UniProtKB - P46090 (GPR1_RAT)
Protein
G-protein coupled receptor 1
Gene
Gpr1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).By similarity
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- neuropeptide signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 1 |
Gene namesi | Name:Gpr1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2728, Gpr1 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Internalizes in presence of its ligand, TAFA1.By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | ExtracellularSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 73 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 74 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 112 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 113 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 134 – 154 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 210 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 211 – 231 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 247 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 248 – 268 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 269 – 286 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 287 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 353 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069509 | 1 – 353 | G-protein coupled receptor 1Add BLAST | 353 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 110 ↔ 187 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P46090 |
PRIDEi | P46090 |
PTM databases
GlyGeni | P46090, 1 site |
PhosphoSitePlusi | P46090 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P46090 |
PhylomeDBi | P46090 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P46090-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVSREMLFE ELDNYSYALE YYSQEPDAEE NVYPGIVHWI SLLLYALAFV
60 70 80 90 100
LGIPGNAIVI WFMGFKWKKT VTTLWFLNLA IADFIFVLFL PLYISYVALS
110 120 130 140 150
FHWPFGRWLC KLNSFIAQLN MFSSVFFLTV ISLDRYIHLI HPGLSHPHRT
160 170 180 190 200
LKNSLLVVLF VWLLASLLGG PTLYFRDTVE VNNRIICYNN FQEYELTLMR
210 220 230 240 250
HHVLTWVKFL FGYLLPLLTM SSCYLCLIFK TKKQNILISS KHLWMILSVV
260 270 280 290 300
IAFMVCWTPF HLFSIWELSI HHNSSFQNVL QGGIPLSTGL AFLNSCLNPI
310 320 330 340 350
LYVIISKKFQ ARFRASVAEV LKRSLWEASC SGTVSEQLRS AETKSLSLLE
TAQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0RCK7 | M0RCK7_RAT | G-protein coupled receptor 1 | Gpr1 rCG_22237 | 353 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74702 Genomic DNA Translation: AAB32978.1 |
PIRi | JC2492 |
RefSeqi | NP_037093.1, NM_012961.1 |
Genome annotation databases
GeneIDi | 25457 |
KEGGi | rno:25457 |
UCSCi | RGD:2728, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S74702 Genomic DNA Translation: AAB32978.1 |
PIRi | JC2492 |
RefSeqi | NP_037093.1, NM_012961.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067327 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P46090, 1 site |
PhosphoSitePlusi | P46090 |
Proteomic databases
PaxDbi | P46090 |
PRIDEi | P46090 |
Genome annotation databases
GeneIDi | 25457 |
KEGGi | rno:25457 |
UCSCi | RGD:2728, rat |
Organism-specific databases
CTDi | 2825 |
RGDi | 2728, Gpr1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P46090 |
PhylomeDBi | P46090 |
Miscellaneous databases
PROi | PR:P46090 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002275, GPR1_orph_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01146, GPR1ORPHANR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR1_RAT | |
Accessioni | P46090Primary (citable) accession number: P46090 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries