UniProtKB - P46187 (RSEC_ECOLI)
Protein
Protein RseC
Gene
rseC
Organism
Escherichia coli (strain K12)
Status
Functioni
May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex.1 Publication
Miscellaneous
Part of the rseD-rpoE-rseA-rseB-rseC operon (PubMed:9159522, PubMed:9159523, PubMed:28924029).3 Publications
Caution
Was originally suggested to positively regulate sigma-E activity in vitro.1 Publication
GO - Biological processi
- response to oxidative stress Source: EcoCyc
Enzyme and pathway databases
BioCyci | EcoCyc:G7347-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Protein RseCCurated |
Gene namesi | Name:rseC2 Publications Ordered Locus Names:b2570, JW2554 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 72 | Cytoplasmic1 PublicationAdd BLAST | 72 | |
Transmembranei | 73 – 95 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 96 – 98 | Periplasmic1 Publication | 3 | |
Transmembranei | 99 – 121 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 122 – 159 | Cytoplasmic1 PublicationAdd BLAST | 38 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
According to PubMed:9159522, insertion mutant shows a modest reduction in sigma-E (rpoE) activity. However, PubMed:9159523 shows that deletion of the gene has no effect on sigma-E activity (PubMed:9159522, PubMed:9159523). Deletion of the gene enhances soxS expression (PubMed:12773378). Mutant shows increased motility and biofilm formation (PubMed:18344336). Deletion mutant is more sensitive than wild-type specifically to hydrogen peroxide exposure, but not other stresses (PubMed:24580753).5 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097483 | 1 – 159 | Protein RseCAdd BLAST | 159 |
Proteomic databases
PaxDbi | P46187 |
PRIDEi | P46187 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260599, 11 interactors |
STRINGi | 511145.b2570 |
Family & Domainsi
Sequence similaritiesi
Belongs to the RseC family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG3086, Bacteria |
HOGENOMi | CLU_124911_0_0_6 |
InParanoidi | P46187 |
Family and domain databases
InterProi | View protein in InterPro IPR026268, RseC IPR007359, SigmaE_reg_RseC_MucC |
PANTHERi | PTHR35867, PTHR35867, 1 hit |
PIRSFi | PIRSF004923, RseC, 1 hit |
i Sequence
Sequence statusi: Complete.
P46187-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKEWATVVS WQNGQALVSC DVKASCSSCA SRAGCGSRVL NKLGPQTTHT
60 70 80 90 100
IVVPCDEPLV PGQKVELGIA EGSLLSSALL VYMSPLVGLF LIASLFQLLF
110 120 130 140 150
ASDVAALCGA ILGGIGGFLI ARGYSRKFAA RAEWQPIILS VALPPGLVRF
ETSSEDASQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37089 Genomic DNA Translation: AAC45317.1 U37455 Genomic DNA Translation: AAC45320.1 D64044 Genomic DNA Translation: BAA10917.1 U00096 Genomic DNA Translation: AAC75623.1 AP009048 Genomic DNA Translation: BAE76746.1 |
PIRi | I83299 |
RefSeqi | NP_417065.1, NC_000913.3 WP_000589068.1, NZ_STEB01000011.1 |
Genome annotation databases
EnsemblBacteriai | AAC75623; AAC75623; b2570 BAE76746; BAE76746; BAE76746 |
GeneIDi | 947052 |
KEGGi | ecj:JW2554 eco:b2570 |
PATRICi | fig|1411691.4.peg.4164 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37089 Genomic DNA Translation: AAC45317.1 U37455 Genomic DNA Translation: AAC45320.1 D64044 Genomic DNA Translation: BAA10917.1 U00096 Genomic DNA Translation: AAC75623.1 AP009048 Genomic DNA Translation: BAE76746.1 |
PIRi | I83299 |
RefSeqi | NP_417065.1, NC_000913.3 WP_000589068.1, NZ_STEB01000011.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260599, 11 interactors |
STRINGi | 511145.b2570 |
Proteomic databases
PaxDbi | P46187 |
PRIDEi | P46187 |
Genome annotation databases
EnsemblBacteriai | AAC75623; AAC75623; b2570 BAE76746; BAE76746; BAE76746 |
GeneIDi | 947052 |
KEGGi | ecj:JW2554 eco:b2570 |
PATRICi | fig|1411691.4.peg.4164 |
Organism-specific databases
EchoBASEi | EB2970 |
Phylogenomic databases
eggNOGi | COG3086, Bacteria |
HOGENOMi | CLU_124911_0_0_6 |
InParanoidi | P46187 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7347-MONOMER |
Miscellaneous databases
PROi | PR:P46187 |
Family and domain databases
InterProi | View protein in InterPro IPR026268, RseC IPR007359, SigmaE_reg_RseC_MucC |
PANTHERi | PTHR35867, PTHR35867, 1 hit |
PIRSFi | PIRSF004923, RseC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RSEC_ECOLI | |
Accessioni | P46187Primary (citable) accession number: P46187 Secondary accession number(s): Q2MAG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families