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Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

Fkbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:Fkbp2
Synonyms:Fkbp13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95542 Fkbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002550723 – 140Peptidyl-prolyl cis-trans isomerase FKBP2Add BLAST118

Proteomic databases

EPDiP45878
PaxDbiP45878
PeptideAtlasiP45878
PRIDEiP45878

PTM databases

iPTMnetiP45878
PhosphoSitePlusiP45878

Expressioni

Gene expression databases

BgeeiENSMUSG00000056629 Expressed in 286 organ(s), highest expression level in seminal vesicle
CleanExiMM_FKBP2
ExpressionAtlasiP45878 baseline and differential
GenevisibleiP45878 MM

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Protein-protein interaction databases

IntActiP45878, 5 interactors
MINTiP45878
STRINGi10090.ENSMUSP00000066839

Structurei

3D structure databases

ProteinModelPortaliP45878
SMRiP45878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 135PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi137 – 140Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP45878
KOiK09569
OMAiGILGMCE
OrthoDBiEOG091G02W1
PhylomeDBiP45878
TreeFamiTF105292

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45878-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSWILTIL SICLSALAAA TGAEGKRKLQ IGVKKRVDHC PIKSRKGDVL
60 70 80 90 100
HMHYTGKLED GTEFDSSLPQ NQPFVFSLGT GQVIKGWDQG LLGMCEGEKR
110 120 130 140
KLVIPSELGY GERGAPPKIP GGATLVFEVE LLKIERRSEL
Length:140
Mass (Da):15,344
Last modified:November 1, 1995 - v1
Checksum:iF4E7FCC7766A0416
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77831 Genomic DNA Translation: AAA37631.1
BC031824 mRNA Translation: AAH31824.1
BC053692 mRNA Translation: AAH53692.1
CCDSiCCDS29515.1
PIRiI49668
RefSeqiNP_001159840.1, NM_001166368.1
NP_032046.1, NM_008020.3
XP_006526736.1, XM_006526673.1
XP_006526737.1, XM_006526674.1
XP_006526738.1, XM_006526675.2
UniGeneiMm.4234

Genome annotation databases

EnsembliENSMUST00000070878; ENSMUSP00000066839; ENSMUSG00000056629
ENSMUST00000177752; ENSMUSP00000136438; ENSMUSG00000056629
GeneIDi14227
KEGGimmu:14227
UCSCiuc008gjt.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77831 Genomic DNA Translation: AAA37631.1
BC031824 mRNA Translation: AAH31824.1
BC053692 mRNA Translation: AAH53692.1
CCDSiCCDS29515.1
PIRiI49668
RefSeqiNP_001159840.1, NM_001166368.1
NP_032046.1, NM_008020.3
XP_006526736.1, XM_006526673.1
XP_006526737.1, XM_006526674.1
XP_006526738.1, XM_006526675.2
UniGeneiMm.4234

3D structure databases

ProteinModelPortaliP45878
SMRiP45878
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP45878, 5 interactors
MINTiP45878
STRINGi10090.ENSMUSP00000066839

PTM databases

iPTMnetiP45878
PhosphoSitePlusiP45878

Proteomic databases

EPDiP45878
PaxDbiP45878
PeptideAtlasiP45878
PRIDEiP45878

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070878; ENSMUSP00000066839; ENSMUSG00000056629
ENSMUST00000177752; ENSMUSP00000136438; ENSMUSG00000056629
GeneIDi14227
KEGGimmu:14227
UCSCiuc008gjt.2 mouse

Organism-specific databases

CTDi2286
MGIiMGI:95542 Fkbp2

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP45878
KOiK09569
OMAiGILGMCE
OrthoDBiEOG091G02W1
PhylomeDBiP45878
TreeFamiTF105292

Miscellaneous databases

ChiTaRSiFkbp2 mouse
PROiPR:P45878
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056629 Expressed in 286 organ(s), highest expression level in seminal vesicle
CleanExiMM_FKBP2
ExpressionAtlasiP45878 baseline and differential
GenevisibleiP45878 MM

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_MOUSE
AccessioniPrimary (citable) accession number: P45878
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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