UniProtKB - P45475 (UBIV_ECOLI)
Protein
Ubiquinone biosynthesis protein UbiV
Gene
ubiV
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for O2-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.UniRule annotation1 Publication
Cofactori
[4Fe-4S] clusterUniRule annotation1 Publication
: ubiquinone biosynthesis Pathwayi
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation1 PublicationView all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 39 | Iron-sulfur (4Fe-4S)UniRule annotation1 Publication | 1 | |
Metal bindingi | 180 | Iron-sulfur (4Fe-4S)UniRule annotation1 Publication | 1 | |
Metal bindingi | 193 | Iron-sulfur (4Fe-4S)UniRule annotation1 Publication | 1 | |
Metal bindingi | 197 | Iron-sulfur (4Fe-4S)UniRule annotation1 Publication | 1 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: EcoCyc
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- ubiquinone biosynthetic process from chorismate Source: EcoCyc
Keywordsi
Biological process | Ubiquinone biosynthesis |
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:G7653-MONOMER |
UniPathwayi | UPA00232 |
Protein family/group databases
MEROPSi | U32.A01 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquinone biosynthesis protein UbiVUniRule annotationCurated |
Gene namesi | Name:ubiV1 PublicationUniRule annotation Synonyms:yhbV Ordered Locus Names:b3159, JW5530 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion mutant is unable to synthesize ubiquinone under strict anaerobic conditions. Mutant shows normal levels of ubiquinone after aerobic growth.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 39 | C → A: Does not bind iron-sulfur cluster; when associated with A-180; A-193 and A-197. 1 Publication | 1 | |
Mutagenesisi | 180 | C → A: Alters ubiquinone synthesis in anaerobic conditions. Does not bind iron-sulfur cluster; when associated with A-39; A-193 and A-197. 1 Publication | 1 | |
Mutagenesisi | 193 | C → A: Alters ubiquinone synthesis in anaerobic conditions. Does not bind iron-sulfur cluster; when associated with A-39; A-180 and A-197. 1 Publication | 1 | |
Mutagenesisi | 197 | C → A: Does not bind iron-sulfur cluster; when associated with A-39; A-180 and A-193. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169459 | 1 – 292 | Ubiquinone biosynthesis protein UbiVAdd BLAST | 292 |
Proteomic databases
jPOSTi | P45475 |
PaxDbi | P45475 |
PRIDEi | P45475 |
Interactioni
Subunit structurei
Forms an heterodimer with UbiU.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 4259276, 54 interactors |
DIPi | DIP-12269N |
IntActi | P45475, 1 interactor |
STRINGi | 511145.b3159 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0826, Bacteria |
HOGENOMi | CLU_056172_0_0_6 |
InParanoidi | P45475 |
PhylomeDBi | P45475 |
Family and domain databases
HAMAPi | MF_02233, UbiV, 1 hit |
InterProi | View protein in InterPro IPR001539, Peptidase_U32 IPR043693, UbiV |
Pfami | View protein in Pfam PF01136, Peptidase_U32, 1 hit |
i Sequence
Sequence statusi: Complete.
P45475-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKYSLGPVLW YWPKETLEEF YQQAATSSAD VIYLGEAVCS KRRATKVGDW
60 70 80 90 100
LEMAKSLAGS GKQIVLSTLA LVQASSELGE LKRYVENGEF LIEASDLGVV
110 120 130 140 150
NMCAERKLPF VAGHALNCYN AVTLKILLKQ GMMRWCMPVE LSRDWLVNLL
160 170 180 190 200
NQCDELGIRN QFEVEVLSYG HLPLAYSARC FTARSEDRPK DECETCCIKY
210 220 230 240 250
PNGRNVLSQE NQQVFVLNGI QTMSGYVYNL GNELASMQGL VDVVRLSPQG
260 270 280 290
TDTFAMLDAF RANENGAAPL PLTANSDCNG YWRRLAGLEL QA
Sequence cautioni
The sequence AAA57962 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57962.1 Different initiation. U00096 Genomic DNA Translation: AAC76193.2 AP009048 Genomic DNA Translation: BAE77205.1 |
PIRi | C65106 |
RefSeqi | NP_417628.2, NC_000913.3 WP_001301318.1, NZ_STEB01000012.1 |
Genome annotation databases
EnsemblBacteriai | AAC76193; AAC76193; b3159 BAE77205; BAE77205; BAE77205 |
GeneIDi | 57728570 949117 |
KEGGi | ecj:JW5530 eco:b3159 |
PATRICi | fig|1411691.4.peg.3571 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57962.1 Different initiation. U00096 Genomic DNA Translation: AAC76193.2 AP009048 Genomic DNA Translation: BAE77205.1 |
PIRi | C65106 |
RefSeqi | NP_417628.2, NC_000913.3 WP_001301318.1, NZ_STEB01000012.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4259276, 54 interactors |
DIPi | DIP-12269N |
IntActi | P45475, 1 interactor |
STRINGi | 511145.b3159 |
Protein family/group databases
MEROPSi | U32.A01 |
Proteomic databases
jPOSTi | P45475 |
PaxDbi | P45475 |
PRIDEi | P45475 |
Genome annotation databases
EnsemblBacteriai | AAC76193; AAC76193; b3159 BAE77205; BAE77205; BAE77205 |
GeneIDi | 57728570 949117 |
KEGGi | ecj:JW5530 eco:b3159 |
PATRICi | fig|1411691.4.peg.3571 |
Organism-specific databases
EchoBASEi | EB2643 |
Phylogenomic databases
eggNOGi | COG0826, Bacteria |
HOGENOMi | CLU_056172_0_0_6 |
InParanoidi | P45475 |
PhylomeDBi | P45475 |
Enzyme and pathway databases
UniPathwayi | UPA00232 |
BioCyci | EcoCyc:G7653-MONOMER |
Miscellaneous databases
PROi | PR:P45475 |
Family and domain databases
HAMAPi | MF_02233, UbiV, 1 hit |
InterProi | View protein in InterPro IPR001539, Peptidase_U32 IPR043693, UbiV |
Pfami | View protein in Pfam PF01136, Peptidase_U32, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIV_ECOLI | |
Accessioni | P45475Primary (citable) accession number: P45475 Secondary accession number(s): Q2M951 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 10, 2021 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families