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Protein

Voltage-dependent anion-selective channel protein 2

Gene

VDAC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Involved in hexokinase bindingBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi253 – 255NADBy similarity3
Nucleotide bindingi271 – 275NADBy similarity5

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  • anion transport Source: UniProtKB
  • binding of sperm to zona pellucida Source: CAFA
  • negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  • negative regulation of protein polymerization Source: Ensembl

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport
LigandNAD, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases
R-HSA-8949215 Mitochondrial calcium ion transport

Protein family/group databases

MoonProtiP45880
TCDBi1.B.8.1.12 the mitochondrial and plastid porin (mpp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 2
Short name:
VDAC-2
Short name:
hVDAC2
Alternative name(s):
Outer mitochondrial membrane protein porin 2
Gene namesi
Name:VDAC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165637.13
HGNCiHGNC:12672 VDAC2
MIMi193245 gene
neXtProtiNX_P45880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 46Beta strandedBy similarity10
Transmembranei50 – 58Beta strandedBy similarity9
Transmembranei65 – 75Beta strandedBy similarityAdd BLAST11
Transmembranei80 – 87Beta strandedBy similarity8
Transmembranei91 – 100Beta strandedBy similarity10
Transmembranei106 – 115Beta strandedBy similarity10
Transmembranei122 – 131Beta strandedBy similarity10
Transmembranei134 – 141Beta strandedBy similarity8
Transmembranei148 – 156Beta strandedBy similarity9
Transmembranei161 – 169Beta strandedBy similarity9
Transmembranei174 – 186Beta strandedBy similarityAdd BLAST13
Transmembranei189 – 196Beta strandedBy similarity8
Transmembranei200 – 209Beta strandedBy similarity10
Transmembranei213 – 222Beta strandedBy similarity10
Transmembranei229 – 238Beta strandedBy similarity10
Transmembranei242 – 249Beta strandedBy similarity8
Transmembranei253 – 262Beta strandedBy similarity10
Transmembranei265 – 274Beta strandedBy similarity10
Transmembranei284 – 293Beta strandedBy similarity10

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7417
OpenTargetsiENSG00000165637
PharmGKBiPA37295

Chemistry databases

ChEMBLiCHEMBL6190
DrugBankiDB01375 Aluminium monostearate
DB06098 PRLX 93936

Polymorphism and mutation databases

BioMutaiVDAC2
DMDMi158518391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000505052 – 294Voltage-dependent anion-selective channel protein 2Add BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei31N6-acetyllysine; alternateCombined sources1
Modified residuei31N6-succinyllysine; alternateBy similarity1
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki72Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei78PhosphotyrosineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Modified residuei120N6-acetyllysine; alternateBy similarity1
Cross-linki120Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki172Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei251PhosphoserineBy similarity1
Modified residuei277N6-acetyllysine; alternateBy similarity1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP45880
PaxDbiP45880
PeptideAtlasiP45880
PRIDEiP45880
ProteomicsDBi55687
55688 [P45880-1]
55689 [P45880-2]
TopDownProteomicsiP45880-3 [P45880-3]

2D gel databases

DOSAC-COBS-2DPAGEiP45880
OGPiP45880
REPRODUCTION-2DPAGEiP45880
SWISS-2DPAGEiP45880
UCD-2DPAGEiP45880

PTM databases

CarbonylDBiP45880
iPTMnetiP45880
PhosphoSitePlusiP45880
SwissPalmiP45880

Expressioni

Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

BgeeiENSG00000165637
CleanExiHS_VDAC2
ExpressionAtlasiP45880 baseline and differential
GenevisibleiP45880 HS

Organism-specific databases

HPAiHPA043475

Interactioni

Subunit structurei

Interacts with hexokinases.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM162AQ96A262EBI-354022,EBI-6123466

Protein-protein interaction databases

BioGridi113260, 136 interactors
CORUMiP45880
IntActiP45880, 54 interactors
MINTiP45880
STRINGi9606.ENSP00000361635

Chemistry databases

BindingDBiP45880

Structurei

3D structure databases

ProteinModelPortaliP45880
SMRiP45880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOVERGENiHBG054036
InParanoidiP45880
KOiK15040
OMAiAKINNAG
OrthoDBiEOG091G0F0O
PhylomeDBiP45880
TreeFamiTF315091

