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Protein

G-protein coupled receptor 6

Gene

GPR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity).By similarity

Caution

Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. It has been demonstrated that it is not the case (PubMed:19286662).2 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 6
Alternative name(s):
Sphingosine 1-phosphate receptor GPR6
Gene namesi
Name:GPR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146360.8
HGNCiHGNC:4515 GPR6
MIMi600553 gene
neXtProtiNX_P46095

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74ExtracellularSequence analysisAdd BLAST74
Transmembranei75 – 94Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini95 – 106CytoplasmicSequence analysisAdd BLAST12
Transmembranei107 – 130Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini131 – 142ExtracellularSequence analysisAdd BLAST12
Transmembranei143 – 164Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini165 – 185CytoplasmicSequence analysisAdd BLAST21
Transmembranei186 – 205Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini206 – 230ExtracellularSequence analysisAdd BLAST25
Transmembranei231 – 249Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini250 – 277CytoplasmicSequence analysisAdd BLAST28
Transmembranei278 – 304Helical; Name=6Sequence analysisAdd BLAST27
Topological domaini305 – 309ExtracellularSequence analysis5
Transmembranei310 – 331Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini332 – 362CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2830
OpenTargetsiENSG00000146360
PharmGKBiPA28904

Chemistry databases

ChEMBLiCHEMBL3714130

Polymorphism and mutation databases

DMDMi1170009

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695141 – 362G-protein coupled receptor 6Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi345S-palmitoyl cysteineBy similarity1
Modified residuei356PhosphoserineSequence analysis1
Modified residuei358PhosphoserineSequence analysis1
Modified residuei360PhosphoserineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP46095
PRIDEiP46095
ProteomicsDBi55721

PTM databases

PhosphoSitePlusiP46095

Expressioni

Gene expression databases

BgeeiENSG00000146360 Expressed in 40 organ(s), highest expression level in caudate nucleus
CleanExiHS_GPR6
ExpressionAtlasiP46095 baseline and differential
GenevisibleiP46095 HS

Interactioni

Protein-protein interaction databases

BioGridi109091, 2 interactors
STRINGi9606.ENSP00000275169

Chemistry databases

BindingDBiP46095

Structurei

3D structure databases

ProteinModelPortaliP46095
SMRiP46095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Val4
Compositional biasi21 – 28Poly-Ala8
Compositional biasi40 – 43Poly-Ala4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000294075
HOVERGENiHBG079561
InParanoidiP46095
KOiK04313
OMAiLFCGCFQ
OrthoDBiEOG091G0CNB
PhylomeDBiP46095
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001151 GPR6
IPR000723 GPR_3/6/12_orphan
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00649 GPR6ORPHANR
PR00644 GPRORPHANR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P46095-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNASAASLND SQVVVVAAEG AAAAATAAGG PDTGEWGPPA AAALGAGGGA
60 70 80 90 100
NGSLELSSQL SAGPPGLLLP AVNPWDVLLC VSGTVIAGEN ALVVALIAST
110 120 130 140 150
PALRTPMFVL VGSLATADLL AGCGLILHFV FQYLVPSETV SLLTVGFLVA
160 170 180 190 200
SFAASVSSLL AITVDRYLSL YNALTYYSRR TLLGVHLLLA ATWTVSLGLG
210 220 230 240 250
LLPVLGWNCL AERAACSVVR PLARSHVALL SAAFFMVFGI MLHLYVRICQ
260 270 280 290 300
VVWRHAHQIA LQQHCLAPPH LAATRKGVGT LAVVLGTFGA SWLPFAIYCV
310 320 330 340 350
VGSHEDPAVY TYATLLPATY NSMINPIIYA FRNQEIQRAL WLLLCGCFQS
360
KVPFRSRSPS EV
Length:362
Mass (Da):37,881
Last modified:November 1, 1995 - v1
Checksum:iAF8C6075603337AD
GO
Isoform 2 (identifier: P46095-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTLLAWCTRGANPAAM

Show »
Length:377
Mass (Da):39,439
Checksum:iE4C69B2CF3E77D89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310Y → H in BAG58241 (PubMed:14702039).Curated1
Sequence conflicti358S → P in BAG58241 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551051M → MTLLAWCTRGANPAAM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36150 Genomic DNA Translation: AAA63181.1
U18549 Genomic DNA Translation: AAA91631.1
AK295250 mRNA Translation: BAG58241.1
AL591076 Genomic DNA No translation available.
BC043414 mRNA Translation: AAH43414.1
BC117298 mRNA Translation: AAI17299.1
BC126301 mRNA Translation: AAI26302.1
CCDSiCCDS5079.1 [P46095-1]
CCDS69172.1 [P46095-2]
PIRiI65990
RefSeqiNP_001273028.1, NM_001286099.1 [P46095-2]
NP_005275.1, NM_005284.4 [P46095-1]
UniGeneiHs.46332

Genome annotation databases

EnsembliENST00000275169; ENSP00000275169; ENSG00000146360 [P46095-1]
ENST00000414000; ENSP00000406986; ENSG00000146360 [P46095-2]
GeneIDi2830
KEGGihsa:2830
UCSCiuc011eav.4 human [P46095-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36150 Genomic DNA Translation: AAA63181.1
U18549 Genomic DNA Translation: AAA91631.1
AK295250 mRNA Translation: BAG58241.1
AL591076 Genomic DNA No translation available.
BC043414 mRNA Translation: AAH43414.1
BC117298 mRNA Translation: AAI17299.1
BC126301 mRNA Translation: AAI26302.1
CCDSiCCDS5079.1 [P46095-1]
CCDS69172.1 [P46095-2]
PIRiI65990
RefSeqiNP_001273028.1, NM_001286099.1 [P46095-2]
NP_005275.1, NM_005284.4 [P46095-1]
UniGeneiHs.46332

3D structure databases

ProteinModelPortaliP46095
SMRiP46095
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109091, 2 interactors
STRINGi9606.ENSP00000275169

Chemistry databases

BindingDBiP46095
ChEMBLiCHEMBL3714130

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP46095

Polymorphism and mutation databases

DMDMi1170009

Proteomic databases

PaxDbiP46095
PRIDEiP46095
ProteomicsDBi55721

Protocols and materials databases

DNASUi2830
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275169; ENSP00000275169; ENSG00000146360 [P46095-1]
ENST00000414000; ENSP00000406986; ENSG00000146360 [P46095-2]
GeneIDi2830
KEGGihsa:2830
UCSCiuc011eav.4 human [P46095-1]

Organism-specific databases

CTDi2830
DisGeNETi2830
EuPathDBiHostDB:ENSG00000146360.8
GeneCardsiGPR6
HGNCiHGNC:4515 GPR6
MIMi600553 gene
neXtProtiNX_P46095
OpenTargetsiENSG00000146360
PharmGKBiPA28904
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000294075
HOVERGENiHBG079561
InParanoidiP46095
KOiK04313
OMAiLFCGCFQ
OrthoDBiEOG091G0CNB
PhylomeDBiP46095
TreeFamiTF330052

Miscellaneous databases

GeneWikiiGPR6
GenomeRNAii2830
PROiPR:P46095
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146360 Expressed in 40 organ(s), highest expression level in caudate nucleus
CleanExiHS_GPR6
ExpressionAtlasiP46095 baseline and differential
GenevisibleiP46095 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001151 GPR6
IPR000723 GPR_3/6/12_orphan
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00649 GPR6ORPHANR
PR00644 GPRORPHANR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR6_HUMAN
AccessioniPrimary (citable) accession number: P46095
Secondary accession number(s): B4DHS9
, J3KQR3, Q17RJ7, Q5SYL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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