NOP2

Functionⁱ

Involved in ribosomal large subunit assembly (PubMed:24120868). S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C₅ position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).Curated1 Publication

Catalytic activityⁱ

S-adenosyl-L-methionine + cytosine(4447) in 28S rRNA = S-adenosyl-L-homocysteine + C₅-methylcytosine(4447) in 28S rRNA.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	416	S-adenosyl-L-methioninePROSITE-ProRule annotation	1
Binding siteⁱ	443	S-adenosyl-L-methioninePROSITE-ProRule annotation	1
Binding siteⁱ	460	S-adenosyl-L-methioninePROSITE-ProRule annotation	1
Active siteⁱ	517	NucleophilePROSITE-ProRule annotation	1

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of cell proliferation
Source: GO_Central
Inferred from direct assayⁱ
- 1394192
regulation of signal transduction by p53 class mediator
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24120868
regulation of transcription by RNA polymerase II Source: Reactome
ribosomal large subunit assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24120868
rRNA base methylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, RNA-binding, Transferase
Biological process	Ribosome biogenesis, rRNA processing
Ligand	S-adenosyl-L-methionine

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC:2.1.1.-1 Publication) Alternative name(s): Nucleolar protein 1 Nucleolar protein 2 homolog Proliferating-cell nucleolar antigen p120 Proliferation-associated nucleolar protein p120
Gene namesⁱ	Name:NOP2 Synonyms:NOL1, NSUN1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111641.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7867 NOP2
MIMⁱ	164031 gene
neXtProtⁱ	NX_P46087

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4839
Open Targets More...OpenTargetsⁱ	ENSG00000111641
PharmGKBⁱ	PA164724026

Polymorphism and mutation databases

BioMutaⁱ	NOP2
DMDMⁱ	146289861

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000211818	1 – 812	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferaseAdd BLAST		812

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	36	PhosphoserineCombined sources	1
Modified residueⁱ	58	PhosphoserineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Cross-linkⁱ	71	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	102	CitrullineBy similarity	1
Modified residueⁱ	164	CitrullineBy similarity	1
Modified residueⁱ	181	PhosphoserineCombined sources	1
Modified residueⁱ	185	PhosphothreonineCombined sources	1
Modified residueⁱ	195	PhosphothreonineCombined sources	1
Cross-linkⁱ	272	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	615	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	649	N6-acetyllysineCombined sources	1
Modified residueⁱ	666	PhosphoserineCombined sources	1
Modified residueⁱ	675	PhosphoserineCombined sources	1
Modified residueⁱ	732	PhosphoserineCombined sources	1
Modified residueⁱ	734	PhosphoserineCombined sources	1
Modified residueⁱ	739	PhosphothreonineCombined sources	1
Modified residueⁱ	776	PhosphothreonineCombined sources	1
Modified residueⁱ	786	PhosphoserineCombined sources	1
Modified residueⁱ	801	PhosphoserineCombined sources	1
Modified residueⁱ	812	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Citrullinated by PADI4.By similarity

Keywords - PTMⁱ

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P46087
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P46087
PaxDbⁱ	P46087
PeptideAtlas More...PeptideAtlasⁱ	P46087
PRIDEⁱ	P46087
ProteomicsDBⁱ	55714 55715 [P46087-2]
TopDownProteomicsⁱ	P46087-2 [P46087-2]

2D gel databases

SWISS-2DPAGEⁱ	P46087

SWISS-2DPAGEⁱ

P46087

PTM databases

iPTMnetⁱ	P46087
PhosphoSitePlusⁱ	P46087
SwissPalmⁱ	P46087

Expressionⁱ

Developmental stageⁱ

Expressed in G1 and peaks during the early S phase of the cell cycle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111641 Expressed in 109 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_NOP2
ExpressionAtlasⁱ	P46087 baseline and differential
Genevisibleⁱ	P46087 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040119

HPAⁱ

HPA040119

Interactionⁱ

Subunit structureⁱ

Interacts with MCRS1 (PubMed:9654073). Interacts with WDR46 (PubMed:23848194). Interacts with RRP1B (PubMed:20926688).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDCA7L	Q96GN5	3	EBI-356811,EBI-5278764
CEP70	Q8NHQ1	3	EBI-356811,EBI-739624
KPNA6	O60684	3	EBI-356811,EBI-359923
MT1F	P04733	3	EBI-356811,EBI-10209483
VPS52	Q8N1B4	3	EBI-356811,EBI-2799833

