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Protein

Chemokine XC receptor 1

Gene

XCR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.Curated

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-416476 G alpha (q) signalling events
SIGNORiP46094

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine XC receptor 1
Alternative name(s):
G-protein coupled receptor 5
Lymphotactin receptor
XC chemokine receptor 1
Gene namesi
Name:XCR1
Synonyms:CCXCR1, GPR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173578.7
HGNCiHGNC:1625 XCR1
MIMi600552 gene
neXtProtiNX_P46094

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 59Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini60 – 69CytoplasmicSequence analysis10
Transmembranei70 – 89Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini90 – 103ExtracellularSequence analysisAdd BLAST14
Transmembranei104 – 125Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini126 – 142CytoplasmicSequence analysisAdd BLAST17
Transmembranei143 – 167Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini168 – 190ExtracellularSequence analysisAdd BLAST23
Transmembranei191 – 209Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini210 – 225CytoplasmicSequence analysisAdd BLAST16
Transmembranei226 – 250Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini251 – 267ExtracellularSequence analysisAdd BLAST17
Transmembranei268 – 291Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini292 – 333CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2829
OpenTargetsiENSG00000173578
PharmGKBiPA35037

Chemistry databases

GuidetoPHARMACOLOGYi75

Polymorphism and mutation databases

BioMutaiXCR1
DMDMi1170008

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702211 – 333Chemokine XC receptor 1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi102 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP46094
PeptideAtlasiP46094
PRIDEiP46094
ProteomicsDBi55720

PTM databases

iPTMnetiP46094
PhosphoSitePlusiP46094

Expressioni

Gene expression databases

BgeeiENSG00000173578 Expressed in 60 organ(s), highest expression level in placenta
CleanExiHS_XCR1
ExpressionAtlasiP46094 baseline and differential
GenevisibleiP46094 HS

Organism-specific databases

HPAiHPA013169

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP46094, 2 interactors
STRINGi9606.ENSP00000310405

Structurei

3D structure databases

ProteinModelPortaliP46094
SMRiP46094
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYH Eukaryota
ENOG410XUKS LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG101128
InParanoidiP46094
KOiK04193
OMAiAYFLSWA
OrthoDBiEOG091G09U3
PhylomeDBiP46094
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR005393 Chemokine_XCR1
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01568 LYMPHOTACTNR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P46094-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESSGNPEST TFFYYDLQSQ PCENQAWVFA TLATTVLYCL VFLLSLVGNS
60 70 80 90 100
LVLWVLVKYE SLESLTNIFI LNLCLSDLVF ACLLPVWISP YHWGWVLGDF
110 120 130 140 150
LCKLLNMIFS ISLYSSIFFL TIMTIHRYLS VVSPLSTLRV PTLRCRVLVT
160 170 180 190 200
MAVWVASILS SILDTIFHKV LSSGCDYSEL TWYLTSVYQH NLFFLLSLGI
210 220 230 240 250
ILFCYVEILR TLFRSRSKRR HRTVKLIFAI VVAYFLSWGP YNFTLFLQTL
260 270 280 290 300
FRTQIIRSCE AKQQLEYALL ICRNLAFSHC CFNPVLYVFV GVKFRTHLKH
310 320 330
VLRQFWFCRL QAPSPASIPH SPGAFAYEGA SFY
Length:333
Mass (Da):38,508
Last modified:November 1, 1995 - v1
Checksum:iC84E7A3EF919CFA5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q689E2Q689E2_HUMAN
Chemokine C motif receptor 1
XCR1
36Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36149 Genomic DNA Translation: AAA62837.1
AY275469 Genomic DNA Translation: AAP32301.1
BC069075 mRNA Translation: AAH69075.1
BC069589 mRNA Translation: AAH69589.1
CCDSiCCDS2736.1
PIRiI65989
RefSeqiNP_001019815.1, NM_001024644.1
NP_005274.1, NM_005283.2
XP_016861685.1, XM_017006196.1
XP_016861686.1, XM_017006197.1
XP_016861687.1, XM_017006198.1
XP_016861688.1, XM_017006199.1
XP_016861689.1, XM_017006200.1
XP_016861690.1, XM_017006201.1
UniGeneiHs.128375
Hs.248116

Genome annotation databases

EnsembliENST00000309285; ENSP00000310405; ENSG00000173578
GeneIDi2829
KEGGihsa:2829
UCSCiuc003cpd.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36149 Genomic DNA Translation: AAA62837.1
AY275469 Genomic DNA Translation: AAP32301.1
BC069075 mRNA Translation: AAH69075.1
BC069589 mRNA Translation: AAH69589.1
CCDSiCCDS2736.1
PIRiI65989
RefSeqiNP_001019815.1, NM_001024644.1
NP_005274.1, NM_005283.2
XP_016861685.1, XM_017006196.1
XP_016861686.1, XM_017006197.1
XP_016861687.1, XM_017006198.1
XP_016861688.1, XM_017006199.1
XP_016861689.1, XM_017006200.1
XP_016861690.1, XM_017006201.1
UniGeneiHs.128375
Hs.248116

3D structure databases

ProteinModelPortaliP46094
SMRiP46094
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP46094, 2 interactors
STRINGi9606.ENSP00000310405

Chemistry databases

GuidetoPHARMACOLOGYi75

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP46094
PhosphoSitePlusiP46094

Polymorphism and mutation databases

BioMutaiXCR1
DMDMi1170008

Proteomic databases

PaxDbiP46094
PeptideAtlasiP46094
PRIDEiP46094
ProteomicsDBi55720

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309285; ENSP00000310405; ENSG00000173578
GeneIDi2829
KEGGihsa:2829
UCSCiuc003cpd.2 human

Organism-specific databases

CTDi2829
DisGeNETi2829
EuPathDBiHostDB:ENSG00000173578.7
GeneCardsiXCR1
HGNCiHGNC:1625 XCR1
HPAiHPA013169
MIMi600552 gene
neXtProtiNX_P46094
OpenTargetsiENSG00000173578
PharmGKBiPA35037
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYH Eukaryota
ENOG410XUKS LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG101128
InParanoidiP46094
KOiK04193
OMAiAYFLSWA
OrthoDBiEOG091G09U3
PhylomeDBiP46094
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-416476 G alpha (q) signalling events
SIGNORiP46094

Miscellaneous databases

ChiTaRSiXCR1 human
GeneWikiiXCR1
GenomeRNAii2829
PROiPR:P46094
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173578 Expressed in 60 organ(s), highest expression level in placenta
CleanExiHS_XCR1
ExpressionAtlasiP46094 baseline and differential
GenevisibleiP46094 HS

Family and domain databases

InterProiView protein in InterPro
IPR005393 Chemokine_XCR1
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01568 LYMPHOTACTNR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXCR1_HUMAN
AccessioniPrimary (citable) accession number: P46094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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