In case of infection by L.pneumophila, ubiquitinated by the SCF(LegU1) complex.1 Publication
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 1001 – 1002 | Cleavage; by CASP31 Publication | 2 |
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
| EPDi | P46379 |
| jPOSTi | P46379 |
| MassIVEi | P46379 |
| MaxQBi | P46379 |
| PaxDbi | P46379 |
| PeptideAtlasi | P46379 |
| PRIDEi | P46379 |
| ProteomicsDBi | 17045 29168 55736 [P46379-1] 55737 [P46379-2] 55738 [P46379-3] |
PTM databases
| GlyGeni | P46379, 2 sites, 2 O-linked glycans (2 sites) |
| iPTMneti | P46379 |
| MetOSitei | P46379 |
| PhosphoSitePlusi | P46379 |
| SwissPalmi | P46379 |
Expressioni
Tissue specificityi
Expressed by immature dendritic cells (at protein level).1 Publication
Gene expression databases
| Bgeei | ENSG00000204463, Expressed in testis and 243 other tissues |
| ExpressionAtlasi | P46379, baseline and differential |
| Genevisiblei | P46379, HS |
Organism-specific databases
| HPAi | ENSG00000204463, Low tissue specificity |
Interactioni
Subunit structurei
Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083).
Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol (PubMed:21636303, PubMed:29042515).
Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability (PubMed:25713138).
Interacts with AIFM1 (By similarity).
Interacts with HSPA2 (By similarity).
Interacts with CTCFL (PubMed:18765639).
Interacts with p300/EP300 (PubMed:17403783).
Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol (PubMed:24981174, PubMed:27193484).
Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation (PubMed:23129660, PubMed:24424410, PubMed:25179605, PubMed:27193484).
Interacts with ricin A chain (PubMed:14960581).
Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex (PubMed:21636303).
Interacts with SYVN1 (PubMed:21636303).
Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination (PubMed:24424410).
Interacts with ZFAND2B (PubMed:24160817, PubMed:26337389).
Interacts with KPNA2 (PubMed:29042515).
Interacts with UBQLN4 (PubMed:27113755).
By similarity15 Publications(Microbial infection) Interacts with L. pneumophila Lpg2160 and LegU1 proteins.
1 PublicationBinary interactionsi
P46379
Isoform 1 [P46379-1]
| With | #Exp. | IntAct |
|---|---|---|
| NCR3 - isoform 1 [O14931-1] | 5 | EBI-9640181,EBI-15013584 |
BAG6 - isoform 2 [P46379-2]
GO - Molecular functioni
- Hsp70 protein binding Source: Ensembl
- identical protein binding Source: IntAct
- misfolded protein binding Source: ParkinsonsUK-UCL
- polyubiquitin modification-dependent protein binding Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
| BioGRIDi | 113647, 395 interactors |
| ComplexPortali | CPX-132, BAT3 complex |
| CORUMi | P46379 |
| DIPi | DIP-31191N |
| IntActi | P46379, 408 interactors |
| MINTi | P46379 |
| STRINGi | 9606.ENSP00000365131 |
Miscellaneous databases
| RNActi | P46379, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| SMRi | P46379 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P46379 |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Domaini | 17 – 92 | Ubiquitin-likePROSITE-ProRule annotationAdd BLAST | 76 | |