Protein-protein interaction databases

BioGridⁱ	110902, 164 interactors
IntActⁱ	P46087, 50 interactors
Molecular INTeraction database More...MINTⁱ	P46087
STRINGⁱ	9606.ENSP00000382392

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P46087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	392 – 398	S-adenosyl-L-methionine bindingPROSITE-ProRule annotation		7

Sequence similaritiesⁱ

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1122 Eukaryota COG0144 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00660000095341
HOGENOMⁱ	HOG000224258
HOVERGENⁱ	HBG082043
InParanoidⁱ	P46087
KEGG Orthology (KO) More...KOⁱ	K14835
OMAⁱ	VQRCYNL
PhylomeDBⁱ	P46087
TreeFamⁱ	TF105660

Family and domain databases

InterProⁱ	View protein in InterPro IPR018314 Fmu/NOL1/Nop2p_CS IPR031341 Methyltr_RsmF_N IPR001678 MeTrfase_RsmB/NOP2 IPR011023 Nop2p IPR012586 P120R_rpt IPR023267 RCMT IPR023273 RCMT_NOP2 IPR029063 SAM-dependent_MTases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01189 Methyltr_RsmB-F, 1 hit PF17125 Methyltr_RsmF_N, 1 hit PF08062 P120R, 3 hits
PRINTSⁱ	PR02008 RCMTFAMILY PR02012 RCMTNOP2
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
TIGRFAMsⁱ	TIGR00446 nop2p, 1 hit
PROSITEⁱ	View protein in PROSITE PS01153 NOL1_NOP2_SUN, 1 hit PS51686 SAM_MT_RSMB_NOP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P46087-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR 
        60         70         80         90        100
AAKRRLGSVE APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA 
       110        120        130        140        150
PRGKKRPAPG SDEEEEEEDS EEDGMVNHGD LWGSEDDADT VDDYGADSNS 
       160        170        180        190        200
EDEEEGEALL PIERAARKQK AREAAAGIQW SEEETEDEEE EKEVTPESGP 
       210        220        230        240        250
PKVEEADGGL QINVDEEPFV LPPAGEMEQD AQAPDLQRVH KRIQDIVGIL 
       260        270        280        290        300
RDFGAQREEG RSRSEYLNRL KKDLAIYYSY GDFLLGKLMD LFPLSELVEF 
       310        320        330        340        350
LEANEVPRPV TLRTNTLKTR RRDLAQALIN RGVNLDPLGK WSKTGLVVYD 
       360        370        380        390        400
SSVPIGATPE YLAGHYMLQG ASSMLPVMAL APQEHERILD MCCAPGGKTS 
       410        420        430        440        450
YMAQLMKNTG VILANDANAE RLKSVVGNLH RLGVTNTIIS HYDGRQFPKV 
       460        470        480        490        500
VGGFDRVLLD APCSGTGVIS KDPAVKTNKD EKDILRCAHL QKELLLSAID 
       510        520        530        540        550
SVNATSKTGG YLVYCTCSIT VEENEWVVDY ALKKRNVRLV PTGLDFGQEG 
       560        570        580        590        600
FTRFRERRFH PSLRSTRRFY PHTHNMDGFF IAKFKKFSNS IPQSQTGNSE 
       610        620        630        640        650
TATPTNVDLP QVIPKSENSS QPAKKAKGAA KTKQQLQKQQ HPKKASFQKL 
       660        670        680        690        700
NGISKGADSE LSTVPSVTKT QASSSFQDSS QPAGKAEGIR EPKVTGKLKQ 
       710        720        730        740        750
RSPKLQSSKK VAFLRQNAPP KGTDTQTPAV LSPSKTQATL KPKDHHQPLG 
       760        770        780        790        800
RAKGVEKQQL PEQPFEKAAF QKQNDTPKGP QPPTVSPIRS SRPPPAKRKK 
       810 
SQSRGNSQLL LS

Length:812

Mass (Da):89,302

Last modified:March 6, 2007 - v2

Checksum:ⁱ4C7A1BE79388F1C5

GO

Isoform 2 (identifier: P46087-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
81-84: Missing.

