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UniProtKB - P45880 (VDAC2_HUMAN)

Entry version 203 (29 Sep 2021)
Sequence version 2 (11 Sep 2007)
Previous versions | rss
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Protein

Voltage-dependent anion-selective channel protein 2

Gene

VDAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity).

The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity).

The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity).

Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432).

Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei84Involved in ceramide and phosphatidylcholine binding1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi253 – 255NADBy similarity3
Nucleotide bindingi271 – 275NADBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processIon transport, Transport
LigandLipid-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P45880

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5689880, Ub-specific processing proteases
R-HSA-8949215, Mitochondrial calcium ion transport

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		P45880

Transport Classification Database

More...TCDBi		1.B.8.1.12, the mitochondrial and plastid porin (mpp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 2
Short name:
VDAC-2
Short name:
hVDAC2
Alternative name(s):
Outer mitochondrial membrane protein porin 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VDAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12672, VDAC2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		193245, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P45880

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000165637

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 46Beta strandedBy similarity10
Transmembranei50 – 58Beta strandedBy similarity9
Transmembranei65 – 75Beta strandedBy similarityAdd BLAST11
Transmembranei80 – 87Beta strandedBy similarity8
Transmembranei91 – 100Beta strandedBy similarity10
Transmembranei106 – 115Beta strandedBy similarity10
Transmembranei122 – 131Beta strandedBy similarity10
Transmembranei134 – 141Beta strandedBy similarity8
Transmembranei148 – 156Beta strandedBy similarity9
Transmembranei161 – 169Beta strandedBy similarity9
Transmembranei174 – 186Beta strandedBy similarityAdd BLAST13
Transmembranei189 – 196Beta strandedBy similarity8
Transmembranei200 – 209Beta strandedBy similarity10
Transmembranei213 – 222Beta strandedBy similarity10
Transmembranei229 – 238Beta strandedBy similarity10
Transmembranei242 – 249Beta strandedBy similarity8
Transmembranei253 – 262Beta strandedBy similarity10
Transmembranei265 – 274Beta strandedBy similarity10
Transmembranei284 – 293Beta strandedBy similarity10

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi84E → Q: Abolishes ceramide and phosphatidylcholine binding. Decreases apoptosis frequency following mitochondrial targeting of ceramide. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7417

Open Targets

More...OpenTargetsi		ENSG00000165637

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37295

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P45880, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6190

Drug and drug target database

More...DrugBanki		DB01375, Aluminium monostearate
DB06098, PRLX 93936

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VDAC2

Domain mapping of disease mutations (DMDM)

More...DMDMi		158518391

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000505052 – 294Voltage-dependent anion-selective channel protein 2Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei31N6-acetyllysine; alternateCombined sources1
Modified residuei31N6-succinyllysine; alternateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei78PhosphotyrosineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Modified residuei120N6-acetyllysine; alternateBy similarity1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei251PhosphoserineBy similarity1
Modified residuei277N6-acetyllysine; alternateBy similarity1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P45880

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P45880

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P45880

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P45880

PeptideAtlas

More...PeptideAtlasi		P45880

PRoteomics IDEntifications database

More...PRIDEi		P45880

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55687 [P45880-3]
55688 [P45880-1]
55689 [P45880-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P45880-3 [P45880-3]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P45880

USC-OGP 2-DE database

More...OGPi		P45880

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		P45880

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P45880

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P45880

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P45880

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P45880, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P45880

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P45880

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P45880

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in all tissues examined (PubMed:8420959).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165637, Expressed in ectocervix and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P45880, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P45880, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165637, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hexokinases (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113260, 335 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P45880

Protein interaction database and analysis system

More...IntActi		P45880, 125 interactors

Molecular INTeraction database

More...MINTi		P45880

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361635

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P45880

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P45880, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P45880

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic mitochondrial porin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3126, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044399_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P45880

Identification of Orthologs from Complete Genome Data

More...OMAi		GYTTPLY

Database of Orthologous Groups

More...OrthoDBi		938262at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P45880

TreeFam database of animal gene trees

More...TreeFami		TF315091

Family and domain databases

Conserved Domains Database

More...CDDi		cd07306, Porin3_VDAC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40
IPR030277, VDAC2

The PANTHER Classification System

More...PANTHERi		PTHR11743, PTHR11743, 1 hit
PTHR11743:SF12, PTHR11743:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01459, Porin_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00185, EUKARYTPORIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00558, EUKARYOTIC_PORIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: P45880-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV 
        60         70         80         90        100
EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED 
       110        120        130        140        150
QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH 
       160        170        180        190        200
GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE 
       210        220        230        240        250
FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN 
       260        270        280        290 
SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA
Length:294
Mass (Da):31,567
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4EAE732E653637E
GO
Isoform 1 (identifier: P45880-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MATHGQTCARP → MSWCNELRLPALKQHSIGRGLESHIT

Show »
Length:309
Mass (Da):33,372
Checksum:i7A94C18F1C07DEBA
GO
Isoform 2 (identifier: P45880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:283
Mass (Da):30,412
Checksum:i9A66CDF9CF0542B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JSD1Q5JSD1_HUMAN
Outer mitochondrial membrane protei...
VDAC2
204Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR02A0A0A0MR02_HUMAN
Outer mitochondrial membrane protei...
VDAC2
282Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JSD2Q5JSD2_HUMAN
Outer mitochondrial membrane protei...
VDAC2
194Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3S1A2A3S1_HUMAN
Outer mitochondrial membrane protei...
VDAC2
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60144 differs from that shown. Reason: Frameshift.Curated
The sequence AAA60145 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00638024A → V1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0050771 – 11MATHGQTCARP → MSWCNELRLPALKQHSIGRG LESHIT in isoform 1. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0050761 – 11Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L08666 mRNA Translation: AAA60144.1 Frameshift.
L08666 mRNA Translation: AAA60145.1 Frameshift.
L06328 mRNA Translation: AAB59457.1
AF152227 AF152226 Genomic DNA Translation: AAD40241.1
CR456964 mRNA Translation: CAG33245.1
AL390034 Genomic DNA No translation available.
AL392111 Genomic DNA No translation available.
BC000165 mRNA Translation: AAH00165.2
BC012883 mRNA Translation: AAH12883.2
BC072407 mRNA Translation: AAH72407.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53544.1 [P45880-1]
CCDS7348.1 [P45880-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A45972
B44422

