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Protein

60S ribosomal protein L7a

Gene

RpL7A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • maturation of LSU-rRNA Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Gene namesi
Name:RpL7A
Synonyms:SURF-3
ORF Names:CG3314
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0014026 RpL7A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367551 – 27160S ribosomal protein L7aAdd BLAST271

Proteomic databases

PaxDbiP46223
PRIDEiP46223

Expressioni

Gene expression databases

BgeeiFBgn0014026
ExpressionAtlasiP46223 baseline and differential
GenevisibleiP46223 DM

Interactioni

Protein-protein interaction databases

BioGridi58075, 40 interactors
IntActiP46223, 2 interactors
MINTiP46223
STRINGi7227.FBpp0070877

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CG1-271[»]
ProteinModelPortaliP46223
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3166 Eukaryota
COG1358 LUCA
InParanoidiP46223
KOiK02936
OMAiRQRSILY
OrthoDBiEOG091G0HPD
PhylomeDBiP46223

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR001921 Ribosomal_L7A/L8
IPR038524 Ribosomal_L7A/L8_sf
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00882 RIBOSOMALL7A
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

P46223-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVKKPRPKK KPVTKKVAPA PLAVKKPVVK KVVNQLFEKR PKNFGIGQNV
60 70 80 90 100
QPKRDLSRFV RWPKYIRVQR QKAVLQKRLK VPPPIHQFSQ TLDKTTAVKL
110 120 130 140 150
FKLLEKYRPE SPLAKKLRLK KIAEAKAKGK DVEPKKKPSY VSAGTNTVTK
160 170 180 190 200
LIEQKKAQLV VIAHDVDPLE LVLFLPALCR KMGVPYCIVK GKARLGRLVR
210 220 230 240 250
RKTCTTLALT TVDNNDKANF GKVLEAVKTN FNERHEEIRR HWGGGILGSK
260 270
SLARISKLER AKARELAQKQ G
Length:271
Mass (Da):30,732
Last modified:September 27, 2005 - v2
Checksum:iA31E9735E891E479
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112P → A in CAA58023 (PubMed:7739520).Curated1
Sequence conflicti116 – 117KL → NV in CAA58023 (PubMed:7739520).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82782 Genomic DNA Translation: CAA58023.1
AE014298 Genomic DNA Translation: AAF46169.1
AE014298 Genomic DNA Translation: AAN09170.1
AE014298 Genomic DNA Translation: AAN09172.1
AY089570 mRNA Translation: AAL90308.1
PIRiA57416
RefSeqiNP_001284944.1, NM_001298015.1
NP_001284945.1, NM_001298016.1
NP_511063.1, NM_078508.6
NP_727094.1, NM_167073.3
NP_727096.1, NM_167075.2
UniGeneiDm.7159

Genome annotation databases

EnsemblMetazoaiFBtr0070915; FBpp0070877; FBgn0014026
FBtr0070916; FBpp0070878; FBgn0014026
FBtr0343328; FBpp0309986; FBgn0014026
FBtr0343329; FBpp0309987; FBgn0014026
FBtr0345293; FBpp0311460; FBgn0014026
GeneIDi31588
KEGGidme:Dmel_CG3314

Similar proteinsi

Entry informationi

Entry nameiRL7A_DROME
AccessioniPrimary (citable) accession number: P46223
Secondary accession number(s): A4V411, Q9W3Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 27, 2005
Last modified: May 23, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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