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UniProtKB - P45843 (SCRT_DROME)

Entry version 160 (02 Dec 2020)
Sequence version 3 (21 Jun 2005)
Previous versions | rss
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Protein

Protein scarlet

Gene

st

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a membrane-spanning permease system necessary for the transport of pigment precursors into pigment cells responsible for eye color. Scarlet and white complex transports a metabolic intermediate (such as 3-hydroxy kynurenine) from the cytoplasm into the pigment granules.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi108 – 115ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding, Pigment

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.204.17, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein scarlet
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:st
ORF Names:CG4314
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0003515, st

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Transmembranei640 – 660HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000933781 – 666Protein scarletAdd BLAST666

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P45843

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0003515, Expressed in adult Malpighian tubule (Drosophila) and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P45843, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P45843, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of scarlet with white.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		65140, 3 interactors

Protein interaction database and analysis system

More...IntActi		P45843, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0075149

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P45843

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 316ABC transporterPROSITE-ProRule annotationAdd BLAST248

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0061, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_57_6_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P45843

Identification of Orthologs from Complete Genome Data

More...OMAi		IHMAQSG

Database of Orthologous Groups

More...OrthoDBi		1022017at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P45843

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR043926, ABCG_dom
IPR027417, P-loop_NTPase
IPR005284, Pigment_permease/Abcg

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01061, ABC2_membrane, 1 hit
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00955, 3a01204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P45843-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDSKRID VEAPERVEQH ELQVMPVGST IEVPSLDSTP KLSKRNSSER 
        60         70         80         90        100
SLPLRSYSKW SPTEQGATLV WRDLCVYTNV GGSGQRMKRI INNSTGAIQP 
       110        120        130        140        150
GTLMALMGSS GSGKTTLMST LAFRQPAGTV VQGDILINGR RIGPFMHRIS 
       160        170        180        190        200
GYVYQDDLFL GSLTVLEHLN FMAHLRLDRR VSKEERRLII KELLERTGLL 
       210        220        230        240        250
SAAQTRIGSG DDKKVLSGGE RKRLAFAVEL LNNPVILFCD EPTTGLDSYS 
       260        270        280        290        300
AQQLVATLYE LAQKGTTILC TIHQPSSQLF DNFNNVMLLA DGRVAFTGSP 
       310        320        330        340        350
QHALSFFANH GYYCPEAYNP ADFLIGVLAT DPGYEQASQR SAQHLCDQFA 
       360        370        380        390        400
VSSAAKQRDM LVNLEIHMAQ SGNFPFDTEV ESFRGVAWYK RFHVVWLRAS 
       410        420        430        440        450
LTLLRDPTIQ WLRFIQKIAM AFIIGACFAG TTEPSQLGVQ AVQGALFIMI 
       460        470        480        490        500
SENTYHPMYS VLNLFPQGFP LFMRETRSGL YSTGQYYAAN ILALLPGMII 
       510        520        530        540        550
EPLIFVIICY WLTGLRSTFY AFGVTAMCVV LVMNVATACG CFFSTAFNSV 
       560        570        580        590        600
PLAMAYLVPL DYIFMITSGI FIQVNSLPVA FWWTQFLSWM LYANEAMTAA 
       610        620        630        640        650
QWSGVQNITC FQESADLPCF HTGQDVLDKY SFNESNVYRN LLAMVGLYFG 
       660 
FHLLGYYCLW RRARKL
Length:666
Mass (Da):74,458
Last modified:June 21, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA4BB9AD69BFB947
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126P → T in AAQ23526 (Ref. 4) Curated1
Sequence conflicti149 – 150IS → NH in AAA82056 (PubMed:8544833).Curated2
Sequence conflicti163 – 164LT → VS in AAA82056 (PubMed:8544833).Curated2
Sequence conflicti249Y → N in AAQ23526 (Ref. 4) Curated1
Sequence conflicti323F → Y in AAQ23526 (Ref. 4) Curated1
Sequence conflicti400 – 401SL → IV in AAA82056 (PubMed:8544833).Curated2
Sequence conflicti631S → T in AAA82056 (PubMed:8544833).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U39739 Genomic DNA Translation: AAA82056.1
AE014296 Genomic DNA Translation: AAF49455.1
BT010208 mRNA Translation: AAQ23526.1
BT011131 mRNA Translation: AAR82798.1
X76201 Genomic DNA Translation: CAA53794.1

NCBI Reference Sequences

More...RefSeqi		NP_524108.1, NM_079384.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0075391; FBpp0075149; FBgn0003515

Database of genes from NCBI RefSeq genomes

More...GeneIDi		39836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG4314

UCSC genome browser

More...UCSCi		CG4314-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39739 Genomic DNA Translation: AAA82056.1
AE014296 Genomic DNA Translation: AAF49455.1
BT010208 mRNA Translation: AAQ23526.1
BT011131 mRNA Translation: AAR82798.1
X76201 Genomic DNA Translation: CAA53794.1
RefSeqiNP_524108.1, NM_079384.5

3D structure databases

SMRiP45843
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65140, 3 interactors
IntActiP45843, 2 interactors
STRINGi7227.FBpp0075149

Protein family/group databases

TCDBi3.A.1.204.17, the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP45843

Genome annotation databases

EnsemblMetazoaiFBtr0075391; FBpp0075149; FBgn0003515
GeneIDi39836
KEGGidme:Dmel_CG4314
UCSCiCG4314-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		20837
FlyBaseiFBgn0003515, st

Phylogenomic databases

eggNOGiKOG0061, Eukaryota
HOGENOMiCLU_000604_57_6_1
InParanoidiP45843
OMAiIHMAQSG
OrthoDBi1022017at2759
PhylomeDBiP45843

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		39836, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		39836

Protein Ontology

More...PROi		PR:P45843

Gene expression databases

BgeeiFBgn0003515, Expressed in adult Malpighian tubule (Drosophila) and 26 other tissues
ExpressionAtlasiP45843, baseline and differential
GenevisibleiP45843, DM

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR043926, ABCG_dom
IPR027417, P-loop_NTPase
IPR005284, Pigment_permease/Abcg
PfamiView protein in Pfam
PF01061, ABC2_membrane, 1 hit
PF19055, ABC2_membrane_7, 1 hit
PF00005, ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00955, 3a01204, 1 hit
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCRT_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45843
Secondary accession number(s): Q6NP00, Q6NR69, Q9VV67
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 21, 2005
Last modified: December 2, 2020
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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