UniProtKB - P46111 (KAX32_LEIHE)
Protein
Potassium channel toxin alpha-KTx 3.2
Gene
N/A
Organism
Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus)
Status
Functioni
Potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels) (PubMed:8204618, PubMed:20007782). Also blocks Kv1.2/KCNA2 (IC50=26.8 nM) (PubMed:8204618, PubMed:20007782).2 Publications
Miscellaneous
Shows weak blocking activity on KCa3.1/KCNN4 (IC50=1152 nM) (PubMed:18042681). Does not block Kv2.1/KCNB1 (Ki >2000 nM) (PubMed:8204618).2 Publications
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 3.2Alternative name(s): Agitoxin-21 Publication Short name: AgTx-21 Publication Short name: AgTx21 Publication |
Organismi | Leiurus hebraeus (Deathstalker scorpion) (Leiurus quinquestriatus hebraeus) |
Taxonomic identifieri | 6884 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Leiurus › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044926 | 1 – 38 | Potassium channel toxin alpha-KTx 3.21 PublicationAdd BLAST | 38 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 8 ↔ 28 | 1 Publication | ||
Disulfide bondi | 14 ↔ 33 | 1 Publication | ||
Disulfide bondi | 18 ↔ 35 | 1 Publication |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P46111 |
SMRi | P46111 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46111 |
Family & Domainsi
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 3 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574, Scorpion_toxin-like_sf IPR001947, Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451, Toxin_2, 1 hit |
PRINTSi | PR00286, CHARYBDTOXIN |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138, SCORP_SHORT_TOXIN, 1 hit |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | B54471 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AGT | NMR | - | A | 1-38 | [»] | |
BMRBi | P46111 | |||||
SMRi | P46111 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46111 |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574, Scorpion_toxin-like_sf IPR001947, Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451, Toxin_2, 1 hit |
PRINTSi | PR00286, CHARYBDTOXIN |
SUPFAMi | SSF57095, SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138, SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KAX32_LEIHE | |
Accessioni | P46111Primary (citable) accession number: P46111 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | October 7, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries