UniProtKB - P46091 (GPR1_HUMAN)
Protein
G-protein coupled receptor 1
Gene
GPR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).By similarity1 Publication
(Microbial infection) Coreceptor for HIV-1.1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P46091 |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 1 |
Gene namesi | Name:GPR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183671.12 |
HGNCi | HGNC:4463, GPR1 |
MIMi | 600239, gene |
neXtProti | NX_P46091 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Internalizes in presence of its ligand, TAFA1.By similarity
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 73 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 74 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 112 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 154 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 210 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 211 – 231 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 247 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 248 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 286 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 287 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 355 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 2825 |
OpenTargetsi | ENSG00000183671 |
PharmGKBi | PA28846 |
Miscellaneous databases
Pharosi | P46091, Tbio |
Chemistry databases
GuidetoPHARMACOLOGYi | 82 |
Polymorphism and mutation databases
BioMutai | GPR1 |
DMDMi | 82654939 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069505 | 1 – 355 | G-protein coupled receptor 1Add BLAST | 355 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P46091 |
PeptideAtlasi | P46091 |
PRIDEi | P46091 |
ProteomicsDBi | 55717 |
PTM databases
GlyGeni | P46091, 1 site |
iPTMneti | P46091 |
PhosphoSitePlusi | P46091 |
Expressioni
Tissue specificityi
Expressed in hippocampus.
Gene expression databases
Bgeei | ENSG00000183671, Expressed in choroid plexus epithelium and 171 other tissues |
ExpressionAtlasi | P46091, baseline and differential |
Genevisiblei | P46091, HS |
Organism-specific databases
HPAi | ENSG00000183671, Tissue enhanced (placenta) |
Interactioni
Binary interactionsi
P46091
With | #Exp. | IntAct |
---|---|---|
Spike glycoprotein E1 (PRO_0000041304) from Rubella virus (strain M33). | 2 | EBI-11477864,EBI-11477759 |
Protein-protein interaction databases
IntActi | P46091, 1 interactor |
MINTi | P46091 |
STRINGi | 9606.ENSP00000480405 |
Miscellaneous databases
RNActi | P46091, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160642 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P46091 |
OMAi | VAMNFHW |
OrthoDBi | 910274at2759 |
PhylomeDBi | P46091 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P46091-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEDLEETLFE EFENYSYDLD YYSLESDLEE KVQLGVVHWV SLVLYCLAFV
60 70 80 90 100
LGIPGNAIVI WFTGFKWKKT VTTLWFLNLA IADFIFLLFL PLYISYVAMN
110 120 130 140 150
FHWPFGIWLC KANSFTAQLN MFASVFFLTV ISLDHYIHLI HPVLSHRHRT
160 170 180 190 200
LKNSLIVIIF IWLLASLIGG PALYFRDTVE FNNHTLCYNN FQKHDPDLTL
210 220 230 240 250
IRHHVLTWVK FIIGYLFPLL TMSICYLCLI FKVKKRSILI SSRHFWTILV
260 270 280 290 300
VVVAFVVCWT PYHLFSIWEL TIHHNSYSHH VMQAGIPLST GLAFLNSCLN
310 320 330 340 350
PILYVLISKK FQARFRSSVA EILKYTLWEV SCSGTVSEQL RNSETKNLCL
LETAQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J456 | C9J456_HUMAN | G-protein coupled receptor 1 | GPR1 | 178 | Annotation score: | ||
C9JKF3 | C9JKF3_HUMAN | G-protein coupled receptor 1 | GPR1 | 137 | Annotation score: | ||
C9JQB7 | C9JQB7_HUMAN | G-protein coupled receptor 1 | GPR1 | 227 | Annotation score: | ||
