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Protein

Solute carrier family 15 member 1

Gene

SLC15A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-427975 Proton/oligopeptide cotransporters

Protein family/group databases

TCDBi2.A.17.4.9 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Gene namesi
Name:SLC15A1
Synonyms:PEPT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000088386.15
HGNCiHGNC:10920 SLC15A1
MIMi600544 gene
neXtProtiNX_P46059

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 53ExtracellularSequence analysisAdd BLAST32
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 82CytoplasmicSequence analysis8
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 118ExtracellularSequence analysisAdd BLAST15
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 198ExtracellularSequence analysisAdd BLAST16
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 276CytoplasmicSequence analysisAdd BLAST57
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 327ExtracellularSequence analysisAdd BLAST30
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 361CytoplasmicSequence analysisAdd BLAST13
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 584ExtracellularSequence analysisAdd BLAST202
Transmembranei585 – 605HelicalSequence analysisAdd BLAST21
Topological domaini606 – 619CytoplasmicSequence analysisAdd BLAST14
Transmembranei620 – 640HelicalSequence analysisAdd BLAST21
Topological domaini641 – 645ExtracellularSequence analysis5
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Topological domaini667 – 708CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6564
OpenTargetsiENSG00000088386
PharmGKBiPA323

Chemistry databases

ChEMBLiCHEMBL4605
DrugBankiDB00855 Aminolevulinic acid
DB01060 Amoxicillin
DB00415 Ampicillin
DB08795 Azidocillin
DB00542 Benazepril
DB01053 Benzylpenicillin
DB01197 Captopril
DB00833 Cefaclor
DB01140 Cefadroxil
DB00456 Cefalotin
DB00535 Cefdinir
DB01413 Cefepime
DB00671 Cefixime
DB00274 Cefmetazole
DB00493 Cefotaxime
DB01333 Cefradine
DB00438 Ceftazidime
DB01415 Ceftibuten
DB01332 Ceftizoxime
DB01212 Ceftriaxone
DB01112 Cefuroxime
DB00567 Cephalexin
DB00672 Chlorpropamide
DB01340 Cilazapril
DB01147 Cloxacillin
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00584 Enalapril
DB01095 Fluvastatin
DB00492 Fosinopril
DB01016 Glyburide
DB01235 Levodopa
DB00722 Lisinopril
DB00447 Loracarbef
DB00968 Methyldopa
DB00211 Midodrine
DB00691 Moexipril
DB00731 Nateglinide
DB00198 Oseltamivir
DB00713 Oxacillin
DB00790 Perindopril
DB00417 Phenoxymethylpenicillin
DB00881 Quinapril
DB00178 Ramipril
DB01348 Spirapril
DB08836 Temocapril
DB01124 Tolbutamide
DB00519 Trandolapril
DB03424 Ubenimex
DB00577 Valaciclovir
DB01610 Valganciclovir
GuidetoPHARMACOLOGYi984

Polymorphism and mutation databases

BioMutaiSLC15A1
DMDMi1172435

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643041 – 708Solute carrier family 15 member 1Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi509N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP46059
PeptideAtlasiP46059
PRIDEiP46059
ProteomicsDBi55711

PTM databases

iPTMnetiP46059
PhosphoSitePlusiP46059

Expressioni

Gene expression databases

BgeeiENSG00000088386
CleanExiHS_SLC15A1
ExpressionAtlasiP46059 baseline and differential
GenevisibleiP46059 HS

Organism-specific databases

HPAiHPA002827

Interactioni

Protein-protein interaction databases

BioGridi112452, 78 interactors
STRINGi9606.ENSP00000365686

Chemistry databases

BindingDBiP46059

Structurei

3D structure databases

ProteinModelPortaliP46059
SMRiP46059
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961
HOGENOMiHOG000285186
HOVERGENiHBG052962
InParanoidiP46059
KOiK14206
OMAiIFAIMTR
OrthoDBiEOG091G0M1S
PhylomeDBiP46059
TreeFamiTF330897

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004768 Oligopep_transport
IPR000109 POT_fam
IPR018456 PTR2_symporter_CS
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 2 hits
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00926 2A1704, 1 hit
PROSITEiView protein in PROSITE
PS01022 PTR2_1, 1 hit
PS01023 PTR2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P46059-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV
110 120 130 140 150
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK
360 370 380 390 400
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL
410 420 430 440 450
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV
460 470 480 490 500
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI
510 520 530 540 550
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF
560 570 580 590 600
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV
610 620 630 640 650
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI
660 670 680 690 700
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS

GANSQKQM
Length:708
Mass (Da):78,806
Last modified:November 1, 1995 - v1
Checksum:iA75475789177A907
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02932121V → I1 PublicationCorresponds to variant dbSNP:rs8187818Ensembl.1
Natural variantiVAR_02932228F → Y1 PublicationCorresponds to variant dbSNP:rs8187817Ensembl.1
Natural variantiVAR_022147117S → N2 PublicationsCorresponds to variant dbSNP:rs2297322Ensembl.1
Natural variantiVAR_029323117S → R1 PublicationCorresponds to variant dbSNP:rs8187821Ensembl.1
Natural variantiVAR_020456122V → M1 PublicationCorresponds to variant dbSNP:rs8187820Ensembl.1
Natural variantiVAR_020457419G → A2 PublicationsCorresponds to variant dbSNP:rs4646227Ensembl.1
Natural variantiVAR_022148450V → I1 PublicationCorresponds to variant dbSNP:rs2274828Ensembl.1
Natural variantiVAR_020458451T → N1 PublicationCorresponds to variant dbSNP:rs8187838Ensembl.1
Natural variantiVAR_022149459R → C. Corresponds to variant dbSNP:rs2274827Ensembl.1
Natural variantiVAR_029324537P → S1 PublicationCorresponds to variant dbSNP:rs8187830Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13173 mRNA Translation: AAB61693.1
U21936 mRNA Translation: AAA63797.1
AL391670 Genomic DNA No translation available.
AL353574 Genomic DNA No translation available.
BC096328 mRNA Translation: AAH96328.1
BC096329 mRNA Translation: AAH96329.1
CCDSiCCDS9489.1
PIRiA56163
RefSeqiNP_005064.1, NM_005073.3
UniGeneiHs.436893

Genome annotation databases

EnsembliENST00000376503; ENSP00000365686; ENSG00000088386
GeneIDi6564
KEGGihsa:6564
UCSCiuc001vno.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS15A1_HUMAN
AccessioniPrimary (citable) accession number: P46059
Secondary accession number(s): Q5VW82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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