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Protein

Mitogen-activated protein kinase 9

Gene

MAPK9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity).By similarity1 Publication
MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.11 Publications

Cofactori

Mg2+1 Publication

Activity regulationi

Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • JUN kinase activity Source: UniProtKB
  • MAP kinase activity Source: GO_Central
  • protein serine/threonine/tyrosine kinase activity Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processBiological rhythms
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24 2681
ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450341 Activation of the AP-1 family of transcription factors
SignaLinkiP45984
SIGNORiP45984

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 9 (EC:2.7.11.247 Publications)
Short name:
MAP kinase 9
Short name:
MAPK 9
Alternative name(s):
JNK-55
Stress-activated protein kinase 1a
Short name:
SAPK1a
Stress-activated protein kinase JNK2
c-Jun N-terminal kinase 2
Gene namesi
Name:MAPK9
Synonyms:JNK2, PRKM9, SAPK1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000050748.17
HGNCiHGNC:6886 MAPK9
MIMi602896 gene
neXtProtiNX_P45984

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5601
OpenTargetsiENSG00000050748
PharmGKBiPA30630

Chemistry databases

ChEMBLiCHEMBL4179
GuidetoPHARMACOLOGYi1497

Polymorphism and mutation databases

BioMutaiMAPK9
DMDMi85700366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001862731 – 424Mitogen-activated protein kinase 9Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei183Phosphothreonine; by MAP2K71 Publication1
Modified residuei185Phosphotyrosine; by MAP2K41 Publication1

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP45984
MaxQBiP45984
PaxDbiP45984
PeptideAtlasiP45984
PRIDEiP45984
ProteomicsDBi55698
55699 [P45984-2]
55700 [P45984-3]
55701 [P45984-4]
55702 [P45984-5]

2D gel databases

REPRODUCTION-2DPAGEiP45984

PTM databases

GlyConnecti1515
iPTMnetiP45984
PhosphoSitePlusiP45984

Expressioni

Gene expression databases

BgeeiENSG00000050748 Expressed in 233 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_MAPK9
ExpressionAtlasiP45984 baseline and differential
GenevisibleiP45984 HS

Organism-specific databases

HPAiCAB008910

Interactioni

Subunit structurei

Interacts with MECOM (By similarity). Interacts with DCLK2 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway (By similarity). Interacts with NFATC4 (PubMed:17875713). Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN (PubMed:10376527). Interacts with BCL10 (PubMed:17189706). Interacts with CTNNB1 and GSK3B (PubMed:19675674). Interacts with MAPKBP1 (PubMed:28089251). Interacts with POU5F1; phosphorylates POU5F1 at 'Ser-355'. Found in a complex with SH3RF1, RAC2, MAP3K7/TAK1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (By similarity).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111587, 123 interactors
DIPiDIP-270N
ELMiP45984
IntActiP45984, 88 interactors
MINTiP45984
STRINGi9606.ENSP00000389338

Chemistry databases

BindingDBiP45984

Structurei

Secondary structure

1424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP45984
SMRiP45984
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45984

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 321Protein kinasePROSITE-ProRule annotationAdd BLAST296

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi183 – 185TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0665 Eukaryota
ENOG410XSHI LUCA
GeneTreeiENSGT00550000074271
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiP45984
KOiK04440
OMAiWEERNKN
OrthoDBiEOG091G09G2
PhylomeDBiP45984
TreeFamiTF105100

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008351 MAPK_JNK
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01772 JNKMAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-2 (identifier: P45984-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI
60 70 80 90 100
NVAVKKLSRP FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE
110 120 130 140 150
FQDVYLVMEL MDANLCQVIH MELDHERMSY LLYQMLCGIK HLHSAGIIHR
160 170 180 190 200
DLKPSNIVVK SDCTLKILDF GLARTACTNF MMTPYVVTRY YRAPEVILGM
210 220 230 240 250
GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ LGTPSAEFMK
260 270 280 290 300
KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK
310 320 330 340 350
MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE
360 370 380 390 400
EWKELIYKEV MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS
410 420
TEQTLASDTD SSLDASTGPL EGCR
Length:424
Mass (Da):48,139
Last modified:January 24, 2006 - v2
Checksum:i9C15DA79981290AF
GO
Isoform Alpha-1 (identifier: P45984-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-424: DAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR → AQMQQ

Show »
Length:382
Mass (Da):44,051
Checksum:iA1963C01247BDFF4
GO
Isoform Beta-1 (identifier: P45984-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-230: GELVKGCVIFQGTDH → AEMVLHKVLFPGRDY
     378-424: DAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR → AQMQQ

Show »
Length:382
Mass (Da):44,223
Checksum:i808ED1F85085CB4E
GO
Isoform Beta-2 (identifier: P45984-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-230: GELVKGCVIFQGTDH → AEMVLHKVLFPGRDY

Show »
Length:424
Mass (Da):48,311
Checksum:iA1B5FB794F373EB9
GO
Isoform 5 (identifier: P45984-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-242: HIDQWNKVIEQLG → RILPRDLGPAMLS
     243-424: Missing.