NCBI Reference Sequences

More...RefSeqi		NP_001171712.1, NM_001184783.2 [P45880-1]
NP_001171752.1, NM_001184823.1 [P45880-3]
NP_001311017.1, NM_001324088.1 [P45880-3]
NP_003366.2, NM_003375.4 [P45880-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313132; ENSP00000361635; ENSG00000165637 [P45880-1]
ENST00000332211; ENSP00000361686; ENSG00000165637 [P45880-3]
ENST00000543351; ENSP00000443092; ENSG00000165637 [P45880-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7417

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7417

UCSC genome browser

More...UCSCi		uc001jwz.5, human [P45880-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08666 mRNA Translation: AAA60144.1 Frameshift.
L08666 mRNA Translation: AAA60145.1 Frameshift.
L06328 mRNA Translation: AAB59457.1
AF152227 AF152226 Genomic DNA Translation: AAD40241.1
CR456964 mRNA Translation: CAG33245.1
AL390034 Genomic DNA No translation available.
AL392111 Genomic DNA No translation available.
BC000165 mRNA Translation: AAH00165.2
BC012883 mRNA Translation: AAH12883.2
BC072407 mRNA Translation: AAH72407.1
CCDSiCCDS53544.1 [P45880-1]
CCDS7348.1 [P45880-3]
PIRiA45972
B44422
RefSeqiNP_001171712.1, NM_001184783.2 [P45880-1]
NP_001171752.1, NM_001184823.1 [P45880-3]
NP_001311017.1, NM_001324088.1 [P45880-3]
NP_003366.2, NM_003375.4 [P45880-3]

3D structure databases

SMRiP45880
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113260, 335 interactors
CORUMiP45880
IntActiP45880, 125 interactors
MINTiP45880
STRINGi9606.ENSP00000361635

Chemistry databases

BindingDBiP45880
ChEMBLiCHEMBL6190
DrugBankiDB01375, Aluminium monostearate
DB06098, PRLX 93936

Protein family/group databases

MoonProtiP45880
TCDBi1.B.8.1.12, the mitochondrial and plastid porin (mpp) family

PTM databases

CarbonylDBiP45880
GlyGeniP45880, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiP45880
PhosphoSitePlusiP45880
SwissPalmiP45880

Genetic variation databases

BioMutaiVDAC2
DMDMi158518391

2D gel databases

DOSAC-COBS-2DPAGEiP45880
OGPiP45880
REPRODUCTION-2DPAGEiP45880
SWISS-2DPAGEiP45880
UCD-2DPAGEiP45880

Proteomic databases

EPDiP45880
jPOSTiP45880
MassIVEiP45880
PaxDbiP45880
PeptideAtlasiP45880
PRIDEiP45880
ProteomicsDBi55687 [P45880-3]
55688 [P45880-1]
55689 [P45880-2]
TopDownProteomicsiP45880-3 [P45880-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29670, 295 antibodies

The DNASU plasmid repository

More...DNASUi		7417

Genome annotation databases

EnsembliENST00000313132; ENSP00000361635; ENSG00000165637 [P45880-1]
ENST00000332211; ENSP00000361686; ENSG00000165637 [P45880-3]
ENST00000543351; ENSP00000443092; ENSG00000165637 [P45880-3]
GeneIDi7417
KEGGihsa:7417
UCSCiuc001jwz.5, human [P45880-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7417
DisGeNETi7417

GeneCards: human genes, protein and diseases

More...GeneCardsi		VDAC2
HGNCiHGNC:12672, VDAC2
HPAiENSG00000165637, Low tissue specificity
MIMi193245, gene
neXtProtiNX_P45880
OpenTargetsiENSG00000165637
PharmGKBiPA37295
VEuPathDBiHostDB:ENSG00000165637

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3126, Eukaryota
GeneTreeiENSGT00950000182869
HOGENOMiCLU_044399_2_0_1
InParanoidiP45880
OMAiGYTTPLY
OrthoDBi938262at2759
PhylomeDBiP45880
TreeFamiTF315091

Enzyme and pathway databases

PathwayCommonsiP45880
ReactomeiR-HSA-5689880, Ub-specific processing proteases
R-HSA-8949215, Mitochondrial calcium ion transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7417, 119 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VDAC2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VDAC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7417
PharosiP45880, Tchem

Protein Ontology

More...PROi		PR:P45880
RNActiP45880, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165637, Expressed in ectocervix and 133 other tissues
ExpressionAtlasiP45880, baseline and differential
GenevisibleiP45880, HS

Family and domain databases

CDDicd07306, Porin3_VDAC, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614, Porin_dom_sf
IPR001925, Porin_Euk
IPR027246, Porin_Euk/Tom40
IPR030277, VDAC2
PANTHERiPTHR11743, PTHR11743, 1 hit
PTHR11743:SF12, PTHR11743:SF12, 1 hit
PfamiView protein in Pfam
PF01459, Porin_3, 1 hit
PRINTSiPR00185, EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558, EUKARYOTIC_PORIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVDAC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45880
Secondary accession number(s): Q5VWK1
, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 11, 2007
Last modified: September 29, 2021
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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