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Entry version 142 (29 Sep 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Probable licABCH operon regulator

Gene

licR

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positive regulator of the licABCH operon.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The regulatory activity of LicR is modulated by phosphorylation and dephosphorylation of the various LicR domains. It becomes activated via phosphoryl group transfer from PEP, EI and HPr on the two conserved histidine residues in the PRD 2 domain, whereas phosphorylation of the EIIA-like domain on His-559 by the PTS EIIB component LicB inactivates LicR (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Kinase, RNA-binding, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU38600-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable licABCH operon regulator
Including the following 2 domains:
Putative phosphotransferase enzyme IIB component (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIB component
Putative phosphotransferase enzyme IIA component
Alternative name(s):
Putative PTS system EIIA component
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:licR
Synonyms:celR
Ordered Locus Names:BSU38600
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi219H → A: Residual activity. 1 Publication1
Mutagenesisi219H → D: Loss of activity. 1 Publication1
Mutagenesisi278H → A: Loss of activity. 1 Publication1
Mutagenesisi278H → E: Loss of activity. 1 Publication1
Mutagenesisi333H → A: Loss of activity. 1 Publication1
Mutagenesisi392H → E: Loss of activity. 1 Publication1
Mutagenesisi392H → I: Residual activity. 1 Publication1
Mutagenesisi559H → G: Increase in activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042451 – 641Probable licABCH operon regulatorAdd BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei219Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei278Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei333Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei392Phosphohistidine; by HPrPROSITE-ProRule annotation1
Modified residuei413Phosphocysteine; by EIIASequence analysis1
Modified residuei559Phosphohistidine; by EIIBPROSITE-ProRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46321

PRoteomics IDEntifications database

More...
PRIDEi
P46321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU38600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46321

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 289PRD 1PROSITE-ProRule annotationAdd BLAST106
Domaini296 – 403PRD 2PROSITE-ProRule annotationAdd BLAST108
Domaini407 – 498PTS EIIB type-2PROSITE-ProRule annotationAdd BLAST92
Domaini499 – 638PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST140

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1762, Bacteria
COG3711, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46321

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLERHYN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46321

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00211, PTS_IIA_fru, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits
3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013196, HTH_11
IPR007737, Mga_HTH
IPR011608, PRD
IPR036634, PRD_sf
IPR016152, PTrfase/Anion_transptr
IPR002178, PTS_EIIA_type-2_dom
IPR036095, PTS_EIIB-like_sf
IPR013011, PTS_EIIB_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08279, HTH_11, 1 hit
PF05043, Mga, 1 hit
PF00874, PRD, 2 hits
PF00359, PTS_EIIA_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF52794, SSF52794, 1 hit
SSF55804, SSF55804, 1 hit
SSF63520, SSF63520, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51372, PRD_2, 2 hits
PS51094, PTS_EIIA_TYPE_2, 1 hit
PS51099, PTS_EIIB_TYPE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46321-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHGRLRDIL RLLMAAEAPV TSSFFAAQLN VTTRTVRNDI KELQGVLSGH
60 70 80 90 100
GAFVQSVRGS GYKLRIDDEQ VFRTLLQDEF QQKKGLPVLP EERMAYLMKR
110 120 130 140 150
LLLADHYLKL DELAEELFIS KSTLQTDLKE VKKRLLPYRI VMETRPNYGF
160 170 180 190 200
KLRGDEVQMR YCMAEYIVDE RETEIDVLNE KADILPKEEI EIIRSAILKK
210 220 230 240 250
MKNDRIPLSN MGLNNLIIHI AIACKRIRTE NYVSLFPKDM DHILHQKEYQ
260 270 280 290 300
AAEAIVKELE SKLSVTFPKD ETAYITMHLL GTKRMTQSQC GEDTFSIEEE
310 320 330 340 350
TDQLTLAMIK AVDRELKLGI LHDKELKIGL ALHMKPAISR NRYGMNLRNP
360 370 380 390 400
MLAAIKEHYP LAFEAGIIAG IVIKEQTGIE IHENEIGYLA LHFGAAIERK
410 420 430 440 450
KTESPPKRCI IVCASGAGSA QLLREKLRSH FGKRLDILGT AEYYSLDQMS
460 470 480 490 500
YESIDFVIST IPIKKELPVP VLKVNTILGG TDFTKIESIL SDEKEKANRY
510 520 530 540 550
LKKELVFFQE DLRSKEEVIQ FLGQKVVECG FADEEIIDSI FEREDMSPTC
560 570 580 590 600
FGNLVAIPHP LVPQTKTTFW AVCTLKKPID WESQRVQFVC LLCVEKENKA
610 620 630 640
DLQSMYKLLG SILDDPAAMN QLIKCRSYQE LSDVFDQKML S
Length:641
Mass (Da):73,315
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFCEF83BFC72A0168
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49992 Genomic DNA Translation: CAA90284.1
D83026 Genomic DNA Translation: BAA11742.1
AL009126 Genomic DNA Translation: CAB15886.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H69651

NCBI Reference Sequences

More...
RefSeqi
NP_391739.1, NC_000964.3
WP_003243034.1, NZ_JNCM01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15886; CAB15886; BSU_38600

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937383

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU38600

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.4179

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49992 Genomic DNA Translation: CAA90284.1
D83026 Genomic DNA Translation: BAA11742.1
AL009126 Genomic DNA Translation: CAB15886.1
PIRiH69651
RefSeqiNP_391739.1, NC_000964.3
WP_003243034.1, NZ_JNCM01000034.1

3D structure databases

SMRiP46321
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU38600

Proteomic databases

PaxDbiP46321
PRIDEiP46321

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
937383

Genome annotation databases

EnsemblBacteriaiCAB15886; CAB15886; BSU_38600
GeneIDi937383
KEGGibsu:BSU38600
PATRICifig|224308.179.peg.4179

Phylogenomic databases

eggNOGiCOG1762, Bacteria
COG3711, Bacteria
InParanoidiP46321
OMAiGLERHYN
PhylomeDBiP46321

Enzyme and pathway databases

BioCyciBSUB:BSU38600-MONOMER

Family and domain databases

CDDicd00211, PTS_IIA_fru, 1 hit
Gene3Di1.10.10.10, 2 hits
3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013196, HTH_11
IPR007737, Mga_HTH
IPR011608, PRD
IPR036634, PRD_sf
IPR016152, PTrfase/Anion_transptr
IPR002178, PTS_EIIA_type-2_dom
IPR036095, PTS_EIIB-like_sf
IPR013011, PTS_EIIB_2
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF08279, HTH_11, 1 hit
PF05043, Mga, 1 hit
PF00874, PRD, 2 hits
PF00359, PTS_EIIA_2, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF52794, SSF52794, 1 hit
SSF55804, SSF55804, 1 hit
SSF63520, SSF63520, 2 hits
PROSITEiView protein in PROSITE
PS51372, PRD_2, 2 hits
PS51094, PTS_EIIA_TYPE_2, 1 hit
PS51099, PTS_EIIB_TYPE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLICR_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46321
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 29, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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