CREB-binding protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• acetyl-CoA

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + L-lysyl-[protein]

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  = CoA

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  + N⁶-acetyl-L-lysyl-[protein]

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:Q92793 (CBP_HUMAN)
  EC:2.3.1.48
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:Q92793 (CBP_HUMAN)
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  acetyl-CoA

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  L-lysyl-[protein]

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  L-lysine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  =

  CoA

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  H⁺

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  N⁶-acetyl-L-lysyl-[protein]

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  N⁶-acetyl-L-lysine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• acetyltransferase activity Source: UniProtKB
• activating transcription factor binding Source: MGI
• cAMP response element binding protein binding Source: CAFA <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions."
    Radhakrishnan I., Perez-Alvarado G.C., Parker D., Dyson H.J., Montminy M.R., Wright P.E.
    Cell 91:741-752(1997) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3."
    Hartman H.B., Yu J., Alenghat T., Ishizuka T., Lazar M.A.
    EMBO Rep. 6:445-451(2005) [PubMed] [Europe PMC] [Abstract]
  • "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules."
    Faure A.J., Schmidt D., Watt S., Schwalie P.C., Wilson M.D., Xu H., Ramsay R.G., Odom D.T., Flicek P.
    Genome Res. 22:2163-2175(2012) [PubMed] [Europe PMC] [Abstract]
• damaged DNA binding Source: UniProtKB
• disordered domain specific binding Source: CAFAInferred from physical interactionⁱ
  • "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators."
    Demarest S.J., Martinez-Yamout M., Chung J., Chen H., Xu W., Dyson H.J., Evans R.M., Wright P.E.
    Nature 415:549-553(2002) [PubMed] [Europe PMC] [Abstract]
  • Ref.19

    "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 340-439 IN COMPLEX WITH 220-269 OF CITED2 AND ZINC IONS.
• DNA binding Source: MGIInferred from direct assayⁱ
  • "Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes."
    Guan H.P., Ishizuka T., Chui P.C., Lehrke M., Lazar M.A.
    Genes Dev. 19:453-461(2005) [PubMed] [Europe PMC] [Abstract]
• histone acetyltransferase activity Source: MGIInferred from direct assayⁱ
  • "Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter."
    Mehra-Chaudhary R., Matsui H., Raghow R.
    Biochem. J. 353:13-22(2001) [PubMed] [Europe PMC] [Abstract]
  • "Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice."
    Li Q., Xiao H., Isobe K.
    J. Gerontol. A Biol. Sci. Med. Sci. 57:B93-8(2002) [PubMed] [Europe PMC] [Abstract]
  • "Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68."
    Hong W., Resnick R.J., Rakowski C., Shalloway D., Taylor S.J., Blobel G.A.
    Mol. Cancer Res. 1:48-55(2002) [PubMed] [Europe PMC] [Abstract]
• MRF binding Source: UniProtKB
• p53 binding Source: MGI
• peptide-lysine-N-acetyltransferase activity Source: Reactome
• peroxisome proliferator activated receptor binding Source: MGI
• protein domain specific binding Source: CAFAInferred from physical interactionⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.19

    "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 340-439 IN COMPLEX WITH 220-269 OF CITED2 AND ZINC IONS.
• protein heterodimerization activity Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators."
    Demarest S.J., Martinez-Yamout M., Chung J., Chen H., Xu W., Dyson H.J., Evans R.M., Wright P.E.
    Nature 415:549-553(2002) [PubMed] [Europe PMC] [Abstract]
• proximal promoter sequence-specific DNA binding Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia."
    Benlhabib H., Mendelson C.R.
    Mol. Cell. Biol. 31:1949-1958(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: MGI
• TFIIB-class transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: MGIInferred from direct assayⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• transcription corepressor activity Source: MGI
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3."
    Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S.
    J. Biol. Chem. 274:8143-8152(1999) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: CAFAInferred from mutant phenotypeⁱ
  • Ref.19

    "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 340-439 IN COMPLEX WITH 220-269 OF CITED2 AND ZINC IONS.

GO - Biological processⁱ

• cell population proliferation Source: MGI
• cellular response to hepatocyte growth factor stimulus Source: MGIInferred from direct assayⁱ
  • "Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases."
    Coudriet G.M., He J., Trucco M., Mars W.M., Piganelli J.D.
    PLoS ONE 5:e15384-e15384(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to UV Source: UniProtKB
• cellular response to virus Source: CAFAInferred from mutant phenotypeⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
• face morphogenesis Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology."
    Viosca J., Lopez-Atalaya J.P., Olivares R., Eckner R., Barco A.
    Neurobiol. Dis. 37:186-194(2010) [PubMed] [Europe PMC] [Abstract]
• germ-line stem cell population maintenance Source: MGIInferred from mutant phenotypeⁱ
  • "Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival."
    Elliott A.M., de Miguel M.P., Rebel V.I., Donovan P.J.
    Dev. Biol. 311:347-358(2007) [PubMed] [Europe PMC] [Abstract]
• histone acetylation Source: UniProtKB
• negative regulation of interferon-beta biosynthetic process Source: CAFAInferred from mutant phenotypeⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGI
• negative regulation of viral process Source: CAFAInferred from mutant phenotypeⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
• N-terminal peptidyl-lysine acetylation Source: UniProtKB
• positive regulation of cell adhesion molecule production Source: MGI
• positive regulation of CREB transcription factor activity Source: MGIInferred from direct assayⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein."
    Seo T., Lee D., Lee B., Chung J.H., Choe J.
    Biochem. Biophys. Res. Commun. 270:23-27(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G1/S transition of mitotic cell cycle Source: MGI
• positive regulation of gene expression Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype."
    Pentz E.S., Cordaillat M., Carretero O.A., Tucker A.E., Sequeira Lopez M.L., Gomez R.A.
    Am. J. Physiol. Heart Circ. Physiol. 302:H2545-52(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NIK/NF-kappaB signaling Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) binds to, and inhibits transactivation of, CREB-binding protein."
    Seo T., Lee D., Lee B., Chung J.H., Choe J.
    Biochem. Biophys. Res. Commun. 270:23-27(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53."
    Yin X., Warner D.R., Roberts E.A., Pisano M.M., Greene R.M.
    Int. J. Mol. Med. 16:251-256(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transforming growth factor beta receptor signaling pathway Source: MGI
• protein acetylation Source: MGI
• protein destabilization Source: UniProtKB
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development."
    Kioussi C., Briata P., Baek S.H., Rose D.W., Hamblet N.S., Herman T., Ohgi K.A., Lin C., Gleiberman A., Wang J., Brault V., Ruiz-Lozano P., Nguyen H.D., Kemler R., Glass C.K., Wynshaw-Boris A., Rosenfeld M.G.
    Cell 111:673-685(2002) [PubMed] [Europe PMC] [Abstract]
• rhythmic process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• activating transcription factor binding Source: MGI
• cAMP response element binding protein binding Source: CAFAInferred from physical interactionⁱ
  • "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions."
    Radhakrishnan I., Perez-Alvarado G.C., Parker D., Dyson H.J., Montminy M.R., Wright P.E.
    Cell 91:741-752(1997) [PubMed] [Europe PMC] [Abstract]
• disordered domain specific binding Source: CAFAInferred from physical interactionⁱ
  • "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators."
    Demarest S.J., Martinez-Yamout M., Chung J., Chen H., Xu W., Dyson H.J., Evans R.M., Wright P.E.
    Nature 415:549-553(2002) [PubMed] [Europe PMC] [Abstract]
  • Ref.19

    "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 340-439 IN COMPLEX WITH 220-269 OF CITED2 AND ZINC IONS.
• MRF binding Source: UniProtKB
• p53 binding Source: MGI
• peroxisome proliferator activated receptor binding Source: MGI
• protein domain specific binding Source: CAFAInferred from physical interactionⁱ
  • "A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies."
    Lin C.H., Hare B.J., Wagner G., Harrison S.C., Maniatis T., Fraenkel E.
    Mol. Cell 8:581-590(2001) [PubMed] [Europe PMC] [Abstract]
  • Ref.19

    "Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites."
    De Guzman R.N., Martinez-Yamout M.A., Dyson H.J., Wright P.E.
    J. Biol. Chem. 279:3042-3049(2004) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 340-439 IN COMPLEX WITH 220-269 OF CITED2 AND ZINC IONS.
• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators."
    Demarest S.J., Martinez-Yamout M., Chung J., Chen H., Xu W., Dyson H.J., Evans R.M., Wright P.E.
    Nature 415:549-553(2002) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: MGI
• TFIIB-class transcription factor binding Source: MGIInferred from physical interactionⁱ
  • "Nuclear protein CBP is a coactivator for the transcription factor CREB."
    Kwok R.P., Lundblad J.R., Chrivia J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G., Green M.R., Goodman R.H.
    Nature 370:223-226(1994) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3."
    Dai P., Akimaru H., Tanaka Y., Maekawa T., Nakafuku M., Ishii S.
    J. Biol. Chem. 274:8143-8152(1999) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL 
        60         70         80         90        100
SLLNSGNLVP DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG 
       110        120        130        140        150
QAQGQPNSTN MASLGAMGKS PLNQGDSSTP NLPKQAASTS GPTPPASQAL 
       160        170        180        190        200
NPQAQKQVGL VTSSPATSQT GPGICMNANF NQTHPGLLNS NSGHSLMNQA 
       210        220        230        240        250
QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE TLTQVSPQMA 
       260        270        280        290        300
GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ 
       310        320        330        340        350
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR 
       360        370        380        390        400
KLIQQQLVLL LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG 
       410        420        430        440        450
KACQVAHCAS SRQIISHWKN CTRHDCPVCL PLKNASDKRN QQTILGSPAS 
       460        470        480        490        500
GIQNTIGSVG AGQQNATSLS NPNPIDPSSM QRAYAALGLP YMNQPQTQLQ 
       510        520        530        540        550
PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ PPNLISESAL 
       560        570        580        590        600
PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR 
       610        620        630        640        650
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY 
       660        670        680        690        700
HLLAEKIYKI QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV 
       710        720        730        740        750
RPPNGPLPLP VNRMQVSQGM NSFNPMSLGN VQLPQAPMGP RAASPMNHSV 
       760        770        780        790        800
QMNSMASVPG MAISPSRMPQ PPNMMGTHAN NIMAQAPTQN QFLPQNQFPS 
       810        820        830        840        850
SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP QASQLPCPPV 
       860        870        880        890        900
TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP 
       910        920        930        940        950
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP 
       960        970        980        990       1000
TPVHTQPPGT PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT 
      1010       1020       1030       1040       1050
EVQTDDAEPE PTESKGEPRS EMMEEDLQGS SQVKEETDTT EQKSEPMEVE 
      1060       1070       1080       1090       1100
EKKPEVKVEA KEEEENSSND TASQSTSPSQ PRKKIFKPEE LRQALMPTLE 
      1110       1120       1130       1140       1150
ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK RKLDTGQYQE 
      1160       1170       1180       1190       1200
PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC 
      1210       1220       1230       1240       1250
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV 
      1260       1270       1280       1290       1300
TLGDDPSQPQ TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD 
      1310       1320       1330       1340       1350
IIWPSGFVCD NCLKKTGRPR KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ 
      1360       1370       1380       1390       1400
NHPEAGEVFV RVVASSDKTV EVKPGMKSRF VDSGEMSESF PYRTKALFAF 
      1410       1420       1430       1440       1450
EEIDGVDVCF FGMHVQNTAL IAPHQIQGRV YISYLDSIHF FRPRCLRTAV 
      1460       1470       1480       1490       1500
YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL 
      1510       1520       1530       1540       1550
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL 
      1560       1570       1580       1590       1600
EESIKELEQE EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS 
      1610       1620       1630       1640       1650
ISRANKKKPS MPNVSNDLSQ KLYATMEKHK EVFFVIHLHA GPVISTQPPI 
      1660       1670       1680       1690       1700
VDPDPLLSCD LMDGRDAFLT LARDKHWEFS SLRRSKWSTL CMLVELHTQG 
      1710       1720       1730       1740       1750
QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT HKMVKWGLGL 
      1760       1770       1780       1790       1800
DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK 
      1810       1820       1830       1840       1850
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK 
      1860       1870       1880       1890       1900
LRQQQIQHRL QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST 
      1910       1920       1930       1940       1950
PQTPQPPAQP QPSPVNMSPA GFPNVARTQP PTIVSAGKPT NQVPAPPPPA 
      1960       1970       1980       1990       2000
QPPPAAVEAA RQIEREAQQQ QHLYRANINN GMPPGRAGMG TPGSQMTPVG 
      2010       2020       2030       2040       2050
LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV MSMQAQAAVA 
      2060       2070       2080       2090       2100
GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA 
      2110       2120       2130       2140       2150
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV 
      2160       2170       2180       2190       2200
PRPGVPPPQP AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ 
      2210       2220       2230       2240       2250
HQQQQQQQQQ QQQQQQNSAS LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ 
      2260       2270       2280       2290       2300
QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA DSTPNIQQAL QQRILQQQQM 
      2310       2320       2330       2340       2350
KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN QVRSPAPVQS 
      2360       2370       2380       2390       2400
PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG 
      2410       2420       2430       2440 
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L          

Experimental Info

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity