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Protein

Endoglucanase type C

Gene
N/A
Organism
Fusarium oxysporum (Fusarium vascular wilt)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei215NucleophileBy similarity1
Active sitei220Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH7 Glycoside Hydrolase Family 7
mycoCLAPiEGL7A_FUSOX

Names & Taxonomyi

Protein namesi
Recommended name:
Endoglucanase type C (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Endoglucanase I
Short name:
EG I
OrganismiFusarium oxysporum (Fusarium vascular wilt)
Taxonomic identifieri5507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium oxysporum species complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000791219 – 429Endoglucanase type CAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi36 ↔ 42
Disulfide bondi66 ↔ 88
Glycosylationi74N-linked (GlcNAc...) asparagine1
Disulfide bondi78 ↔ 84
Disulfide bondi156 ↔ 383
Disulfide bondi190 ↔ 213
Disulfide bondi194 ↔ 212
Disulfide bondi233 ↔ 252
Disulfide bondi241 ↔ 246
Disulfide bondi257 ↔ 333
Glycosylationi265N-linked (GlcNAc...) asparagine1
Glycosylationi318N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP46237
SMRiP46237
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46237

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUY5 Eukaryota
ENOG410YC82 LUCA

Family and domain databases

CDDicd07999 GH7_CBH_EG, 1 hit
Gene3Di2.70.100.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001722 Glyco_hydro_7
IPR037019 Glyco_hydro_7_sf
PANTHERiPTHR33753 PTHR33753, 1 hit
PfamiView protein in Pfam
PF00840 Glyco_hydro_7, 1 hit
PRINTSiPR00734 GLHYDRLASE7
SUPFAMiSSF49899 SSF49899, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P46237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLSLILSA LAVQVAVAQT PDKAKEQHPK LETYRCTKAS GCKKQTNYIV
60 70 80 90 100
ADAGIHGIRQ KNGAGCGDWG QKPNATACPD EASCAKNCIL SGMDSNAYKN
110 120 130 140 150
AGITTSGNKL RLQQLINNQL VSPRVYLLEE NKKKYEMLHL TGTEFSFDVE
160 170 180 190 200
MEKLPCGMNG ALYLSEMPQD GGKSTSRNSK AGAYYGAGYC DAQCYVTPFI
210 220 230 240 250
NGVGNIKGQG VCCNELDIWE ANSRATHIAP HPCSKPGLYG CTGDECGSSG
260 270 280 290 300
ICDKAGCGWN HNRINVTDFY GRGKQYKVDS TRKFTVTSQF VANKQGDLIE
310 320 330 340 350
LHRHYIQDNK VIESAVVNIS GPPKINFIND KYCAATGANE YMRLGGTKQM
360 370 380 390 400
GDAMSRGMVL AMSVWWSEGD FMAWLDQGVA GPCDATEGDP KNIVKVQPNP
410 420
EVTFSNIRIG EIGSTSSVKA PAYPGPHRL
Length:429
Mass (Da):46,445
Last modified:November 1, 1995 - v1
Checksum:iFAE8A880B1F880F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29378 mRNA Translation: AAA65586.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29378 mRNA Translation: AAA65586.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OVWX-ray2.70A/B/C/D20-416[»]
2OVWX-ray2.30A/B/C/D20-429[»]
3OVWX-ray2.30A/B20-429[»]
4OVWX-ray2.30A/B20-429[»]
ProteinModelPortaliP46237
SMRiP46237
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH7 Glycoside Hydrolase Family 7
mycoCLAPiEGL7A_FUSOX

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IUY5 Eukaryota
ENOG410YC82 LUCA

Miscellaneous databases

EvolutionaryTraceiP46237

Family and domain databases

CDDicd07999 GH7_CBH_EG, 1 hit
Gene3Di2.70.100.10, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001722 Glyco_hydro_7
IPR037019 Glyco_hydro_7_sf
PANTHERiPTHR33753 PTHR33753, 1 hit
PfamiView protein in Pfam
PF00840 Glyco_hydro_7, 1 hit
PRINTSiPR00734 GLHYDRLASE7
SUPFAMiSSF49899 SSF49899, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGUNC_FUSOX
AccessioniPrimary (citable) accession number: P46237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 20, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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