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Protein

Cofilin-2

Gene

Cfl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.3 Publications

GO - Molecular functioni

  • actin filament binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin-2
Alternative name(s):
Cofilin, muscle isoform
Gene namesi
Name:Cfl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:101763 Cfl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149082 – 166Cofilin-2Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei6PhosphothreonineCombined sources1

Post-translational modificationi

The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP45591
PaxDbiP45591
PeptideAtlasiP45591
PRIDEiP45591

2D gel databases

REPRODUCTION-2DPAGEiP45591

PTM databases

iPTMnetiP45591
PhosphoSitePlusiP45591
SwissPalmiP45591

Expressioni

Tissue specificityi

Predominantly expressed in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000062929 Expressed in 290 organ(s), highest expression level in muscle of leg
CleanExiMM_CFL2
ExpressionAtlasiP45591 baseline and differential
GenevisibleiP45591 MM

Interactioni

Subunit structurei

Interacts with CSRP3; possibly two molecules of CFL2 can interact with one molecule if CSRP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198685, 3 interactors
IntActiP45591, 6 interactors
MINTiP45591
STRINGi10090.ENSMUSP00000077262

Structurei

3D structure databases

ProteinModelPortaliP45591
SMRiP45591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153ADF-HPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 34Nuclear localization signalSequence analysis5

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
GeneTreeiENSGT00440000033289
HOGENOMiHOG000039697
HOVERGENiHBG000381
InParanoidiP45591
KOiK05765
OMAiGLYDATY
OrthoDBiEOG091G0PWC
PhylomeDBiP45591
TreeFamiTF328601

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
PANTHERiPTHR11913 PTHR11913, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P45591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE
60 70 80 90 100
EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV
110 120 130 140 150
FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG
160
EKLGGSVVVS LEGKPL
Length:166
Mass (Da):18,710
Last modified:November 1, 1995 - v1
Checksum:i48B6D7E5AE9FE1CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VJ71A0A1Y7VJ71_MOUSE
Cofilin-2
Cfl2
58Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29468 mRNA Translation: AAA37433.1
BC007138 mRNA Translation: AAH07138.1
CCDSiCCDS36448.1
PIRiA53812
RefSeqiNP_031714.1, NM_007688.2
UniGeneiMm.276826

Genome annotation databases

EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929
GeneIDi12632
KEGGimmu:12632
UCSCiuc007nnx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29468 mRNA Translation: AAA37433.1
BC007138 mRNA Translation: AAH07138.1
CCDSiCCDS36448.1
PIRiA53812
RefSeqiNP_031714.1, NM_007688.2
UniGeneiMm.276826

3D structure databases

ProteinModelPortaliP45591
SMRiP45591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198685, 3 interactors
IntActiP45591, 6 interactors
MINTiP45591
STRINGi10090.ENSMUSP00000077262

PTM databases

iPTMnetiP45591
PhosphoSitePlusiP45591
SwissPalmiP45591

2D gel databases

REPRODUCTION-2DPAGEiP45591

Proteomic databases

EPDiP45591
PaxDbiP45591
PeptideAtlasiP45591
PRIDEiP45591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078124; ENSMUSP00000077262; ENSMUSG00000062929
GeneIDi12632
KEGGimmu:12632
UCSCiuc007nnx.1 mouse

Organism-specific databases

CTDi1073
MGIiMGI:101763 Cfl2

Phylogenomic databases

eggNOGiKOG1735 Eukaryota
ENOG41122P5 LUCA
GeneTreeiENSGT00440000033289
HOGENOMiHOG000039697
HOVERGENiHBG000381
InParanoidiP45591
KOiK05765
OMAiGLYDATY
OrthoDBiEOG091G0PWC
PhylomeDBiP45591
TreeFamiTF328601

Miscellaneous databases

ChiTaRSiCfl2 mouse
PROiPR:P45591
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062929 Expressed in 290 organ(s), highest expression level in muscle of leg
CleanExiMM_CFL2
ExpressionAtlasiP45591 baseline and differential
GenevisibleiP45591 MM

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
PANTHERiPTHR11913 PTHR11913, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOF2_MOUSE
AccessioniPrimary (citable) accession number: P45591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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