C9JSU0 | C9JSU0_HUMAN | G-protein-coupled receptor 1 | GPR1 | 82 | Annotation score: | ||
C9JCK1 | C9JCK1_HUMAN | G-protein-coupled receptor 1 | GPR1 | 73 | Annotation score: | ||
C9JFR8 | C9JFR8_HUMAN | G-protein-coupled receptor 1 | GPR1 | 19 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | F → L in AAA64592 (PubMed:7851889).Curated | 1 | |
Sequence conflicti | 237 – 238 | SI → TV in AAA64592 (PubMed:7851889).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023839 | 307 | I → V3 PublicationsCorresponds to variant dbSNP:rs3732083Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13666 Genomic DNA Translation: AAA64592.1 EF577403 mRNA Translation: ABQ52423.1 AK290976 mRNA Translation: BAF83665.1 AK075130 mRNA Translation: BAG52070.1 AC007383 Genomic DNA Translation: AAY15063.1 CH471063 Genomic DNA Translation: EAW70383.1 BC067833 mRNA Translation: AAH67833.1 |
CCDSi | CCDS2368.1 |
PIRi | A55733 |
RefSeqi | NP_001091669.1, NM_001098199.1 NP_001248381.1, NM_001261452.1 NP_001248382.1, NM_001261453.1 NP_001248383.1, NM_001261454.1 NP_001248384.1, NM_001261455.1 NP_005270.2, NM_005279.3 XP_005246528.1, XM_005246471.2 XP_016859321.1, XM_017003832.1 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13666 Genomic DNA Translation: AAA64592.1 EF577403 mRNA Translation: ABQ52423.1 AK290976 mRNA Translation: BAF83665.1 AK075130 mRNA Translation: BAG52070.1 AC007383 Genomic DNA Translation: AAY15063.1 CH471063 Genomic DNA Translation: EAW70383.1 BC067833 mRNA Translation: AAH67833.1 |
CCDSi | CCDS2368.1 |
PIRi | A55733 |
RefSeqi | NP_001091669.1, NM_001098199.1 NP_001248381.1, NM_001261452.1 NP_001248382.1, NM_001261453.1 NP_001248383.1, NM_001261454.1 NP_001248384.1, NM_001261455.1 NP_005270.2, NM_005279.3 XP_005246528.1, XM_005246471.2 XP_016859321.1, XM_017003832.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P46091, 1 interactor |
MINTi | P46091 |
STRINGi | 9606.ENSP00000480405 |
Chemistry databases
GuidetoPHARMACOLOGYi | 82 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P46091, 1 site |
iPTMneti | P46091 |
PhosphoSitePlusi | P46091 |
Polymorphism and mutation databases
BioMutai | GPR1 |
DMDMi | 82654939 |
Proteomic databases
PaxDbi | P46091 |
PeptideAtlasi | P46091 |
PRIDEi | P46091 |
ProteomicsDBi | 55717 |
Protocols and materials databases
Antibodypediai | 1410, 229 antibodies |
DNASUi | 2825 |
Genome annotation databases
Organism-specific databases
CTDi | 2825 |
DisGeNETi | 2825 |
EuPathDBi | HostDB:ENSG00000183671.12 |
GeneCardsi | GPR1 |
HGNCi | HGNC:4463, GPR1 |
HPAi | ENSG00000183671, Tissue enhanced (placenta) |
MIMi | 600239, gene |
neXtProti | NX_P46091 |
OpenTargetsi | ENSG00000183671 |
PharmGKBi | PA28846 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160642 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P46091 |
OMAi | VAMNFHW |
OrthoDBi | 910274at2759 |
PhylomeDBi | P46091 |
TreeFami | TF330976 |
Enzyme and pathway databases
PathwayCommonsi | P46091 |
Miscellaneous databases
BioGRID-ORCSi | 2825, 1 hit in 836 CRISPR screens |
GeneWikii | GPR1 |
GenomeRNAii | 2825 |
Pharosi | P46091, Tbio |
PROi | PR:P46091 |
RNActi | P46091, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183671, Expressed in choroid plexus epithelium and 171 other tissues |
ExpressionAtlasi | P46091, baseline and differential |
Genevisiblei | P46091, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR1_HUMAN | |
Accessioni | P46091Primary (citable) accession number: P46091 Secondary accession number(s): A5JUU6 Q6NVX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 22, 2005 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries