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Entry version 201 (16 Oct 2019)
Sequence version 2 (28 Nov 2006)
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Protein

Proliferation marker protein Ki-67

Gene

MKI67

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).By similarity3 Publications

Caution

Was thought to play a key role in cell proliferation, and is commonly used as a marker of cell proliferation (PubMed:6339421, PubMed:21960707). However, its primary function is uncoupled from cell proliferation: it is required to maintain mitotic chromosomes dispersed by forming a steric and electrostatic charge barrier (PubMed:27362226).1 Publication2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi3034 – 3041ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proliferation marker protein Ki-67Curated
Alternative name(s):
Antigen identified by monoclonal antibody Ki-671 Publication
Short name:
Antigen KI-67Curated
Short name:
Antigen Ki67Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MKI67Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7107 MKI67

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176741 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P46013

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Widely used as a marker to assess cell proliferation, as it is detected in the nucleus of proliferating cells only (PubMed:6339421, PubMed:21960707). In cancer research field for example, MKI67 is the most widely used marker for comparing proliferation between tumor samples (PubMed:21960707, PubMed:26680267).2 Publications1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
4288

Open Targets

More...
OpenTargetsi
ENSG00000148773

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30825

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P46013

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MKI67

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118572663

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843011 – 3256Proliferation marker protein Ki-67Add BLAST3256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei125PhosphoserineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei166PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei264PhosphoserineCombined sources1
Modified residuei296PhosphoserineBy similarity1
Modified residuei308PhosphoserineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei347PhosphothreonineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei374PhosphoserineBy similarity1
Modified residuei401PhosphothreonineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei538PhosphoserineCombined sources1
Modified residuei543PhosphothreonineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei761PhosphothreonineCombined sources1
Modified residuei859PhosphoserineCombined sources1
Modified residuei1017PhosphothreonineCombined sources1
Cross-linki1022Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1035Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1071PhosphoserineCombined sources1
Modified residuei1091PhosphothreonineCombined sources1
Cross-linki1093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1093Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1098PhosphoserineCombined sources1
Modified residuei1111PhosphothreonineCombined sources1
Modified residuei1131PhosphoserineCombined sources1
Modified residuei1139PhosphothreonineCombined sources1
Modified residuei1142PhosphoserineCombined sources1
Modified residuei1167PhosphothreonineCombined sources1
Modified residuei1169PhosphoserineBy similarity1
Modified residuei1176PhosphothreonineCombined sources1
Cross-linki1185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1193PhosphothreonineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1233PhosphothreonineCombined sources1
Modified residuei1253PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1261PhosphothreonineCombined sources1
Modified residuei1298PhosphothreonineCombined sources1
Modified residuei1315PhosphothreonineCombined sources1
Modified residuei1327PhosphothreonineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1335PhosphothreonineCombined sources1
Cross-linki1337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1355PhosphothreonineCombined sources1
Modified residuei1376PhosphoserineCombined sources1
Modified residuei1383PhosphothreonineCombined sources1
Modified residuei1386PhosphoserineBy similarity1
Modified residuei1420PhosphothreonineBy similarity1
Modified residuei1437PhosphothreonineBy similarity1
Modified residuei1496PhosphoserineCombined sources1
Modified residuei1503PhosphothreonineCombined sources1
Modified residuei1506PhosphoserineCombined sources1
Modified residuei1540PhosphothreonineCombined sources1
Modified residuei1552PhosphotyrosineCombined sources1
Modified residuei1557PhosphothreonineCombined sources1
Modified residuei1569PhosphothreonineCombined sources1
Modified residuei1571PhosphoserineCombined sources1
Modified residuei1617PhosphoserineBy similarity1
Modified residuei1639N6-acetyllysineCombined sources1
Cross-linki1643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1679PhosphoserineCombined sources1
Modified residuei1689PhosphoserineCombined sources1
Cross-linki1703Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1719PhosphothreonineCombined sources1
Modified residuei1721PhosphoserineCombined sources1
Modified residuei1740PhosphoserineCombined sources1
Modified residuei1747PhosphothreonineCombined sources1
Modified residuei1764PhosphothreonineCombined sources1
Modified residuei1784PhosphothreonineCombined sources1
Modified residuei1801PhosphothreonineCombined sources1
Modified residuei1815PhosphoserineCombined sources1
Modified residuei1841PhosphothreonineCombined sources1
Modified residuei1861PhosphoserineCombined sources1
Modified residuei1864PhosphoserineCombined sources1
Modified residuei1869PhosphothreonineCombined sources1
Modified residuei1897PhosphothreonineCombined sources1
Modified residuei1906PhosphothreonineBy similarity1
Modified residuei1923PhosphothreonineCombined sources1
Modified residuei1937PhosphoserineCombined sources1
Modified residuei1963PhosphothreonineCombined sources1
Modified residuei1983PhosphoserineCombined sources1
Modified residuei2005N6-acetyllysineCombined sources1
Cross-linki2009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki2009Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2028PhosphothreonineBy similarity1
Modified residuei2065PhosphothreonineCombined sources1
Cross-linki2067Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki2067Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2072PhosphoserineCombined sources1
Modified residuei2085PhosphothreonineCombined sources1
Modified residuei2105PhosphoserineCombined sources1
Modified residuei2113PhosphothreonineCombined sources1
Modified residuei2116PhosphoserineBy similarity1
Modified residuei2135PhosphoserineCombined sources1
Modified residuei2146PhosphothreonineBy similarity1
Modified residuei2163PhosphothreonineBy similarity1
Modified residuei2203PhosphothreonineCombined sources1
Modified residuei2223PhosphoserineCombined sources1
Modified residuei2231PhosphothreonineCombined sources1
Modified residuei2233PhosphothreonineCombined sources1
Modified residuei2239PhosphoserineCombined sources1
Modified residuei2259PhosphothreonineBy similarity1
Modified residuei2261PhosphoserineBy similarity1
Modified residuei2268PhosphothreonineCombined sources1
Modified residuei2285PhosphothreonineCombined sources1
Modified residuei2325PhosphothreonineCombined sources1
Modified residuei2328PhosphothreonineCombined sources1
Modified residuei2333PhosphothreonineCombined sources1
Modified residuei2344PhosphoserineCombined sources1
Modified residuei2352PhosphothreonineCombined sources1
Modified residuei2389PhosphothreonineCombined sources1
Modified residuei2395PhosphoserineCombined sources1
Modified residuei2406PhosphothreonineCombined sources1
Modified residuei2420PhosphoserineCombined sources1
Modified residuei2426PhosphothreonineCombined sources1
Modified residuei2446PhosphothreonineCombined sources1
Modified residuei2466PhosphoserineCombined sources1
Cross-linki2492Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei2505PhosphoserineCombined sources1
Modified residuei2528PhosphoserineCombined sources1
Modified residuei2588PhosphoserineCombined sources1
Cross-linki2613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki2613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2638PhosphoserineCombined sources1
Modified residuei2708PhosphoserineCombined sources1
Cross-linki2734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki2734Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei2827PhosphoserineCombined sources1
Modified residuei2828PhosphoserineCombined sources1
Modified residuei2838PhosphoserineBy similarity1
Cross-linki2852Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki2852Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki2967Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei2986N6-acetyllysineBy similarity1
Modified residuei3041PhosphoserineCombined sources1
Modified residuei3128PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Hyperphosphorylated in mitosis (PubMed:10502411, PubMed:10653604). Hyperphosphorylated form does not bind DNA.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P46013

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P46013

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P46013

MaxQB - The MaxQuant DataBase

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MaxQBi
P46013

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P46013

PeptideAtlas

More...
PeptideAtlasi
P46013

PRoteomics IDEntifications database

More...
PRIDEi
P46013

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55705 [P46013-1]
55706 [P46013-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P46013

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P46013

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P46013

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P46013

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression occurs preferentially during late G1, S, G2 and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected (at protein level) (PubMed:6206131). Present at highest level in G2 phase and during mitosis (at protein level). In interphase, forms fiber-like structures in fibrillarin-deficient regions surrounding nucleoli (PubMed:2674163, PubMed:8799815).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148773 Expressed in 157 organ(s), highest expression level in lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P46013 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000058
CAB068198
HPA000451
HPA001164

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KIF15 (PubMed:10878014).

Interacts (via the FHA domain) with NIFK (PubMed:11342549, PubMed:14659764, PubMed:16244663).

Interacts with PPP1CC (PubMed:24867636).

Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (PubMed:19131338, PubMed:23178126).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110434, 71 interactors

Database of interacting proteins

More...
DIPi
DIP-28132N

Protein interaction database and analysis system

More...
IntActi
P46013, 470 interactors

Molecular INTeraction database

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MINTi
P46013

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357643

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P46013

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P46013

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 76FHAPROSITE-ProRule annotationAdd BLAST50
Domaini502 – 549PP1-bindingSequence analysisAdd BLAST48
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1001 – 1112K167R 1Sequence analysisAdd BLAST112
Repeati1123 – 1234K167R 2Sequence analysisAdd BLAST112
Repeati1245 – 1356K167R 3Sequence analysisAdd BLAST112
Repeati1367 – 1477K167R 4Sequence analysisAdd BLAST111
Repeati1488 – 1597K167R 5Sequence analysisAdd BLAST110
Repeati1609 – 1720K167R 6Sequence analysisAdd BLAST112
Repeati1731 – 1842K167R 7Sequence analysisAdd BLAST112
Repeati1854 – 1964K167R 8Sequence analysisAdd BLAST111
Repeati1975 – 2086K167R 9Sequence analysisAdd BLAST112
Repeati2097 – 2204K167R 10Sequence analysisAdd BLAST108
Repeati2215 – 2326K167R 11Sequence analysisAdd BLAST112
Repeati2336 – 2447K167R 12Sequence analysisAdd BLAST112
Repeati2458 – 2569K167R 13Sequence analysisAdd BLAST112
Repeati2700 – 2805K167R 15Sequence analysisAdd BLAST106
Repeati2819 – 2928K167R 16Sequence analysisAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1000 – 292816 X 122 AA approximate repeats1 PublicationAdd BLAST1929

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JR7C Eukaryota
ENOG410ZXYW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154352

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113223

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P46013

KEGG Orthology (KO)

More...
KOi
K17582

Identification of Orthologs from Complete Genome Data

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OMAi
GNSTGHK

Database of Orthologous Groups

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OrthoDBi
290017at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P46013

TreeFam database of animal gene trees

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TreeFami
TF336000

Family and domain databases

Conserved Domains Database

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CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000253 FHA_dom
IPR012568 KI67R
IPR029334 PP1-bd
IPR008984 SMAD_FHA_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00498 FHA, 1 hit
PF08065 KI67R, 16 hits
PF15276 PP1_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00240 FHA, 1 hit
SM01295 K167R, 16 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Long (identifier: P46013-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPTRRLVTI KRSGVDGPHF PLSLSTCLFG RGIECDIRIQ LPVVSKQHCK
60 70 80 90 100
IEIHEQEAIL HNFSSTNPTQ VNGSVIDEPV RLKHGDVITI IDRSFRYENE
110 120 130 140 150
SLQNGRKSTE FPRKIREQEP ARRVSRSSFS SDPDEKAQDS KAYSKITEGK
160 170 180 190 200
VSGNPQVHIK NVKEDSTADD SKDSVAQGTT NVHSSEHAGR NGRNAADPIS
210 220 230 240 250
GDFKEISSVK LVSRYGELKS VPTTQCLDNS KKNESPFWKL YESVKKELDV
260 270 280 290 300
KSQKENVLQY CRKSGLQTDY ATEKESADGL QGETQLLVSR KSRPKSGGSG
310 320 330 340 350
HAVAEPASPE QELDQNKGKG RDVESVQTPS KAVGASFPLY EPAKMKTPVQ
360 370 380 390 400
YSQQQNSPQK HKNKDLYTTG RRESVNLGKS EGFKAGDKTL TPRKLSTRNR
410 420 430 440 450
TPAKVEDAAD SATKPENLSS KTRGSIPTDV EVLPTETEIH NEPFLTLWLT
460 470 480 490 500
QVERKIQKDS LSKPEKLGTT AGQMCSGLPG LSSVDINNFG DSINESEGIP
510 520 530 540 550
LKRRRVSFGG HLRPELFDEN LPPNTPLKRG EAPTKRKSLV MHTPPVLKKI
560 570 580 590 600
IKEQPQPSGK QESGSEIHVE VKAQSLVISP PAPSPRKTPV ASDQRRRSCK
610 620 630 640 650
TAPASSSKSQ TEVPKRGGRK SGNLPSKRVS ISRSQHDILQ MICSKRRSGA
660 670 680 690 700
SEANLIVAKS WADVVKLGAK QTQTKVIKHG PQRSMNKRQR RPATPKKPVG
710 720 730 740 750
EVHSQFSTGH ANSPCTIIIG KAHTEKVHVP ARPYRVLNNF ISNQKMDFKE
760 770 780 790 800
DLSGIAEMFK TPVKEQPQLT STCHIAISNS ENLLGKQFQG TDSGEEPLLP
810 820 830 840 850
TSESFGGNVF FSAQNAAKQP SDKCSASPPL RRQCIRENGN VAKTPRNTYK
860 870 880 890 900
MTSLETKTSD TETEPSKTVS TANRSGRSTE FRNIQKLPVE SKSEETNTEI
910 920 930 940 950
VECILKRGQK ATLLQQRREG EMKEIERPFE TYKENIELKE NDEKMKAMKR
960 970 980 990 1000
SRTWGQKCAP MSDLTDLKSL PDTELMKDTA RGQNLLQTQD HAKAPKSEKG
1010 1020 1030 1040 1050
KITKMPCQSL QPEPINTPTH TKQQLKASLG KVGVKEELLA VGKFTRTSGE
1060 1070 1080 1090 1100
TTHTHREPAG DGKSIRTFKE SPKQILDPAA RVTGMKKWPR TPKEEAQSLE
1110 1120 1130 1140 1150
DLAGFKELFQ TPGPSEESMT DEKTTKIACK SPPPESVDTP TSTKQWPKRS
1160 1170 1180 1190 1200
LRKADVEEEF LALRKLTPSA GKAMLTPKPA GGDEKDIKAF MGTPVQKLDL
1210 1220 1230 1240 1250
AGTLPGSKRQ LQTPKEKAQA LEDLAGFKEL FQTPGHTEEL VAAGKTTKIP
1260 1270 1280 1290 1300
CDSPQSDPVD TPTSTKQRPK RSIRKADVEG ELLACRNLMP SAGKAMHTPK
1310 1320 1330 1340 1350
PSVGEEKDII IFVGTPVQKL DLTENLTGSK RRPQTPKEEA QALEDLTGFK
1360 1370 1380 1390 1400
ELFQTPGHTE EAVAAGKTTK MPCESSPPES ADTPTSTRRQ PKTPLEKRDV
1410 1420 1430 1440 1450
QKELSALKKL TQTSGETTHT DKVPGGEDKS INAFRETAKQ KLDPAASVTG
