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UniProtKB - P46104 (LMRA_STRLN)
Protein
Lincomycin resistance protein
Gene
lmrA
Organism
Streptomyces lincolnensis
Status
Functioni
Proton-dependent transporter. May mediate the efflux of lincomycin.
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Biological process | Antibiotic resistance, Transport |
Protein family/group databases
TCDBi | 2.A.1.3.9, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Lincomycin resistance protein |
Gene namesi | Name:lmrA |
Organismi | Streptomyces lincolnensis |
Taxonomic identifieri | 1915 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 50 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 67 – 87 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 127 – 147 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 185 – 205 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 215 – 235 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 285 – 305 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 318 – 338 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 421 – 441 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 446 – 466 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173327 | 1 – 481 | Lincomycin resistance proteinAdd BLAST | 481 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P46104-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVFARATSL FSRAARTRAA DEAARSRSRW VTLVFLAVLQ LLIAVDVTVV
60 70 80 90 100
NIALPAIRDS FHVDTRQLTW VVTGYTVVGG GLLMVGGRIA DLFGRRRTLL
110 120 130 140 150
FGAFLFGASS LAAGLAPNLE LLVLARFGQG AGEALSLPAA MSLIACSSRT
160 170 180 190 200
APFQGVERLA SVASVGLVLG FLLSGVITQL FSWRWIFLIN IPLVSLVLVA
210 220 230 240 250
VLLLVKKDET TARNPVDLPG ALLFTAAPLL LIFGVNELGE DEPRLPLAVG
260 270 280 290 300
SLLAAAVCAA AFVAVERRTA HPLVPLTFFG NRVRLVANGA TVLLSAALST
310 320 330 340 350
SFFLLTMHLQ EERDLSPIEA GLSFLPLGLS LILACVLVRG LIERIGTTGA
360 370 380 390 400
AVLGMALAGP RHRLFALLPS DNSLLTSVFP GMILLLRMAT GLVALQNAAL
410 420 430 440 450
HAVTEADAGV ASGVQRCADQ LGGASGIAVY VSIGFSPHLG GDWDPFTVAY
460 470 480
SLAGIGLIAA VLAVLALSPD RRLAAPREQE D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59926 Genomic DNA Translation: CAA42550.1 X79146 Genomic DNA Translation: CAA55745.1 |
PIRi | S69808 |
Genome annotation databases
KEGGi | ag:CAA42550 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59926 Genomic DNA Translation: CAA42550.1 X79146 Genomic DNA Translation: CAA55745.1 |
PIRi | S69808 |
3D structure databases
SMRi | P46104 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1915.SLINC_0232 |
Protein family/group databases
TCDBi | 2.A.1.3.9, the major facilitator superfamily (mfs) |
Genome annotation databases
KEGGi | ag:CAA42550 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LMRA_STRLN | |
Accessioni | P46104Primary (citable) accession number: P46104 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |