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UniProtKB - P45799 (NUDE_ECOLI)
Protein
ADP compounds hydrolase NudE
Gene
nudE
Organism
Escherichia coli (strain K12)
Status
Functioni
Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A).
Catalytic activityi
Cofactori
Mg2+Note: Mg2+. Other divalent cations can also be used.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 40 | Substrate; via amide nitrogen and carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 95 | Divalent metal cationBy similarity | 1 | |
Metal bindingi | 99 | Divalent metal cationBy similarity | 1 | |
Binding sitei | 118 | Substrate; via carbonyl oxygen1 Publication | 1 |
GO - Molecular functioni
- ADP-ribose diphosphatase activity Source: RHEA
- ADP-sugar diphosphatase activity Source: EcoCyc
- magnesium ion binding Source: EcoCyc
GO - Biological processi
- nucleoside phosphate metabolic process Source: GO_Central
- ribose phosphate metabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7740-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:nudE Synonyms:yrfE Ordered Locus Names:b3397, JW3360 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056989 | 1 – 186 | ADP compounds hydrolase NudEAdd BLAST | 186 |
Proteomic databases
jPOSTi | P45799 |
PaxDbi | P45799 |
PRIDEi | P45799 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4261276, 223 interactors |
IntActi | P45799, 1 interactor |
STRINGi | 511145.b3397 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P45799 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P45799 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 172 | Nudix hydrolasePROSITE-ProRule annotationAdd BLAST | 128 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 80 – 101 | Nudix boxAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the Nudix hydrolase family.Curated
Phylogenomic databases
eggNOGi | COG0494, Bacteria |
HOGENOMi | CLU_062658_4_0_6 |
InParanoidi | P45799 |
PhylomeDBi | P45799 |
Family and domain databases
InterProi | View protein in InterPro IPR015797, NUDIX_hydrolase-like_dom_sf IPR020084, NUDIX_hydrolase_CS IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS00893, NUDIX_BOX, 1 hit |
i Sequence
Sequence statusi: Complete.
P45799-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKSLQKPTI LNVETVARSR LFTVESVDLE FSNGVRRVYE RMRPTNREAV
60 70 80 90 100
MIVPIVDDHL ILIREYAVGT ESYELGFSKG LIDPGESVYE AANRELKEEV
110 120 130 140 150
GFGANDLTFL KKLSMAPSYF SSKMNIVVAQ DLYPESLEGD EPEPLPQVRW
160 170 180
PLAHMMDLLE DPDFNEARNV SALFLVREWL KGQGRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58194.1 U00096 Genomic DNA Translation: AAC76422.1 AP009048 Genomic DNA Translation: BAE77894.1 |
PIRi | H65134 |
RefSeqi | NP_417856.1, NC_000913.3 WP_000045744.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76422; AAC76422; b3397 BAE77894; BAE77894; BAE77894 |
GeneIDi | 66672723 947906 |
KEGGi | ecj:JW3360 eco:b3397 |
PATRICi | fig|1411691.4.peg.3333 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58194.1 U00096 Genomic DNA Translation: AAC76422.1 AP009048 Genomic DNA Translation: BAE77894.1 |
PIRi | H65134 |
RefSeqi | NP_417856.1, NC_000913.3 WP_000045744.1, NZ_STEB01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VHG | X-ray | 2.70 | A/B | 2-186 | [»] | |
1VHZ | X-ray | 2.32 | A/B | 2-186 | [»] | |
SMRi | P45799 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261276, 223 interactors |
IntActi | P45799, 1 interactor |
STRINGi | 511145.b3397 |
Chemistry databases
DrugBanki | DB02059, Adenosine-5-Diphosphoribose |
Proteomic databases
jPOSTi | P45799 |
PaxDbi | P45799 |
PRIDEi | P45799 |
Genome annotation databases
EnsemblBacteriai | AAC76422; AAC76422; b3397 BAE77894; BAE77894; BAE77894 |
GeneIDi | 66672723 947906 |
KEGGi | ecj:JW3360 eco:b3397 |
PATRICi | fig|1411691.4.peg.3333 |
Organism-specific databases
EchoBASEi | EB2762 |
Phylogenomic databases
eggNOGi | COG0494, Bacteria |
HOGENOMi | CLU_062658_4_0_6 |
InParanoidi | P45799 |
PhylomeDBi | P45799 |
Enzyme and pathway databases
BioCyci | EcoCyc:G7740-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P45799 |
PROi | PR:P45799 |
Family and domain databases
InterProi | View protein in InterPro IPR015797, NUDIX_hydrolase-like_dom_sf IPR020084, NUDIX_hydrolase_CS IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00293, NUDIX, 1 hit |
SUPFAMi | SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS51462, NUDIX, 1 hit PS00893, NUDIX_BOX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NUDE_ECOLI | |
Accessioni | P45799Primary (citable) accession number: P45799 Secondary accession number(s): Q2M762 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families