« Hide

        10         20         30         40         50
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR 
        60         70         80         90        100
AAKRRLGSVE APKTNKSPEA KPLPGKLPKG AVQTAGKKGP QSLFNAPRGK 
       110        120        130        140        150
KRPAPGSDEE EEEEDSEEDG MVNHGDLWGS EDDADTVDDY GADSNSEDEE 
       160        170        180        190        200
EGEALLPIER AARKQKAREA AAGIQWSEEE TEDEEEEKEV TPESGPPKVE 
       210        220        230        240        250
EADGGLQINV DEEPFVLPPA GEMEQDAQAP DLQRVHKRIQ DIVGILRDFG 
       260        270        280        290        300
AQREEGRSRS EYLNRLKKDL AIYYSYGDFL LGKLMDLFPL SELVEFLEAN 
       310        320        330        340        350
EVPRPVTLRT NTLKTRRRDL AQALINRGVN LDPLGKWSKT GLVVYDSSVP 
       360        370        380        390        400
IGATPEYLAG HYMLQGASSM LPVMALAPQE HERILDMCCA PGGKTSYMAQ 
       410        420        430        440        450
LMKNTGVILA NDANAERLKS VVGNLHRLGV TNTIISHYDG RQFPKVVGGF 
       460        470        480        490        500
DRVLLDAPCS GTGVISKDPA VKTNKDEKDI LRCAHLQKEL LLSAIDSVNA 
       510        520        530        540        550
TSKTGGYLVY CTCSITVEEN EWVVDYALKK RNVRLVPTGL DFGQEGFTRF 
       560        570        580        590        600
RERRFHPSLR STRRFYPHTH NMDGFFIAKF KKFSNSIPQS QTGNSETATP 
       610        620        630        640        650
TNVDLPQVIP KSENSSQPAK KAKGAAKTKQ QLQKQQHPKK ASFQKLNGIS 
       660        670        680        690        700
KGADSELSTV PSVTKTQASS SFQDSSQPAG KAEGIREPKV TGKLKQRSPK 
       710        720        730        740        750
LQSSKKVAFL RQNAPPKGTD TQTPAVLSPS KTQATLKPKD HHQPLGRAKG 
       760        770        780        790        800
VEKQQLPEQP FEKAAFQKQN DTPKGPQPPT VSPIRSSRPP PAKRKKSQSR 

GNSQLLLS

Show »

Length:808

Mass (Da):88,973

Checksum:ⁱ5984B2D2A8F64780

GO

Isoform 3 (identifier: P46087-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
81-84: Missing.
597-812: GNSETATPTN...SRGNSQLLLS → DGVLLCRSGW...QAILVPQTPK

« Hide

        10         20         30         40         50
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR 
        60         70         80         90        100
AAKRRLGSVE APKTNKSPEA KPLPGKLPKG AVQTAGKKGP QSLFNAPRGK 
       110        120        130        140        150
KRPAPGSDEE EEEEDSEEDG MVNHGDLWGS EDDADTVDDY GADSNSEDEE 
       160        170        180        190        200
EGEALLPIER AARKQKAREA AAGIQWSEEE TEDEEEEKEV TPESGPPKVE 
       210        220        230        240        250
EADGGLQINV DEEPFVLPPA GEMEQDAQAP DLQRVHKRIQ DIVGILRDFG 
       260        270        280        290        300
AQREEGRSRS EYLNRLKKDL AIYYSYGDFL LGKLMDLFPL SELVEFLEAN 
       310        320        330        340        350
EVPRPVTLRT NTLKTRRRDL AQALINRGVN LDPLGKWSKT GLVVYDSSVP 
       360        370        380        390        400
IGATPEYLAG HYMLQGASSM LPVMALAPQE HERILDMCCA PGGKTSYMAQ 
       410        420        430        440        450
LMKNTGVILA NDANAERLKS VVGNLHRLGV TNTIISHYDG RQFPKVVGGF 
       460        470        480        490        500
DRVLLDAPCS GTGVISKDPA VKTNKDEKDI LRCAHLQKEL LLSAIDSVNA 
       510        520        530        540        550
TSKTGGYLVY CTCSITVEEN EWVVDYALKK RNVRLVPTGL DFGQEGFTRF 
       560        570        580        590        600
RERRFHPSLR STRRFYPHTH NMDGFFIAKF KKFSNSIPQS QTDGVLLCRS 
       610        620 
GWTAVVQSQL IATSTFQVQA ILVPQTPK

Show »

Length:628

Mass (Da):69,615

Checksum:ⁱF29EB2BF00FC514F

GO

Isoform 4 (identifier: P46087-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
158-158: A → AAGVQWLGLGSLQPPPPGFKQFSCLSFPSSWDLQ

« Hide

        10         20         30         40         50
MGRKLDPTKE KRGPGRKARK QKGAETELVR FLPAVSDENS KRLSSRARKR 
        60         70         80         90        100
AAKRRLGSVE APKTNKSPEA KPLPGKLPKG ISAGAVQTAG KKGPQSLFNA 
       110        120        130        140        150
PRGKKRPAPG SDEEEEEEDS EEDGMVNHGD LWGSEDDADT VDDYGADSNS 
       160        170        180        190        200
EDEEEGEAAG VQWLGLGSLQ PPPPGFKQFS CLSFPSSWDL QLLPIERAAR 
       210        220        230        240        250
KQKAREAAAG IQWSEEETED EEEEKEVTPE SGPPKVEEAD GGLQINVDEE 
       260        270        280        290        300
PFVLPPAGEM EQDAQAPDLQ RVHKRIQDIV GILRDFGAQR EEGRSRSEYL 
       310        320        330        340        350
NRLKKDLAIY YSYGDFLLGK LMDLFPLSEL VEFLEANEVP RPVTLRTNTL 
       360        370        380        390        400
KTRRRDLAQA LINRGVNLDP LGKWSKTGLV VYDSSVPIGA TPEYLAGHYM 
       410        420        430        440        450
LQGASSMLPV MALAPQEHER ILDMCCAPGG KTSYMAQLMK NTGVILANDA 
       460        470        480        490        500
NAERLKSVVG NLHRLGVTNT IISHYDGRQF PKVVGGFDRV LLDAPCSGTG 
       510        520        530        540        550
VISKDPAVKT NKDEKDILRC AHLQKELLLS AIDSVNATSK TGGYLVYCTC 
       560        570        580        590        600
SITVEENEWV VDYALKKRNV RLVPTGLDFG QEGFTRFRER RFHPSLRSTR 
       610        620        630        640        650
RFYPHTHNMD GFFIAKFKKF SNSIPQSQTG NSETATPTNV DLPQVIPKSE 
       660        670        680        690        700
NSSQPAKKAK GAAKTKQQLQ KQQHPKKASF QKLNGISKGA DSELSTVPSV 
       710        720        730        740        750
TKTQASSSFQ DSSQPAGKAE GIREPKVTGK LKQRSPKLQS SKKVAFLRQN 
       760        770        780        790        800
APPKGTDTQT PAVLSPSKTQ ATLKPKDHHQ PLGRAKGVEK QQLPEQPFEK 
       810        820        830        840 
AAFQKQNDTP KGPQPPTVSP IRSSRPPPAK RKKSQSRGNS QLLLS

Show »

Length:845

Mass (Da):92,860

Checksum:ⁱB3AD501991F1F8F4

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GYR3	F5GYR3_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	275	Annotation score:
F5H8G6	F5H8G6_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	98	Annotation score:
F5GWB7	F5GWB7_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	159	Annotation score:
F5H5X6	F5H5X6_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	250	Annotation score:
F5H709	F5H709_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	176	Annotation score:
F5H359	F5H359_HUMAN	Probable 28S rRNA (cytosine(4447)-C... Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase	NOP2	81	Annotation score:

Sequence cautionⁱ

The sequence AAA36398 differs from that shown. Reason: Frameshift at position 780.Curated

The sequence CAA39119 differs from that shown. Reason: Frameshift at position 780.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	559	F → L in AAI28185 (PubMed:15489334).Curated	1
Sequence conflictⁱ	630	A → G in AAA36398 (PubMed:2576976).Curated	1
Sequence conflictⁱ	760 – 761	LP → FA in AAA36398 (PubMed:2576976).Curated	2
Sequence conflictⁱ	760 – 761	LP → FA in CAA39119 (PubMed:1394192).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030938	73	L → S2 PublicationsCorresponds to variant dbSNP:rs1128164Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_023494	81 – 84	Missing in isoform 2 and isoform 3. 2 Publications	4
Alternative sequenceⁱVSP_045308	158	A → AAGVQWLGLGSLQPPPPGFK QFSCLSFPSSWDLQ in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_045309	597 – 812	GNSET…QLLLS → DGVLLCRSGWTAVVQSQLIA TSTFQVQAILVPQTPK in isoform 3. 1 PublicationAdd BLAST	216