1460 1470 1480 1490 1500
SKRHPKTKEK AQPLEDLAGL KELFQTPVCT DKPTTHEKTT KIACRSQPDP
1510 1520 1530 1540 1550
VDTPTSSKPQ SKRSLRKVDV EEEFFALRKR TPSAGKAMHT PKPAVSGEKN
1560 1570 1580 1590 1600
IYAFMGTPVQ KLDLTENLTG SKRRLQTPKE KAQALEDLAG FKELFQTRGH
1610 1620 1630 1640 1650
TEESMTNDKT AKVACKSSQP DPDKNPASSK RRLKTSLGKV GVKEELLAVG
1660 1670 1680 1690 1700
KLTQTSGETT HTHTEPTGDG KSMKAFMESP KQILDSAASL TGSKRQLRTP
1710 1720 1730 1740 1750
KGKSEVPEDL AGFIELFQTP SHTKESMTNE KTTKVSYRAS QPDLVDTPTS
1760 1770 1780 1790 1800
SKPQPKRSLR KADTEEEFLA FRKQTPSAGK AMHTPKPAVG EEKDINTFLG
1810 1820 1830 1840 1850
TPVQKLDQPG NLPGSNRRLQ TRKEKAQALE ELTGFRELFQ TPCTDNPTTD
1860 1870 1880 1890 1900
EKTTKKILCK SPQSDPADTP TNTKQRPKRS LKKADVEEEF LAFRKLTPSA
1910 1920 1930 1940 1950
GKAMHTPKAA VGEEKDINTF VGTPVEKLDL LGNLPGSKRR PQTPKEKAKA
1960 1970 1980 1990 2000
LEDLAGFKEL FQTPGHTEES MTDDKITEVS CKSPQPDPVK TPTSSKQRLK
2010 2020 2030 2040 2050
ISLGKVGVKE EVLPVGKLTQ TSGKTTQTHR ETAGDGKSIK AFKESAKQML
2060 2070 2080 2090 2100
DPANYGTGME RWPRTPKEEA QSLEDLAGFK ELFQTPDHTE ESTTDDKTTK
2110 2120 2130 2140 2150
IACKSPPPES MDTPTSTRRR PKTPLGKRDI VEELSALKQL TQTTHTDKVP
2160 2170 2180 2190 2200
GDEDKGINVF RETAKQKLDP AASVTGSKRQ PRTPKGKAQP LEDLAGLKEL
2210 2220 2230 2240 2250
FQTPICTDKP TTHEKTTKIA CRSPQPDPVG TPTIFKPQSK RSLRKADVEE
2260 2270 2280 2290 2300
ESLALRKRTP SVGKAMDTPK PAGGDEKDMK AFMGTPVQKL DLPGNLPGSK
2310 2320 2330 2340 2350
RWPQTPKEKA QALEDLAGFK ELFQTPGTDK PTTDEKTTKI ACKSPQPDPV
2360 2370 2380 2390 2400
DTPASTKQRP KRNLRKADVE EEFLALRKRT PSAGKAMDTP KPAVSDEKNI
2410 2420 2430 2440 2450
NTFVETPVQK LDLLGNLPGS KRQPQTPKEK AEALEDLVGF KELFQTPGHT
2460 2470 2480 2490 2500
EESMTDDKIT EVSCKSPQPE SFKTSRSSKQ RLKIPLVKVD MKEEPLAVSK
2510 2520 2530 2540 2550
LTRTSGETTQ THTEPTGDSK SIKAFKESPK QILDPAASVT GSRRQLRTRK
2560 2570 2580 2590 2600
EKARALEDLV DFKELFSAPG HTEESMTIDK NTKIPCKSPP PELTDTATST
2610 2620 2630 2640 2650
KRCPKTRPRK EVKEELSAVE RLTQTSGQST HTHKEPASGD EGIKVLKQRA
2660 2670 2680 2690 2700
KKKPNPVEEE PSRRRPRAPK EKAQPLEDLA GFTELSETSG HTQESLTAGK
2710 2720 2730 2740 2750
ATKIPCESPP LEVVDTTAST KRHLRTRVQK VQVKEEPSAV KFTQTSGETT
2760 2770 2780 2790 2800
DADKEPAGED KGIKALKESA KQTPAPAASV TGSRRRPRAP RESAQAIEDL
2810 2820 2830 2840 2850
AGFKDPAAGH TEESMTDDKT TKIPCKSSPE LEDTATSSKR RPRTRAQKVE
2860 2870 2880 2890 2900
VKEELLAVGK LTQTSGETTH TDKEPVGEGK GTKAFKQPAK RKLDAEDVIG
2910 2920 2930 2940 2950
SRRQPRAPKE KAQPLEDLAS FQELSQTPGH TEELANGAAD SFTSAPKQTP
2960 2970 2980 2990 3000
DSGKPLKISR RVLRAPKVEP VGDVVSTRDP VKSQSKSNTS LPPLPFKRGG
3010 3020 3030 3040 3050
GKDGSVTGTK RLRCMPAPEE IVEELPASKK QRVAPRARGK SSEPVVIMKR
3060 3070 3080 3090 3100
SLRTSAKRIE PAEELNSNDM KTNKEEHKLQ DSVPENKGIS LRSRRQNKTE
3110 3120 3130 3140 3150
AEQQITEVFV LAERIEINRN EKKPMKTSPE MDIQNPDDGA RKPIPRDKVT
3160 3170 3180 3190 3200
ENKRCLRSAR QNESSQPKVA EESGGQKSAK VLMQNQKGKG EAGNSDSMCL
3210 3220 3230 3240 3250
RSRKTKSQPA ASTLESKSVQ RVTRSVKRCA ENPKKAEDNV CVKKIRTRSH

RDSEDI
Length:3,256
Mass (Da):358,694
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1332BC6C799AD64D
GO
Isoform Short (identifier: P46013-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-495: Missing.

Show »
Length:2,896
Mass (Da):319,444
Checksum:i4FACAA90AC686C72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti619 – 626RKSGNLPS → ERVATCLQ in CAA46519 (PubMed:8227122).Curated8
Sequence conflicti619 – 626RKSGNLPS → ERVATCLQ in CAA46520 (PubMed:8227122).Curated8
Sequence conflicti2205I → V in CAA46519 (PubMed:8227122).Curated1
Sequence conflicti2205I → V in CAA46520 (PubMed:8227122).Curated1
Sequence conflicti2892 – 2893KL → NV in CAA46519 (PubMed:8227122).Curated2
Sequence conflicti2892 – 2893KL → NV in CAA46520 (PubMed:8227122).Curated2
Sequence conflicti3246R → T in CAA46519 (PubMed:8227122).Curated1
Sequence conflicti3246R → T in CAA46520 (PubMed:8227122).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029055104N → S. Corresponds to variant dbSNP:rs2071498Ensembl.1
Natural variantiVAR_029056238W → R. Corresponds to variant dbSNP:rs7095325Ensembl.1
Natural variantiVAR_029057497E → D. Corresponds to variant dbSNP:rs11016076Ensembl.1
Natural variantiVAR_029058574Q → P. Corresponds to variant dbSNP:rs4471342Ensembl.1
Natural variantiVAR_024161631I → L. Corresponds to variant dbSNP:rs997983Ensembl.1
Natural variantiVAR_033995832R → W. Corresponds to variant dbSNP:rs34916904Ensembl.1
Natural variantiVAR_024162854L → V. Corresponds to variant dbSNP:rs2240Ensembl.1
Natural variantiVAR_029059872A → V1 PublicationCorresponds to variant dbSNP:rs2853344Ensembl.1
Natural variantiVAR_0241631042G → S. Corresponds to variant dbSNP:rs2152143Ensembl.1
Natural variantiVAR_0290601120T → S. Corresponds to variant dbSNP:rs11016074Ensembl.1
Natural variantiVAR_0218381247T → I. Corresponds to variant dbSNP:rs4750685Ensembl.1
Natural variantiVAR_0200471403E → V. Corresponds to variant dbSNP:rs3740423Ensembl.1
Natural variantiVAR_0290611470L → W1 PublicationCorresponds to variant dbSNP:rs2853345Ensembl.1
Natural variantiVAR_0290621559V → M. Corresponds to variant dbSNP:rs7918199Ensembl.1
Natural variantiVAR_0290631622P → L1 PublicationCorresponds to variant dbSNP:rs2782871Ensembl.1
Natural variantiVAR_0290641849T → A1 PublicationCorresponds to variant dbSNP:rs2782872Ensembl.1
Natural variantiVAR_0290651876R → Q. Corresponds to variant dbSNP:rs11591817Ensembl.1
Natural variantiVAR_0339961951L → I. Corresponds to variant dbSNP:rs34116632Ensembl.1
Natural variantiVAR_0290662101I → T. Corresponds to variant dbSNP:rs11016073Ensembl.1
Natural variantiVAR_0241642337T → N. Corresponds to variant dbSNP:rs7083622Ensembl.1
Natural variantiVAR_0290672363N → S. Corresponds to variant dbSNP:rs7071768Ensembl.1
Natural variantiVAR_0616712607R → H. Corresponds to variant dbSNP:rs34688192Ensembl.1
Natural variantiVAR_0241652608P → L. Corresponds to variant dbSNP:rs1063535Ensembl.1
Natural variantiVAR_0290682649R → H. Corresponds to variant dbSNP:rs12777740Ensembl.1
Natural variantiVAR_0241662720T → P. Corresponds to variant dbSNP:rs1050767Ensembl.1
Natural variantiVAR_0290692760D → G. Corresponds to variant dbSNP:rs10082391Ensembl.1
Natural variantiVAR_0290702786R → Q. Corresponds to variant dbSNP:rs10764749Ensembl.1
Natural variantiVAR_0290712793S → N. Corresponds to variant dbSNP:rs10082533Ensembl.1
Natural variantiVAR_0290722845R → H. Corresponds to variant dbSNP:rs11016072Ensembl.1
Natural variantiVAR_0241672868T → S. Corresponds to variant dbSNP:rs2071496Ensembl.1
Natural variantiVAR_0290732904Q → R. Corresponds to variant dbSNP:rs11016071Ensembl.1
Natural variantiVAR_0290743097N → D1 PublicationCorresponds to variant dbSNP:rs2798669Ensembl.1
Natural variantiVAR_0339973102E → G. Corresponds to variant dbSNP:rs34750407Ensembl.1
Natural variantiVAR_0148583150T → S. Corresponds to variant dbSNP:rs11106Ensembl.1
Natural variantiVAR_0148593217K → E. Corresponds to variant dbSNP:rs8473Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004298136 – 495Missing in isoform Short. 1 PublicationAdd BLAST360

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X65550 mRNA Translation: CAA46519.1
X65551 mRNA Translation: CAA46520.1
AL355529 Genomic DNA No translation available.
AL390236 Genomic DNA No translation available.
X94762 Genomic DNA Translation: CAA64388.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53588.1 [P46013-2]
CCDS7659.1 [