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Protein

ATP-binding cassette sub-family G member 1

Gene

ABCG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.

Miscellaneous

A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi118 – 125ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ADP binding Source: BHF-UCL
  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: BHF-UCL
  • cholesterol binding Source: BHF-UCL
  • cholesterol transporter activity Source: BHF-UCL
  • glycoprotein transporter activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL
  • phospholipid transporter activity Source: BHF-UCL
  • protein dimerization activity Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • sterol-transporting ATPase activity Source: BHF-UCL
  • toxin transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1369062 ABC transporters in lipid homeostasis
R-HSA-8964058 HDL remodeling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P45844

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.204.12 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000420

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family G member 1
Alternative name(s):
ATP-binding cassette transporter 8
White protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCG1
Synonyms:ABC8, WHT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160179.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:73 ABCG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603076 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P45844

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 426CytoplasmicSequence analysisAdd BLAST426
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei427 – 445HelicalSequence analysisAdd BLAST19
Topological domaini446 – 456ExtracellularSequence analysisAdd BLAST11
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Topological domaini478 – 506CytoplasmicSequence analysisAdd BLAST29
Transmembranei507 – 525HelicalSequence analysisAdd BLAST19
Topological domaini526 – 533ExtracellularSequence analysis8
Transmembranei534 – 555HelicalSequence analysisAdd BLAST22
Topological domaini556 – 567CytoplasmicSequence analysisAdd BLAST12
Transmembranei568 – 586HelicalSequence analysisAdd BLAST19
Topological domaini587 – 649ExtracellularSequence analysisAdd BLAST63
Transmembranei650 – 669HelicalSequence analysisAdd BLAST20
Topological domaini670 – 678CytoplasmicSequence analysis9

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30C → A: No significant effect. 1 Publication1
Mutagenesisi154C → A: No significant effect. 1 Publication1
Mutagenesisi315C → A or S: Significantly decreases ABCG1-mediated cholesterol efflux. 1 Publication1
Mutagenesisi394C → A: No significant effect. 1 Publication1
Mutagenesisi406C → A: No significant effect. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9619

Open Targets

More...
OpenTargetsi
ENSG00000160179

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24408

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00171 Adenosine triphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABCG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17433715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933841 – 678ATP-binding cassette sub-family G member 1Add BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi30S-palmitoyl cysteine1 Publication1
Lipidationi154S-palmitoyl cysteine1 Publication1
Lipidationi315S-palmitoyl cysteine1 Publication1
Lipidationi394S-palmitoyl cysteine1 Publication1
Lipidationi406S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P45844

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P45844

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P45844

PeptideAtlas

More...
PeptideAtlasi
P45844

PRoteomics IDEntifications database

More...
PRIDEi
P45844

ProteomicsDB human proteome resource

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ProteomicsDBi
55678
55679 [P45844-2]
55680 [P45844-3]
55681 [P45844-4]
55682 [P45844-5]
55683 [P45844-6]
55684 [P45844-7]
55685 [P45844-8]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P45844-8 [P45844-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P45844

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P45844

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P45844

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160179 Expressed in 213 organ(s), highest expression level in adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P45844 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P45844 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031470
HPA031471

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form heterodimers with several heterologous partners of the ABCG subfamily.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABCG4Q9H1722EBI-8584087,EBI-8584118

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114980, 60 interactors

Protein interaction database and analysis system

More...
IntActi
P45844, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354995

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P45844

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P45844

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini77 – 317ABC transporterPROSITE-ProRule annotationAdd BLAST241
Domaini415 – 673ABC transmembrane type-2Add BLAST259

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0061 Eukaryota
COG1131 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160131

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103052

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P45844

KEGG Orthology (KO)

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KOi
K05679

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGQCIYR

Database of Orthologous Groups

More...
OrthoDBi
1022017at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P45844

