UniProtKB - P46019 (KPB2_HUMAN)
Protein
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Gene
PHKA2
Organism
Homo sapiens (Human)
Status
Functioni
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
Activity regulationi
By phosphorylation of various serine residues and by calcium.
: glycogen metabolism Pathwayi
This protein is involved in the pathway glycogen metabolism, which is part of Glycan biosynthesis.View all proteins of this organism that are known to be involved in the pathway glycogen metabolism and in Glycan biosynthesis.
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- phosphorylase kinase activity Source: ProtInc
GO - Biological processi
- carbohydrate metabolic process Source: ProtInc
- cellular protein modification process Source: ProtInc
- generation of precursor metabolites and energy Source: ProtInc
- glycogen catabolic process Source: Reactome
Keywordsi
Molecular function | Calmodulin-binding |
Biological process | Carbohydrate metabolism, Glycogen metabolism |
Enzyme and pathway databases
BioCyci | MetaCyc:HS00576-MONOMER |
BRENDAi | 2.7.11.19, 2681 |
PathwayCommonsi | P46019 |
Reactomei | R-HSA-70221, Glycogen breakdown (glycogenolysis) |
UniPathwayi | UPA00163 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphorylase b kinase regulatory subunit alpha, liver isoformShort name: Phosphorylase kinase alpha L subunit |
Gene namesi | Name:PHKA2 Synonyms:PHKLA, PYK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8926, PHKA2 |
MIMi | 300798, gene |
neXtProti | NX_P46019 |
VEuPathDBi | HostDB:ENSG00000044446.11 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- phosphorylase kinase complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Glycogen storage disease 9A (GSD9A)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA metabolic disorder resulting in a mild liver glycogenosis with clinical symptoms that include hepatomegaly, growth retardation, muscle weakness, elevation of glutamate-pyruvate transaminase and glutamate-oxaloacetate transaminase, hypercholesterolemia, hypertriglyceridemia, and fasting hyperketosis. Two subtypes are known: type 1 or classic type with no phosphorylase kinase activity in liver or erythrocytes, and type 2 or variant type with no phosphorylase kinase activity in liver, but normal activity in erythrocytes. Unlike other glycogenosis diseases, glycogen storage disease type 9A is generally a benign condition. Patients improve with age and are often asymptomatic as adults. Accurate diagnosis is therefore also of prognostic interest.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_062393 | 120 | T → TYNTAT in GSD9A. | 1 | |
Natural variantiVAR_006177 | 132 | H → P in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852291EnsemblClinVar. | 1 | |
Natural variantiVAR_006178 | 132 | H → Y in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852292EnsemblClinVar. | 1 | |
Natural variantiVAR_006179 | 141 | Missing in GSD9A; type 1. 1 Publication | 1 | |
Natural variantiVAR_006180 | 186 | R → C in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852294EnsemblClinVar. | 1 | |
Natural variantiVAR_006181 | 186 | R → H in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852290EnsemblClinVar. | 1 | |
Natural variantiVAR_012270 | 189 – 190 | Missing in GSD9A; type 2. 1 Publication | 2 | |
Natural variantiVAR_012269 | 189 | K → E in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852295EnsemblClinVar. | 1 | |
Natural variantiVAR_012271 | 193 | G → V in GSD9A; type 2. 1 Publication | 1 | |
Natural variantiVAR_006182 | 251 | Missing in GSD9A; type 2. 1 Publication | 1 | |
Natural variantiVAR_012272 | 295 | R → H in GSD9A; type 1 and type 2. 1 PublicationCorresponds to variant dbSNP:rs797044877EnsemblClinVar. | 1 | |
Natural variantiVAR_006183 | 299 | D → G in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852289EnsemblClinVar. | 1 | |
Natural variantiVAR_012273 | 399 | P → S in GSD9A; type 1. 1 Publication | 1 | |
Natural variantiVAR_062394 | 498 | P → L in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs199792389EnsemblClinVar. | 1 | |
Natural variantiVAR_012274 | 818 – 825 | Missing in GSD9A; type 1. 1 Publication | 8 | |
Natural variantiVAR_062395 | 869 | P → R in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs777137574Ensembl. | 1 | |
Natural variantiVAR_062396 | 916 | R → W in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs1569297427EnsemblClinVar. | 1 | |
Natural variantiVAR_012275 | 953 – 954 | NL → I in GSD9A; type 1. | 2 | |
Natural variantiVAR_062397 | 1070 | Missing in GSD9A. 1 Publication | 1 | |
Natural variantiVAR_006184 | 1111 | R → RTR in GSD9A; type 2. | 1 | |
Natural variantiVAR_062398 | 1113 | M → I in GSD9A. 1 Publication | 1 | |
Natural variantiVAR_006185 | 1114 | T → I in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852293EnsemblClinVar. | 1 | |
Natural variantiVAR_012276 | 1125 | E → K in GSD9A; type 1. 1 PublicationCorresponds to variant dbSNP:rs1555988071EnsemblClinVar. | 1 | |
Natural variantiVAR_006186 | 1205 | P → L in GSD9A; type 1. 1 PublicationCorresponds to variant dbSNP:rs137852288EnsemblClinVar. | 1 | |
Natural variantiVAR_012277 | 1207 | G → W in GSD9A; type 1. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Glycogen storage diseaseOrganism-specific databases
DisGeNETi | 5256 |
GeneReviewsi | PHKA2 |
MalaCardsi | PHKA2 |
MIMi | 306000, phenotype |
OpenTargetsi | ENSG00000044446 |
Orphaneti | 264580, Glycogen storage disease due to liver phosphorylase kinase deficiency |
PharmGKBi | PA33267 |
Miscellaneous databases
Pharosi | P46019, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2111324 |
Genetic variation databases
BioMutai | PHKA2 |
DMDMi | 1170685 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057730 | 1 – 1235 | Phosphorylase b kinase regulatory subunit alpha, liver isoformAdd BLAST | 1235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 695 | PhosphoserineCombined sources | 1 | |
Modified residuei | 729 | PhosphoserineCombined sources | 1 | |
Modified residuei | 735 | PhosphoserineCombined sources | 1 | |
Modified residuei | 983 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1015 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1044 | PhosphoserineCombined sources | 1 | |
Lipidationi | 1232 | S-farnesyl cysteineBy similarity | 1 |
Post-translational modificationi
Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.By similarity
Keywords - PTMi
Lipoprotein, Phosphoprotein, PrenylationProteomic databases
EPDi | P46019 |
jPOSTi | P46019 |
MassIVEi | P46019 |
MaxQBi | P46019 |
PaxDbi | P46019 |
PeptideAtlasi | P46019 |
PRIDEi | P46019 |
ProteomicsDBi | 55707 |
PTM databases
iPTMneti | P46019 |
PhosphoSitePlusi | P46019 |
Expressioni
Tissue specificityi
Predominantly expressed in liver and other non-muscle tissues.
Gene expression databases
Bgeei | ENSG00000044446, Expressed in right lobe of liver and 223 other tissues |
Genevisiblei | P46019, HS |
Organism-specific databases
HPAi | ENSG00000044446, Low tissue specificity |
Interactioni
Subunit structurei
Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
Binary interactionsi
Hide detailsP46019
With | #Exp. | IntAct |
---|---|---|
PHKB - isoform 4 [Q93100-4] | 3 | EBI-1642846,EBI-11064505 |
PHKG2 [P15735] | 6 | EBI-1642846,EBI-1383819 |
SPRED1 [Q7Z699] | 3 | EBI-1642846,EBI-5235340 |
UROD [P06132] | 3 | EBI-1642846,EBI-2871776 |
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 111274, 32 interactors |
IntActi | P46019, 19 interactors |
MINTi | P46019 |
STRINGi | 9606.ENSP00000369274 |
Miscellaneous databases
RNActi | P46019, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 807 – 837 | Calmodulin-bindingSequence analysisAdd BLAST | 31 | |
Regioni | 1059 – 1099 | Calmodulin-bindingSequence analysisAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the phosphorylase b kinase regulatory chain family.Curated
Phylogenomic databases
eggNOGi | KOG3635, Eukaryota |
GeneTreei | ENSGT00950000183118 |
HOGENOMi | CLU_004177_1_0_1 |
InParanoidi | P46019 |
OMAi | EHNMVPT |
OrthoDBi | 55049at2759 |
PhylomeDBi | P46019 |
TreeFami | TF313970 |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR011613, GH15-like IPR008734, PHK_A/B_su |
PANTHERi | PTHR10749, PTHR10749, 1 hit |
Pfami | View protein in Pfam PF00723, Glyco_hydro_15, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
i Sequence
Sequence statusi: Complete.