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32110 mRNA Translation: AAA36398.1 Sequence problems. M33132 Genomic DNA No translation available. X55504 mRNA Translation: CAA39119.1 Frameshift. AK056208 mRNA Translation: BAG51648.1 AC006064 Genomic DNA No translation available. BC082985 mRNA Translation: AAH82985.1 BC000656 mRNA Translation: AAH00656.1 BC065257 mRNA Translation: AAH65257.1 BC106072 mRNA Translation: AAI06073.1 BC128183 mRNA Translation: AAI28184.1 BC128184 mRNA Translation: AAI28185.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44811.1 [P46087-2] CCDS58202.1 [P46087-3] CCDS58203.1 [P46087-1] CCDS58204.1 [P46087-4]
PIRⁱ	A48168
NCBI Reference Sequences More...RefSeqⁱ	NP_001028886.1, NM_001033714.2 [P46087-2] NP_001245237.1, NM_001258308.1 [P46087-1] NP_001245238.1, NM_001258309.1 [P46087-4] NP_001245239.1, NM_001258310.1 [P46087-3] NP_006161.2, NM_006170.3 [P46087-2] XP_005253748.1, XM_005253691.1 [P46087-1]
UniGeneⁱ	Hs.534334

Genome annotation databases

Ensemblⁱ	ENST00000322166; ENSP00000313272; ENSG00000111641 [P46087-1] ENST00000382421; ENSP00000371858; ENSG00000111641 [P46087-4] ENST00000399466; ENSP00000382392; ENSG00000111641 [P46087-2] ENST00000537442; ENSP00000444437; ENSG00000111641 [P46087-1] ENST00000541778; ENSP00000443150; ENSG00000111641 [P46087-2] ENST00000545200; ENSP00000439422; ENSG00000111641 [P46087-3] ENST00000617555; ENSP00000484384; ENSG00000111641 [P46087-3] ENST00000620535; ENSP00000479320; ENSG00000111641 [P46087-4]
GeneIDⁱ	4839
KEGGⁱ	hsa:4839
UCSC genome browser More...UCSCⁱ	uc031yro.1 human [P46087-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Fragment)		HUMAN		275	UniRef100_P46087
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Fragment)		HUMAN		176
P46087-2	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Fragment)		HUMAN		250	UniRef100_P46087-2

Protein	Similar proteins		Species	Score	Length	Source
P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Fragment)		HUMAN		275	UniRef90_P46087
Uncharacterized protein		RHIRO		830
Uncharacterized protein		MACMU		819
Uncharacterized protein		CHLSB		816
NOP2 nucleolar protein		PONAB		814
+70
P46087-3	Uncharacterized protein		NOMLE		629	UniRef90_P46087-3
NOP2 isoform 14		PANTR		628
Uncharacterized protein		PANPA		628
NOP2 nucleolar protein		GORGO		628
Uncharacterized protein		MACMU		627
+10
P46087-4	NOP2 isoform 3		PONAB		847	UniRef90_P46087-4
Uncharacterized protein		AOTNA		847
NOP2 isoform 16		PANTR		845
Uncharacterized protein		PANPA		845
Uncharacterized protein		Cebus capucinus imitator		845
+9

Protein	Similar proteins		Species	Score	Length	Source
P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (Fragment)		HUMAN		275	UniRef50_P46087
Uncharacterized protein		RHIRO		830
Uncharacterized protein		MACMU		819
Uncharacterized protein		CHLSB		816
NOP2 nucleolar protein		PONAB		814
+97
P46087-3	Uncharacterized protein		NOMLE		629	UniRef50_P46087-3
NOP2 isoform 14		PANTR		628
Uncharacterized protein		PANPA		628
NOP2 nucleolar protein		GORGO		628
Uncharacterized protein		MANLE		627
+57
P46087-4	NOP2 isoform 3		PONAB		847	UniRef50_P46087-4
Uncharacterized protein		AOTNA		847
Uncharacterized protein		Cebus capucinus imitator		845
NOP2 isoform 16		PANTR		845
Uncharacterized protein		PANPA		845
+106

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M32110 mRNA Translation: AAA36398.1 Sequence problems. M33132 Genomic DNA No translation available. X55504 mRNA Translation: CAA39119.1 Frameshift. AK056208 mRNA Translation: BAG51648.1 AC006064 Genomic DNA No translation available. BC082985 mRNA Translation: AAH82985.1 BC000656 mRNA Translation: AAH00656.1 BC065257 mRNA Translation: AAH65257.1 BC106072 mRNA Translation: AAI06073.1 BC128183 mRNA Translation: AAI28184.1 BC128184 mRNA Translation: AAI28185.1
CCDSⁱ	CCDS44811.1 [P46087-2] CCDS58202.1 [P46087-3] CCDS58203.1 [P46087-1] CCDS58204.1 [P46087-4]
PIRⁱ	A48168
RefSeqⁱ	NP_001028886.1, NM_001033714.2 [P46087-2] NP_001245237.1, NM_001258308.1 [P46087-1] NP_001245238.1, NM_001258309.1 [P46087-4] NP_001245239.1, NM_001258310.1 [P46087-3] NP_006161.2, NM_006170.3 [P46087-2] XP_005253748.1, XM_005253691.1 [P46087-1]
UniGeneⁱ	Hs.534334

