UniProtKB - P46059 (S15A1_HUMAN)
Protein
Solute carrier family 15 member 1
Gene
SLC15A1
Organism
Homo sapiens (Human)
Status
Functioni
Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7896779, PubMed:18367661, PubMed:19685173). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity).By similarity3 Publications
Catalytic activityi
- This reaction proceeds in the forward3 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- dipeptide transmembrane transporter activity Source: UniProtKB
- peptide:proton symporter activity Source: UniProtKB
- proton-dependent oligopeptide secondary active transmembrane transporter activity Source: Ensembl
- tripeptide transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- dipeptide import across plasma membrane Source: UniProtKB
- ion transport Source: Reactome
- protein transport Source: UniProtKB-KW
- tripeptide import across plasma membrane Source: ARUK-UCL
Keywordsi
Biological process | Peptide transport, Protein transport, Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P46059 |
Reactomei | R-HSA-427975, Proton/oligopeptide cotransporters |
Protein family/group databases
TCDBi | 2.A.17.4.9, the proton-dependent oligopeptide transporter (pot/ptr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 15 member 1CuratedAlternative name(s): Intestinal H(+)/peptide cotransporter1 Publication Oligopeptide transporter, small intestine isoform1 Publication Peptide transporter 11 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10920, SLC15A1 |
MIMi | 600544, gene |
neXtProti | NX_P46059 |
VEuPathDBi | HostDB:ENSG00000088386.15 |
Subcellular locationi
Other locations
- Membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: ARUK-UCL
Other locations
- brush border Source: Ensembl
- spanning component of membrane Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 22 – 53 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 54 – 74 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 75 – 82 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 104 – 118 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 119 – 139 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 161 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 198 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 276 | CytoplasmicSequence analysisAdd BLAST | 57 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 327 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 328 – 348 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 349 – 361 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 362 – 382 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 383 – 584 | ExtracellularSequence analysisAdd BLAST | 202 | |
Transmembranei | 585 – 605 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 606 – 619 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 620 – 640 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 641 – 645 | ExtracellularSequence analysis | 5 | |
Transmembranei | 646 – 666 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 667 – 708 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 588 | Y → C: Reduced transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 594 | G → A: Does not affect transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 594 | G → C: Nearly abolished transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 594 | G → V: Abolished transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 595 | E → C: Nearly abolished transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 595 | E → D: Does not affect transmembrane transport of dipeptides. 1 Publication | 1 | |
Mutagenesisi | 595 | E → K or R: Abolished transmembrane transport of dipeptides. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6564 |
OpenTargetsi | ENSG00000088386 |
PharmGKBi | PA323 |
Miscellaneous databases
Pharosi | P46059, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4605 |
DrugBanki | DB00855, Aminolevulinic acid DB01060, Amoxicillin DB00415, Ampicillin DB08795, Azidocillin DB00542, Benazepril DB03793, Benzoic acid DB01053, Benzylpenicillin DB01197, Captopril DB00833, Cefaclor DB01140, Cefadroxil DB00456, Cefalotin DB00535, Cefdinir DB01413, Cefepime DB00671, Cefixime DB00274, Cefmetazole DB00493, Cefotaxime DB01333, Cefradine DB00438, Ceftazidime DB01415, Ceftibuten DB01332, Ceftizoxime DB01212, Ceftriaxone DB01112, Cefuroxime DB00567, Cephalexin DB00672, Chlorpropamide DB01340, Cilazapril DB01147, Cloxacillin DB01000, Cyclacillin DB09213, Dexibuprofen DB00485, Dicloxacillin DB00584, Enalapril DB01095, Fluvastatin DB00492, Fosinopril DB01016, Glyburide DB01235, Levodopa DB01255, Lisdexamfetamine DB00722, Lisinopril DB00447, Loracarbef DB00563, Methotrexate DB00968, Methyldopa DB00211, Midodrine DB00691, Moexipril DB00731, Nateglinide DB00198, Oseltamivir DB00713, Oxacillin DB00790, Perindopril DB00417, Phenoxymethylpenicillin DB00881, Quinapril DB00178, Ramipril DB01348, Spirapril DB01956, Taurine DB08836, Temocapril DB01124, Tolbutamide DB00519, Trandolapril DB03424, Ubenimex DB00577, Valaciclovir DB01610, Valganciclovir |
DrugCentrali | P46059 |
GuidetoPHARMACOLOGYi | 984 |
Genetic variation databases
BioMutai | SLC15A1 |
DMDMi | 1172435 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064304 | 1 – 708 | Solute carrier family 15 member 1Add BLAST | 708 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 408 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 509 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 514 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 562 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P46059 |
PaxDbi | P46059 |
PeptideAtlasi | P46059 |
PRIDEi | P46059 |
ProteomicsDBi | 55711 |
PTM databases
GlyGeni | P46059, 7 sites |
iPTMneti | P46059 |
PhosphoSitePlusi | P46059 |
Expressioni
Gene expression databases
Bgeei | ENSG00000088386, Expressed in small intestine and 151 other tissues |
ExpressionAtlasi | P46059, baseline and differential |
Genevisiblei | P46059, HS |
Organism-specific databases
HPAi | ENSG00000088386, Tissue enriched (intestine) |
Interactioni
Subunit structurei
Interacts (via extracellular domain region) with trypsin.
