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UniProtKB - P46223 (RL7A_DROME)
Protein
60S ribosomal protein L7a
Gene
RpL7A
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: FlyBase
GO - Biological processi
- cytoplasmic translation Source: FlyBase
- maturation of LSU-rRNA Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane R-DME-72689, Formation of a pool of free 40S subunits R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P46223 |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L7a |
Gene namesi | Name:RpL7A Synonyms:SURF-3 ORF Names:CG3314 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0014026, RpL7A |
VEuPathDBi | VectorBase:FBgn0014026 |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: GO_Central
- cytosolic ribosome Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000136755 | 1 – 271 | 60S ribosomal protein L7aAdd BLAST | 271 |
Proteomic databases
PaxDbi | P46223 |
PRIDEi | P46223 |
Expressioni
Gene expression databases
Bgeei | FBgn0014026, Expressed in embryo and 38 other tissues |
ExpressionAtlasi | P46223, baseline and differential |
Genevisiblei | P46223, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 58075, 125 interactors |
IntActi | P46223, 2 interactors |
MINTi | P46223 |
STRINGi | 7227.FBpp0070877 |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL8 family.Curated
Phylogenomic databases
eggNOGi | KOG3166, Eukaryota |
HOGENOMi | CLU_055193_0_1_1 |
InParanoidi | P46223 |
OMAi | RYVKWPK |
OrthoDBi | 1200503at2759 |
PhylomeDBi | P46223 |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064, L30e-like IPR001921, Ribosomal_L7A/L8 IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492, Ribosomal_L7Ae/L8/Nhp2 IPR004037, Ribosomal_L7Ae_CS |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
PRINTSi | PR00881, L7ARS6FAMILY PR00882, RIBOSOMALL7A |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS01082, RIBOSOMAL_L7AE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P46223-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVVKKPRPKK KPVTKKVAPA PLAVKKPVVK KVVNQLFEKR PKNFGIGQNV
60 70 80 90 100
QPKRDLSRFV RWPKYIRVQR QKAVLQKRLK VPPPIHQFSQ TLDKTTAVKL
110 120 130 140 150
FKLLEKYRPE SPLAKKLRLK KIAEAKAKGK DVEPKKKPSY VSAGTNTVTK
160 170 180 190 200
LIEQKKAQLV VIAHDVDPLE LVLFLPALCR KMGVPYCIVK GKARLGRLVR
210 220 230 240 250
RKTCTTLALT TVDNNDKANF GKVLEAVKTN FNERHEEIRR HWGGGILGSK
260 270
SLARISKLER AKARELAQKQ G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX2JCS6 | X2JCS6_DROME | 60S ribosomal protein L7a | RpL7A Dmel\CG3314, L7A, L7a, Rp L7A, RPL7a | 271 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 112 | P → A in CAA58023 (PubMed:7739520).Curated | 1 | |
Sequence conflicti | 116 – 117 | KL → NV in CAA58023 (PubMed:7739520).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82782 Genomic DNA Translation: CAA58023.1 AE014298 Genomic DNA Translation: AAF46169.1 AE014298 Genomic DNA Translation: AAN09170.1 AE014298 Genomic DNA Translation: AAN09172.1 AY089570 mRNA Translation: AAL90308.1 |
PIRi | A57416 |
RefSeqi | NP_001284944.1, NM_001298015.1 NP_001284945.1, NM_001298016.1 NP_511063.1, NM_078508.6 NP_727094.1, NM_167073.3 NP_727096.1, NM_167075.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0070915; FBpp0070877; FBgn0014026 FBtr0070916; FBpp0070878; FBgn0014026 FBtr0343328; FBpp0309986; FBgn0014026 FBtr0343329; FBpp0309987; FBgn0014026 FBtr0345293; FBpp0311460; FBgn0014026 |
GeneIDi | 31588 |
KEGGi | dme:Dmel_CG3314 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82782 Genomic DNA Translation: CAA58023.1 AE014298 Genomic DNA Translation: AAF46169.1 AE014298 Genomic DNA Translation: AAN09170.1 AE014298 Genomic DNA Translation: AAN09172.1 AY089570 mRNA Translation: AAL90308.1 |
PIRi | A57416 |
RefSeqi | NP_001284944.1, NM_001298015.1 NP_001284945.1, NM_001298016.1 NP_511063.1, NM_078508.6 NP_727094.1, NM_167073.3 NP_727096.1, NM_167075.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V6W | electron microscopy | 6.00 | CG | 1-271 | [»] | |
6XU6 | electron microscopy | 3.50 | CG | 31-271 | [»] | |
6XU7 | electron microscopy | 4.90 | CG | 31-271 | [»] | |
6XU8 | electron microscopy | 3.00 | CG | 31-271 | [»] | |
SMRi | P46223 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 58075, 125 interactors |
IntActi | P46223, 2 interactors |
MINTi | P46223 |
STRINGi | 7227.FBpp0070877 |
Proteomic databases
PaxDbi | P46223 |
PRIDEi | P46223 |
Protocols and materials databases
DNASUi | 31588 |
Genome annotation databases
EnsemblMetazoai | FBtr0070915; FBpp0070877; FBgn0014026 FBtr0070916; FBpp0070878; FBgn0014026 FBtr0343328; FBpp0309986; FBgn0014026 FBtr0343329; FBpp0309987; FBgn0014026 FBtr0345293; FBpp0311460; FBgn0014026 |
GeneIDi | 31588 |
KEGGi | dme:Dmel_CG3314 |
Organism-specific databases
CTDi | 6130 |
FlyBasei | FBgn0014026, RpL7A |
VEuPathDBi | VectorBase:FBgn0014026 |
Phylogenomic databases
eggNOGi | KOG3166, Eukaryota |
HOGENOMi | CLU_055193_0_1_1 |
InParanoidi | P46223 |
OMAi | RYVKWPK |
OrthoDBi | 1200503at2759 |
PhylomeDBi | P46223 |
Enzyme and pathway databases
Reactomei | R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane R-DME-72689, Formation of a pool of free 40S subunits R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P46223 |
Miscellaneous databases
BioGRID-ORCSi | 31588, 1 hit in 1 CRISPR screen |
ChiTaRSi | RpL7A, fly |
GenomeRNAii | 31588 |
PROi | PR:P46223 |
Gene expression databases
Bgeei | FBgn0014026, Expressed in embryo and 38 other tissues |
ExpressionAtlasi | P46223, baseline and differential |
Genevisiblei | P46223, DM |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064, L30e-like IPR001921, Ribosomal_L7A/L8 IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492, Ribosomal_L7Ae/L8/Nhp2 IPR004037, Ribosomal_L7Ae_CS |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
PRINTSi | PR00881, L7ARS6FAMILY PR00882, RIBOSOMALL7A |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS01082, RIBOSOMAL_L7AE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL7A_DROME | |
Accessioni | P46223Primary (citable) accession number: P46223 Secondary accession number(s): A4V411, Q9W3Z2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | September 27, 2005 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families