3D structure databases

ProteinModelPortalⁱ	P46087
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110902, 164 interactors
IntActⁱ	P46087, 50 interactors
MINTⁱ	P46087
STRINGⁱ	9606.ENSP00000382392

PTM databases

iPTMnetⁱ	P46087
PhosphoSitePlusⁱ	P46087
SwissPalmⁱ	P46087

Polymorphism and mutation databases

BioMutaⁱ	NOP2
DMDMⁱ	146289861

2D gel databases

SWISS-2DPAGEⁱ	P46087

SWISS-2DPAGEⁱ

P46087

Proteomic databases

EPDⁱ	P46087
MaxQBⁱ	P46087
PaxDbⁱ	P46087
PeptideAtlasⁱ	P46087
PRIDEⁱ	P46087
ProteomicsDBⁱ	55714 55715 [P46087-2]
TopDownProteomicsⁱ	P46087-2 [P46087-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000322166; ENSP00000313272; ENSG00000111641 [P46087-1] ENST00000382421; ENSP00000371858; ENSG00000111641 [P46087-4] ENST00000399466; ENSP00000382392; ENSG00000111641 [P46087-2] ENST00000537442; ENSP00000444437; ENSG00000111641 [P46087-1] ENST00000541778; ENSP00000443150; ENSG00000111641 [P46087-2] ENST00000545200; ENSP00000439422; ENSG00000111641 [P46087-3] ENST00000617555; ENSP00000484384; ENSG00000111641 [P46087-3] ENST00000620535; ENSP00000479320; ENSG00000111641 [P46087-4]
GeneIDⁱ	4839
KEGGⁱ	hsa:4839
UCSCⁱ	uc031yro.1 human [P46087-1]

Organism-specific databases

CTDⁱ	4839
DisGeNETⁱ	4839
EuPathDBⁱ	HostDB:ENSG00000111641.10
GeneCardsⁱ	NOP2
HGNCⁱ	HGNC:7867 NOP2
HPAⁱ	HPA040119
MIMⁱ	164031 gene
neXtProtⁱ	NX_P46087
OpenTargetsⁱ	ENSG00000111641
PharmGKBⁱ	PA164724026
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1122 Eukaryota COG0144 LUCA
GeneTreeⁱ	ENSGT00660000095341
HOGENOMⁱ	HOG000224258
HOVERGENⁱ	HBG082043
InParanoidⁱ	P46087
KOⁱ	K14835
OMAⁱ	VQRCYNL
PhylomeDBⁱ	P46087
TreeFamⁱ	TF105660

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Miscellaneous databases

ChiTaRSⁱ	NOP2 human
GeneWikiⁱ	NOL1
GenomeRNAiⁱ	4839
Protein Ontology More...PROⁱ	PR:P46087
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111641 Expressed in 109 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_NOP2
ExpressionAtlasⁱ	P46087 baseline and differential
Genevisibleⁱ	P46087 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018314 Fmu/NOL1/Nop2p_CS IPR031341 Methyltr_RsmF_N IPR001678 MeTrfase_RsmB/NOP2 IPR011023 Nop2p IPR012586 P120R_rpt IPR023267 RCMT IPR023273 RCMT_NOP2 IPR029063 SAM-dependent_MTases
Pfamⁱ	View protein in Pfam PF01189 Methyltr_RsmB-F, 1 hit PF17125 Methyltr_RsmF_N, 1 hit PF08062 P120R, 3 hits
PRINTSⁱ	PR02008 RCMTFAMILY PR02012 RCMTNOP2
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
TIGRFAMsⁱ	TIGR00446 nop2p, 1 hit
PROSITEⁱ	View protein in PROSITE PS01153 NOL1_NOP2_SUN, 1 hit PS51686 SAM_MT_RSMB_NOP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOP2_HUMAN
Accessionⁱ	P46087Primary (citable) accession number: P46087 Secondary accession number(s): A1A4Z3 , B3KPD6, Q05BA7, Q0P5S5, Q3KQS4, Q58F30
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	March 6, 2007
	Last modified:	November 7, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P46087 (NOP2_HUMAN)

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Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