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Entry version 153 (07 Apr 2021)
Sequence version 2 (02 Nov 2001)
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Protein

60S ribosomal protein L8-1

Gene

RPL8A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L8-1
Alternative name(s):
60S ribosomal protein L2
Protein EMBRYO DEFECTIVE 2296
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL8A
Synonyms:EMB2296, RPL2
Ordered Locus Names:At2g18020
ORF Names:T27K22.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G18020

The Arabidopsis Information Resource

More...
TAIRi
locus:2060917, AT2G18020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001297331 – 25860S ribosomal protein L8-1Add BLAST258

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46286

PRoteomics IDEntifications database

More...
PRIDEi
P46286

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228120

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46286

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P46286, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46286, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1671, 21 interactors

Protein interaction database and analysis system

More...
IntActi
P46286, 12 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT2G18020.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P46286

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2309, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036235_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46286

Identification of Orthologs from Complete Genome Data

More...
OMAi
IGHNPEE

Database of Orthologous Groups

More...
OrthoDBi
1156335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46286

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit
4.10.950.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01320_A, Ribosomal_L2_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022666, Rbsml_prot_L2_RNA-bd_dom
IPR014722, Rib_L2_dom2
IPR002171, Ribosomal_L2
IPR023672, Ribosomal_L2_arc
IPR022669, Ribosomal_L2_C
IPR022671, Ribosomal_L2_CS
IPR014726, Ribosomal_L2_dom3
IPR008991, Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13691, PTHR13691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00181, Ribosomal_L2, 1 hit
PF03947, Ribosomal_L2_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002158, Ribosomal_L2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01383, Ribosomal_L2, 1 hit
SM01382, Ribosomal_L2_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104, SSF50104, 1 hit
SSF50249, SSF50249, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00467, RIBOSOMAL_L2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46286-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRVIRAQRK GAGSVFKSHT HHRKGPAKFR SLDFGERNGY LKGVVTEIIH
60 70 80 90 100
DPGRGAPLAR VTFRHPFRFK KQKELFVAAE GMYTGQFLYC GKKATLVVGN
110 120 130 140 150
VLPLRSIPEG AVVCNVEHHV GDRGVLARAS GDYAIVIAHN PDSDTTRIKL
160 170 180 190 200
PSGSKKIVPS GCRAMIGQVA GGGRTEKPML KAGNAYHKYR VKRNSWPKVR
210 220 230 240 250
GVAMNPVEHP HGGGNHQHIG HASTVRRDAP PGQKVGLIAA RRTGRLRGQA

AASAAKAD
Length:258
Mass (Da):27,859
Last modified:November 2, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC88C5942DF9AC4B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81 – 87GMYTGQF → VCTPVSS in CAA60445 (Ref. 1) Curated7
Sequence conflicti139H → E in CAA60445 (Ref. 1) Curated1
Sequence conflicti162C → S in CAA60445 (Ref. 1) Curated1
Sequence conflicti222A → S in CAA60445 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X86765 mRNA Translation: CAA60445.1
AC006201 Genomic DNA Translation: AAD20124.1
CP002685 Genomic DNA Translation: AEC06716.1
AY128314 mRNA Translation: AAM91517.1
BT001177 mRNA Translation: AAN65064.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C84559

NCBI Reference Sequences

More...
RefSeqi
NP_179393.1, NM_127358.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G18020.1; AT2G18020.1; AT2G18020

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
816314

Gramene; a comparative resource for plants

More...
Gramenei
AT2G18020.1; AT2G18020.1; AT2G18020

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G18020

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86765 mRNA Translation: CAA60445.1
AC006201 Genomic DNA Translation: AAD20124.1
CP002685 Genomic DNA Translation: AEC06716.1
AY128314 mRNA Translation: AAM91517.1
BT001177 mRNA Translation: AAN65064.1
PIRiC84559
RefSeqiNP_179393.1, NM_127358.6

3D structure databases

SMRiP46286
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1671, 21 interactors
IntActiP46286, 12 interactors
STRINGi3702.AT2G18020.1

PTM databases

iPTMnetiP46286

Proteomic databases

PaxDbiP46286
PRIDEiP46286
ProteomicsDBi228120

Genome annotation databases

EnsemblPlantsiAT2G18020.1; AT2G18020.1; AT2G18020
GeneIDi816314
GrameneiAT2G18020.1; AT2G18020.1; AT2G18020
KEGGiath:AT2G18020

Organism-specific databases

AraportiAT2G18020
TAIRilocus:2060917, AT2G18020

Phylogenomic databases

eggNOGiKOG2309, Eukaryota
HOGENOMiCLU_036235_0_3_1
InParanoidiP46286
OMAiIGHNPEE
OrthoDBi1156335at2759
PhylomeDBiP46286

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P46286

Gene expression databases

ExpressionAtlasiP46286, baseline and differential
GenevisibleiP46286, AT

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_A, Ribosomal_L2_A, 1 hit
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022666, Rbsml_prot_L2_RNA-bd_dom
IPR014722, Rib_L2_dom2
IPR002171, Ribosomal_L2
IPR023672, Ribosomal_L2_arc
IPR022669, Ribosomal_L2_C
IPR022671, Ribosomal_L2_CS
IPR014726, Ribosomal_L2_dom3
IPR008991, Translation_prot_SH3-like_sf
PANTHERiPTHR13691, PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181, Ribosomal_L2, 1 hit
PF03947, Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158, Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383, Ribosomal_L2, 1 hit
SM01382, Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104, SSF50104, 1 hit
SSF50249, SSF50249, 1 hit
PROSITEiView protein in PROSITE
PS00467, RIBOSOMAL_L2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL81_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46286
Secondary accession number(s): Q9SL44
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2001
Last modified: April 7, 2021
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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