| Repeati | 242 – 270 | 11 PublicationAdd BLAST | 29 | |
| Repeati | 415 – 443 | 21 PublicationAdd BLAST | 29 | |
| Repeati | 574 – 602 | 31 PublicationAdd BLAST | 29 | |
| Repeati | 608 – 636 | 41 PublicationAdd BLAST | 29 |
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 87 – 126 | DisorderedSequence analysisAdd BLAST | 40 | |
| Regioni | 189 – 272 | DisorderedSequence analysisAdd BLAST | 84 | |
| Regioni | 242 – 636 | 4 X 29 AA approximate repeats1 PublicationAdd BLAST | 395 | |
| Regioni | 385 – 441 | DisorderedSequence analysisAdd BLAST | 57 | |
| Regioni | 461 – 528 | DisorderedSequence analysisAdd BLAST | 68 | |
| Regioni | 560 – 603 | DisorderedSequence analysisAdd BLAST | 44 | |
| Regioni | 651 – 692 | DisorderedSequence analysisAdd BLAST | 42 | |
| Regioni | 947 – 1132 | DisorderedSequence analysisAdd BLAST | 186 | |
| Regioni | 1010 – 1040 | Required for interaction with GET42 PublicationsAdd BLAST | 31 | |
| Regioni | 1022 – 1132 | Sufficient for the delivery of client proteins to the endoplasmic reticulum1 PublicationAdd BLAST | 111 | |
| Regioni | 1058 – 1115 | BAG-similar domain, required and sufficient for interaction with UBL4A2 PublicationsAdd BLAST | 58 |
Motif
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Motifi | 1012 – 1054 | Nuclear localization site2 PublicationsAdd BLAST | 43 |
Compositional bias
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Compositional biasi | 93 – 111 | Polar residuesSequence analysisAdd BLAST | 19 | |
| Compositional biasi | 197 – 211 | Pro residuesSequence analysisAdd BLAST | 15 | |
| Compositional biasi | 228 – 244 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
| Compositional biasi | 249 – 268 | Pro residuesSequence analysisAdd BLAST | 20 | |
| Compositional biasi | 396 – 410 | Pro residuesSequence analysisAdd BLAST | 15 | |
| Compositional biasi | 571 – 586 | Polar residuesSequence analysisAdd BLAST | 16 | |
| Compositional biasi | 654 – 683 | Pro residuesSequence analysisAdd BLAST | 30 |
Domaini
The ubiquitin-like domain mediates interaction with the E3 ubiquitin-protein ligase RNF126 which is responsible for the BAG6-dependent ubiquitination of client proteins (PubMed:21743475, PubMed:24981174, PubMed:28104892, PubMed:27193484). SGTA also binds this domain and competes with RNF126 to antagonize client protein ubiquitination and degradation (PubMed:28104892). The ubiquitin-like domain also mediates the interaction with USP13 (PubMed:24424410).5 Publications
Keywords - Domaini
RepeatPhylogenomic databases
| eggNOGi | KOG4248, Eukaryota |
| GeneTreei | ENSGT00390000016199 |
| HOGENOMi | CLU_012159_0_0_1 |
| InParanoidi | P46379 |
| OrthoDBi | 1233552at2759 |
| PhylomeDBi | P46379 |
| TreeFami | TF328437 |
Family and domain databases
| InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
| Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
| SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
| SUPFAMi | SSF54236, SSF54236, 1 hit |
| PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
Sequences (5+)i
Sequence statusi: Complete.
This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 26 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P46379-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV
60 70 80 90 100
SIPSEKQRLI YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS
110 120 130 140 150
GTGSASATHG GGSPPGTRGP GASVHDRNAN SYVMVGTFNL PSDGSAVDVH
160 170 180 190 200
INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL SRMETLPYLQ CRGGPQPQHS
210 220 230 240 250
QPPPQPPAVT PEPVALSSQT SEPVESEAPP REPMEAEEVE ERAPAQNPEL
260 270 280 290 300
TPGPAPAGPT PAPETNAPNH PSPAEYVEVL QELQRLESRL QPFLQRYYEV
310 320 330 340 350
LGAAATTDYN NNHEGREEDQ RLINLVGESL RLLGNTFVAL SDLRCNLACT
360 370 380 390 400
PPRHLHVVRP MSHYTTPMVL QQAAIPIQIN VGTTVTMTGN GTRPPPTPNA
410 420 430 440 450
EAPPPGPGQA SSVAPSSTNV ESSAEGAPPP GPAPPPATSH PRVIRISHQS
460 470 480 490 500
VEPVVMMHMN IQDSGTQPGG VPSAPTGPLG PPGHGQTLGQ QVPGFPTAPT
510 520 530 540 550
RVVIARPTPP QARPSHPGGP PVSGTLQGAG LGTNASLAQM VSGLVGQLLM
560 570 580 590 600
QPVLVAQGTP GMAPPPAPAT ASASAGTTNT ATTAGPAPGG PAQPPPTPQP
610 620 630 640 650
SMADLQFSQL LGNLLGPAGP GAGGSGVASP TITVAMPGVP AFLQGMTDFL
660 670 680 690 700
QATQTAPPPP PPPPPPPPAP EQQTMPPPGS PSGGAGSPGG LGLESLSPEF
710 720 730 740 750
FTSVVQGVLS SLLGSLGARA GSSESIAAFI QRLSGSSNIF EPGADGALGF
760 770 780 790 800
FGALLSLLCQ NFSMVDVVML LHGHFQPLQR LQPQLRSFFH QHYLGGQEPT
810 820 830 840 850
PSNIRMATHT LITGLEEYVR ESFSLVQVQP GVDIIRTNLE FLQEQFNSIA
860 870 880 890 900
AHVLHCTDSG FGARLLELCN QGLFECLALN LHCLGGQQME LAAVINGRIR
910 920 930 940 950
RMSRGVNPSL VSWLTTMMGL RLQVVLEHMP VGPDAILRYV RRVGDPPQPL
960 970 980 990 1000
PEEPMEVQGA ERASPEPQRE NASPAPGTTA EEAMSRGPPP APEGGSRDEQ
1010 1020 1030 1040 1050
DGASAETEPW AAAVPPEWVP IIQQDIQSQR KVKPQPPLSD AYLSGMPAKR
1060 1070 1080 1090 1100
RKTMQGEGPQ LLLSEAVSRA AKAAGARPLT SPESLSRDLE APEVQESYRQ
1110 1120 1130
QLRSDIQKRL QEDPNYSPQR FPNAQRAFAD DP
Computationally mapped potential isoform sequencesi
There are 26 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| A0A024RCR6 | A0A024RCR6_HUMAN | BCL2-associated athanogene 6 | BAG6 BAT3, hCG_2005629 | 1,126 | Annotation score: | ||
| F6S6P2 | F6S6P2_HUMAN | BCL2-associated athanogene 6 | BAG6 | 515 | Annotation score: | ||
| X6REW1 | X6REW1_HUMAN | BCL2-associated athanogene 6 | BAG6 | 742 | Annotation score: | ||
| A0A7I2V508 | A0A7I2V508_HUMAN | BCL2-associated athanogene 6 | BAG6 | 1,173 | Annotation score: | ||
| A0A7P0MQS5 | A0A7P0MQS5_HUMAN | BCL2-associated athanogene 6 | BAG6 | 1,100 | Annotation score: | ||
| A0A0G2JK23 | A0A0G2JK23_HUMAN | BCL2-associated athanogene 6 | BAG6 | 1,132 | Annotation score: | ||
| A0A0G2JL47 | A0A0G2JL47_HUMAN | BCL2-associated athanogene 6 | BAG6 | 1,077 | Annotation score: | ||
| A0A0G2JJM1 | A0A0G2JJM1_HUMAN | BCL2-associated athanogene 6 | BAG6 | 742 | Annotation score: | ||
| H0Y4L1 | H0Y4L1_HUMAN | Large proline-rich protein BAG6 | BAG6 | 136 | Annotation score: | ||
| H0Y7K4 | H0Y7K4_HUMAN | Large proline-rich protein BAG6 | BAG6 | 185 | Annotation score: | ||
| There are more potential isoformsShow all | |||||||
Sequence cautioni
The sequence AAD18085 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB63390 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 43 | K → R in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 47 | A → R in AAA35587 (PubMed:2156268).Curated | 1 | |
