UniProtKB - P46118 (HEXR_ECOLI)
Protein
HTH-type transcriptional regulator HexR
Gene
hexR
Organism
Escherichia coli (strain K12)
Status
Functioni
Represses the expression of the hex regulon (zwf, eda, glp and gap).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 37 – 56 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- carbohydrate derivative binding Source: InterPro
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: EcoCyc
GO - Biological processi
- carbohydrate derivative metabolic process Source: InterPro
- cellular response to DNA damage stimulus Source: EcoliWiki
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12860-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator HexRAlternative name(s): Hex regulon repressor |
Gene namesi | Name:hexR Synonyms:yebK Ordered Locus Names:b1853, JW1842 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068623 | 1 – 289 | HTH-type transcriptional regulator HexRAdd BLAST | 289 |
Proteomic databases
jPOSTi | P46118 |
PaxDbi | P46118 |
PRIDEi | P46118 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260935, 14 interactors |
DIPi | DIP-9891N |
IntActi | P46118, 2 interactors |
STRINGi | 511145.b1853 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 77 | HTH rpiR-typePROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 121 – 260 | SISPROSITE-ProRule annotationAdd BLAST | 140 |
Phylogenomic databases
eggNOGi | COG1737, Bacteria |
HOGENOMi | CLU_055769_0_0_6 |
InParanoidi | P46118 |
PhylomeDBi | P46118 |
Family and domain databases
CDDi | cd05013, SIS_RpiR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR000281, HTH_RpiR IPR035472, RpiR-like_SIS IPR001347, SIS IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01418, HTH_6, 1 hit PF01380, SIS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51071, HTH_RPIR, 1 hit PS51464, SIS, 1 hit |
i Sequence
Sequence statusi: Complete.
P46118-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNMLEKIQSQ LEHLSKSERK VAEVILASPD NAIHSSIAAM ALEANVSEPT
60 70 80 90 100
VNRFCRSMDT RGFPDFKLHL AQSLANGTPY VNRNVNEDDS VESYTGKIFE
110 120 130 140 150
SAMATLDHVR HSLDKSAINR AVDLLTQAKK IAFFGLGSSA AVAHDAMNKF
160 170 180 190 200
FRFNVPVVYS DDIVLQRMSC MNCSDGDVVV LISHTGRTKN LVELAQLARE
210 220 230 240 250
NDAMVIALTS AGTPLAREAT LAITLDVPED TDIYMPMVSR LAQLTVIDVL
260 270 280
ATGFTLRRGA KFRDNLKRVK EALKESRFDK QLLNLSDDR
Sequence cautioni
The sequence M55005 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 82 | N → Y in AAA68942 (Ref. 5) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74923.1 AP009048 Genomic DNA Translation: BAA15661.1 M55005 Genomic DNA No translation available. U27210 Genomic DNA Translation: AAA68942.1 |
PIRi | E64947 |
RefSeqi | NP_416367.1, NC_000913.3 WP_001056706.1, NZ_SSZK01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC74923; AAC74923; b1853 BAA15661; BAA15661; BAA15661 |
GeneIDi | 946373 |
KEGGi | ecj:JW1842 eco:b1853 |
PATRICi | fig|1411691.4.peg.395 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00096 Genomic DNA Translation: AAC74923.1 AP009048 Genomic DNA Translation: BAA15661.1 M55005 Genomic DNA No translation available. U27210 Genomic DNA Translation: AAA68942.1 |
PIRi | E64947 |
RefSeqi | NP_416367.1, NC_000913.3 WP_001056706.1, NZ_SSZK01000001.1 |
3D structure databases
SMRi | P46118 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260935, 14 interactors |
DIPi | DIP-9891N |
IntActi | P46118, 2 interactors |
STRINGi | 511145.b1853 |
Proteomic databases
jPOSTi | P46118 |
PaxDbi | P46118 |
PRIDEi | P46118 |
Genome annotation databases
EnsemblBacteriai | AAC74923; AAC74923; b1853 BAA15661; BAA15661; BAA15661 |
GeneIDi | 946373 |
KEGGi | ecj:JW1842 eco:b1853 |
PATRICi | fig|1411691.4.peg.395 |
Organism-specific databases
EchoBASEi | EB2702 |
Phylogenomic databases
eggNOGi | COG1737, Bacteria |
HOGENOMi | CLU_055769_0_0_6 |
InParanoidi | P46118 |
PhylomeDBi | P46118 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12860-MONOMER |
Miscellaneous databases
PROi | PR:P46118 |
Family and domain databases
CDDi | cd05013, SIS_RpiR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR000281, HTH_RpiR IPR035472, RpiR-like_SIS IPR001347, SIS IPR036388, WH-like_DNA-bd_sf |
Pfami | View protein in Pfam PF01418, HTH_6, 1 hit PF01380, SIS, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51071, HTH_RPIR, 1 hit PS51464, SIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HEXR_ECOLI | |
Accessioni | P46118Primary (citable) accession number: P46118 Secondary accession number(s): P76282 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |