UniProtKB - P46136 (YDDG_ECOLI)
Protein
Aromatic amino acid exporter YddG
Gene
yddG
Organism
Escherichia coli (strain K12)
Status
Functioni
Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan.1 Publication
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: EcoCyc
- aromatic amino acid transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- amino acid export across plasma membrane Source: EcoCyc
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12713-MONOMER MetaCyc:EG12713-MONOMER |
Protein family/group databases
TCDBi | 2.A.7.17.2, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Aromatic amino acid exporter YddG |
Gene namesi | Name:yddG Ordered Locus Names:b1473, JW1469 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 33 | PeriplasmicSequence analysis | 6 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 62 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 63 – 83 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 92 | PeriplasmicSequence analysis | 9 | |
Transmembranei | 93 – 113 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 114 – 118 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 155 | PeriplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 182 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 183 – 203 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 204 – 218 | PeriplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 219 – 239 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 240 – 243 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 244 – 264 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 267 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 268 – 288 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 293 | CytoplasmicSequence analysis | 5 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000168943 | 1 – 293 | Aromatic amino acid exporter YddGAdd BLAST | 293 |
Proteomic databases
PaxDbi | P46136 |
PRIDEi | P46136 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260205, 15 interactors |
STRINGi | 511145.b1473 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 137 | EamA 1Add BLAST | 123 | |
Domaini | 167 – 285 | EamA 2Add BLAST | 119 |
Sequence similaritiesi
Belongs to the drug/metabolite transporter (DMT) superfamily. Aromatic amino acid/paraquat exporter (ArAA/P-E) (TC 2.A.7.17) family. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0697, Bacteria |
HOGENOMi | CLU_058959_1_1_6 |
InParanoidi | P46136 |
PhylomeDBi | P46136 |
Family and domain databases
InterProi | View protein in InterPro IPR000620, EamA_dom |
Pfami | View protein in Pfam PF00892, EamA, 2 hits |
i Sequence
Sequence statusi: Complete.
P46136-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTRQKATLIG LIAIVLWSTM VGLIRGVSEG LGPVGGAAAI YSLSGLLLIF
60 70 80 90 100
TVGFPRIRQI PKGYLLAGSL LFVSYEICLA LSLGYAATHH QAIEVGMVNY
110 120 130 140 150
LWPSLTILFA ILFNGQKTNW LIVPGLLLAL VGVCWVLGGD NGLHYDEIIN
160 170 180 190 200
NITTSPLSYF LAFIGAFIWA AYCTVTNKYA RGFNGITVFV LLTGASLWVY
210 220 230 240 250
YFLTPQPEMI FSTPVMIKLI SAAFTLGFAY AAWNVGILHG NVTIMAVGSY
260 270 280 290
FTPVLSSALA AVLLSAPLSF SFWQGALMVC GGSLLCWLAT RRG
Sequence cautioni
The sequence BAA15122 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAD13437.3 AP009048 Genomic DNA Translation: BAA15122.1 Different initiation. M75029 Genomic DNA No translation available. |
PIRi | D64900 |
RefSeqi | NP_415990.5, NC_000913.3 WP_000198205.1, NZ_SSZK01000038.1 |
Genome annotation databases
EnsemblBacteriai | AAD13437; AAD13437; b1473 BAA15122; BAA15122; BAA15122 |
GeneIDi | 945942 |
KEGGi | ecj:JW1469 eco:b1473 |
PATRICi | fig|511145.12.peg.1539 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAD13437.3 AP009048 Genomic DNA Translation: BAA15122.1 Different initiation. M75029 Genomic DNA No translation available. |
PIRi | D64900 |
RefSeqi | NP_415990.5, NC_000913.3 WP_000198205.1, NZ_SSZK01000038.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260205, 15 interactors |
STRINGi | 511145.b1473 |
Protein family/group databases
TCDBi | 2.A.7.17.2, the drug/metabolite transporter (dmt) superfamily |
Proteomic databases
PaxDbi | P46136 |
PRIDEi | P46136 |
Genome annotation databases
EnsemblBacteriai | AAD13437; AAD13437; b1473 BAA15122; BAA15122; BAA15122 |
GeneIDi | 945942 |
KEGGi | ecj:JW1469 eco:b1473 |
PATRICi | fig|511145.12.peg.1539 |
Organism-specific databases
EchoBASEi | EB2574 |
Phylogenomic databases
eggNOGi | COG0697, Bacteria |
HOGENOMi | CLU_058959_1_1_6 |
InParanoidi | P46136 |
PhylomeDBi | P46136 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12713-MONOMER MetaCyc:EG12713-MONOMER |
Miscellaneous databases
PROi | PR:P46136 |
Family and domain databases
InterProi | View protein in InterPro IPR000620, EamA_dom |
Pfami | View protein in Pfam PF00892, EamA, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YDDG_ECOLI | |
Accessioni | P46136Primary (citable) accession number: P46136 Secondary accession number(s): P76124, P77342 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 10, 2007 | |
Last modified: | December 2, 2020 | |
This is version 129 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families