TreeFam database of animal gene trees

More...
TreeFami
TF105210

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR020064 ABCG1
IPR027417 P-loop_NTPase
IPR005284 Pigment_permease/Abcg

The PANTHER Classification System

More...
PANTHERi
PTHR19241:SF177 PTHR19241:SF177, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00955 3a01204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P45844-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN
60 70 80 90 100
GHLKKVDNNL TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL
110 120 130 140 150
LKGISGKFNS GELVAIMGPS GAGKSTLMNI LAGYRETGMK GAVLINGLPR
160 170 180 190 200
DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV SAHLKLQEKD EGRREMVKEI
210 220 230 240 250
LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF DEPTSGLDSA
260 270 280 290 300
SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK
310 320 330 340 350
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD
360 370 380 390 400
SDHKRDLGGD AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS
410 420 430 440 450
CLTQFCILFK RTFLSIMRDS VLTHLRITSH IGIGLLIGLL YLGIGNEAKK
460 470 480 490 500
VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE MGVFLREHLN YWYSLKAYYL
510 520 530 540 550
AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL GTMTSLVAQS
560 570 580 590 600
LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS
610 620 630 640 650
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL
660 670
DFIVLGIFFI SLRLIAYFVL RYKIRAER
Length:678
Mass (Da):75,592
Last modified:December 5, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB901CABDA6C19E09
GO
Isoform 2 (identifier: P45844-2) [UniParc]FASTAAdd to basket
Also known as: J

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MRISLPRAPERDGGVSASSLLDTVT
     375-386: Missing.

Show »
Length:677
Mass (Da):75,380
Checksum:iA08150CF2AF519E3
GO
Isoform 3 (identifier: P45844-3) [UniParc]FASTAAdd to basket
Also known as: ABDE

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MLGTQGWTKQRKPCPQ
     375-386: Missing.

Show »
Length:668
Mass (Da):74,611
Checksum:iA4184D543C1BC91E
GO
Isoform 4 (identifier: P45844-4) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     375-386: Missing.

Show »
Length:666
Mass (Da):74,155
Checksum:i0BBC80F8A08CA01B
GO
Isoform 5 (identifier: P45844-5) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MACLMAAFSVGTAM → MIMRLPQPHGT
     375-386: Missing.

Show »
Length:663
Mass (Da):74,032
Checksum:iE9B3EB2B69D9AB20
GO
Isoform 6 (identifier: P45844-6) [UniParc]FASTAAdd to basket
Also known as: HI

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.
     375-386: Missing.

Show »
Length:662
Mass (Da):73,737
Checksum:iA40C0D83D0D42B35
GO
Isoform 7 (identifier: P45844-7) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: Missing.
     375-386: Missing.

Show »
Length:644
Mass (Da):71,960
Checksum:i5124B0E187F391B8
GO
Isoform 8 (identifier: P45844-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: MACLMAAFSV...VPEGPWWRKK → MVRRGWSVCT...WGFPGDPMEE

