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Protein

1-phosphatidylinositol phosphodiesterase

Gene

plc

Organism
Staphylococcus aureus (strain Newman)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptorPROSITE-ProRule annotation1
Active sitei90Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLipid degradation, Lipid metabolism, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol phosphodiesterase (EC:4.6.1.13)
Alternative name(s):
Phosphatidylinositol diacylglycerol-lyase
Phosphatidylinositol-specific phospholipase C
Short name:
PI-PLC
Gene namesi
Name:plc
Ordered Locus Names:NWMN_0041
OrganismiStaphylococcus aureus (strain Newman)
Taxonomic identifieri426430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000006386 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002429727 – 3121-phosphatidylinositol phosphodiesteraseAdd BLAST286

Proteomic databases

PRIDEiP45723

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP45723
SMRiP45723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 176PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST150

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000095714
KOiK01771
OMAiMPGTHNT

Family and domain databases

Gene3Di3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
PfamiView protein in Pfam
PF00388 PI-PLC-X, 1 hit
SMARTiView protein in SMART
SM00148 PLCXc, 1 hit
SUPFAMiSSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50007 PIPLC_X_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45723-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGWYHSAHA SDSLSKSPEN WMSKLDDGKH LTEINIPGSH DSGSFTLKDP
60 70 80 90 100
VKSVWAKTQD KDYLTQMKSG VRFFDIRGRA SADNMISVHH GMVYLHHELG
110 120 130 140 150
KFLDDAKYYL SAYPNETIVM SMKKDYDSDS KVTKTFEEIF REYYYNNPQY
160 170 180 190 200
QNLFYTGSNA NPTLKETKGK IVLFNRMGGT YIKSGYGADT SGIQWADNAT
210 220 230 240 250
FETKINNGSL NLKVQDEYKD YYDKKVEAVK NLLAKAKTDS NKDNVYVNFL
260 270 280 290 300
SVASGGSAFN STYNYASHIN PEIAKTIKAN GKARTGWLIV DYAGYTWPGY
310
DDIVSEIIDS NK
Length:312
Mass (Da):35,255
Last modified:January 15, 2008 - v2
Checksum:i6E2F1ADB3EE5382D
GO

Sequence cautioni

The sequence BAF66313 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234 – 236AKA → LKL in AAA16442 (PubMed:8225585).Curated3
Sequence conflicti258 – 260AFN → DL in AAA16442 (PubMed:8225585).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19298 Unassigned DNA Translation: AAA16442.1
AP009351 Genomic DNA Translation: BAF66313.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiBAF66313; BAF66313; NWMN_0041
KEGGisae:NWMN_0041

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19298 Unassigned DNA Translation: AAA16442.1
AP009351 Genomic DNA Translation: BAF66313.1 Different initiation.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3V16X-ray2.05A11-312[»]
3V18X-ray2.34A12-312[»]
3V1HX-ray1.90A13-312[»]
4F2BX-ray2.16A/B11-312[»]
4F2TX-ray2.30A11-312[»]
4F2UX-ray2.19A11-312[»]
4I8YX-ray2.10A11-312[»]
4I90X-ray1.65A11-312[»]
4I9JX-ray1.85A11-312[»]
4I9MX-ray2.20A11-312[»]
4I9TX-ray2.00A11-312[»]
4RV3X-ray2.00A12-312[»]
4S3GX-ray2.50A11-312[»]
ProteinModelPortaliP45723
SMRiP45723
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP45723

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF66313; BAF66313; NWMN_0041
KEGGisae:NWMN_0041

Phylogenomic databases

HOGENOMiHOG000095714
KOiK01771
OMAiMPGTHNT

Family and domain databases

Gene3Di3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
PfamiView protein in Pfam
PF00388 PI-PLC-X, 1 hit
SMARTiView protein in SMART
SM00148 PLCXc, 1 hit
SUPFAMiSSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50007 PIPLC_X_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLC_STAAE
AccessioniPrimary (citable) accession number: P45723
Secondary accession number(s): A6QD81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 15, 2008
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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