By similarityProtein-protein interaction databases
BioGRIDi | 112452, 79 interactors |
IntActi | P46059, 64 interactors |
STRINGi | 9606.ENSP00000365686 |
Chemistry databases
BindingDBi | P46059 |
Miscellaneous databases
RNActi | P46059, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 383 – 584 | Extracellular domain (ECD)By similarityAdd BLAST | 202 |
Domaini
The extracellular domain (ECD) region specifically binds trypsin.By similarity
Sequence similaritiesi
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000155995 |
HOGENOMi | CLU_004790_3_0_1 |
InParanoidi | P46059 |
OMAi | KVAKCIG |
OrthoDBi | 925637at2759 |
PhylomeDBi | P46059 |
TreeFami | TF330897 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR004768, Oligopep_transport IPR000109, POT_fam IPR018456, PTR2_symporter_CS |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 2 hits |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00926, 2A1704, 1 hit |
PROSITEi | View protein in PROSITE PS01022, PTR2_1, 1 hit PS01023, PTR2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P46059-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGMSKSHSFF GYPLSIFFIV VNEFCERFSY YGMRAILILY FTNFISWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVTSV
110 120 130 140 150
SSINDLTDHN HDGTPDSLPV HVVLSLIGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NAGSLLSTII TPMLRVQQCG IHSKQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFKPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAFPKREH WLDWAKEKYD ERLISQIKMV TRVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MSGKIGALEI QPDQMQTVNA ILIVIMVPIF DAVLYPLIAK
360 370 380 390 400
CGFNFTSLKK MAVGMVLASM AFVVAAIVQV EIDKTLPVFP KGNEVQIKVL
410 420 430 440 450
NIGNNTMNIS LPGEMVTLGP MSQTNAFMTF DVNKLTRINI SSPGSPVTAV
460 470 480 490 500
TDDFKQGQRH TLLVWAPNHY QVVKDGLNQK PEKGENGIRF VNTFNELITI
510 520 530 540 550
TMSGKVYANI SSYNASTYQF FPSGIKGFTI SSTEIPPQCQ PNFNTFYLEF
560 570 580 590 600
GSAYTYIVQR KNDSCPEVKV FEDISANTVN MALQIPQYFL LTCGEVVFSV
610 620 630 640 650
TGLEFSYSQA PSNMKSVLQA GWLLTVAVGN IIVLIVAGAG QFSKQWAEYI
660 670 680 690 700
LFAALLLVVC VIFAIMARFY TYINPAEIEA QFDEDEKKNR LEKSNPYFMS
GANSQKQM
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029321 | 21 | V → I1 PublicationCorresponds to variant dbSNP:rs8187818Ensembl. | 1 | |
Natural variantiVAR_029322 | 28 | F → Y1 PublicationCorresponds to variant dbSNP:rs8187817Ensembl. | 1 | |
Natural variantiVAR_022147 | 117 | S → N2 PublicationsCorresponds to variant dbSNP:rs2297322Ensembl. | 1 | |
Natural variantiVAR_029323 | 117 | S → R1 PublicationCorresponds to variant dbSNP:rs8187821Ensembl. | 1 | |
Natural variantiVAR_020456 | 122 | V → M1 PublicationCorresponds to variant dbSNP:rs8187820EnsemblClinVar. | 1 | |
Natural variantiVAR_020457 | 419 | G → A2 PublicationsCorresponds to variant dbSNP:rs4646227Ensembl. | 1 | |
Natural variantiVAR_022148 | 450 | V → I1 PublicationCorresponds to variant dbSNP:rs2274828Ensembl. | 1 | |
Natural variantiVAR_020458 | 451 | T → N1 PublicationCorresponds to variant dbSNP:rs8187838Ensembl. | 1 | |
Natural variantiVAR_022149 | 459 | R → C. Corresponds to variant dbSNP:rs2274827Ensembl. | 1 | |
Natural variantiVAR_029324 | 537 | P → S1 PublicationCorresponds to variant dbSNP:rs8187830Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13173 mRNA Translation: AAB61693.1 U21936 mRNA Translation: AAA63797.1 AL391670 Genomic DNA No translation available. AL353574 Genomic DNA No translation available. BC096328 mRNA Translation: AAH96328.1 BC096329 mRNA Translation: AAH96329.1 |
CCDSi | CCDS9489.1 |
PIRi | A56163 |
RefSeqi | NP_005064.1, NM_005073.3 |
Genome annotation databases
Ensembli | ENST00000376503; ENSP00000365686; ENSG00000088386 |
GeneIDi | 6564 |
KEGGi | hsa:6564 |
UCSCi | uc001vno.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13173 mRNA Translation: AAB61693.1 U21936 mRNA Translation: AAA63797.1 AL391670 Genomic DNA No translation available. AL353574 Genomic DNA No translation available. BC096328 mRNA Translation: AAH96328.1 BC096329 mRNA Translation: AAH96329.1 |
