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Protein

FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

Gene

fkpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • protein refolding Source: EcoliWiki

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciEcoCyc:G7716-MONOMER
BRENDAi5.2.1.8 2026

Names & Taxonomyi

Protein namesi
Recommended name:
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:fkpA
Synonyms:yzzS
Ordered Locus Names:b3347, JW3309
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12900 fkpA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000002553626 – 270FKBP-type peptidyl-prolyl cis-trans isomerase FkpAAdd BLAST245

Proteomic databases

EPDiP45523
PaxDbiP45523
PRIDEiP45523

2D gel databases

SWISS-2DPAGEiP45523

Interactioni

Protein-protein interaction databases

BioGridi4263165, 57 interactors
DIPiDIP-9625N
IntActiP45523, 17 interactors
MINTiP45523
STRINGi316385.ECDH10B_3522

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP45523
SMRiP45523
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45523

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 249PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST86

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108V1T Bacteria
COG0545 LUCA
HOGENOMiHOG000154888
InParanoidiP45523
KOiK03772
PhylomeDBiP45523

Family and domain databases

Gene3Di1.10.287.460, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR000774 PPIase_FKBP_N
IPR036944 PPIase_FKBP_N_sf
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF01346 FKBP_N, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P45523-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLFKVTLL ATTMAVALHA PITFAAEAAK PATAADSKAA FKNDDQKSAY
60 70 80 90 100
ALGASLGRYM ENSLKEQEKL GIKLDKDQLI AGVQDAFADK SKLSDQEIEQ
110 120 130 140 150
TLQAFEARVK SSAQAKMEKD AADNEAKGKE YREKFAKEKG VKTSSTGLVY
160 170 180 190 200
QVVEAGKGEA PKDSDTVVVN YKGTLIDGKE FDNSYTRGEP LSFRLDGVIP
210 220 230 240 250
GWTEGLKNIK KGGKIKLVIP PELAYGKAGV PGIPPNSTLV FDVELLDVKP
260 270
APKADAKPEA DAKAADSAKK
Length:270
Mass (Da):28,882
Last modified:November 1, 1995 - v1
Checksum:iDBC73B8676BB63EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28082 Genomic DNA Translation: AAC41459.1
U18997 Genomic DNA Translation: AAA58144.1
U00096 Genomic DNA Translation: AAC76372.1
AP009048 Genomic DNA Translation: BAE77944.1
PIRiI65035
RefSeqiNP_417806.1, NC_000913.3
WP_000838250.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76372; AAC76372; b3347
BAE77944; BAE77944; BAE77944
GeneIDi947850
KEGGiecj:JW3309
eco:b3347
PATRICifig|1411691.4.peg.3384

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28082 Genomic DNA Translation: AAC41459.1
U18997 Genomic DNA Translation: AAA58144.1
U00096 Genomic DNA Translation: AAC76372.1
AP009048 Genomic DNA Translation: BAE77944.1
PIRiI65035
RefSeqiNP_417806.1, NC_000913.3
WP_000838250.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q6HX-ray1.97A/B26-249[»]
1Q6IX-ray2.25A/B26-249[»]
1Q6UX-ray2.45A26-270[»]
4QCCX-ray7.08A/B45-116[»]
ProteinModelPortaliP45523
SMRiP45523
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263165, 57 interactors
DIPiDIP-9625N
IntActiP45523, 17 interactors
MINTiP45523
STRINGi316385.ECDH10B_3522

2D gel databases

SWISS-2DPAGEiP45523

Proteomic databases

EPDiP45523
PaxDbiP45523
PRIDEiP45523

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76372; AAC76372; b3347
BAE77944; BAE77944; BAE77944
GeneIDi947850
KEGGiecj:JW3309
eco:b3347
PATRICifig|1411691.4.peg.3384

Organism-specific databases

EchoBASEiEB2737
EcoGeneiEG12900 fkpA

Phylogenomic databases

eggNOGiENOG4108V1T Bacteria
COG0545 LUCA
HOGENOMiHOG000154888
InParanoidiP45523
KOiK03772
PhylomeDBiP45523

Enzyme and pathway databases

BioCyciEcoCyc:G7716-MONOMER
BRENDAi5.2.1.8 2026

Miscellaneous databases

EvolutionaryTraceiP45523
PROiPR:P45523

Family and domain databases

Gene3Di1.10.287.460, 1 hit
InterProiView protein in InterPro
IPR001179 PPIase_FKBP_dom
IPR000774 PPIase_FKBP_N
IPR036944 PPIase_FKBP_N_sf
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF01346 FKBP_N, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBA_ECOLI
AccessioniPrimary (citable) accession number: P45523
Secondary accession number(s): P39175, Q2M712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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