Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toxin Cll1

Gene
N/A
Organism
Centruroides limpidus (Mexican scorpion) (Centruroides limpidus limpidus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Beta toxin that binds site-4 of sodium channels (Nav) and reduces peak current (observed on Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN5A, Nav1.5/SCN4A, and Nav1.6/SCN8A (IC50=44.9 nM)), shifts the voltage of activation toward more negative potentials (observed on Nav1.6, Nav1.1 (weak), Nav1.2 (weak), and Nav1.7 (weak)), and induces resurgent currents at negative voltages following brief and strong depolarizations (observed on Nav1.6, Nav1.1 (weak), Nav1.2 (weak), and Nav1.4 (weak)) (PubMed:22200496). This toxin is only active on crustaceans (PubMed:7727365).2 Publications

Miscellaneous

Does not show inhibition of peak current on Nav1.7 (at 560 nM).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Protein family/group databases

TCDBi8.B.1.2.1 the long (4c-c) scorpion toxin (l-st) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Toxin Cll1Curated
Alternative name(s):
Cll toxin 11 Publication
Crustacean toxin 11 Publication
OrganismiCentruroides limpidus (Mexican scorpion) (Centruroides limpidus limpidus)
Taxonomic identifieri6876 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000667651 – 66Toxin Cll11 PublicationAdd BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi12 ↔ 651 Publication
Disulfide bondi16 ↔ 411 Publication
Disulfide bondi25 ↔ 461 Publication
Disulfide bondi29 ↔ 481 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP45667

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP45667
SMRiP45667
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 66LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Complete.

P45667-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KEGYLVNKST GCKYGCFWLG KNENCDKECK AKNQGGSYGY CYSFACWCEG
60
LPESTPTYPL PNKSCS
Length:66
Mass (Da):7,338
Last modified:November 1, 1995 - v1
Checksum:iA478E63796F54DAA
GO

Sequence databases

PIRiA55869

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA55869

3D structure databases

ProteinModelPortaliP45667
SMRiP45667
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi8.B.1.2.1 the long (4c-c) scorpion toxin (l-st) superfamily

Proteomic databases

PRIDEiP45667

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCXR_CENLI
AccessioniPrimary (citable) accession number: P45667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again