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Protein

Phosphorylase b kinase regulatory subunit alpha, liver isoform

Gene

PHKA2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

Enzyme regulationi

By phosphorylation of various serine residues and by calcium.

Pathwayi: glycogen metabolism

This protein is involved in the pathway glycogen metabolism, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen metabolism and in Glycan biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processCarbohydrate metabolism, Glycogen metabolism

Enzyme and pathway databases

UniPathwayiUPA00163

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Short name:
Phosphorylase kinase alpha L subunit
Gene namesi
Name:PHKA2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577321 – 1235Phosphorylase b kinase regulatory subunit alpha, liver isoformAdd BLAST1235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei697PhosphoserineBy similarity1
Modified residuei731PhosphoserineBy similarity1
Modified residuei737PhosphoserineBy similarity1
Modified residuei984PhosphoserineBy similarity1
Modified residuei1016PhosphoserineBy similarity1
Modified residuei1044PhosphoserineBy similarity1
Lipidationi1232S-farnesyl cysteineBy similarity1

Post-translational modificationi

Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.By similarity

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Expressioni

Tissue specificityi

Predominantly expressed in liver and other non-muscle tissues.

Interactioni

Subunit structurei

Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022300

Structurei

3D structure databases

ProteinModelPortaliP46018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni808 – 838Calmodulin-bindingSequence analysisAdd BLAST31
Regioni1059 – 1099Calmodulin-bindingSequence analysisAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3635 Eukaryota
ENOG410XPJZ LUCA
HOGENOMiHOG000231478
HOVERGENiHBG000273
InParanoidiP46018
KOiK07190

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR011613 GH15-like
IPR008734 PHK_A/B_su
PANTHERiPTHR10749 PTHR10749, 1 hit
PfamiView protein in Pfam
PF00723 Glyco_hydro_15, 1 hit
SUPFAMiSSF48208 SSF48208, 1 hit

Sequencei

Sequence statusi: Complete.

P46018-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRSNSGVR LDGYARLVQQ TILCYQNPVT GLLSASHEQK DAWVRDNIYS
60 70 80 90 100
ILAVWGLGMA YRKNADRDED KAKAYELEQN VVKLMRGLLQ CMMRQVDKVE
110 120 130 140 150
KFKYTQSTKD SLHAKYNTAT CSTVVGDDQW GHLQVDATSL FLLFLAQMTA
160 170 180 190 200
SGLRIIFTLD EVAFIQNLVF YIEAAYKVAD YGMWERGDKT NQGIPELNAS
210 220 230 240 250
SVGMAKAALE AIDELDLFGA HGGRKSVIHV LPDEVEHCQS ILFSMLPRAS
260 270 280 290 300
TSKEIDAGLL SIISFPAFAV EDANLVNVTK SEIISKLQGR YGCCRFLRDG
310 320 330 340 350
YKTPREDPNR LHYDPAELKL FENIECEWPV FWTYFIIDGI FNGDALQVQE
360 370 380 390 400
YQEALEGILI RGKDGIRLVP ELYAIPPNKV DEEYKNPHTV DRVPLGKLPH
410 420 430 440 450
LWGQSLYILS SLLAEGFLAT GEIDPLNRRF STSVKPDVVV QVTVLAENSH
460 470 480 490 500
IKELLRKHGV DVQSIADIYP IRVQPGRILS HIYAKLGRNK NMKLSGRPYR
510 520 530 540 550
HIGVLGTSKL YVIRNQIFTF TPQFTDQHHF YLALDNEMIV EMLRIELAYL
560 570 580 590 600
CTCWRMTGRP TLTFPITHTM LTNDGSDIHS AVLSTIRKLE DGYFGGARVQ
610 620 630 640 650
LGNLSEFLTT SFYTYLTFLD PDCDEKLFDD ASEGSFSPDS DSDLGGYLEE
660 670 680 690 700
TYNQVTESQD ELDKYINHLL QSTYSKCHLP PLCKKMEDHN VFSAIHSTRD
710 720 730 740 750
ILSMMAKAKG LEVPFAPMTL PTKALSVHRK SLNLVDSPQP LLKRILKRLH
760 770 780 790 800
WPKDERGDVD CEKLVEQLKD CCTLQDQADI LYILYVLKGP SWDTALSGQH
810 820 830 840 850
GVTVHNLLSE LYGKAGLNQE WGLIRYISGL LRKKVEVLAE ACADLLSHQK
860 870 880 890 900
QLTVGLPPEP REKTISAPLP PEELTELIYE ASGEDISIAV LTQEIVVYLA
910 920 930 940 950
MYVRAQPALF VEMLRLRIGL IIQVMATELA RSLNCSGEEA SESLMNLSPF
960 970 980 990 1000
DMKNLLHHIL SGKEFGVERS MRPIHSSASS PAISIHEVGH TGVTKTERSG
1010 1020 1030 1040 1050
INRLRSEMKQ MTRRFSADEQ FFPVSQTVSS SAYSKSVRSS TPSSPTGTSS
1060 1070 1080 1090 1100
SDSGGHHISW GERQGQWLRR RRLDGAINRV PVGFYQRVWK ILQKCHGLSI
1110 1120 1130 1140 1150
DGYVLPSSTT REMTPQEIKF AVHVESVLNR VSQPEYRQLL VEAIMVLTLL
1160 1170 1180 1190 1200
SDTEMESIGG IIHVDQIVQM ANQLFLQEQI STGAMDTLEK DQATGICHFF
1210 1220 1230
YDSAPSGAYG TMTYLTRAVA SHLQELLPSS GCQTQ
Length:1,235
Mass (Da):138,770
Last modified:November 1, 1995 - v1
Checksum:iB8E218C1D8C6F376
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60421 mRNA Translation: CAA42952.1
PIRiS24109
RefSeqiNP_001129153.1, NM_001135681.1
UniGeneiOcu.2085

Genome annotation databases

GeneIDi100190898
KEGGiocu:100190898

Similar proteinsi

Entry informationi

Entry nameiKPB2_RABIT
AccessioniPrimary (citable) accession number: P46018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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