P46019-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRSRSNSGVR LDGYARLVQQ TILCYQNPVT GLLSASHEQK DAWVRDNIYS
60 70 80 90 100
ILAVWGLGMA YRKNADRDED KAKAYELEQN VVKLMRGLLQ CMMRQVAKVE
110 120 130 140 150
KFKHTQSTKD SLHAKYNTAT CGTVVGDDQW GHLQVDATSL FLLFLAQMTA
160 170 180 190 200
SGLRIIFTLD EVAFIQNLVF YIEAAYKVAD YGMWERGDKT NQGIPELNAS
210 220 230 240 250
SVGMAKAALE AIDELDLFGA HGGRKSVIHV LPDEVEHCQS ILFSMLPRAS
260 270 280 290 300
TSKEIDAGLL SIISFPAFAV EDVNLVNVTK NEIISKLQGR YGCCRFLRDG
310 320 330 340 350
YKTPREDPNR LHYDPAELKL FENIECEWPV FWTYFIIDGV FSGDAVQVQE
360 370 380 390 400
YREALEGILI RGKNGIRLVP ELYAVPPNKV DEEYKNPHTV DRVPMGKVPH
410 420 430 440 450
LWGQSLYILS SLLAEGFLAA GEIDPLNRRF STSVKPDVVV QVTVLAENNH
460 470 480 490 500
IKDLLRKHGV NVQSIADIHP IQVQPGRILS HIYAKLGRNK NMNLSGRPYR
510 520 530 540 550
HIGVLGTSKL YVIRNQIFTF TPQFTDQHHF YLALDNEMIV EMLRIELAYL
560 570 580 590 600
CTCWRMTGRP TLTFPISRTM LTNDGSDIHS AVLSTIRKLE DGYFGGARVK
610 620 630 640 650
LGNLSEFLTT SFYTYLTFLD PDCDEKLFDN ASEGTFSPDS DSDLVGYLED
660 670 680 690 700
TCNQESQDEL DHYINHLLQS TSLRSYLPPL CKNTEDRHVF SAIHSTRDIL
710 720 730 740 750
SVMAKAKGLE VPFVPMTLPT KVLSAHRKSL NLVDSPQPLL EKVPESDFQW
760 770 780 790 800
PRDDHGDVDC EKLVEQLKDC SNLQDQADIL YILYVIKGPS WDTNLSGQHG
810 820 830 840 850
VTVQNLLGEL YGKAGLNQEW GLIRYISGLL RKKVEVLAEA CTDLLSHQKQ
860 870 880 890 900
LTVGLPPEPR EKIISAPLPP EELTKLIYEA SGQDISIAVL TQEIVVYLAM
910 920 930 940 950
YVRAQPSLFV EMLRLRIGLI IQVMATELAR SLNCSGEEAS ESLMNLSPFD
960 970 980 990 1000
MKNLLHHILS GKEFGVERSV RPIHSSTSSP TISIHEVGHT GVTKTERSGI
1010 1020 1030 1040 1050
NRLRSEMKQM TRRFSADEQF FSVGQAASSS AHSSKSARSS TPSSPTGTSS
1060 1070 1080 1090 1100
SDSGGHHIGW GERQGQWLRR RRLDGAINRV PVGFYQRVWK ILQKCHGLSI
1110 1120 1130 1140 1150
DGYVLPSSTT REMTPHEIKF AVHVESVLNR VPQPEYRQLL VEAIMVLTLL
1160 1170 1180 1190 1200
SDTEMTSIGG IIHVDQIVQM ASQLFLQDQV SIGAMDTLEK DQATGICHFF
1210 1220 1230
YDSAPSGAYG TMTYLTRAVA SYLQELLPNS GCQMQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 527 | Q → E in AAH14036 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 756 | G → S in AAH14036 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024563 | 38 | E → Q. Corresponds to variant dbSNP:rs17313469EnsemblClinVar. | 1 | |
Natural variantiVAR_062393 | 120 | T → TYNTAT in GSD9A. | 1 | |
Natural variantiVAR_006177 | 132 | H → P in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852291EnsemblClinVar. | 1 | |
Natural variantiVAR_006178 | 132 | H → Y in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852292EnsemblClinVar. | 1 | |
Natural variantiVAR_006179 | 141 | Missing in GSD9A; type 1. 1 Publication | 1 | |
Natural variantiVAR_006180 | 186 | R → C in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852294EnsemblClinVar. | 1 | |
Natural variantiVAR_006181 | 186 | R → H in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852290EnsemblClinVar. | 1 | |
Natural variantiVAR_012270 | 189 – 190 | Missing in GSD9A; type 2. 1 Publication | 2 | |
Natural variantiVAR_012269 | 189 | K → E in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852295EnsemblClinVar. | 1 | |
Natural variantiVAR_012271 | 193 | G → V in GSD9A; type 2. 1 Publication | 1 | |
Natural variantiVAR_006182 | 251 | Missing in GSD9A; type 2. 1 Publication | 1 | |
Natural variantiVAR_012272 | 295 | R → H in GSD9A; type 1 and type 2. 1 PublicationCorresponds to variant dbSNP:rs797044877EnsemblClinVar. | 1 | |
Natural variantiVAR_006183 | 299 | D → G in GSD9A; type 2. 2 PublicationsCorresponds to variant dbSNP:rs137852289EnsemblClinVar. | 1 | |
Natural variantiVAR_012273 | 399 | P → S in GSD9A; type 1. 1 Publication | 1 | |
Natural variantiVAR_050518 | 416 | G → R. Corresponds to variant dbSNP:rs16980929EnsemblClinVar. | 1 | |
Natural variantiVAR_062394 | 498 | P → L in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs199792389EnsemblClinVar. | 1 | |
Natural variantiVAR_012274 | 818 – 825 | Missing in GSD9A; type 1. 1 Publication | 8 | |
Natural variantiVAR_062395 | 869 | P → R in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs777137574Ensembl. | 1 | |
Natural variantiVAR_062396 | 916 | R → W in GSD9A. 1 PublicationCorresponds to variant dbSNP:rs1569297427EnsemblClinVar. | 1 | |
Natural variantiVAR_012275 | 953 – 954 | NL → I in GSD9A; type 1. | 2 | |
Natural variantiVAR_062397 | 1070 | Missing in GSD9A. 1 Publication | 1 | |
Natural variantiVAR_006184 | 1111 | R → RTR in GSD9A; type 2. | 1 | |
Natural variantiVAR_062398 | 1113 | M → I in GSD9A. 1 Publication | 1 | |
Natural variantiVAR_006185 | 1114 | T → I in GSD9A; type 2. 1 PublicationCorresponds to variant dbSNP:rs137852293EnsemblClinVar. | 1 | |
Natural variantiVAR_012276 | 1125 | E → K in GSD9A; type 1. 1 PublicationCorresponds to variant dbSNP:rs1555988071EnsemblClinVar. | 1 | |
Natural variantiVAR_006186 | 1205 | P → L in GSD9A; type 1. 1 PublicationCorresponds to variant dbSNP:rs137852288EnsemblClinVar. | 1 | |
Natural variantiVAR_012277 | 1207 | G → W in GSD9A; type 1. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80497 mRNA Translation: CAA56662.1 D38616 mRNA Translation: BAA07606.1 AF044572 , AF044540, AF044541, AF044542, AF044543, AF044544, AF044545, AF044546, AF044547, AF044548, AF044549, AF044550, AF044551, AF044552, AF044553, AF044554, AF044555, AF044556, AF044557, AF044558, AF044559, AF044560, AF044561, AF044562, AF044563, AF044564, AF044565, AF044566, AF044567, AF044568, AF044569, AF044570, AF044571 Genomic DNA Translation: AAD32846.1 AK289996 mRNA Translation: BAF82685.1 AL096700 Genomic DNA No translation available. AL732509 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98951.1 BC014036 mRNA Translation: AAH14036.1 Y15154 Genomic DNA Translation: CAA75421.1 X73875 mRNA Translation: CAA52084.1 |
CCDSi | CCDS14190.1 |
RefSeqi | NP_000283.1, NM_000292.2 |
Genome annotation databases
Ensembli | ENST00000379942; ENSP00000369274; ENSG00000044446 |
GeneIDi | 5256 |
KEGGi | hsa:5256 |
UCSCi | uc004cyv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80497 mRNA Translation: CAA56662.1 D38616 mRNA Translation: BAA07606.1 AF044572 , AF044540, AF044541, AF044542, AF044543, AF044544, AF044545, AF044546, AF044547, AF044548, AF044549, AF044550, AF044551, AF044552, AF044553, AF044554, AF044555, AF044556, AF044557, AF044558, AF044559, AF044560, AF044561, AF044562, AF044563, AF044564, AF044565, AF044566, AF044567, AF044568, AF044569, AF044570, AF044571 Genomic DNA Translation: AAD32846.1 AK289996 mRNA Translation: BAF82685.1 AL096700 Genomic DNA No translation available. AL732509 Genomic DNA No translation available. CH471074 Genomic DNA Translation: EAW98951.1 BC014036 mRNA Translation: AAH14036.1 Y15154 Genomic DNA Translation: CAA75421.1 X73875 mRNA Translation: CAA52084.1 |
CCDSi | CCDS14190.1 |
RefSeqi | NP_000283.1, NM_000292.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111274, 32 interactors |
IntActi | P46019, 19 interactors |
MINTi | P46019 |
STRINGi | 9606.ENSP00000369274 |
Chemistry databases
ChEMBLi | CHEMBL2111324 |
PTM databases
iPTMneti | P46019 |
PhosphoSitePlusi | P46019 |
Genetic variation databases
BioMutai | PHKA2 |
DMDMi | 1170685 |
Proteomic databases
EPDi | P46019 |
jPOSTi | P46019 |
MassIVEi | P46019 |
MaxQBi | P46019 |
PaxDbi | P46019 |
PeptideAtlasi | P46019 |
PRIDEi | P46019 |
ProteomicsDBi | 55707 |
Protocols and materials databases
Antibodypediai | 24169, 86 antibodies |
DNASUi | 5256 |
Genome annotation databases
Ensembli | ENST00000379942; ENSP00000369274; ENSG00000044446 |
GeneIDi | 5256 |
KEGGi | hsa:5256 |
UCSCi | uc004cyv.5, human |
Organism-specific databases
CTDi | 5256 |
DisGeNETi | 5256 |
GeneCardsi | PHKA2 |
GeneReviewsi | PHKA2 |
HGNCi | HGNC:8926, PHKA2 |
HPAi | ENSG00000044446, Low tissue specificity |
MalaCardsi | PHKA2 |
MIMi | 300798, gene 306000, phenotype |
neXtProti | NX_P46019 |
OpenTargetsi | ENSG00000044446 |
Orphaneti | 264580, Glycogen storage disease due to liver phosphorylase kinase deficiency |
PharmGKBi | PA33267 |
VEuPathDBi | HostDB:ENSG00000044446.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3635, Eukaryota |
GeneTreei | ENSGT00950000183118 |
HOGENOMi | CLU_004177_1_0_1 |
InParanoidi | P46019 |
OMAi | EHNMVPT |
OrthoDBi | 55049at2759 |
PhylomeDBi | P46019 |
TreeFami | TF313970 |
Enzyme and pathway databases
UniPathwayi | UPA00163 |
BioCyci | MetaCyc:HS00576-MONOMER |
BRENDAi | 2.7.11.19, 2681 |
PathwayCommonsi | P46019 |
Reactomei | R-HSA-70221, Glycogen breakdown (glycogenolysis) |
Miscellaneous databases
BioGRID-ORCSi | 5256, 4 hits in 500 CRISPR screens |
ChiTaRSi | PHKA2, human |
GeneWikii | PHKA2 |
GenomeRNAii | 5256 |
Pharosi | P46019, Tbio |
PROi | PR:P46019 |
RNActi | P46019, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000044446, Expressed in right lobe of liver and 223 other tissues |
Genevisiblei | P46019, HS |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR011613, GH15-like IPR008734, PHK_A/B_su |
PANTHERi | PTHR10749, PTHR10749, 1 hit |
Pfami | View protein in Pfam PF00723, Glyco_hydro_15, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KPB2_HUMAN | |
Accessioni | P46019Primary (citable) accession number: P46019 Secondary accession number(s): A8K1T1 Q9UDA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 200 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families