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Protein

5-hydroxytryptamine receptor 3A

Gene

HTR3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.2 Publications

Miscellaneous

The HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.9.2.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-hydroxytryptamine receptor 3A
Short name:
5-HT3-A
Short name:
5-HT3A
Alternative name(s):
5-hydroxytryptamine receptor 3
Short name:
5-HT-3
Short name:
5-HT3R
Serotonin receptor 3A
Serotonin-gated ion channel receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HTR3A
Synonyms:5HT3R, HTR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166736.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5297 HTR3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182139 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46098

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 241ExtracellularSequence analysisAdd BLAST218
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei242 – 268Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini269 – 273CytoplasmicSequence analysis5
Transmembranei274 – 292Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini293 – 302ExtracellularSequence analysis10
Transmembranei303 – 321Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini322 – 455CytoplasmicSequence analysisAdd BLAST134
Transmembranei456 – 475Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini476 – 478ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi178W → S: Abolished ligand binding to the heteromeric receptor. 1 Publication1
Mutagenesisi432R → Q: Little effect on conductance. Massive increase of conductance; when associated with D-436 and A-440. 1 Publication1
Mutagenesisi436R → D: Increased conductance. Massive increase of conductance; when associated with Q-432 and A-440. 1 Publication1
Mutagenesisi440R → A: Increased conductance. Massive increase of conductance; when associated with Q-432 and D-436. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3359

Open Targets

More...
OpenTargetsi
ENSG00000166736

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29555

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1899

Drug and drug target database

More...
DrugBanki
DB00969 Alosetron
DB00543 Amoxapine
DB01238 Aripiprazole
DB01161 Chloroprocaine
DB04885 Cilansetron
DB00604 Cisapride
DB00363 Clozapine
DB05049 DDP733
DB00757 Dolasetron
DB01049 Ergoloid mesylate
DB00898 Ethanol
DB00889 Granisetron
DB00408 Loxapine
DB01043 Memantine
DB00333 Methadone
DB01233 Metoclopramide
DB00370 Mirtazapine
DB00334 Olanzapine
DB00904 Ondansetron
DB00377 Palonosetron
DB00721 Procaine
DB01224 Quetiapine
DB04917 Renzapride
DB00728 Rocuronium
DB06204 Tapentadol
DB13025 Tiapride
DB00726 Trimipramine
DB11699 Tropisetron
DB01199 Tubocurarine
DB09068 Vortioxetine
DB00246 Ziprasidone

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
373

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HTR3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1168222

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000040824 – 4785-hydroxytryptamine receptor 3AAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 171By similarity
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P46098

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55722
55723 [P46098-2]
55724 [P46098-3]
55725 [P46098-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46098

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46098

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166736 Expressed in 73 organ(s), highest expression level in islet of Langerhans

CleanEx database of gene expression profiles

More...
CleanExi
HS_HTR3A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P46098 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P46098 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA069442

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109591, 112 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2175 5-hydroxytryptamine-3A receptor complex
CPX-271 5-hydroxytryptamine-3A/B receptor complex
CPX-272 5-hydroxytryptamine-3A/D receptor complex
CPX-273 5-hydroxytryptamine-3A/E receptor complex
CPX-276 5-hydroxytryptamine-3A/C receptor complex

Protein interaction database and analysis system

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IntActi
P46098, 4 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P46098

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P46098

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46098

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni414 – 450HA-stretchAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157705

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241519

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46098

KEGG Orthology (KO)

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KOi
K04819

Identification of Orthologs from Complete Genome Data

More...
OMAi
WSIWQYS

Database of Orthologous Groups

More...
OrthoDBi
611108at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P46098

TreeFam database of animal gene trees

More...
TreeFami
TF315605

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.170.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008132 5HT3_rcpt
IPR008133 5HT3_rcpt_A
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS

The PANTHER Classification System

More...
PANTHERi
PTHR18945 PTHR18945, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01709 5HT3ARECEPTR
PR01708 5HT3RECEPTOR
PR00252 NRIONCHANNEL