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030277 VDAC2
PANTHERiPTHR11743:SF12 PTHR11743:SF12, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: P45880-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATHGQTCAR PMCIPPSYAD LGKAARDIFN KGFGFGLVKL DVKTKSCSGV
60 70 80 90 100
EFSTSGSSNT DTGKVTGTLE TKYKWCEYGL TFTEKWNTDN TLGTEIAIED
110 120 130 140 150
QICQGLKLTF DTTFSPNTGK KSGKIKSSYK RECINLGCDV DFDFAGPAIH
160 170 180 190 200
GSAVFGYEGW LAGYQMTFDS AKSKLTRNNF AVGYRTGDFQ LHTNVNDGTE
210 220 230 240 250
FGGSIYQKVC EDLDTSVNLA WTSGTNCTRF GIAAKYQLDP TASISAKVNN
260 270 280 290
SSLIGVGYTQ TLRPGVKLTL SALVDGKSIN AGGHKVGLAL ELEA
Length:294
Mass (Da):31,567
Last modified:September 11, 2007 - v2
Checksum:iF4EAE732E653637E
GO
Isoform 1 (identifier: P45880-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MATHGQTCARP → MSWCNELRLPALKQHSIGRGLESHIT

Show »
Length:309
Mass (Da):33,372
Checksum:i7A94C18F1C07DEBA
GO
Isoform 2 (identifier: P45880-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:283
Mass (Da):30,412
Checksum:i9A66CDF9CF0542B9
GO

Sequence cautioni

Isoform 1 : The sequence AAA60144 differs from that shown. Reason: Frameshift at position 303.Curated
Isoform 2 : The sequence AAA60145 differs from that shown. Reason: Frameshift at position 277.Curated
The sequence CAH73106 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40910 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00638024A → V1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0050771 – 11MATHGQTCARP → MSWCNELRLPALKQHSIGRG LESHIT in isoform 1. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0050761 – 11Missing in isoform 2. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08666 mRNA Translation: AAA60144.1 Frameshift.
L08666 mRNA Translation: AAA60145.1 Frameshift.
L06328 mRNA Translation: AAB59457.1
AF152227
, AF152220, AF152221, AF152222, AF152223, AF152224, AF152225, AF152226 Genomic DNA Translation: AAD40241.1
CR456964 mRNA Translation: CAG33245.1
AL390034, AL392111 Genomic DNA Translation: CAH73108.1
AL392111, AL390034 Genomic DNA Translation: CAI40914.1
AL390034, AL392111 Genomic DNA Translation: CAH73107.1
AL392111, AL390034 Genomic DNA Translation: CAI40911.1
AL390034, AL392111 Genomic DNA Translation: CAH73106.1 Sequence problems.
AL392111, AL390034 Genomic DNA Translation: CAI40910.1 Sequence problems.
BC000165 mRNA Translation: AAH00165.2
BC012883 mRNA Translation: AAH12883.2
BC072407 mRNA Translation: AAH72407.1
CCDSiCCDS53544.1 [P45880-1]
CCDS7348.1 [P45880-3]
PIRiA45972
B44422
RefSeqiNP_001171712.1, NM_001184783.2 [P45880-1]
NP_001171752.1, NM_001184823.1 [P45880-3]
NP_001311017.1, NM_001324088.1 [P45880-3]
NP_003366.2, NM_003375.4 [P45880-3]
UniGeneiHs.355927

Genome annotation databases

EnsembliENST00000313132; ENSP00000361635; ENSG00000165637 [P45880-1]
ENST00000332211; ENSP00000361686; ENSG00000165637 [P45880-3]
ENST00000543351; ENSP00000443092; ENSG00000165637 [P45880-3]
GeneIDi7417
KEGGihsa:7417
UCSCiuc001jwz.5 human [P45880-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVDAC2_HUMAN
AccessioniPrimary (citable) accession number: P45880
Secondary accession number(s): Q5VWK1
, Q5VWK3, Q6IB40, Q7L3J5, Q9BWK8, Q9Y5I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: September 11, 2007
Last modified: July 18, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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