| Sequence conflicti | 150 | H → D in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 511 | Q → R in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 561 | G → D in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 617 | P → L in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 679 | G → R in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 839 | L → R in BAG63924 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 842 | L → P in BAG63924 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 853 | V → M in CAI46045 (PubMed:17974005).Curated | 1 | |
| Sequence conflicti | 854 | L → Q in BAG65616 (PubMed:14702039).Curated | 1 | |
| Sequence conflicti | 927 | E → D in BAG65616 (PubMed:14702039).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_023531 | 625 | S → P5 PublicationsCorresponds to variant dbSNP:rs1052486Ensembl. | 1 | |
| Natural variantiVAR_037150 | 728 | A → V. Corresponds to variant dbSNP:rs11548856Ensembl. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_015695 | 185 – 190 | Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 3 Publications | 6 | |
| Alternative sequenceiVSP_030519 | 489 | G → GSTLIQLPSLPPEFMHAVAH QITHQAMVAAVASAAAG in isoform 3. Curated | 1 | |
| Alternative sequenceiVSP_045910 | 527 | Missing in isoform 4. 1 Publication | 1 | |
| Alternative sequenceiVSP_045911 | 561 – 685 | Missing in isoform 4. 1 PublicationAdd BLAST | 125 | |
| Alternative sequenceiVSP_045912 | 969 – 1016 | Missing in isoform 4. 1 PublicationAdd BLAST | 48 | |
| Alternative sequenceiVSP_045913 | 1053 – 1101 | Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST | 49 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33519 mRNA Translation: AAA35587.1 M33521, M33520 Genomic DNA Translation: AAA35588.1 BX647244 mRNA Translation: CAI46045.1 AK302695 mRNA Translation: BAG63924.1 AK304879 mRNA Translation: BAG65616.1 AF129756 Genomic DNA Translation: AAD18085.1 Different initiation. BA000025 Genomic DNA Translation: BAB63390.1 Different initiation. AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR753892 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03455.1 BC003133 mRNA Translation: AAH03133.1 |
| CCDSi | CCDS4709.1 [P46379-2] CCDS56414.1 [P46379-4] CCDS56415.1 [P46379-5] |
| PIRi | A35098 |
| RefSeqi | NP_001092004.1, NM_001098534.1 [P46379-2] NP_001186626.1, NM_001199697.1 [P46379-4] NP_001186627.1, NM_001199698.1 [P46379-5] NP_004630.3, NM_004639.3 NP_542433.1, NM_080702.2 [P46379-2] NP_542434.1, NM_080703.2 [P46379-2] XP_016866776.1, XM_017011287.1 [P46379-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M33519 mRNA Translation: AAA35587.1 M33521, M33520 Genomic DNA Translation: AAA35588.1 BX647244 mRNA Translation: CAI46045.1 AK302695 mRNA Translation: BAG63924.1 AK304879 mRNA Translation: BAG65616.1 AF129756 Genomic DNA Translation: AAD18085.1 Different initiation. BA000025 Genomic DNA Translation: BAB63390.1 Different initiation. AL662801 Genomic DNA No translation available. AL662847 Genomic DNA No translation available. AL670886 Genomic DNA No translation available. AL805934 Genomic DNA No translation available. BX511262 Genomic DNA No translation available. CR354443 Genomic DNA No translation available. CR753842 Genomic DNA No translation available. CR753892 Genomic DNA No translation available. CR759761 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03455.1 BC003133 mRNA Translation: AAH03133.1 |
| CCDSi | CCDS4709.1 [P46379-2] CCDS56414.1 [P46379-4] CCDS56415.1 [P46379-5] |
| PIRi | A35098 |