Show »
Length:242
Mass (Da):27,334
Checksum:iB37D5C58904AE9F1
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D7R525D7R525_HUMAN
Mitogen-activated protein kinase
MAPK9
214Annotation score:
J3KNK1J3KNK1_HUMAN
Mitogen-activated protein kinase
MAPK9
339Annotation score:
E5RJ57E5RJ57_HUMAN
Mitogen-activated protein kinase 9
MAPK9
103Annotation score:
D7R528D7R528_HUMAN
Mitogen-activated protein kinase 9 ...
MAPK9
124Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51N → S in AAA56831 (PubMed:7969172).Curated1
Sequence conflicti51N → S in AAC50606 (PubMed:8654373).Curated1
Sequence conflicti51N → S in AAC50608 (PubMed:8654373).Curated1
Sequence conflicti51N → S in AAC50609 (PubMed:8654373).Curated1
Sequence conflicti377S → P in AAA74740 (PubMed:8001819).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04226013V → M in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04226156K → N in a head & Neck squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_042262246A → T1 PublicationCorresponds to variant dbSNP:rs35421153Ensembl.1
Natural variantiVAR_025175268G → A1 PublicationCorresponds to variant dbSNP:rs35693958Ensembl.1
Natural variantiVAR_042263366R → I1 PublicationCorresponds to variant dbSNP:rs55736180Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004834216 – 230GELVK…QGTDH → AEMVLHKVLFPGRDY in isoform Beta-1 and isoform Beta-2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_041908230 – 242HIDQW…IEQLG → RILPRDLGPAMLS in isoform 5. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_041909243 – 424Missing in isoform 5. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_004835378 – 424DAAVS…LEGCR → AQMQQ in isoform Alpha-1 and isoform Beta-1. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31951 mRNA Translation: AAA56831.1
U09759 mRNA Translation: AAA74740.1
U34821 mRNA Translation: AAC50606.1
U35002 mRNA Translation: AAC50608.1
U35003 mRNA Translation: AAC50609.1
EU927388 mRNA Translation: ACH57450.1
CR536580 mRNA Translation: CAG38817.1
AK289638 mRNA Translation: BAF82327.1
DQ066599 Genomic DNA Translation: AAY46156.1
AB451302 mRNA Translation: BAG70116.1
AB451355 mRNA Translation: BAG70169.1
AC008610 Genomic DNA No translation available.
AC104115 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53759.1
CH471165 Genomic DNA Translation: EAW53757.1
CH471165 Genomic DNA Translation: EAW53758.1
CH471165 Genomic DNA Translation: EAW53762.1
BC032539 mRNA Translation: AAH32539.1
CCDSiCCDS43409.1 [P45984-2]
CCDS43410.1 [P45984-3]
CCDS4453.1 [P45984-1]
CCDS4454.1 [P45984-4]
CCDS47356.1 [P45984-5]
PIRiA55480
S71102
RefSeqiNP_001128516.1, NM_001135044.1 [P45984-5]
NP_001295173.1, NM_001308244.1
NP_002743.3, NM_002752.4 [P45984-1]
NP_620707.1, NM_139068.2 [P45984-2]
NP_620708.1, NM_139069.2 [P45984-3]
NP_620709.1, NM_139070.2 [P45984-4]
XP_006714954.1, XM_006714891.2
XP_016865127.1, XM_017009638.1
XP_016865130.1, XM_017009641.1
UniGeneiHs.484371

Genome annotation databases

EnsembliENST00000343111; ENSP00000345524; ENSG00000050748 [P45984-3]
ENST00000393360; ENSP00000377028; ENSG00000050748 [P45984-2]
ENST00000425491; ENSP00000397422; ENSG00000050748 [P45984-5]
ENST00000452135; ENSP00000394560; ENSG00000050748 [P45984-1]
ENST00000455781; ENSP00000389338; ENSG00000050748 [P45984-4]
GeneIDi5601
KEGGihsa:5601
UCSCiuc003mls.5 human [P45984-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31951 mRNA Translation: AAA56831.1
U09759 mRNA Translation: AAA74740.1
U34821 mRNA Translation: AAC50606.1
U35002 mRNA Translation: AAC50608.1
U35003 mRNA Translation: AAC50609.1
EU927388 mRNA Translation: ACH57450.1
CR536580 mRNA Translation: CAG38817.1
AK289638 mRNA Translation: BAF82327.1
DQ066599 Genomic DNA Translation: AAY46156.1
AB451302 mRNA Translation: BAG70116.1
AB451355 mRNA Translation: BAG70169.1
AC008610 Genomic DNA No translation available.
AC104115 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53759.1
CH471165 Genomic DNA Translation: EAW53757.1
CH471165 Genomic DNA Translation: EAW53758.1
CH471165 Genomic DNA Translation: EAW53762.1
BC032539 mRNA Translation: AAH32539.1
CCDSiCCDS43409.1 [P45984-2]
CCDS43410.1 [P45984-3]
CCDS4453.1 [P45984-1]
CCDS4454.1 [P45984-4]
CCDS47356.1 [P45984-5]
PIRiA55480
S71102
RefSeqiNP_001128516.1, NM_001135044.1 [P45984-5]
NP_001295173.1, NM_001308244.1
NP_002743.3, NM_002752.4 [P45984-1]
NP_620707.1, NM_139068.2 [P45984-2]
NP_620708.1, NM_139069.2 [P45984-3]
NP_620709.1, NM_139070.2 [P45984-4]
XP_006714954.1, XM_006714891.2
XP_016865127.1, XM_017009638.1
XP_016865130.1, XM_017009641.1
UniGeneiHs.484371

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E7OX-ray2.14A/B7-362[»]
3NPCX-ray2.35A/B1-364[»]
ProteinModelPortaliP45984
SMRiP45984
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111587, 123 interactors
DIPiDIP-270N
ELMiP45984
IntActiP45984, 88 interactors
MINTiP45984
STRINGi9606.ENSP00000389338

Chemistry databases

BindingDBiP45984
ChEMBLiCHEMBL4179
GuidetoPHARMACOLOGYi1497

PTM databases

GlyConnecti1515
iPTMnetiP45984
PhosphoSitePlusiP45984

Polymorphism and mutation databases

BioMutaiMAPK9
DMDMi85700366

2D gel databases

REPRODUCTION-2DPAGEiP45984

Proteomic databases

EPDiP45984
MaxQBiP45984
PaxDbiP45984
PeptideAtlasiP45984
PRIDEiP45984
ProteomicsDBi55698
55699 [P45984-2]
55700 [P45984-3]
55701 [P45984-4]
55702 [P45984-5]

Protocols and materials databases

DNASUi5601
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343111; ENSP00000345524; ENSG00000050748 [P45984-3]
ENST00000393360; ENSP00000377028; ENSG00000050748 [P45984-2]
ENST00000425491; ENSP00000397422; ENSG00000050748 [P45984-5]
ENST00000452135; ENSP00000394560; ENSG00000050748 [P45984-1]
ENST00000455781; ENSP00000389338; ENSG00000050748 [P45984-4]
GeneIDi5601
KEGGihsa:5601
UCSCiuc003mls.5 human [P45984-1]

Organism-specific databases

CTDi5601
DisGeNETi5601
EuPathDBiHostDB:ENSG00000050748.17
GeneCardsiMAPK9
HGNCiHGNC:6886 MAPK9
HPAiCAB008910
MIMi602896 gene
neXtProtiNX_P45984
OpenTargetsiENSG00000050748
PharmGKBiPA30630
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0665 Eukaryota
ENOG410XSHI LUCA
GeneTreeiENSGT00550000074271
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiP45984
KOiK04440
OMAiWEERNKN
OrthoDBiEOG091G09G2
PhylomeDBiP45984
TreeFamiTF105100

Enzyme and pathway databases

BRENDAi2.7.11.24 2681
ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450341 Activation of the AP-1 family of transcription factors
SignaLinkiP45984
SIGNORiP45984

Miscellaneous databases

ChiTaRSiMAPK9 human
EvolutionaryTraceiP45984
GeneWikiiMitogen-activated_protein_kinase_9
GenomeRNAii5601
PROiPR:P45984
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000050748 Expressed in 233 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_MAPK9
ExpressionAtlasiP45984 baseline and differential
GenevisibleiP45984 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR008351 MAPK_JNK
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01772 JNKMAPKINASE
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMK09_HUMAN
AccessioniPrimary (citable) accession number: P45984
Secondary accession number(s): A8K0S3
, B5BU66, B5M0B4, D3DWQ8, D3DWQ9, Q15708, Q15710, Q15711, Q8N5C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2006
Last modified: November 7, 2018
This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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