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UniProtKB - P46059 (S15A1_HUMAN)

Entry version 172 (25 May 2022)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
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Protein

Solute carrier family 15 member 1

Gene

SLC15A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7896779, PubMed:18367661, PubMed:19685173).

Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P46059

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-427975, Proton/oligopeptide cotransporters

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P46059

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.17.4.9, the proton-dependent oligopeptide transporter (pot/ptr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 15 member 1Curated
Alternative name(s):
Intestinal H(+)/peptide cotransporter1 Publication
Oligopeptide transporter, small intestine isoform1 Publication
Peptide transporter 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC15A1Imported
Synonyms:PEPT11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10920, SLC15A1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600544, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P46059

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000088386

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 53ExtracellularSequence analysisAdd BLAST32
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 82CytoplasmicSequence analysis8
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 118ExtracellularSequence analysisAdd BLAST15
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 198ExtracellularSequence analysisAdd BLAST16
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 276CytoplasmicSequence analysisAdd BLAST57
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 327ExtracellularSequence analysisAdd BLAST30
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 361CytoplasmicSequence analysisAdd BLAST13
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 584ExtracellularSequence analysisAdd BLAST202
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 619CytoplasmicSequence analysisAdd BLAST14
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 645ExtracellularSequence analysis5
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Topological domaini667 – 708CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi588Y → C: Reduced transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi594G → A: Does not affect transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi594G → C: Nearly abolished transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi594G → V: Abolished transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi595E → C: Nearly abolished transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi595E → D: Does not affect transmembrane transport of dipeptides. 1 Publication1
Mutagenesisi595E → K or R: Abolished transmembrane transport of dipeptides. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		6564

Open Targets

More...OpenTargetsi		ENSG00000088386

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA323

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P46059, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4605

Drug and drug target database

More...DrugBanki		DB00855, Aminolevulinic acid
DB01060, Amoxicillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00542, Benazepril
DB03793, Benzoic acid
DB01053, Benzylpenicillin
DB01197, Captopril
DB00833, Cefaclor
DB01140, Cefadroxil
DB00456, Cefalotin
DB00535, Cefdinir
DB01413, Cefepime
DB00671, Cefixime
DB00274, Cefmetazole
DB00493, Cefotaxime
DB01333, Cefradine
DB01415, Ceftibuten
DB01332, Ceftizoxime
DB01212, Ceftriaxone
DB01112, Cefuroxime
DB00567, Cephalexin
DB00672, Chlorpropamide
DB01340, Cilazapril
DB01147, Cloxacillin
DB01000, Cyclacillin
DB09213, Dexibuprofen
DB00485, Dicloxacillin
DB00584, Enalapril
DB01095, Fluvastatin
DB00492, Fosinopril
DB01016, Glyburide
DB01235, Levodopa
DB01255, Lisdexamfetamine
DB00722, Lisinopril
DB00447, Loracarbef
DB00563, Methotrexate
DB00968, Methyldopa
DB00211, Midodrine
DB00691, Moexipril
DB00731, Nateglinide
DB00198, Oseltamivir
DB00713, Oxacillin
DB00790, Perindopril
DB00417, Phenoxymethylpenicillin
DB00881, Quinapril
DB00178, Ramipril
DB01348, Spirapril
DB01956, Taurine
DB08836, Temocapril
DB01124, Tolbutamide
DB00519, Trandolapril
DB03424, Ubenimex
DB00577, Valaciclovir
DB01610, Valganciclovir

DrugCentral

More...DrugCentrali		P46059

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		984

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC15A1

Domain mapping of disease mutations (DMDM)

More...DMDMi		1172435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643041 – 708Solute carrier family 15 member 1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P46059

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P46059

PeptideAtlas

More...PeptideAtlasi		P46059

PRoteomics IDEntifications database

More...PRIDEi		P46059

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55711

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P46059, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P46059

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P46059

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000088386, Expressed in small intestine and 151 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P46059, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P46059, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000088386, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via extracellular domain region) with trypsin.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112452, 81 interactors

Protein interaction database and analysis system

More...IntActi		P46059, 64 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365686

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P46059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P46059, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1708
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P46059

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P46059

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni383 – 584Extracellular domain (ECD)By similarityAdd BLAST202

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain (ECD) region specifically binds trypsin.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1237, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155995

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004790_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P46059

Identification of Orthologs from Complete Genome Data

More...OMAi		YNASEYQ

Database of Orthologous Groups

More...OrthoDBi		925637at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P46059

TreeFam database of animal gene trees

More...TreeFami		TF330897

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036259, MFS_trans_sf
IPR004768, Oligopep_transport
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS

The PANTHER Classification System

More...PANTHERi		PTHR11654, PTHR11654, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00854, PTR2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00926, 2A1704, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P46059-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN 
        60         70         80         90        100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV 
       110        120        130        140        150
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ 
       160        170        180        190        200
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL 
       210        220        230        240        250
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH 
       260        270        280        290        300
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ 
       310        320        330        340        350
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK 
       360        370        380        390        400
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL 
       410        420        430        440        450
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV 
       460        470        480        490        500
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI 
       510        520        530        540        550
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF 
       560        570        580        590        600
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV 
       610        620        630        640        650
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI 
       660        670        680        690        700
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS 

GANSQKQM
Length:708
Mass (Da):78,806
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA75475789177A907
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02932121V → I1 PublicationCorresponds to variant dbSNP:rs8187818Ensembl.1
Natural variantiVAR_02932228F → Y1 PublicationCorresponds to variant dbSNP:rs8187817Ensembl.1
Natural variantiVAR_022147117S → N2 PublicationsCorresponds to variant dbSNP:rs2297322Ensembl.1
Natural variantiVAR_029323117S → R1 PublicationCorresponds to variant dbSNP:rs8187821Ensembl.1
Natural variantiVAR_020456122V → M1 PublicationCorresponds to variant dbSNP:rs8187820EnsemblClinVar.1
Natural variantiVAR_020457419G → A2 PublicationsCorresponds to variant dbSNP:rs4646227Ensembl.1
Natural variantiVAR_022148450V → I1 PublicationCorresponds to variant dbSNP:rs2274828Ensembl.1
Natural variantiVAR_020458451T → N1 PublicationCorresponds to variant dbSNP:rs8187838Ensembl.1
Natural variantiVAR_022149459R → C. Corresponds to variant dbSNP:rs2274827Ensembl.1
Natural variantiVAR_029324537P → S1 PublicationCorresponds to variant dbSNP:rs8187830Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U13173 mRNA Translation: AAB61693.1
U21936 mRNA Translation: AAA63797.1
AL391670 Genomic DNA No translation available.
AL353574 Genomic DNA No translation available.
BC096328 mRNA Translation: AAH96328.1
BC096329 mRNA Translation: AAH96329.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9489.1

Protein sequence database of the Protein Information Resource

More...PIRi		A56163

NCBI Reference Sequences

More...RefSeqi		NP_005064.1, NM_005073.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376503.10; ENSP00000365686.4; ENSG00000088386.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6564

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376503.10; ENSP00000365686.4; NM_005073.4; NP_005064.1

UCSC genome browser

More...UCSCi		uc001vno.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA Translation: AAB61693.1
U21936 mRNA Translation: AAA63797.1
AL391670 Genomic DNA No translation available.
AL353574 Genomic DNA No translation available.
BC096328 mRNA Translation: AAH96328.1
BC096329 mRNA Translation: AAH96329.1
CCDSiCCDS9489.1
PIRiA56163
RefSeqiNP_005064.1, NM_005073.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7PMWelectron microscopy4.10A1-708[»]
7PMXelectron microscopy3.50A1-708[»]
7PN1electron microscopy3.90A1-708[»]
AlphaFoldDBiP46059
SMRiP46059
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112452, 81 interactors
IntActiP46059, 64 interactors
STRINGi9606.ENSP00000365686

