UniProtKB - P45843 (SCRT_DROME)
Protein
Protein scarlet
Gene
st
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 108 – 115 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- amine transmembrane transporter activity Source: FlyBase
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- pigment binding Source: UniProtKB-KW
GO - Biological processi
- aminergic neurotransmitter loading into synaptic vesicle Source: FlyBase
- eye pigment precursor transport Source: FlyBase
- ommochrome biosynthetic process Source: FlyBase
Keywordsi
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding, Pigment |
Protein family/group databases
TCDBi | 3.A.1.204.17, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Protein scarlet |
Gene namesi | Name:st ORF Names:CG4314 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003515, st |
Subcellular locationi
Other locations
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
- Cytoplasmic granule membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Pigment granules within pigment cells and retinula cells of the compound eye.
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of pigment granule membrane Source: FlyBase
- presynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 418 – 438 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 445 – 465 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 491 – 511 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 519 – 539 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 552 – 572 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 577 – 597 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 640 – 660 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093378 | 1 – 666 | Protein scarletAdd BLAST | 666 |
Proteomic databases
PaxDbi | P45843 |
Expressioni
Gene expression databases
Bgeei | FBgn0003515, Expressed in adult Malpighian tubule (Drosophila) and 26 other tissues |
ExpressionAtlasi | P45843, baseline and differential |
Genevisiblei | P45843, DM |
Interactioni
Subunit structurei
Heterodimer of scarlet with white.
1 PublicationProtein-protein interaction databases
BioGRIDi | 65140, 3 interactors |
IntActi | P45843, 2 interactors |
STRINGi | 7227.FBpp0075149 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 316 | ABC transporterPROSITE-ProRule annotationAdd BLAST | 248 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0061, Eukaryota |
HOGENOMi | CLU_000604_57_6_1 |
InParanoidi | P45843 |
OMAi | IHMAQSG |
OrthoDBi | 1022017at2759 |
PhylomeDBi | P45843 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR043926, ABCG_dom IPR027417, P-loop_NTPase IPR005284, Pigment_permease/Abcg |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 1 hit PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00955, 3a01204, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P45843-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDSDSKRID VEAPERVEQH ELQVMPVGST IEVPSLDSTP KLSKRNSSER
60 70 80 90 100
SLPLRSYSKW SPTEQGATLV WRDLCVYTNV GGSGQRMKRI INNSTGAIQP
110 120 130 140 150
GTLMALMGSS GSGKTTLMST LAFRQPAGTV VQGDILINGR RIGPFMHRIS
160 170 180 190 200
GYVYQDDLFL GSLTVLEHLN FMAHLRLDRR VSKEERRLII KELLERTGLL
210 220 230 240 250
SAAQTRIGSG DDKKVLSGGE RKRLAFAVEL LNNPVILFCD EPTTGLDSYS
260 270 280 290 300
AQQLVATLYE LAQKGTTILC TIHQPSSQLF DNFNNVMLLA DGRVAFTGSP
310 320 330 340 350
QHALSFFANH GYYCPEAYNP ADFLIGVLAT DPGYEQASQR SAQHLCDQFA
360 370 380 390 400
VSSAAKQRDM LVNLEIHMAQ SGNFPFDTEV ESFRGVAWYK RFHVVWLRAS
410 420 430 440 450
LTLLRDPTIQ WLRFIQKIAM AFIIGACFAG TTEPSQLGVQ AVQGALFIMI
460 470 480 490 500
SENTYHPMYS VLNLFPQGFP LFMRETRSGL YSTGQYYAAN ILALLPGMII
510 520 530 540 550
EPLIFVIICY WLTGLRSTFY AFGVTAMCVV LVMNVATACG CFFSTAFNSV
560 570 580 590 600
PLAMAYLVPL DYIFMITSGI FIQVNSLPVA FWWTQFLSWM LYANEAMTAA
610 620 630 640 650
QWSGVQNITC FQESADLPCF HTGQDVLDKY SFNESNVYRN LLAMVGLYFG
660
FHLLGYYCLW RRARKL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 126 | P → T in AAQ23526 (Ref. 4) Curated | 1 | |
Sequence conflicti | 149 – 150 | IS → NH in AAA82056 (PubMed:8544833).Curated | 2 | |
Sequence conflicti | 163 – 164 | LT → VS in AAA82056 (PubMed:8544833).Curated | 2 | |
Sequence conflicti | 249 | Y → N in AAQ23526 (Ref. 4) Curated | 1 | |
Sequence conflicti | 323 | F → Y in AAQ23526 (Ref. 4) Curated | 1 | |
Sequence conflicti | 400 – 401 | SL → IV in AAA82056 (PubMed:8544833).Curated | 2 | |
Sequence conflicti | 631 | S → T in AAA82056 (PubMed:8544833).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39739 Genomic DNA Translation: AAA82056.1 AE014296 Genomic DNA Translation: AAF49455.1 BT010208 mRNA Translation: AAQ23526.1 BT011131 mRNA Translation: AAR82798.1 X76201 Genomic DNA Translation: CAA53794.1 |
RefSeqi | NP_524108.1, NM_079384.5 |
Genome annotation databases
EnsemblMetazoai | FBtr0075391; FBpp0075149; FBgn0003515 |
GeneIDi | 39836 |
KEGGi | dme:Dmel_CG4314 |
UCSCi | CG4314-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39739 Genomic DNA Translation: AAA82056.1 AE014296 Genomic DNA Translation: AAF49455.1 BT010208 mRNA Translation: AAQ23526.1 BT011131 mRNA Translation: AAR82798.1 X76201 Genomic DNA Translation: CAA53794.1 |
RefSeqi | NP_524108.1, NM_079384.5 |
3D structure databases
SMRi | P45843 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 65140, 3 interactors |
IntActi | P45843, 2 interactors |
STRINGi | 7227.FBpp0075149 |
Protein family/group databases
TCDBi | 3.A.1.204.17, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P45843 |
Genome annotation databases
EnsemblMetazoai | FBtr0075391; FBpp0075149; FBgn0003515 |
GeneIDi | 39836 |
KEGGi | dme:Dmel_CG4314 |
UCSCi | CG4314-RA, d. melanogaster |
Organism-specific databases
CTDi | 20837 |
FlyBasei | FBgn0003515, st |
Phylogenomic databases
eggNOGi | KOG0061, Eukaryota |
HOGENOMi | CLU_000604_57_6_1 |
InParanoidi | P45843 |
OMAi | IHMAQSG |
OrthoDBi | 1022017at2759 |
PhylomeDBi | P45843 |
Miscellaneous databases
BioGRID-ORCSi | 39836, 0 hits in 1 CRISPR screen |
GenomeRNAii | 39836 |
PROi | PR:P45843 |
Gene expression databases
Bgeei | FBgn0003515, Expressed in adult Malpighian tubule (Drosophila) and 26 other tissues |
ExpressionAtlasi | P45843, baseline and differential |
Genevisiblei | P45843, DM |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR013525, ABC_2_trans IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR043926, ABCG_dom IPR027417, P-loop_NTPase IPR005284, Pigment_permease/Abcg |
Pfami | View protein in Pfam PF01061, ABC2_membrane, 1 hit PF19055, ABC2_membrane_7, 1 hit PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00955, 3a01204, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCRT_DROME | |
Accessioni | P45843Primary (citable) accession number: P45843 Secondary accession number(s): Q6NP00, Q6NR69, Q9VV67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families