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00860 LIC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P46098-1) [UniParc]FASTAAdd to basket
Also known as: 5-HT3R-AS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR
60 70 80 90 100
PVRDWRKPTT VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE
110 120 130 140 150
DFDNITKLSI PTDSIWVPDI LINEFVDVGK SPNIPYVYIR HQGEVQNYKP
160 170 180 190 200
LQVVTACSLD IYNFPFDVQN CSLTFTSWLH TIQDINISLW RLPEKVKSDR
210 220 230 240 250
SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR RPLFYVVSLL
260 270 280 290 300
LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI
310 320 330 340 350
GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER
360 370 380 390 400
IAWLLCLREQ STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD
410 420 430 440 450
RCSPPPPPRE ASLAVCGLLQ ELSSIRQFLE KRDEIREVAR DWLRVGSVLD
460 470
KLLFHIYLLA VLAYSITLVM LWSIWQYA
Length:478
Mass (Da):55,280
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24CA9A232286FBC9
GO
Isoform 2 (identifier: P46098-2) [UniParc]FASTAAdd to basket
Also known as: 5-HT3R-AL

The sequence of this isoform differs from the canonical sequence as follows:
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Show »
Length:510
Mass (Da):58,388
Checksum:i3DF54EB0BF54C519
GO
Isoform 3 (identifier: P46098-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MLLWVQQALLALLLPTLLAQGE → MHRSFLQ

Show »
Length:463
Mass (Da):53,763
Checksum:iFA630E3384245F9C
GO
Isoform 4 (identifier: P46098-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM

Note: No experimental confirmation available.
Show »
Length:484
Mass (Da):55,894
Checksum:i74F70567007BCB51
GO
Isoform 5 (identifier: P46098-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLGKLAM
     306-306: G → GKAPPGSRAQSGEKPAPSHLLHVSLASALGCTG

Note: No experimental confirmation available.Curated
Show »
Length:516
Mass (Da):59,002
Checksum:i91E8DBE4B4802BA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J205A0A0B4J205_HUMAN
5-hydroxytryptamine receptor 3A
HTR3A
238Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46R → T in AAB37533 (PubMed:8848005).Curated1
Sequence conflicti125F → L in AAB37533 (PubMed:8848005).Curated1
Sequence conflicti321A → T in AAB37533 (PubMed:8848005).Curated1
Sequence conflicti386S → T in AAB37533 (PubMed:8848005).Curated1
Isoform 5 (identifier: P46098-5)
Sequence conflicti342C → W in CD014118 (PubMed:15028279).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03739833A → T1 PublicationCorresponds to variant dbSNP:rs117793058Ensembl.1
Natural variantiVAR_037399253S → N. Corresponds to variant dbSNP:rs4938063Ensembl.1
Natural variantiVAR_037400344R → H1 PublicationCorresponds to variant dbSNP:rs35815285Ensembl.1
Natural variantiVAR_037401391P → R1 Publication1
Natural variantiVAR_037402409R → Q1 PublicationCorresponds to variant dbSNP:rs183698487Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422141 – 22MLLWV…LAQGE → MHRSFLQ in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0434841M → MLGKLAM in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_000078306G → GKAPPGSRAQSGEKPAPSHL LHVSLASALGCTG in isoform 2 and isoform 5. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D49394 mRNA Translation: BAA08387.1
S82612 mRNA Translation: AAB37533.2
AJ003078 mRNA Translation: CAA05851.1
AJ003079 mRNA Translation: CAA05852.1
AJ005205 Genomic DNA Translation: CAA06442.3
AF498984 mRNA Translation: AAM21131.1
BT007204 mRNA Translation: AAP35868.1
CD014118 mRNA No translation available.
AK299973 mRNA Translation: BAG61798.1
AP000908 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67238.1
CH471065 Genomic DNA Translation: EAW67240.1
BC002354 mRNA Translation: AAH02354.1
BC004453 mRNA Translation: AAH04453.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS53710.1 [P46098-3]
CCDS8365.2 [P46098-1]
CCDS8366.2 [P46098-2]

NCBI Reference Sequences

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RefSeqi
NP_000860.2, NM_000869.5 [P46098-1]
NP_001155244.1, NM_001161772.2 [P46098-3]
NP_998786.2, NM_213621.3 [P46098-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.413899

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000299961; ENSP00000299961; ENSG00000166736 [P46098-3]
ENST00000355556; ENSP00000347754; ENSG00000166736 [P46098-5]
ENST00000375498; ENSP00000364648; ENSG00000166736 [P46098-4]
ENST00000504030; ENSP00000424189; ENSG00000166736 [P46098-1]
ENST00000506841; ENSP00000424776; ENSG00000166736 [P46098-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3359

