UniProtKB - P45544 (FRLR_ECOLI)
Protein
Probable fructoselysine utilization operon transcriptional repressor
Gene
frlR
Organism
Escherichia coli (strain K12)
Status
Functioni
May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.1 Publication
: fructoselysine degradation Pathwayi
This protein regulates the pathway fructoselysine degradation, which is part of Carbohydrate metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway fructoselysine degradation and in Carbohydrate metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 57 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:G7727-MONOMER |
UniPathwayi | UPA00784 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable fructoselysine utilization operon transcriptional repressor1 PublicationAlternative name(s): HTH-type transcriptional regulator FrlRCurated |
Gene namesi | Name:frlR1 Publication Synonyms:yhfR Ordered Locus Names:b3375, JW5698 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050642 | 1 – 243 | Probable fructoselysine utilization operon transcriptional repressorAdd BLAST | 243 |
Proteomic databases
PaxDbi | P45544 |
PRIDEi | P45544 |
Expressioni
Inductioni
Induced by fructoselysine. Makes part of the frl operon with FrlA, FrlB, FrlC and FrlD.1 Publication
Interactioni
Binary interactionsi
P45544
With | #Exp. | IntAct |
---|---|---|
topB [P14294] | 2 | EBI-562481,EBI-552080 |
Protein-protein interaction databases
BioGRIDi | 4259581, 14 interactors 852194, 4 interactors |
DIPi | DIP-12327N |
IntActi | P45544, 6 interactors |
STRINGi | 511145.b3375 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 78 | HTH gntR-typePROSITE-ProRule annotationAdd BLAST | 69 |
Phylogenomic databases
eggNOGi | COG2188, Bacteria |
HOGENOMi | CLU_063236_3_0_6 |
InParanoidi | P45544 |
PhylomeDBi | P45544 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.40.1410.10, 1 hit |
InterProi | View protein in InterPro IPR028978, Chorismate_lyase_/UTRA_dom_sf IPR000524, Tscrpt_reg_HTH_GntR IPR011663, UTRA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00392, GntR, 1 hit PF07702, UTRA, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00345, HTH_GNTR, 1 hit SM00866, UTRA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF64288, SSF64288, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
i Sequence
Sequence statusi: Complete.
P45544-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATDRYSHQ LLYATVRQRL LDDIAQGVYQ AGQQIPTENE LCTQYNVSRI
60 70 80 90 100
TIRKAISDLV ADGVLIRWQG KGTFVQSQKV ENALLTVSGF TDFGVSQGKA
110 120 130 140 150
TKEKVIEQER VSAAPFCEKL NIPGNSEVFH LCRVMYLDKE PLFIDSSWIP
160 170 180 190 200
LSRYPDFDEI YVEGSSTYQL FQERFDTRVV SDKKTIDIFA ATRPQAKWLK
210 220 230 240
CELGEPLFRI SKIAFDQNDK PVHVSELFCR ANRITLTIDN KRH
Sequence cautioni
The sequence AAA58172 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58172.1 Different initiation. U00096 Genomic DNA Translation: AAC76400.2 AP009048 Genomic DNA Translation: BAE77916.1 |
PIRi | B65132 |
RefSeqi | NP_417834.6, NC_000913.3 WP_001276847.1, NZ_STEB01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC76400; AAC76400; b3375 BAE77916; BAE77916; BAE77916 |
GeneIDi | 57729361 947885 |
KEGGi | ecj:JW5698 eco:b3375 |
PATRICi | fig|1411691.4.peg.3355 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA58172.1 Different initiation. U00096 Genomic DNA Translation: AAC76400.2 AP009048 Genomic DNA Translation: BAE77916.1 |
PIRi | B65132 |
RefSeqi | NP_417834.6, NC_000913.3 WP_001276847.1, NZ_STEB01000004.1 |
3D structure databases
SMRi | P45544 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259581, 14 interactors 852194, 4 interactors |
DIPi | DIP-12327N |
IntActi | P45544, 6 interactors |
STRINGi | 511145.b3375 |
Proteomic databases
PaxDbi | P45544 |
PRIDEi | P45544 |
Genome annotation databases
EnsemblBacteriai | AAC76400; AAC76400; b3375 BAE77916; BAE77916; BAE77916 |
GeneIDi | 57729361 947885 |
KEGGi | ecj:JW5698 eco:b3375 |
PATRICi | fig|1411691.4.peg.3355 |
Organism-specific databases
EchoBASEi | EB2749 |
Phylogenomic databases
eggNOGi | COG2188, Bacteria |
HOGENOMi | CLU_063236_3_0_6 |
InParanoidi | P45544 |
PhylomeDBi | P45544 |
Enzyme and pathway databases
UniPathwayi | UPA00784 |
BioCyci | EcoCyc:G7727-MONOMER |
Miscellaneous databases
PROi | PR:P45544 |
Family and domain databases
CDDi | cd07377, WHTH_GntR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.40.1410.10, 1 hit |
InterProi | View protein in InterPro IPR028978, Chorismate_lyase_/UTRA_dom_sf IPR000524, Tscrpt_reg_HTH_GntR IPR011663, UTRA IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00392, GntR, 1 hit PF07702, UTRA, 1 hit |
PRINTSi | PR00035, HTHGNTR |
SMARTi | View protein in SMART SM00345, HTH_GNTR, 1 hit SM00866, UTRA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF64288, SSF64288, 1 hit |
PROSITEi | View protein in PROSITE PS50949, HTH_GNTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FRLR_ECOLI | |
Accessioni | P45544Primary (citable) accession number: P45544 Secondary accession number(s): Q2M740 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | December 15, 1998 | |
Last modified: | February 10, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways