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Protein

Transcription factor GATA-6

Gene

Gata6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
DNA-binding protein GATA-GT2
GATA-binding factor 6
Gene namesi
Name:Gata6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2666 Gata6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834261 – 587Transcription factor GATA-6Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266PhosphoserineCombined sources1
Cross-linki423Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP46153
PRIDEiP46153

PTM databases

iPTMnetiP46153
PhosphoSitePlusiP46153

Expressioni

Tissue specificityi

Expressed predominantly in gastric mucosa and at much lower levels in the intestine.

Interactioni

Subunit structurei

Interacts with LMCD1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247966, 1 interactor
STRINGi10116.ENSRNOP00000036967

Structurei

3D structure databases

SMRiP46153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi173 – 183Poly-AlaAdd BLAST11
Compositional biasi322 – 328Poly-His7
Compositional biasi443 – 447Poly-Thr5

Domaini

The GATA-type zinc fingers mediate interaction with LMCD1.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri384 – 408GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri438 – 462GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiP46153
KOiK17897
PhylomeDBiP46153

Family and domain databases

CDDicd00202 ZnF_GATA, 2 hits
Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR039355 Transcription_factor_GATA
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071 PTHR10071, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P46153-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG
60 70 80 90 100
DRGPCGASNC RTPQLDTEAV AGPPGRSLLL SPYTSHPFAA AHGAAAPGVA
110 120 130 140 150
GPGSALSTWE DLLLFTDLDQ AATASKLLWS SRGAKLSPFA AEQPEEMYQT
160 170 180 190 200
LAALSSQGPA AYDGAPGGFV HSAAAAAAAA AAASSPVYVP TTRVGSMLPG
210 220 230 240 250
LPYLQGAGSG PSNHAGGAGA HPGWPQASAD SPPYGGGGAA GGGAAGPGGA
260 270 280 290 300
GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGAGAGS VSGGGGSLAA
310 320 330 340 350
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMGAPLT PAWPAGPFET
360 370 380 390 400
PVLHSLQSRA GAPLPVPRGP SADLLEDLSE SRECVNCGSI QTPLWRRDGT
410 420 430 440 450
GHYLCNACGL YSKMNGLSRP LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR
460 470 480 490 500
RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NINKSKACSG
510 520 530 540 550
NSSVPMTPTS SSSNSDDCTK NTSPPTQSTA SGVGASVMSA VGESANPENS
560 570 580
DLKYSGQDGL YIGVSLSSPA EVTSSVRQDS WCALALA
Length:587
Mass (Da):59,168
Last modified:November 25, 2008 - v2
Checksum:i2D1C1515B66B1BCE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M7P7F1M7P7_RAT
Transcription factor GATA-6
Gata6
586Annotation score:
A0A0G2JXX6A0A0G2JXX6_RAT
Transcription factor GATA-6
Gata6
438Annotation score:

Sequence cautioni

The sequence AAA92577 differs from that shown. Reason: Frameshift at positions 430 and 432.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431S → I in AAA92577 (PubMed:8248184).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109887 Genomic DNA No translation available.
AABR03111467 Genomic DNA No translation available.
AABR03111603 Genomic DNA No translation available.
AABR03112401 Genomic DNA No translation available.
AABR03112926 Genomic DNA No translation available.
AABR03113211 Genomic DNA No translation available.
L22760 mRNA Translation: AAA92577.1 Frameshift.
PIRiA49645
RefSeqiNP_062058.2, NM_019185.2
UniGeneiRn.164914
Rn.8701

Genome annotation databases

GeneIDi29300
KEGGirno:29300
UCSCiRGD:2666 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03109887 Genomic DNA No translation available.
AABR03111467 Genomic DNA No translation available.
AABR03111603 Genomic DNA No translation available.
AABR03112401 Genomic DNA No translation available.
AABR03112926 Genomic DNA No translation available.
AABR03113211 Genomic DNA No translation available.
L22760 mRNA Translation: AAA92577.1 Frameshift.
PIRiA49645
RefSeqiNP_062058.2, NM_019185.2
UniGeneiRn.164914
Rn.8701

3D structure databases

SMRiP46153
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247966, 1 interactor
STRINGi10116.ENSRNOP00000036967

PTM databases

iPTMnetiP46153
PhosphoSitePlusiP46153

Proteomic databases

PaxDbiP46153
PRIDEiP46153

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29300
KEGGirno:29300
UCSCiRGD:2666 rat

Organism-specific databases

CTDi2627
RGDi2666 Gata6

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiP46153
KOiK17897
PhylomeDBiP46153

Miscellaneous databases

PROiPR:P46153

Family and domain databases

CDDicd00202 ZnF_GATA, 2 hits
Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR039355 Transcription_factor_GATA
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071 PTHR10071, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGATA6_RAT
AccessioniPrimary (citable) accession number: P46153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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