| RefSeqi | NP_001092004.1, NM_001098534.1 [P46379-2] NP_001186626.1, NM_001199697.1 [P46379-4] NP_001186627.1, NM_001199698.1 [P46379-5] NP_004630.3, NM_004639.3 NP_542433.1, NM_080702.2 [P46379-2] NP_542434.1, NM_080703.2 [P46379-2] XP_016866776.1, XM_017011287.1 [P46379-3] |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1WX9 | NMR | - | A | 17-89 | [»] | |
| 2N9P | NMR | - | C | 17-101 | [»] | |
| 4DWF | X-ray | 1.80 | A/B | 13-101 | [»] | |
| 4EEW | X-ray | 1.30 | A/B | 1-87 | [»] | |
| 4WWR | X-ray | 2.00 | A/C/E/G | 1060-1111 | [»] | |
| 4X86 | X-ray | 1.85 | B | 1048-1123 | [»] | |
| 6AU8 | X-ray | 1.80 | C | 1008-1050 | [»] | |
| SMRi | P46379 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 113647, 395 interactors |
| ComplexPortali | CPX-132, BAT3 complex |
| CORUMi | P46379 |
| DIPi | DIP-31191N |
| IntActi | P46379, 408 interactors |
| MINTi | P46379 |
| STRINGi | 9606.ENSP00000365131 |
PTM databases
| GlyGeni | P46379, 2 sites, 2 O-linked glycans (2 sites) |
| iPTMneti | P46379 |
| MetOSitei | P46379 |
| PhosphoSitePlusi | P46379 |
| SwissPalmi | P46379 |
Genetic variation databases
| BioMutai | BAG6 |
| DMDMi | 76800648 |
Proteomic databases
| EPDi | P46379 |
| jPOSTi | P46379 |
| MassIVEi | P46379 |
| MaxQBi | P46379 |
| PaxDbi | P46379 |
| PeptideAtlasi | P46379 |
| PRIDEi | P46379 |
| ProteomicsDBi | 17045 29168 55736 [P46379-1] 55737 [P46379-2] 55738 [P46379-3] |
Protocols and materials databases
| Antibodypediai | 27346, 293 antibodies from 37 providers |
| DNASUi | 7917 |
Genome annotation databases
Organism-specific databases
| CTDi | 7917 |
| DisGeNETi | 7917 |
| GeneCardsi | BAG6 |
| HGNCi | HGNC:13919, BAG6 |
| HPAi | ENSG00000204463, Low tissue specificity |
| MIMi | 142590, gene |
| neXtProti | NX_P46379 |
| OpenTargetsi | ENSG00000204463 |
| PharmGKBi | PA25264 |
| VEuPathDBi | HostDB:ENSG00000204463 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG4248, Eukaryota |
| GeneTreei | ENSGT00390000016199 |
| HOGENOMi | CLU_012159_0_0_1 |
| InParanoidi | P46379 |
| OrthoDBi | 1233552at2759 |
| PhylomeDBi | P46379 |
| TreeFami | TF328437 |
Enzyme and pathway databases
| PathwayCommonsi | P46379 |
| Reactomei | R-HSA-9609523, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane |
| SignaLinki | P46379 |
Miscellaneous databases
| BioGRID-ORCSi | 7917, 40 hits in 1055 CRISPR screens |
| ChiTaRSi | BAG6, human |
| EvolutionaryTracei | P46379 |
| GeneWikii | HLA-B_associated_transcript_3 |
| GenomeRNAii | 7917 |
| Pharosi | P46379, Tbio |
| PROi | PR:P46379 |
| RNActi | P46379, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000204463, Expressed in testis and 243 other tissues |
| ExpressionAtlasi | P46379, baseline and differential |
| Genevisiblei | P46379, HS |
Family and domain databases
| InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
| Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
| SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
| SUPFAMi | SSF54236, SSF54236, 1 hit |
| PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
| MobiDBi | Search... |
Entry informationi
| Entry namei | BAG6_HUMAN | |
| Accessioni | P46379Primary (citable) accession number: P46379 Secondary accession number(s): A2ADJ7 Q9BCN4 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
| Last sequence update: | September 27, 2005 | |
| Last modified: | February 23, 2022 | |
| This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references
