UniProtKB - P46060 (RAGP1_HUMAN)
Ran GTPase-activating protein 1
RANGAP1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 562 | Hydrophobic interaction with UBE2IBy similarity | 1 | |
Sitei | 565 | Hydrophobic interaction with UBE2IBy similarity | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- GTPase activator activity Source: UniProtKB
- Ran GTPase binding Source: UniProtKB
- RNA binding Source: FlyBase
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- activation of GTPase activity Source: UniProtKB
- cellular response to vasopressin Source: Ensembl
- negative regulation of protein export from nucleus Source: BHF-UCL
- protein sumoylation Source: Reactome
- response to axon injury Source: Ensembl
- signal transduction Source: ProtInc
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | P46060 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-165054, Rev-mediated nuclear export of HIV RNA R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3108232, SUMO E3 ligases SUMOylate target proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P46060 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Ran GTPase-activating protein 1Short name: RanGAP1 |
Gene namesi | Name:RANGAP1 Synonyms:KIAA1835, SD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9854, RANGAP1 |
MIMi | 602362, gene |
neXtProti | NX_P46060 |
VEuPathDBi | HostDB:ENSG00000100401.19 |
Subcellular locationi
Nucleus
- nucleoplasm 1 Publication
- Nucleus envelope 2 Publications
Cytoskeleton
- spindle 2 Publications
Other locations
- Cytoplasm 1 Publication1 Publication
- kinetochore 1 Publication
Note: Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305).2 Publications
Cytoskeleton
- mitotic spindle Source: Ensembl
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear envelope Source: BHF-UCL
- nuclear membrane Source: HPA
- nuclear pore Source: ProtInc
- nuclear pore cytoplasmic filaments Source: Ensembl
- nucleoplasm Source: UniProtKB-SubCell
Other locations
- aggresome Source: HPA
- axon cytoplasm Source: Ensembl
- condensed chromosome kinetochore Source: UniProtKB-SubCell
- cytoplasm Source: ProtInc
- cytoplasmic periphery of the nuclear pore complex Source: Ensembl
- dendrite Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- perinuclear region of cytoplasm Source: FlyBase
Keywords - Cellular componenti
Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 91 | R → A: Abolishes RAN GTPase activation. 1 Publication | 1 | |
Mutagenesisi | 356 | S → A: No effect on phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 358 | S → A: Strongly decreased phosphorylation. No effect on sumoylation. 1 Publication | 1 | |
Mutagenesisi | 524 | K → R: Loss of cross-link to SUMO1. Abolishes association with nuclear pores during interphase, and with mitotic spindles during mitosis. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5905 |
OpenTargetsi | ENSG00000100401 |
PharmGKBi | PA34216 |
Miscellaneous databases
Pharosi | P46060, Tbio |
Genetic variation databases
BioMutai | RANGAP1 |
DMDMi | 1172922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000056737 | 2 – 587 | Ran GTPase-activating protein 1Add BLAST | 586 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate | ||
Cross-linki | 8 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 15 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 24 | PhosphoserineCombined sources | 1 | |
Cross-linki | 279 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 301 | PhosphoserineCombined sources | 1 | |
Modified residuei | 358 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 409 | Phosphothreonine; by CDK21 Publication | 1 | |
Modified residuei | 428 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 435 | PhosphoserineCombined sources | 1 | |
Modified residuei | 436 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 442 | PhosphoserineCombined sources1 Publication | 1 | |
Cross-linki | 452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 524 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 524 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources1 Publication | ||
Cross-linki | 524 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 586 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P46060 |
jPOSTi | P46060 |
MassIVEi | P46060 |
MaxQBi | P46060 |
PaxDbi | P46060 |
PeptideAtlasi | P46060 |
PRIDEi | P46060 |
ProteomicsDBi | 55712 |
PTM databases
iPTMneti | P46060 |
MetOSitei | P46060 |
PhosphoSitePlusi | P46060 |
SwissPalmi | P46060 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100401, Expressed in left testis and 233 other tissues |
ExpressionAtlasi | P46060, baseline and differential |
Genevisiblei | P46060, HS |
Organism-specific databases
HPAi | ENSG00000100401, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:8146159).
Interacts with RAN (PubMed:7891706, PubMed:8896452, PubMed:16428860).
Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961).
Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:27160050, PubMed:15931224, PubMed:22194619).
Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358 (PubMed:15037602, PubMed:27160050, PubMed:15931224). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (PubMed:15037602, PubMed:15931224).
Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (PubMed:27160050).
Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860).
Interacts with TRAF6 (PubMed:18093978).
Interacts with SUMO1 and SENP1 (PubMed:17099698).
Interacts (when sumoylated) with MYCBP2; interaction inhibits MYCBP2 E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119).
11 PublicationsBinary interactionsi
Hide detailsP46060
With | #Exp. | IntAct |
---|---|---|
HTT [P42858] | 10 | EBI-396091,EBI-466029 |
RANBP2 [P49792] | 4 | EBI-396091,EBI-973138 |
SUMO1 [P63165] | 14 | EBI-396091,EBI-80140 |
UBE2I [P63279] | 12 | EBI-396091,EBI-80168 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- Ran GTPase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111840, 185 interactors |
ComplexPortali | CPX-4747, SUMO1 E3 ligase (RANBP2) complex CPX-4922, SUMO2 E3 ligase (RANBP2) complex |
DIPi | DIP-29079N |
IntActi | P46060, 77 interactors |
MINTi | P46060 |
STRINGi | 9606.ENSP00000401470 |
Miscellaneous databases
RNActi | P46060, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P46060 |
SMRi | P46060 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P46060 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 48 – 71 | LRR 1Add BLAST | 24 | |
Repeati | 111 – 134 | LRR 2Add BLAST | 24 | |
Repeati | 207 – 230 | LRR 3Add BLAST | 24 | |
Repeati | 235 – 258 | LRR 4Add BLAST | 24 | |
Repeati | 292 – 319 | LRR 5Add BLAST | 28 | |
Repeati | 320 – 343 | LRR 6Add BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 523 – 526 | SUMO conjugation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 359 – 399 | Asp/Glu-rich (highly acidic)Add BLAST | 41 | |
Compositional biasi | 359 – 397 | Asp/Glu-rich (highly acidic)Add BLAST | 39 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG1909, Eukaryota |
GeneTreei | ENSGT00440000039203 |
HOGENOMi | CLU_028747_2_0_1 |
InParanoidi | P46060 |
OMAi | WGVDELD |
OrthoDBi | 1357476at2759 |
PhylomeDBi | P46060 |
TreeFami | TF318283 |
Family and domain databases
Gene3Di | 1.25.40.200, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR009109, Ran_GTPase_activating_1_C IPR036720, RanGAP1_C_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF07834, RanGAP1_C, 1 hit |
SUPFAMi | SSF69099, SSF69099, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS
60 70 80 90 100
LEALRLEGNT VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL
110 120 130 140 150
ISLGEGLITA GAQLVELDLS DNAFGPDGVQ GFEALLKSSA CFTLQELKLN
160 170 180 190 200
NCGMGIGGGK ILAAALTECH RKSSAQGKPL ALKVFVAGRN RLENDGATAL
210 220 230 240 250
AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV INLNDNTFTE
260 270 280 290 300
KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL
310 320 330 340 350
SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM
360 370 380 390 400
AKVLASLSDD EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ
410 420 430 440 450
RGQGEKSATP SRKILDPNTG EPAPVLSSPP PADVSTFLAF PSPEKLLRLG
460 470 480 490 500
PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF KDEATVRMAV QDAVDALMQK
510 520 530 540 550
AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM ALNHMVQQDY
560 570 580
FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y4Q3 | H0Y4Q3_HUMAN | Ran GTPase-activating protein 1 | RANGAP1 | 253 | Annotation score: | ||
B0QYT4 | B0QYT4_HUMAN | Ran GTPase-activating protein 1 | RANGAP1 | 133 | Annotation score: | ||
B0QYT5 | B0QYT5_HUMAN | Ran GTPase-activating protein 1 | RANGAP1 | 100 | Annotation score: | ||
B0QYT6 | B0QYT6_HUMAN | Ran GTPase-activating protein 1 | RANGAP1 | 37 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029240 | 133 | E → Q. Corresponds to variant dbSNP:rs2229752Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82260 mRNA Translation: CAA57714.1 AB058738 mRNA Translation: BAB47464.1 Different initiation. CR456557 mRNA Translation: CAG30443.1 AL035681 Genomic DNA No translation available. BC014044 mRNA Translation: AAH14044.1 BC041396 mRNA Translation: AAH41396.1 |
CCDSi | CCDS14012.1 |
PIRi | JC5300 |
RefSeqi | NP_001265580.1, NM_001278651.1 NP_001304859.1, NM_001317930.1 NP_002874.1, NM_002883.3 XP_006724352.1, XM_006724289.3 XP_011528596.1, XM_011530294.2 XP_011528597.1, XM_011530295.2 XP_016884382.1, XM_017028893.1 XP_016884383.1, XM_017028894.1 XP_016884384.1, XM_017028895.1 XP_016884385.1, XM_017028896.1 XP_016884386.1, XM_017028897.1 |
Genome annotation databases
Ensembli | ENST00000356244; ENSP00000348577; ENSG00000100401 ENST00000405486; ENSP00000385866; ENSG00000100401 ENST00000455915; ENSP00000401470; ENSG00000100401 |
GeneIDi | 5905 |
KEGGi | hsa:5905 |
UCSCi | uc003azs.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X82260 mRNA Translation: CAA57714.1 AB058738 mRNA Translation: BAB47464.1 Different initiation. CR456557 mRNA Translation: CAG30443.1 AL035681 Genomic DNA No translation available. BC014044 mRNA Translation: AAH14044.1 BC041396 mRNA Translation: AAH41396.1 |
CCDSi | CCDS14012.1 |
PIRi | JC5300 |
RefSeqi | NP_001265580.1, NM_001278651.1 NP_001304859.1, NM_001317930.1 NP_002874.1, NM_002883.3 XP_006724352.1, XM_006724289.3 XP_011528596.1, XM_011530294.2 XP_011528597.1, XM_011530295.2 XP_016884382.1, XM_017028893.1 XP_016884383.1, XM_017028894.1 XP_016884384.1, XM_017028895.1 XP_016884385.1, XM_017028896.1 XP_016884386.1, XM_017028897.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z5S | X-ray | 3.01 | C | 418-587 | [»] | |
2GRN | X-ray | 1.80 | B | 419-587 | [»] | |
2GRO | X-ray | 1.70 | B | 419-587 | [»] | |
2GRP | X-ray | 2.05 | B | 419-587 | [»] | |
2GRQ | X-ray | 1.70 | B | 419-587 | [»] | |
2GRR | X-ray | 1.30 | B | 419-587 | [»] | |
2IO2 | X-ray | 2.90 | C | 418-587 | [»] | |
2IO3 | X-ray | 3.20 | C | 418-587 | [»] | |
2IY0 | X-ray | 2.77 | C | 432-587 | [»] | |
3UIN | X-ray | 2.60 | C | 419-587 | [»] | |
3UIO | X-ray | 2.60 | C | 419-587 | [»] | |
3UIP | X-ray | 2.29 | C | 419-587 | [»] | |
5D2M | X-ray | 2.40 | C/F | 418-587 | [»] | |
BMRBi | P46060 | |||||
SMRi | P46060 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111840, 185 interactors |
ComplexPortali | CPX-4747, SUMO1 E3 ligase (RANBP2) complex CPX-4922, SUMO2 E3 ligase (RANBP2) complex |
DIPi | DIP-29079N |
IntActi | P46060, 77 interactors |
MINTi | P46060 |
STRINGi | 9606.ENSP00000401470 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | P46060 |
MetOSitei | P46060 |
PhosphoSitePlusi | P46060 |
SwissPalmi | P46060 |
Genetic variation databases
BioMutai | RANGAP1 |
DMDMi | 1172922 |
Proteomic databases
EPDi | P46060 |
jPOSTi | P46060 |
MassIVEi | P46060 |
MaxQBi | P46060 |
PaxDbi | P46060 |
PeptideAtlasi | P46060 |
PRIDEi | P46060 |
ProteomicsDBi | 55712 |
Protocols and materials databases
Antibodypediai | 3803, 374 antibodies |
DNASUi | 5905 |
Genome annotation databases
Ensembli | ENST00000356244; ENSP00000348577; ENSG00000100401 ENST00000405486; ENSP00000385866; ENSG00000100401 ENST00000455915; ENSP00000401470; ENSG00000100401 |
GeneIDi | 5905 |
KEGGi | hsa:5905 |
UCSCi | uc003azs.5, human |
Organism-specific databases
CTDi | 5905 |
DisGeNETi | 5905 |
GeneCardsi | RANGAP1 |
HGNCi | HGNC:9854, RANGAP1 |
HPAi | ENSG00000100401, Low tissue specificity |
MIMi | 602362, gene |
neXtProti | NX_P46060 |
OpenTargetsi | ENSG00000100401 |
PharmGKBi | PA34216 |
VEuPathDBi | HostDB:ENSG00000100401.19 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1909, Eukaryota |
GeneTreei | ENSGT00440000039203 |
HOGENOMi | CLU_028747_2_0_1 |
InParanoidi | P46060 |
OMAi | WGVDELD |
OrthoDBi | 1357476at2759 |
PhylomeDBi | P46060 |
TreeFami | TF318283 |
Enzyme and pathway databases
PathwayCommonsi | P46060 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-165054, Rev-mediated nuclear export of HIV RNA R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-3108232, SUMO E3 ligases SUMOylate target proteins R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9615933, Postmitotic nuclear pore complex (NPC) reformation R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P46060 |
Miscellaneous databases
BioGRID-ORCSi | 5905, 756 hits in 880 CRISPR screens |
ChiTaRSi | RANGAP1, human |
EvolutionaryTracei | P46060 |
GeneWikii | RANGAP1 |
GenomeRNAii | 5905 |
Pharosi | P46060, Tbio |
PROi | PR:P46060 |
RNActi | P46060, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100401, Expressed in left testis and 233 other tissues |
ExpressionAtlasi | P46060, baseline and differential |
Genevisiblei | P46060, HS |
Family and domain databases
Gene3Di | 1.25.40.200, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR009109, Ran_GTPase_activating_1_C IPR036720, RanGAP1_C_sf |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF07834, RanGAP1_C, 1 hit |
SUPFAMi | SSF69099, SSF69099, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAGP1_HUMAN | |
Accessioni | P46060Primary (citable) accession number: P46060 Secondary accession number(s): Q96JJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 222 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families