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Entry version 188 (13 Feb 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Crk-like protein

Gene

CRKL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate the transduction of intracellular signals.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-170968 Frs2-mediated activation
R-HSA-186763 Downstream signal transduction
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-912631 Regulation of signaling by CBL

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P46109

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P46109

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Crk-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRKL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099942.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2363 CRKL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602007 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46109

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi160W → L: Abolishes interaction with DOCK5. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1399

MalaCards human disease database

More...
MalaCardsi
CRKL

Open Targets

More...
OpenTargetsi
ENSG00000099942

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
261330 Distal 22q11.2 microdeletion syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26881

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CRKL

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1169094

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793471 – 303Crk-like proteinAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphotyrosineCombined sources1
Modified residuei207PhosphotyrosineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P46109

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P46109

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P46109

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46109

PeptideAtlas

More...
PeptideAtlasi
P46109

PRoteomics IDEntifications database

More...
PRIDEi
P46109

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55734

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P46109

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46109

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46109

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099942 Expressed in 238 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46109 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000532
HPA001100

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107789, 120 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P46109

Database of interacting proteins

More...
DIPi
DIP-29165N

Protein interaction database and analysis system

More...
IntActi
P46109, 97 interactors

Molecular INTeraction database

More...
MINTi
P46109

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346300

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZXX-ray2.80A237-303[»]
2BZYX-ray2.50A/B237-303[»]
2DBKNMR-A229-303[»]
2EO3NMR-A1-104[»]
2LQNNMR-A1-303[»]
2LQWNMR-A1-303[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P46109

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46109

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P46109

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 102SH2PROSITE-ProRule annotationAdd BLAST89
Domaini123 – 183SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini235 – 296SH3 2PROSITE-ProRule annotationAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4792 Eukaryota
ENOG4110574 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00820000127055

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000236288

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105616

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46109

KEGG Orthology (KO)

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KOi
K04438

Identification of Orthologs from Complete Genome Data

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OMAi
FPGMSRE

Database of Orthologous Groups

More...
OrthoDBi
1414461at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46109

TreeFam database of animal gene trees

More...
TreeFami
TF321436

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11759 SH3_CRK_C, 1 hit
cd11758 SH3_CRK_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035458 CRK_SH3_C
IPR035457 CRK_SH3_N
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46109-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL
60 70 80 90 100
SVSENSRVSH YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE
110 120 130 140 150
PAPRYPSPPM GSVSAPNLPT AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL
160 170 180 190 200
VIIEKPEEQW WSARNKDGRV GMIPVPYVEK LVRSSPHGKH GNRNSNSYGI
210 220 230 240 250
PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA KAIQKRVPCA
260 270 280 290 300
YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD

ENE
Length:303
Mass (Da):33,777
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i294CF1EE2CD44B81
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X59656 mRNA Translation: CAA42199.1
CR456423 mRNA Translation: CAG30309.1
AK292909 mRNA Translation: BAF85598.1
CH471176 Genomic DNA Translation: EAX02932.1
CH471176 Genomic DNA Translation: EAX02933.1
CH471176 Genomic DNA Translation: EAX02934.1
BC043500 mRNA Translation: AAH43500.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13785.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S41754

NCBI Reference Sequences

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RefSeqi
NP_005198.1, NM_005207.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.5613

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354336; ENSP00000346300; ENSG00000099942
ENST00000411769; ENSP00000396646; ENSG00000099942

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1399

UCSC genome browser

More...
UCSCi
uc002ztf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59656 mRNA Translation: CAA42199.1
CR456423 mRNA Translation: CAG30309.1
AK292909 mRNA Translation: BAF85598.1
CH471176 Genomic DNA Translation: EAX02932.1
CH471176 Genomic DNA Translation: EAX02933.1
CH471176 Genomic DNA Translation: EAX02934.1
BC043500 mRNA Translation: AAH43500.1
CCDSiCCDS13785.1
PIRiS41754
RefSeqiNP_005198.1, NM_005207.3
UniGeneiHs.5613

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZXX-ray2.80A237-303[»]
2BZYX-ray2.50A/B237-303[»]
2DBKNMR-A229-303[»]
2EO3NMR-A1-104[»]
2LQNNMR-A1-303[»]
2LQWNMR-A1-303[»]
ProteinModelPortaliP46109
SMRiP46109
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107789, 120 interactors
CORUMiP46109
DIPiDIP-29165N
IntActiP46109, 97 interactors
MINTiP46109
STRINGi9606.ENSP00000346300

PTM databases

iPTMnetiP46109
PhosphoSitePlusiP46109

Polymorphism and mutation databases

BioMutaiCRKL
DMDMi1169094

2D gel databases

OGPiP46109

Proteomic databases

EPDiP46109
jPOSTiP46109
MaxQBiP46109
PaxDbiP46109
PeptideAtlasiP46109
PRIDEiP46109
ProteomicsDBi55734

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1399
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354336; ENSP00000346300; ENSG00000099942
ENST00000411769; ENSP00000396646; ENSG00000099942
GeneIDi1399
KEGGihsa:1399
UCSCiuc002ztf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1399
DisGeNETi1399
EuPathDBiHostDB:ENSG00000099942.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CRKL
HGNCiHGNC:2363 CRKL
HPAiHPA000532
HPA001100
MalaCardsiCRKL
MIMi602007 gene
neXtProtiNX_P46109
OpenTargetsiENSG00000099942
Orphaneti261330 Distal 22q11.2 microdeletion syndrome
PharmGKBiPA26881

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4792 Eukaryota
ENOG4110574 LUCA
GeneTreeiENSGT00820000127055
HOGENOMiHOG000236288
HOVERGENiHBG105616
InParanoidiP46109
KOiK04438
OMAiFPGMSRE
OrthoDBi1414461at2759
PhylomeDBiP46109
TreeFamiTF321436

Enzyme and pathway databases

ReactomeiR-HSA-170968 Frs2-mediated activation
R-HSA-186763 Downstream signal transduction
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-8875656 MET receptor recycling
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-912631 Regulation of signaling by CBL
SignaLinkiP46109
SIGNORiP46109

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CRKL human
EvolutionaryTraceiP46109

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CRKL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1399

Protein Ontology

More...
PROi
PR:P46109

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000099942 Expressed in 238 organ(s), highest expression level in secondary oocyte
GenevisibleiP46109 HS

Family and domain databases

CDDicd11759 SH3_CRK_C, 1 hit
cd11758 SH3_CRK_N, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035458 CRK_SH3_C
IPR035457 CRK_SH3_N
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRKL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46109
Secondary accession number(s): A8KA44, D3DX35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 13, 2019
This is version 188 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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