CCDSi | CCDS9489.1 |
PIRi | A56163 |
RefSeqi | NP_005064.1, NM_005073.3 |
3D structure databases
SMRi | P46059 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112452, 79 interactors |
IntActi | P46059, 64 interactors |
STRINGi | 9606.ENSP00000365686 |
Chemistry databases
BindingDBi | P46059 |
ChEMBLi | CHEMBL4605 |
DrugBanki | DB00855, Aminolevulinic acid DB01060, Amoxicillin DB00415, Ampicillin DB08795, Azidocillin DB00542, Benazepril DB03793, Benzoic acid DB01053, Benzylpenicillin DB01197, Captopril DB00833, Cefaclor DB01140, Cefadroxil DB00456, Cefalotin DB00535, Cefdinir DB01413, Cefepime DB00671, Cefixime DB00274, Cefmetazole DB00493, Cefotaxime DB01333, Cefradine DB00438, Ceftazidime DB01415, Ceftibuten DB01332, Ceftizoxime DB01212, Ceftriaxone DB01112, Cefuroxime DB00567, Cephalexin DB00672, Chlorpropamide DB01340, Cilazapril DB01147, Cloxacillin DB01000, Cyclacillin DB09213, Dexibuprofen DB00485, Dicloxacillin DB00584, Enalapril DB01095, Fluvastatin DB00492, Fosinopril DB01016, Glyburide DB01235, Levodopa DB01255, Lisdexamfetamine DB00722, Lisinopril DB00447, Loracarbef DB00563, Methotrexate DB00968, Methyldopa DB00211, Midodrine DB00691, Moexipril DB00731, Nateglinide DB00198, Oseltamivir DB00713, Oxacillin DB00790, Perindopril DB00417, Phenoxymethylpenicillin DB00881, Quinapril DB00178, Ramipril DB01348, Spirapril DB01956, Taurine DB08836, Temocapril DB01124, Tolbutamide DB00519, Trandolapril DB03424, Ubenimex DB00577, Valaciclovir DB01610, Valganciclovir |
DrugCentrali | P46059 |
GuidetoPHARMACOLOGYi | 984 |
Protein family/group databases
TCDBi | 2.A.17.4.9, the proton-dependent oligopeptide transporter (pot/ptr) family |
PTM databases
GlyGeni | P46059, 7 sites |
iPTMneti | P46059 |
PhosphoSitePlusi | P46059 |
Genetic variation databases
BioMutai | SLC15A1 |
DMDMi | 1172435 |
Proteomic databases
MassIVEi | P46059 |
PaxDbi | P46059 |
PeptideAtlasi | P46059 |
PRIDEi | P46059 |
ProteomicsDBi | 55711 |
Protocols and materials databases
Antibodypediai | 10820, 224 antibodies |
Genome annotation databases
Ensembli | ENST00000376503; ENSP00000365686; ENSG00000088386 |
GeneIDi | 6564 |
KEGGi | hsa:6564 |
UCSCi | uc001vno.4, human |
Organism-specific databases
CTDi | 6564 |
DisGeNETi | 6564 |
GeneCardsi | SLC15A1 |
HGNCi | HGNC:10920, SLC15A1 |
HPAi | ENSG00000088386, Tissue enriched (intestine) |
MIMi | 600544, gene |
neXtProti | NX_P46059 |
OpenTargetsi | ENSG00000088386 |
PharmGKBi | PA323 |
VEuPathDBi | HostDB:ENSG00000088386.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000155995 |
HOGENOMi | CLU_004790_3_0_1 |
InParanoidi | P46059 |
OMAi | KVAKCIG |
OrthoDBi | 925637at2759 |
PhylomeDBi | P46059 |
TreeFami | TF330897 |
Enzyme and pathway databases
PathwayCommonsi | P46059 |
Reactomei | R-HSA-427975, Proton/oligopeptide cotransporters |
Miscellaneous databases
BioGRID-ORCSi | 6564, 3 hits in 869 CRISPR screens |
ChiTaRSi | SLC15A1, human |
GeneWikii | Peptide_transporter_1 |
GenomeRNAii | 6564 |
Pharosi | P46059, Tchem |
PROi | PR:P46059 |
RNActi | P46059, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000088386, Expressed in small intestine and 151 other tissues |
ExpressionAtlasi | P46059, baseline and differential |
Genevisiblei | P46059, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR004768, Oligopep_transport IPR000109, POT_fam IPR018456, PTR2_symporter_CS |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 2 hits |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00926, 2A1704, 1 hit |
PROSITEi | View protein in PROSITE PS01022, PTR2_1, 1 hit PS01023, PTR2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S15A1_HUMAN | |
Accessioni | P46059Primary (citable) accession number: P46059 Secondary accession number(s): Q5VW82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families