RANGAP1

Functionⁱ

GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050).4 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	562	Hydrophobic interaction with UBE2IBy similarity		1
Siteⁱ	565	Hydrophobic interaction with UBE2IBy similarity		1

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
GTPase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16428860
Ran GTPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16428860
RNA binding
Source: FlyBase
Inferred from direct assayⁱ
- 26308891
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of GTPase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16428860
cellular response to vasopressin Source: Ensembl
negative regulation of protein export from nucleus
Source: BHF-UCL
Inferred from direct assayⁱ
- 16449645
response to axon injury Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7878053

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	P46060

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ran GTPase-activating protein 1 Short name: RanGAP1
Gene namesⁱ	Name:RANGAP1 Synonyms:KIAA1835, SD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100401.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9854 RANGAP1
MIMⁱ	602362 gene
neXtProtⁱ	NX_P46060

Keywords - Cellular componentⁱ

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	91	R → A: Abolishes RAN GTPase activation. 1 Publication	1
Mutagenesisⁱ	356	S → A: No effect on phosphorylation. 1 Publication	1
Mutagenesisⁱ	358	S → A: Strongly decreased phosphorylation. No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	524	K → R: Loss of cross-link to SUMO1. Abolishes association with nuclear pores during interphase, and with mitotic spindles during mitosis. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5905
Open Targets More...OpenTargetsⁱ	ENSG00000100401
PharmGKBⁱ	PA34216

Polymorphism and mutation databases

BioMutaⁱ	RANGAP1
DMDMⁱ	1172922

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000056737	2 – 587	Ran GTPase-activating protein 1Add BLAST		586

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Cross-linkⁱ	8	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Cross-linkⁱ	8	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	15	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	24	PhosphoserineCombined sources	1
Cross-linkⁱ	279	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	301	PhosphoserineCombined sources	1
Modified residueⁱ	358	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	409	Phosphothreonine; by CDK21 Publication	1
Modified residueⁱ	428	PhosphoserineCombined sources1 Publication	1
Modified residueⁱ	435	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphothreonineCombined sources	1
Modified residueⁱ	442	PhosphoserineCombined sources1 Publication	1
Cross-linkⁱ	452	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	524	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	524	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources1 Publication
Cross-linkⁱ	524	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	586	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylation occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBE2I, on nuclear pore complex (NPC) diassembly and during mitosis.1 Publication

Sumoylated (PubMed:11854305, PubMed:15037602, PubMed:26304119, PubMed:27160050). Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis (PubMed:11854305). Also required for interaction with RANBP2 and is mediated by UBE2I (PubMed:27160050).1 Publication5 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P46060
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P46060
PaxDbⁱ	P46060
PeptideAtlas More...PeptideAtlasⁱ	P46060
PRIDEⁱ	P46060
ProteomicsDBⁱ	55712

PTM databases

iPTMnetⁱ	P46060
PhosphoSitePlusⁱ	P46060
SwissPalmⁱ	P46060

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain, thymus and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000100401 Expressed in 220 organ(s), highest expression level in right testis
CleanExⁱ	HS_RANGAP1
ExpressionAtlasⁱ	P46060 baseline and differential
Genevisibleⁱ	P46060 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004293 HPA050110 HPA062034

HPAⁱ

CAB004293
HPA050110
HPA062034

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:8146159). Interacts with RAN (PubMed:7891706, PubMed:8896452, PubMed:16428860). Forms a complex with RANBP2/NUP358, NXF1 and NXT1 (PubMed:14729961). Forms a tight complex in association with RANBP2/NUP358 and UBE2I/UBC9, the ubiquitin-conjugating enzyme E2 (PubMed:15037602, PubMed:27160050, PubMed:15931224, PubMed:22194619). Interacts with UBE2I; the interaction conjugates SUMO1 to RANGAP1, and subsequently stabilizes interactions of sumoylated RANGAP1 with RANBP2/NUP358 (PubMed:15037602, PubMed:27160050, PubMed:15931224). The complex composed of RANBP2, SUMO1, RANGAP1 and UBE2I associates with nuclear pore complexes (PubMed:15037602, PubMed:15931224). Identified in a complex composed of RAN, RANBP2, sumoylated RANGAP1, UBE2I and XPO1 (PubMed:27160050). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860). Interacts with TRAF6 (PubMed:18093978). Interacts with SUMO1 and SENP1 (PubMed:17099698). Interacts (when sumoylated) with MYCBP2; interaction inhibits MYCBP2 E3 ubiquitin-protein ligase activity and promotes MYCBP2 translocation to the nucleus (PubMed:26304119).11 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SUMO1	P63165	13	EBI-396091,EBI-80140
UBE2I	P63279	8	EBI-396091,EBI-80168

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
Ran GTPase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16428860
ubiquitin protein ligase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111840, 140 interactors
Database of interacting proteins More...DIPⁱ	DIP-29079N
IntActⁱ	P46060, 56 interactors
Molecular INTeraction database More...MINTⁱ	P46060
STRINGⁱ	9606.ENSP00000348577

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	434 – 439	Combined sources	6
Helixⁱ	443 – 448	Combined sources	6
Helixⁱ	450 – 452	Combined sources	3
Helixⁱ	453 – 459	Combined sources	7
Helixⁱ	466 – 477	Combined sources	12
Helixⁱ	484 – 502	Combined sources	19
Beta strandⁱ	503 – 507	Combined sources	5
Helixⁱ	509 – 519	Combined sources	11
Beta strandⁱ	522 – 526	Combined sources	5
Helixⁱ	536 – 545	Combined sources	10
Beta strandⁱ	548 – 551	Combined sources	4
Helixⁱ	553 – 555	Combined sources	3
Helixⁱ	556 – 564	Combined sources	9
Helixⁱ	568 – 571	Combined sources	4
Helixⁱ	574 – 586	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P46060
SMRⁱ	P46060
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P46060

EvolutionaryTraceⁱ

P46060

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	48 – 71	LRR 1Add BLAST	24
Repeatⁱ	111 – 134	LRR 2Add BLAST	24
Repeatⁱ	207 – 230	LRR 3Add BLAST	24
Repeatⁱ	235 – 258	LRR 4Add BLAST	24
Repeatⁱ	292 – 319	LRR 5Add BLAST	28
Repeatⁱ	320 – 343	LRR 6Add BLAST	24

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	523 – 526	SUMO conjugation		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	359 – 399	Asp/Glu-rich (highly acidic)Add BLAST		41
Compositional biasⁱ	359 – 397	Asp/Glu-rich (highly acidic)Add BLAST		39

Sequence similaritiesⁱ

Belongs to the RNA1 family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1909 Eukaryota COG5238 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000039203
HOGENOMⁱ	HOG000195026
HOVERGENⁱ	HBG017720
InParanoidⁱ	P46060
KEGG Orthology (KO) More...KOⁱ	K14319
OMAⁱ	WGVDELD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02K4
PhylomeDBⁱ	P46060
TreeFamⁱ	TF318283

Family and domain databases

Gene3Dⁱ	1.25.40.200, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR009109 Ran_GTPase_activating_1_C IPR027038 RanGap IPR036720 RanGAP1_C_sf
PANTHERⁱ	PTHR24113 PTHR24113, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF07834 RanGAP1_C, 1 hit
SUPFAMⁱ	SSF69099 SSF69099, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P46060-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASEDIAKLA ETLAKTQVAG GQLSFKGKSL KLNTAEDAKD VIKEIEDFDS 
        60         70         80         90        100
LEALRLEGNT VGVEAARVIA KALEKKSELK RCHWSDMFTG RLRTEIPPAL 
       110        120        130        140        150
ISLGEGLITA GAQLVELDLS DNAFGPDGVQ GFEALLKSSA CFTLQELKLN 
       160        170        180        190        200
NCGMGIGGGK ILAAALTECH RKSSAQGKPL ALKVFVAGRN RLENDGATAL 
       210        220        230        240        250
AEAFRVIGTL EEVHMPQNGI NHPGITALAQ AFAVNPLLRV INLNDNTFTE 
       260        270        280        290        300
KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL 
       310        320        330        340        350
SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM 
       360        370        380        390        400
AKVLASLSDD EDEEEEEEGE EEEEEAEEEE EEDEEEEEEE EEEEEEEPQQ 
       410        420        430        440        450
RGQGEKSATP SRKILDPNTG EPAPVLSSPP PADVSTFLAF PSPEKLLRLG 
       460        470        480        490        500
PKSSVLIAQQ TDTSDPEKVV SAFLKVSSVF KDEATVRMAV QDAVDALMQK 
       510        520        530        540        550
AFNSSSFNSN TFLTRLLVHM GLLKSEDKVK AIANLYGPLM ALNHMVQQDY 
       560        570        580 
FPKALAPLLL AFVTKPNSAL ESCSFARHSL LQTLYKV

Length:587

Mass (Da):63,542

Last modified:November 1, 1995 - v1

Checksum:ⁱ3C18068AAC06B98F

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y4Q3	H0Y4Q3_HUMAN	Ran GTPase-activating protein 1 Ran GTPase-activating protein 1	RANGAP1	253	Annotation score:
B0QYT4	B0QYT4_HUMAN	Ran GTPase-activating protein 1 Ran GTPase-activating protein 1	RANGAP1	133	Annotation score:
B0QYT5	B0QYT5_HUMAN	Ran GTPase-activating protein 1 Ran GTPase-activating protein 1	RANGAP1	100	Annotation score:
B0QYT6	B0QYT6_HUMAN	Ran GTPase-activating protein 1 Ran GTPase-activating protein 1	RANGAP1	37	Annotation score:

Sequence cautionⁱ

The sequence BAB47464 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_029240	133	E → Q. Corresponds to variant dbSNP:rs2229752Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82260 mRNA Translation: CAA57714.1 AB058738 mRNA Translation: BAB47464.1 Different initiation. CR456557 mRNA Translation: CAG30443.1 AL035681 Genomic DNA No translation available. BC014044 mRNA Translation: AAH14044.1 BC041396 mRNA Translation: AAH41396.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14012.1
PIRⁱ	JC5300
NCBI Reference Sequences More...RefSeqⁱ	NP_001265580.1, NM_001278651.1 NP_001304859.1, NM_001317930.1 NP_002874.1, NM_002883.3 XP_006724352.1, XM_006724289.3 XP_011528596.1, XM_011530294.2 XP_011528597.1, XM_011530295.2 XP_016884382.1, XM_017028893.1 XP_016884383.1, XM_017028894.1 XP_016884384.1, XM_017028895.1 XP_016884385.1, XM_017028896.1 XP_016884386.1, XM_017028897.1
UniGeneⁱ	Hs.183800

Genome annotation databases

Ensemblⁱ	ENST00000356244; ENSP00000348577; ENSG00000100401 ENST00000405486; ENSP00000385866; ENSG00000100401 ENST00000455915; ENSP00000401470; ENSG00000100401
GeneIDⁱ	5905
KEGGⁱ	hsa:5905
UCSC genome browser More...UCSCⁱ	uc003azs.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P46060	Ran GTPase activating protein 1, isoform CRA_d		HUMAN		587	UniRef100_P46060
RANGAP1 isoform 6 (Fragment)		PONAB		133
RANGAP1 isoform 6 (Fragment)		PANTR		133
Uncharacterized protein (Fragment)		HUMAN		213
Ran GTPase-activating protein 1 (Fragment)		HUMAN		133
+7

Protein	Similar proteins		Species	Score	Length	Source
P46060	Ran GTPase activating protein 1, isoform CRA_d		HUMAN		587	UniRef90_P46060
RANGAP1 isoform 6 (Fragment)		PONAB		133
RANGAP1 isoform 6 (Fragment)		PANTR		133
Uncharacterized protein		Cebus capucinus imitator		642
Uncharacterized protein		MACFA		641
+107

Protein	Similar proteins		Species	Score	Length	Source
P46060	Ran GTPase-activating protein 1	)	MOUSE		589	UniRef50_P46061
Ran GTPase-activating protein 1		XENLA		580
RAN GTPase-activating protein 1		RAT		586
ran GTPase-activating protein 1		ALLSI		576
Ran GTPase-activating protein 1		ALLMI		568
+473

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X82260 mRNA Translation: CAA57714.1 AB058738 mRNA Translation: BAB47464.1 Different initiation. CR456557 mRNA Translation: CAG30443.1 AL035681 Genomic DNA No translation available. BC014044 mRNA Translation: AAH14044.1 BC041396 mRNA Translation: AAH41396.1
CCDSⁱ	CCDS14012.1
PIRⁱ	JC5300
RefSeqⁱ	NP_001265580.1, NM_001278651.1 NP_001304859.1, NM_001317930.1 NP_002874.1, NM_002883.3 XP_006724352.1, XM_006724289.3 XP_011528596.1, XM_011530294.2 XP_011528597.1, XM_011530295.2 XP_016884382.1, XM_017028893.1 XP_016884383.1, XM_017028894.1 XP_016884384.1, XM_017028895.1 XP_016884385.1, XM_017028896.1 XP_016884386.1, XM_017028897.1
UniGeneⁱ	Hs.183800

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Z5S	X-ray	3.01	C	418-587	[»]
	2GRN	X-ray	1.80	B	419-587	[»]
	2GRO	X-ray	1.70	B	419-587	[»]
	2GRP	X-ray	2.05	B	419-587	[»]
	2GRQ	X-ray	1.70	B	419-587	[»]
	2GRR	X-ray	1.30	B	419-587	[»]
	2IO2	X-ray	2.90	C	418-587	[»]
	2IO3	X-ray	3.20	C	418-587	[»]
	2IY0	X-ray	2.77	C	432-587	[»]
	3UIN	X-ray	2.60	C	419-587	[»]
	3UIO	X-ray	2.60	C	419-587	[»]
	3UIP	X-ray	2.29	C	419-587	[»]
	5D2M	X-ray	2.40	C/F	418-587	[»]
ProteinModelPortalⁱ	P46060
SMRⁱ	P46060
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111840, 140 interactors
DIPⁱ	DIP-29079N
IntActⁱ	P46060, 56 interactors
MINTⁱ	P46060
STRINGⁱ	9606.ENSP00000348577

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	P46060
PhosphoSitePlusⁱ	P46060
SwissPalmⁱ	P46060

Polymorphism and mutation databases

BioMutaⁱ	RANGAP1
DMDMⁱ	1172922

Proteomic databases

EPDⁱ	P46060
MaxQBⁱ	P46060
PaxDbⁱ	P46060
PeptideAtlasⁱ	P46060
PRIDEⁱ	P46060
ProteomicsDBⁱ	55712

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5905
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356244; ENSP00000348577; ENSG00000100401 ENST00000405486; ENSP00000385866; ENSG00000100401 ENST00000455915; ENSP00000401470; ENSG00000100401
GeneIDⁱ	5905
KEGGⁱ	hsa:5905
UCSCⁱ	uc003azs.5 human

Organism-specific databases

CTDⁱ	5905
DisGeNETⁱ	5905
EuPathDBⁱ	HostDB:ENSG00000100401.19
GeneCardsⁱ	RANGAP1
HGNCⁱ	HGNC:9854 RANGAP1
HPAⁱ	CAB004293 HPA050110 HPA062034
MIMⁱ	602362 gene
neXtProtⁱ	NX_P46060
OpenTargetsⁱ	ENSG00000100401
PharmGKBⁱ	PA34216
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1909 Eukaryota COG5238 LUCA
GeneTreeⁱ	ENSGT00440000039203
HOGENOMⁱ	HOG000195026
HOVERGENⁱ	HBG017720
InParanoidⁱ	P46060
KOⁱ	K14319
OMAⁱ	WGVDELD
OrthoDBⁱ	EOG091G02K4
PhylomeDBⁱ	P46060
TreeFamⁱ	TF318283

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-165054 Rev-mediated nuclear export of HIV RNA R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-4615885 SUMOylation of DNA replication proteins R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	P46060

Miscellaneous databases

ChiTaRSⁱ	RANGAP1 human
EvolutionaryTraceⁱ	P46060
GeneWikiⁱ	RANGAP1
GenomeRNAiⁱ	5905
Protein Ontology More...PROⁱ	PR:P46060
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100401 Expressed in 220 organ(s), highest expression level in right testis
CleanExⁱ	HS_RANGAP1
ExpressionAtlasⁱ	P46060 baseline and differential
Genevisibleⁱ	P46060 HS

Family and domain databases

Gene3Dⁱ	1.25.40.200, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR009109 Ran_GTPase_activating_1_C IPR027038 RanGap IPR036720 RanGAP1_C_sf
PANTHERⁱ	PTHR24113 PTHR24113, 1 hit
Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF07834 RanGAP1_C, 1 hit
SUPFAMⁱ	SSF69099 SSF69099, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RAGP1_HUMAN
Accessionⁱ	P46060Primary (citable) accession number: P46060 Secondary accession number(s): Q96JJ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 204 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P46060 (RAGP1_HUMAN)

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Ran GTPase-activating protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