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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme 1

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase 1, chloroplastic, Fructose-bisphosphate aldolase 2, chloroplastic, Fructose-bisphosphate aldolase, cytoplasmic isozyme 2, Fructose-bisphosphate aldolase, cytoplasmic isozyme 1
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Active sitei183Proton acceptorBy similarity1
Active sitei225Schiff-base intermediate with dihydroxyacetone-PBy similarity1
Sitei357Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme 1 (EC:4.1.2.13)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeHologaleginaIRL cladeFabeaePisum

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169231 – 357Fructose-bisphosphate aldolase, cytoplasmic isozyme 1Add BLAST357

Proteomic databases

PRIDEiP46256

Structurei

3D structure databases

ProteinModelPortaliP46256
SMRiP46256
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P46256-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFVGKYAD ELIKNAKYIA TPGKGILAAD ESTGTIGKRL ASINVENIEA
60 70 80 90 100
NRQALRELLF TSPNALQYLS GVILFEETLY QKSSEGKPFV EILQENNVIP
110 120 130 140 150
GIKVDKGVVE LAGTDGETTT QGFDSLGARC QQYYKAGARF AKWRAVLKIG
160 170 180 190 200
PNEPSELSIQ QNAQGLARYA IICQENGLVL FVEPEILTDG SHDIAKCAAV
210 220 230 240 250
TETVLAACYK ALNDQHVLLE GTLLKPNMVT PGSDSPKVSP EVIGEYTVNA
260 270 280 290 300
LRRTVPAAVP GIVFLSGGQS EEQATLNLNA MNKFDVVKPW TLSFSFGRAL
310 320 330 340 350
QQSTLKTWSG KKENVGKAQD VFLARCKANS EATLGKYGGG SGTGLASESL

HVKDYKY
Length:357
Mass (Da):38,446
Last modified:November 1, 1995 - v1
Checksum:iBB30E70BA0401D61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89828 mRNA Translation: CAA61946.1
PIRiS58168

Similar proteinsi

Entry informationi

Entry nameiALF1_PEA
AccessioniPrimary (citable) accession number: P46256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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