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3359

UCSC genome browser

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UCSCi
uc010rxa.3 human [P46098-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49394 mRNA Translation: BAA08387.1
S82612 mRNA Translation: AAB37533.2
AJ003078 mRNA Translation: CAA05851.1
AJ003079 mRNA Translation: CAA05852.1
AJ005205 Genomic DNA Translation: CAA06442.3
AF498984 mRNA Translation: AAM21131.1
BT007204 mRNA Translation: AAP35868.1
CD014118 mRNA No translation available.
AK299973 mRNA Translation: BAG61798.1
AP000908 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67238.1
CH471065 Genomic DNA Translation: EAW67240.1
BC002354 mRNA Translation: AAH02354.1
BC004453 mRNA Translation: AAH04453.2
CCDSiCCDS53710.1 [P46098-3]
CCDS8365.2 [P46098-1]
CCDS8366.2 [P46098-2]
RefSeqiNP_000860.2, NM_000869.5 [P46098-1]
NP_001155244.1, NM_001161772.2 [P46098-3]
NP_998786.2, NM_213621.3 [P46098-2]
UniGeneiHs.413899

3D structure databases

ProteinModelPortaliP46098
SMRiP46098
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109591, 112 interactors
ComplexPortaliCPX-2175 5-hydroxytryptamine-3A receptor complex
CPX-271 5-hydroxytryptamine-3A/B receptor complex
CPX-272 5-hydroxytryptamine-3A/D receptor complex
CPX-273 5-hydroxytryptamine-3A/E receptor complex
CPX-276 5-hydroxytryptamine-3A/C receptor complex
IntActiP46098, 4 interactors

Chemistry databases

BindingDBiP46098
ChEMBLiCHEMBL1899
DrugBankiDB00969 Alosetron
DB00543 Amoxapine
DB01238 Aripiprazole
DB01161 Chloroprocaine
DB04885 Cilansetron
DB00604 Cisapride
DB00363 Clozapine
DB05049 DDP733
DB00757 Dolasetron
DB01049 Ergoloid mesylate
DB00898 Ethanol
DB00889 Granisetron
DB00408 Loxapine
DB01043 Memantine
DB00333 Methadone
DB01233 Metoclopramide
DB00370 Mirtazapine
DB00334 Olanzapine
DB00904 Ondansetron
DB00377 Palonosetron
DB00721 Procaine
DB01224 Quetiapine
DB04917 Renzapride
DB00728 Rocuronium
DB06204 Tapentadol
DB13025 Tiapride
DB00726 Trimipramine
DB11699 Tropisetron
DB01199 Tubocurarine
DB09068 Vortioxetine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi373

Protein family/group databases

TCDBi1.A.9.2.1 the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family

PTM databases

iPTMnetiP46098
PhosphoSitePlusiP46098

Polymorphism and mutation databases

BioMutaiHTR3A
DMDMi1168222

Proteomic databases

PRIDEiP46098
ProteomicsDBi55722
55723 [P46098-2]
55724 [P46098-3]
55725 [P46098-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3359
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299961; ENSP00000299961; ENSG00000166736 [P46098-3]
ENST00000355556; ENSP00000347754; ENSG00000166736 [P46098-5]
ENST00000375498; ENSP00000364648; ENSG00000166736 [P46098-4]
ENST00000504030; ENSP00000424189; ENSG00000166736 [P46098-1]
ENST00000506841; ENSP00000424776; ENSG00000166736 [P46098-2]
GeneIDi3359
KEGGihsa:3359
UCSCiuc010rxa.3 human [P46098-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3359
DisGeNETi3359
EuPathDBiHostDB:ENSG00000166736.11

GeneCards: human genes, protein and diseases

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GeneCardsi
HTR3A
HGNCiHGNC:5297 HTR3A
HPAiHPA069442
MIMi182139 gene
neXtProtiNX_P46098
OpenTargetsiENSG00000166736
PharmGKBiPA29555

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000157705
HOGENOMiHOG000241519
HOVERGENiHBG106638
InParanoidiP46098
KOiK04819
OMAiWSIWQYS
OrthoDBi611108at2759
PhylomeDBiP46098
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HTR3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3359

Protein Ontology

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PROi
PR:P46098

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166736 Expressed in 73 organ(s), highest expression level in islet of Langerhans
CleanExiHS_HTR3A
ExpressionAtlasiP46098 baseline and differential
GenevisibleiP46098 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR008132 5HT3_rcpt
IPR008133 5HT3_rcpt_A
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01709 5HT3ARECEPTR
PR01708 5HT3RECEPTOR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei5HT3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46098
Secondary accession number(s): B4DSY6
, G5E986, O60854, Q7KZM7, Q99918, Q9BSZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 16, 2019
This is version 191 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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