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UniProtKB - P46223 (RL7A_DROME)

Entry version 143 (12 Aug 2020)
Sequence version 2 (27 Sep 2005)
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Protein

60S ribosomal protein L7a

Gene

RpL7A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DME-72689, Formation of a pool of free 40S subunits
R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L7a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RpL7A
Synonyms:SURF-3
ORF Names:CG3314
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0014026, RpL7A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001367551 – 27160S ribosomal protein L7aAdd BLAST271

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46223

PRoteomics IDEntifications database

More...PRIDEi		P46223

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0014026, Expressed in embryo and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P46223, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P46223, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		58075, 125 interactors

Protein interaction database and analysis system

More...IntActi		P46223, 2 interactors

Molecular INTeraction database

More...MINTi		P46223

STRING: functional protein association networks

More...STRINGi		7227.FBpp0070877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic ribosomal protein eL8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3166, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055193_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46223

KEGG Orthology (KO)

More...KOi		K02936

Identification of Orthologs from Complete Genome Data

More...OMAi		RYVKWPK

Database of Orthologous Groups

More...OrthoDBi		1200503at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46223

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1330.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029064, L30e-like
IPR001921, Ribosomal_L7A/L8
IPR038524, Ribosomal_L7A/L8_sf
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492, Ribosomal_L7Ae/L8/Nhp2
IPR004037, Ribosomal_L7Ae_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00881, L7ARS6FAMILY
PR00882, RIBOSOMALL7A

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55315, SSF55315, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01082, RIBOSOMAL_L7AE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P46223-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVKKPRPKK KPVTKKVAPA PLAVKKPVVK KVVNQLFEKR PKNFGIGQNV 
        60         70         80         90        100
QPKRDLSRFV RWPKYIRVQR QKAVLQKRLK VPPPIHQFSQ TLDKTTAVKL 
       110        120        130        140        150
FKLLEKYRPE SPLAKKLRLK KIAEAKAKGK DVEPKKKPSY VSAGTNTVTK 
       160        170        180        190        200
LIEQKKAQLV VIAHDVDPLE LVLFLPALCR KMGVPYCIVK GKARLGRLVR 
       210        220        230        240        250
RKTCTTLALT TVDNNDKANF GKVLEAVKTN FNERHEEIRR HWGGGILGSK 
       260        270 
SLARISKLER AKARELAQKQ G
Length:271
Mass (Da):30,732
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA31E9735E891E479
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JCS6X2JCS6_DROME
60S ribosomal protein L7a
RpL7A Dmel\CG3314, L7A, L7a, Rp L7A, RPL7a
271Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti112P → A in CAA58023 (PubMed:7739520).Curated1
Sequence conflicti116 – 117KL → NV in CAA58023 (PubMed:7739520).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X82782 Genomic DNA Translation: CAA58023.1
AE014298 Genomic DNA Translation: AAF46169.1
AE014298 Genomic DNA Translation: AAN09170.1
AE014298 Genomic DNA Translation: AAN09172.1
AY089570 mRNA Translation: AAL90308.1

Protein sequence database of the Protein Information Resource

More...PIRi		A57416

NCBI Reference Sequences

More...RefSeqi		NP_001284944.1, NM_001298015.1
NP_001284945.1, NM_001298016.1
NP_511063.1, NM_078508.6
NP_727094.1, NM_167073.3
NP_727096.1, NM_167075.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0070915; FBpp0070877; FBgn0014026
FBtr0070916; FBpp0070878; FBgn0014026
FBtr0343328; FBpp0309986; FBgn0014026
FBtr0343329; FBpp0309987; FBgn0014026
FBtr0345293; FBpp0311460; FBgn0014026

Database of genes from NCBI RefSeq genomes

More...GeneIDi		31588

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG3314

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82782 Genomic DNA Translation: CAA58023.1
AE014298 Genomic DNA Translation: AAF46169.1
AE014298 Genomic DNA Translation: AAN09170.1
AE014298 Genomic DNA Translation: AAN09172.1
AY089570 mRNA Translation: AAL90308.1
PIRiA57416
RefSeqiNP_001284944.1, NM_001298015.1
NP_001284945.1, NM_001298016.1
NP_511063.1, NM_078508.6
NP_727094.1, NM_167073.3
NP_727096.1, NM_167075.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CG1-271[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi58075, 125 interactors
IntActiP46223, 2 interactors
MINTiP46223
STRINGi7227.FBpp0070877

Proteomic databases

PaxDbiP46223
PRIDEiP46223

Genome annotation databases

EnsemblMetazoaiFBtr0070915; FBpp0070877; FBgn0014026
FBtr0070916; FBpp0070878; FBgn0014026
FBtr0343328; FBpp0309986; FBgn0014026
FBtr0343329; FBpp0309987; FBgn0014026
FBtr0345293; FBpp0311460; FBgn0014026
GeneIDi31588
KEGGidme:Dmel_CG3314

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6130
FlyBaseiFBgn0014026, RpL7A

Phylogenomic databases

eggNOGiKOG3166, Eukaryota
HOGENOMiCLU_055193_0_1_1
InParanoidiP46223
KOiK02936
OMAiRYVKWPK
OrthoDBi1200503at2759
PhylomeDBiP46223

Enzyme and pathway databases

ReactomeiR-DME-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339, SRP-dependent cotranslational protein targeting to membrane
R-DME-72689, Formation of a pool of free 40S subunits
R-DME-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		31588, 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RpL7A, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		31588

Protein Ontology

More...PROi		PR:P46223

Gene expression databases

BgeeiFBgn0014026, Expressed in embryo and 38 other tissues
ExpressionAtlasiP46223, baseline and differential
GenevisibleiP46223, DM

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064, L30e-like
IPR001921, Ribosomal_L7A/L8
IPR038524, Ribosomal_L7A/L8_sf
IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492, Ribosomal_L7Ae/L8/Nhp2
IPR004037, Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248, Ribosomal_L7Ae, 1 hit
PRINTSiPR00881, L7ARS6FAMILY
PR00882, RIBOSOMALL7A
SUPFAMiSSF55315, SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082, RIBOSOMAL_L7AE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL7A_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46223
Secondary accession number(s): A4V411, Q9W3Z2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 27, 2005
Last modified: August 12, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
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