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Protein

Potassium channel toxin alpha-KTx 3.2

Gene
N/A
Organism
Leiurus quinquestriatus hebraeus (Yellow scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels) (PubMed:8204618, PubMed:20007782). Also blocks Kv1.2/KCNA2 (IC50=26.8 nM) (PubMed:8204618, PubMed:20007782).2 Publications

Miscellaneous

Shows weak blocking activity on KCa3.1/KCNN4 (IC50=1152 nM) (PubMed:18042681). Does not block Kv2.1/KCNB1 (Ki >2000 nM) (PubMed:8204618).2 Publications

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 3.2
Alternative name(s):
Agitoxin-21 Publication
Short name:
AgTx-21 Publication
Short name:
AgTx21 Publication
OrganismiLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifieri6884 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449261 – 38Potassium channel toxin alpha-KTx 3.21 PublicationAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi8 ↔ 281 Publication
Disulfide bondi14 ↔ 331 Publication
Disulfide bondi18 ↔ 351 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Helixi15 – 21Combined sources7
Beta strandi23 – 29Combined sources7
Beta strandi32 – 37Combined sources6

3D structure databases

ProteinModelPortaliP46111
SMRiP46111
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP46111

Family & Domainsi

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P46111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GVPINVSCTG SPQCIKPCKD AGMRFGKCMN RKCHCTPK
Length:38
Mass (Da):4,097
Last modified:November 1, 1995 - v1
Checksum:iC8BB8513F87B51CD
GO

Sequence databases

PIRiB54471

Similar proteinsi

Entry informationi

Entry nameiKAX32_LEIQH
AccessioniPrimary (citable) accession number: P46111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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