Chemistry databases

BindingDBiP46059
ChEMBLiCHEMBL4605
DrugBankiDB00855, Aminolevulinic acid
DB01060, Amoxicillin
DB00415, Ampicillin
DB08795, Azidocillin
DB00542, Benazepril
DB03793, Benzoic acid
DB01053, Benzylpenicillin
DB01197, Captopril
DB00833, Cefaclor
DB01140, Cefadroxil
DB00456, Cefalotin
DB00535, Cefdinir
DB01413, Cefepime
DB00671, Cefixime
DB00274, Cefmetazole
DB00493, Cefotaxime
DB01333, Cefradine
DB01415, Ceftibuten
DB01332, Ceftizoxime
DB01212, Ceftriaxone
DB01112, Cefuroxime
DB00567, Cephalexin
DB00672, Chlorpropamide
DB01340, Cilazapril
DB01147, Cloxacillin
DB01000, Cyclacillin
DB09213, Dexibuprofen
DB00485, Dicloxacillin
DB00584, Enalapril
DB01095, Fluvastatin
DB00492, Fosinopril
DB01016, Glyburide
DB01235, Levodopa
DB01255, Lisdexamfetamine
DB00722, Lisinopril
DB00447, Loracarbef
DB00563, Methotrexate
DB00968, Methyldopa
DB00211, Midodrine
DB00691, Moexipril
DB00731, Nateglinide
DB00198, Oseltamivir
DB00713, Oxacillin
DB00790, Perindopril
DB00417, Phenoxymethylpenicillin
DB00881, Quinapril
DB00178, Ramipril
DB01348, Spirapril
DB01956, Taurine
DB08836, Temocapril
DB01124, Tolbutamide
DB00519, Trandolapril
DB03424, Ubenimex
DB00577, Valaciclovir
DB01610, Valganciclovir
DrugCentraliP46059
GuidetoPHARMACOLOGYi984

Protein family/group databases

TCDBi2.A.17.4.9, the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

GlyGeniP46059, 7 sites
iPTMnetiP46059
PhosphoSitePlusiP46059

Genetic variation databases

BioMutaiSLC15A1
DMDMi1172435

Proteomic databases

MassIVEiP46059
PaxDbiP46059
PeptideAtlasiP46059
PRIDEiP46059
ProteomicsDBi55711

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10820, 229 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		6564

Genome annotation databases

EnsembliENST00000376503.10; ENSP00000365686.4; ENSG00000088386.17
GeneIDi6564
KEGGihsa:6564
MANE-SelectiENST00000376503.10; ENSP00000365686.4; NM_005073.4; NP_005064.1
UCSCiuc001vno.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6564
DisGeNETi6564

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC15A1
HGNCiHGNC:10920, SLC15A1
HPAiENSG00000088386, Tissue enriched (intestine)
MIMi600544, gene
neXtProtiNX_P46059
OpenTargetsiENSG00000088386
PharmGKBiPA323
VEuPathDBiHostDB:ENSG00000088386

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1237, Eukaryota
GeneTreeiENSGT00940000155995
HOGENOMiCLU_004790_3_0_1
InParanoidiP46059
OMAiYNASEYQ
OrthoDBi925637at2759
PhylomeDBiP46059
TreeFamiTF330897

Enzyme and pathway databases

PathwayCommonsiP46059
ReactomeiR-HSA-427975, Proton/oligopeptide cotransporters
SignaLinkiP46059

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6564, 11 hits in 1062 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC15A1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Peptide_transporter_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6564
PharosiP46059, Tchem

Protein Ontology

More...PROi		PR:P46059
RNActiP46059, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000088386, Expressed in small intestine and 151 other tissues
ExpressionAtlasiP46059, baseline and differential
GenevisibleiP46059, HS

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR036259, MFS_trans_sf
IPR004768, Oligopep_transport
IPR000109, POT_fam
IPR018456, PTR2_symporter_CS
PANTHERiPTHR11654, PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854, PTR2, 2 hits
SUPFAMiSSF103473, SSF103473, 1 hit
TIGRFAMsiTIGR00926, 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022, PTR2_1, 1 hit
PS01023, PTR2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS15A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 25, 2022
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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