Show »
Length:785
Mass (Da):86,628
Checksum:i3E17CE17CA58C7EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PGV9E9PGV9_HUMAN
ATP-binding cassette sub-family G m...
ABCG1
824Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKD9C9JKD9_HUMAN
ATP-binding cassette sub-family G m...
ABCG1
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC51098 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK28841 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA95530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB13728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC00730 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38S → T in AAK28839 (PubMed:11162488).Curated1
Sequence conflicti38S → T in AAK28841 (PubMed:11162488).Curated1
Sequence conflicti448A → T in CAA62631 (PubMed:8659545).Curated1
Sequence conflicti448A → T in AAK28838 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28839 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28840 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28841 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAK28842 (PubMed:11162488).Curated1
Sequence conflicti448A → T in AAL06598 (PubMed:11500512).Curated1
Sequence conflicti533R → A in AAC51098 (PubMed:9034316).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012279668F → L1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0107181 – 95MACLM…WWRKK → MVRRGWSVCTAILLARLWCL VPTHTFLSEYPEAAEYPHPG WVYWLQMAVAPGHLRAWVMR NNVTTNIPSAFSGTLTHEEK AVLTVFTGTATAVHVQVAAL ASAKLESSVFVTDCVSCKIE NVCDSALQGKRVPMSGLQGS SIVIMPPSNRPLASAASCTW SVQVQGGPHHLGVVAISGKV LSAAHGAGRAYGWGFPGDPM EE in isoform 8. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0000501 – 22Missing in isoform 7. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_0000471 – 14MACLM…VGTAM → MRISLPRAPERDGGVSASSL LDTVT in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000481 – 14MACLM…VGTAM → MLGTQGWTKQRKPCPQ in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000491 – 14MACLM…VGTAM → MIMRLPQPHGT in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0000461 – 4Missing in isoform 6. 1 Publication4
Alternative sequenceiVSP_000051375 – 386Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X91249 mRNA Translation: CAA62631.1 Different initiation.
AB038161 Genomic DNA Translation: BAB13728.2 Different initiation.
AJ289137
, AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA Translation: CAC00730.1 Different initiation.
AF323658
, AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28836.1
AF323664 mRNA Translation: AAK28842.1
AF323658
, AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28833.1
AF323660 mRNA Translation: AAK28838.1
AF323663 mRNA Translation: AAK28841.1 Different initiation.
AF323658
, AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28835.1
AF323662 mRNA Translation: AAK28840.1
AF323658
, AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28837.1
AF323658
, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28834.1
AF323661 mRNA Translation: AAK28839.1
AY048757 mRNA Translation: AAL06598.1
AP001746 Genomic DNA Translation: BAA95530.1 Different initiation.
BC029158 mRNA Translation: AAH29158.2
U34919 mRNA Translation: AAC51098.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13681.1 [P45844-5]
CCDS13682.1 [P45844-1]
CCDS13683.1 [P45844-2]
CCDS42937.1 [P45844-3]
CCDS42938.1 [P45844-4]

NCBI Reference Sequences

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RefSeqi
NP_004906.3, NM_004915.3 [P45844-1]
NP_058198.2, NM_016818.2 [P45844-4]
NP_997057.1, NM_207174.1 [P45844-2]
NP_997510.1, NM_207627.1 [P45844-3]
NP_997511.1, NM_207628.1 [P45844-7]
NP_997512.1, NM_207629.1 [P45844-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.124649
Hs.418279

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000343687; ENSP00000339744; ENSG00000160179 [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179 [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179 [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179 [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179 [P45844-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9619

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9619

UCSC genome browser

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UCSCi
uc002zan.3 human [P45844-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91249 mRNA Translation: CAA62631.1 Different initiation.
AB038161 Genomic DNA Translation: BAB13728.2 Different initiation.
AJ289137
, AJ289138, AJ289139, AJ289140, AJ289141, AJ289142, AJ289143, AJ289144, AJ289145, AJ289146, AJ289147, AJ289148, AJ289149, AJ289150, AJ289151 Genomic DNA Translation: CAC00730.1 Different initiation.
AF323658
, AF323644, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28836.1
AF323664 mRNA Translation: AAK28842.1
AF323658
, AF323640, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28833.1
AF323660 mRNA Translation: AAK28838.1
AF323663 mRNA Translation: AAK28841.1 Different initiation.
AF323658
, AF323642, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28835.1
AF323662 mRNA Translation: AAK28840.1
AF323658
, AF323643, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28837.1
AF323658
, AF323645, AF323646, AF323647, AF323648, AF323649, AF323650, AF323651, AF323652, AF323653, AF323654, AF323655, AF323656, AF323657 Genomic DNA Translation: AAK28834.1
AF323661 mRNA Translation: AAK28839.1
AY048757 mRNA Translation: AAL06598.1
AP001746 Genomic DNA Translation: BAA95530.1 Different initiation.
BC029158 mRNA Translation: AAH29158.2
U34919 mRNA Translation: AAC51098.1 Different initiation.
CCDSiCCDS13681.1 [P45844-5]
CCDS13682.1 [P45844-1]
CCDS13683.1 [P45844-2]
CCDS42937.1 [P45844-3]
CCDS42938.1 [P45844-4]
RefSeqiNP_004906.3, NM_004915.3 [P45844-1]
NP_058198.2, NM_016818.2 [P45844-4]
NP_997057.1, NM_207174.1 [P45844-2]
NP_997510.1, NM_207627.1 [P45844-3]
NP_997511.1, NM_207628.1 [P45844-7]
NP_997512.1, NM_207629.1 [P45844-5]
UniGeneiHs.124649
Hs.418279

