UniProtKB - P45591 (COF2_MOUSE)
Protein
Cofilin-2
Gene
Cfl2
Organism
Mus musculus (Mouse)
Status
Functioni
Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.3 Publications
GO - Molecular functioni
- actin filament binding Source: UniProtKB
GO - Biological processi
- actin filament depolymerization Source: UniProtKB
- actin filament fragmentation Source: UniProtKB
- actin filament organization Source: MGI
- actin filament severing Source: GO_Central
- cell motility Source: GO_Central
- muscle cell cellular homeostasis Source: MGI
- positive regulation of actin filament depolymerization Source: MGI
- sarcomere organization Source: MGI
- skeletal muscle tissue development Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cofilin-2Alternative name(s): Cofilin, muscle isoform |
Gene namesi | Name:Cfl2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101763, Cfl2 |
Subcellular locationi
Cytoskeleton
Nucleus
Note: Colocalizes with CSPR3 in the Z line of sarcomeres.By similarity
Cytoskeleton
- actin cytoskeleton Source: GO_Central
- cortical actin cytoskeleton Source: GO_Central
Nucleus
- nuclear matrix Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000214908 | 2 – 166 | Cofilin-2Add BLAST | 165 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 6 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P45591 |
jPOSTi | P45591 |
PaxDbi | P45591 |
PeptideAtlasi | P45591 |
PRIDEi | P45591 |
2D gel databases
REPRODUCTION-2DPAGEi | P45591 |
PTM databases
iPTMneti | P45591 |
PhosphoSitePlusi | P45591 |
SwissPalmi | P45591 |
Expressioni
Tissue specificityi
Predominantly expressed in skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000062929, Expressed in muscle of leg and 303 other tissues |
ExpressionAtlasi | P45591, baseline and differential |
Genevisiblei | P45591, MM |
Interactioni
Subunit structurei
Interacts with CSRP3; possibly two molecules of CFL2 can interact with one molecule if CSRP3.
By similarityGO - Molecular functioni
- actin filament binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 198685, 9 interactors |
IntActi | P45591, 6 interactors |
MINTi | P45591 |
STRINGi | 10090.ENSMUSP00000077262 |
Miscellaneous databases
RNActi | P45591, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 153 | ADF-HPROSITE-ProRule annotationAdd BLAST | 150 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 30 – 34 | Nuclear localization signalSequence analysis | 5 |
Sequence similaritiesi
Belongs to the actin-binding proteins ADF family.Curated
Phylogenomic databases
eggNOGi | KOG1735, Eukaryota |
GeneTreei | ENSGT00950000183000 |
HOGENOMi | CLU_094004_0_0_1 |
InParanoidi | P45591 |
OMAi | TFISWTP |
OrthoDBi | 1370477at2759 |
PhylomeDBi | P45591 |
TreeFami | TF328601 |
Family and domain databases
CDDi | cd11286, ADF_cofilin_like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR017904, ADF/Cofilin |
PANTHERi | PTHR11913, PTHR11913, 1 hit |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
PRINTSi | PR00006, COFILIN |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P45591-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE
60 70 80 90 100
EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV
110 120 130 140 150
FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG
160
EKLGGSVVVS LEGKPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1Y7VJ71 | A0A1Y7VJ71_MOUSE | Cofilin-2 | Cfl2 | 58 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29468 mRNA Translation: AAA37433.1 BC007138 mRNA Translation: AAH07138.1 |
CCDSi | CCDS36448.1 |
PIRi | A53812 |
RefSeqi | NP_031714.1, NM_007688.2 |
Genome annotation databases
Ensembli | ENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929 |
GeneIDi | 12632 |
KEGGi | mmu:12632 |
UCSCi | uc007nnx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L29468 mRNA Translation: AAA37433.1 BC007138 mRNA Translation: AAH07138.1 |
CCDSi | CCDS36448.1 |
PIRi | A53812 |
RefSeqi | NP_031714.1, NM_007688.2 |
3D structure databases
BMRBi | P45591 |
SMRi | P45591 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198685, 9 interactors |
IntActi | P45591, 6 interactors |
MINTi | P45591 |
STRINGi | 10090.ENSMUSP00000077262 |
PTM databases
iPTMneti | P45591 |
PhosphoSitePlusi | P45591 |
SwissPalmi | P45591 |
2D gel databases
REPRODUCTION-2DPAGEi | P45591 |
Proteomic databases
EPDi | P45591 |
jPOSTi | P45591 |
PaxDbi | P45591 |
PeptideAtlasi | P45591 |
PRIDEi | P45591 |
Protocols and materials databases
Antibodypediai | 9589, 333 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929 |
GeneIDi | 12632 |
KEGGi | mmu:12632 |
UCSCi | uc007nnx.1, mouse |
Organism-specific databases
CTDi | 1073 |
MGIi | MGI:101763, Cfl2 |
Phylogenomic databases
eggNOGi | KOG1735, Eukaryota |
GeneTreei | ENSGT00950000183000 |
HOGENOMi | CLU_094004_0_0_1 |
InParanoidi | P45591 |
OMAi | TFISWTP |
OrthoDBi | 1370477at2759 |
PhylomeDBi | P45591 |
TreeFami | TF328601 |
Miscellaneous databases
BioGRID-ORCSi | 12632, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cfl2, mouse |
PROi | PR:P45591 |
RNActi | P45591, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062929, Expressed in muscle of leg and 303 other tissues |
ExpressionAtlasi | P45591, baseline and differential |
Genevisiblei | P45591, MM |
Family and domain databases
CDDi | cd11286, ADF_cofilin_like, 1 hit |
Gene3Di | 3.40.20.10, 1 hit |
InterProi | View protein in InterPro IPR002108, ADF-H IPR029006, ADF-H/Gelsolin-like_dom_sf IPR017904, ADF/Cofilin |
PANTHERi | PTHR11913, PTHR11913, 1 hit |
Pfami | View protein in Pfam PF00241, Cofilin_ADF, 1 hit |
PRINTSi | PR00006, COFILIN |
SMARTi | View protein in SMART SM00102, ADF, 1 hit |
PROSITEi | View protein in PROSITE PS51263, ADF_H, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COF2_MOUSE | |
Accessioni | P45591Primary (citable) accession number: P45591 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families