UniProtKB - P45629 (KAX23_CENLI)
Protein
Potassium channel toxin alpha-KTx 2.3
Gene
N/A
Organism
Centruroides limpidus (Mexican scorpion)
Status
Functioni
Inhibitor of voltage-gated potassium channels (Kv). It is capable of displacing the binding of radio-labeled noxiustoxin (AC P08815) to rat brain synaptosomes with high affinity (about 100 pM). It is also capable of inhibiting transient potassium-currents (resembling I(A)-type currents), in cultured rat cerebellar granule cells. About 50% of the peak currents are reduced by application of a 1.5 µM solution of this toxin.1 Publication
Miscellaneous
This toxin is found in the venom of both male and female C.limpidus.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 28 | Basic residue of the functional dyadBy similarity | 1 | |
Sitei | 37 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 2.3Alternative name(s): C.1.limpidus toxin 11 Publication Short name: CllTx11 Publication Toxin II.10.9.11 Publication |
Organismi | Centruroides limpidus (Mexican scorpion) |
Taxonomic identifieri | 6876 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044902 | 1 – 38 | Potassium channel toxin alpha-KTx 2.32 PublicationsAdd BLAST | 38 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 7 ↔ 29 | By similarity | ||
Disulfide bondi | 13 ↔ 34 | By similarity | ||
Disulfide bondi | 17 ↔ 36 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
ProteinModelPortali | P45629 |
SMRi | P45629 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domaini
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 02 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | S53330 |
3D structure databases
ProteinModelPortali | P45629 |
SMRi | P45629 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
PRINTSi | PR00286 CHARYBDTOXIN |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX23_CENLI | |
Accessioni | P45629Primary (citable) accession number: P45629 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 5, 2018 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families