3D structure databases

ProteinModelPortaliP45844
SMRiP45844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114980, 60 interactors
IntActiP45844, 6 interactors
STRINGi9606.ENSP00000354995

Chemistry databases

DrugBankiDB00171 Adenosine triphosphate
SwissLipidsiSLP:000000420

Protein family/group databases

TCDBi3.A.1.204.12 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiP45844
PhosphoSitePlusiP45844
SwissPalmiP45844

Polymorphism and mutation databases

BioMutaiABCG1
DMDMi17433715

Proteomic databases

jPOSTiP45844
MaxQBiP45844
PaxDbiP45844
PeptideAtlasiP45844
PRIDEiP45844
ProteomicsDBi55678
55679 [P45844-2]
55680 [P45844-3]
55681 [P45844-4]
55682 [P45844-5]
55683 [P45844-6]
55684 [P45844-7]
55685 [P45844-8]
TopDownProteomicsiP45844-8 [P45844-8]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9619
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343687; ENSP00000339744; ENSG00000160179 [P45844-2]
ENST00000347800; ENSP00000291524; ENSG00000160179 [P45844-5]
ENST00000361802; ENSP00000354995; ENSG00000160179 [P45844-1]
ENST00000398449; ENSP00000381467; ENSG00000160179 [P45844-4]
ENST00000398457; ENSP00000381475; ENSG00000160179 [P45844-3]
GeneIDi9619
KEGGihsa:9619
UCSCiuc002zan.3 human [P45844-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9619
DisGeNETi9619
EuPathDBiHostDB:ENSG00000160179.18

GeneCards: human genes, protein and diseases

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GeneCardsi
ABCG1
HGNCiHGNC:73 ABCG1
HPAiHPA031470
HPA031471
MIMi603076 gene
neXtProtiNX_P45844
OpenTargetsiENSG00000160179
PharmGKBiPA24408

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0061 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00940000160131
HOVERGENiHBG103052
InParanoidiP45844
KOiK05679
OMAiQGQCIYR
OrthoDBi1022017at2759
PhylomeDBiP45844
TreeFamiTF105210

Enzyme and pathway databases

ReactomeiR-HSA-1369062 ABC transporters in lipid homeostasis
R-HSA-8964058 HDL remodeling
SIGNORiP45844

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ABCG1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ABCG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9619

Protein Ontology

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PROi
PR:P45844

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160179 Expressed in 213 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP45844 baseline and differential
GenevisibleiP45844 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR020064 ABCG1
IPR027417 P-loop_NTPase
IPR005284 Pigment_permease/Abcg
PANTHERiPTHR19241:SF177 PTHR19241:SF177, 1 hit
PfamiView protein in Pfam
PF01061 ABC2_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00955 3a01204, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45844
Secondary accession number(s): Q86SU8
, Q96L76, Q9BXK6, Q9BXK7, Q9BXK8, Q9BXK9, Q9BXL0, Q9BXL1, Q9BXL2, Q9BXL3, Q9BXL4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 5, 2001
Last modified: January 16, 2019
This is version 192 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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