UniProtKB - P46068 (DSDC_ECOLI)
Protein
HTH-type transcriptional regulator DsdC
Gene
dsdC
Organism
Escherichia coli (strain K12)
Status
Functioni
Regulates the expression of the dsdX-dsdA operon.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 32 – 51 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00297 |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional regulator DsdCAlternative name(s): D-serine deaminase activator |
Gene namesi | Name:dsdC1 Publication Ordered Locus Names:b2364, JW2361 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
No longer induces the dsdX-dsdA operon.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105621 | 1 – 311 | HTH-type transcriptional regulator DsdCAdd BLAST | 311 |
Proteomic databases
PaxDbi | P46068 |
PRIDEi | P46068 |
Expressioni
Inductioni
By growth in D-serine.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260553, 5 interactors |
DIPi | DIP-9480N |
IntActi | P46068, 5 interactors |
STRINGi | 511145.b2364 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 72 | HTH lysR-typePROSITE-ProRule annotationAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the LysR transcriptional regulatory family.Curated
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_37_0_6 |
InParanoidi | P46068 |
PhylomeDBi | P46068 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011781, DsdC IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR02036, dsdC, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
i Sequence
Sequence statusi: Complete.
P46068-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPLREIRNR LLNGWQLSKM HTFEVAARHQ SFALAAEELS LSPSAVSHRI
60 70 80 90 100
NQLEEELGIQ LFVRSHRKVE LTHEGKRVYW ALKSSLDTLN QEILDIKNQE
110 120 130 140 150
LSGTLTLYSR PSIAQCWLVP ALGDFTRRYP SISLTVLTGN DNVNLQRAGI
160 170 180 190 200
DLAIYFDDAP SAQLTHHFLM DEEILPVCSP EYAQRHALTN TVINLCHCTL
210 220 230 240 250
LHDRQAWSND SGTDEWHSWA QHYAVNLPTS SGIGFDRSDL AVIAAMNHIG
260 270 280 290 300
VAMGRKRLVQ KRLASGELVA PFGDMTVKCH QHYYITTLPG RQWPKIEAFI
310
IWLREQVKTT S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 159 | A → R in CAA62931 (PubMed:7592420).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91821 Genomic DNA Translation: CAA62931.1 U00096 Genomic DNA Translation: AAC75423.1 AP009048 Genomic DNA Translation: BAA16224.1 X86379 Genomic DNA No translation available. |
PIRi | A65010 |
RefSeqi | NP_416865.1, NC_000913.3 WP_001326971.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75423; AAC75423; b2364 BAA16224; BAA16224; BAA16224 |
GeneIDi | 948828 |
KEGGi | ecj:JW2361 eco:b2364 |
PATRICi | fig|1411691.4.peg.4365 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91821 Genomic DNA Translation: CAA62931.1 U00096 Genomic DNA Translation: AAC75423.1 AP009048 Genomic DNA Translation: BAA16224.1 X86379 Genomic DNA No translation available. |
PIRi | A65010 |
RefSeqi | NP_416865.1, NC_000913.3 WP_001326971.1, NZ_LN832404.1 |
3D structure databases
SMRi | P46068 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260553, 5 interactors |
DIPi | DIP-9480N |
IntActi | P46068, 5 interactors |
STRINGi | 511145.b2364 |
Proteomic databases
PaxDbi | P46068 |
PRIDEi | P46068 |
Genome annotation databases
EnsemblBacteriai | AAC75423; AAC75423; b2364 BAA16224; BAA16224; BAA16224 |
GeneIDi | 948828 |
KEGGi | ecj:JW2361 eco:b2364 |
PATRICi | fig|1411691.4.peg.4365 |
Organism-specific databases
EchoBASEi | EB2953 |
Phylogenomic databases
eggNOGi | COG0583, Bacteria |
HOGENOMi | CLU_039613_37_0_6 |
InParanoidi | P46068 |
PhylomeDBi | P46068 |
Enzyme and pathway databases
BioCyci | EcoCyc:PD00297 |
Miscellaneous databases
PROi | PR:P46068 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011781, DsdC IPR005119, LysR_subst-bd IPR000847, Tscrpt_reg_HTH_LysR IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00126, HTH_1, 1 hit PF03466, LysR_substrate, 1 hit |
PRINTSi | PR00039, HTHLYSR |
SUPFAMi | SSF46785, SSF46785, 1 hit |
TIGRFAMsi | TIGR02036, dsdC, 1 hit |
PROSITEi | View protein in PROSITE PS50931, HTH_LYSR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSDC_ECOLI | |
Accessioni | P46068Primary (citable) accession number: P46068 Secondary accession number(s): P77443 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families