UniProtKB - P45448 (NR5A2_MOUSE)

BLAST

>sp|P45448|NR5A2_MOUSE Nuclear receptor subfamily 5 group A member 2 OS=Mus musculus OX=10090 GN=Nr5a2 PE=1 SV=3
MSASLDTGDFQEFLKHGLTAIASAPGSETRHSPKREEQLREKRAGLPDRHRRPIPARSRL
VMLPKVETEAPGLVRSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYG
LLTCESCKGFFKRTVQNQKRYTCIENQNCQIDKTQRKRCPYCRFKKCIDVGMKLEAVRAD
RMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTSAIQNIHSASK
GLPLSHVALPPTDYDRSPFVTSPISMTMPPHSSLHGYQPYGHFPSRAIKSEYPDPYSSSP
ESMMGYSYMDGYQTNSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQSNRNRQEKLSA
FGLLCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVAHGKEG
TIFLVTGEHVDYSTIISHTEVAFNNLLSLAQELVVRLRSLQFDQREFVCLKFLVLFSSDV
KNLENLQLVEGVQEQVNAALLDYTVCNYPQQTEKFGQLLLRLPEIRAISKQAEDYLYYKH
VNGDVPYNNLLIEMLHAKRA

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History
Entry version 167 (07 Nov 2018)
Sequence version 3 (30 May 2000)
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Protein

Nuclear receptor subfamily 5 group A member 2

Gene

Nr5a2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	535	Lipid headgroupBy similarity		1
Binding siteⁱ	539	Lipid headgroupBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	104 – 175	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	72
Zinc fingerⁱ	107 – 127	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	143 – 167	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

chromatin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484
DNA binding
Source: MGI
Inferred from direct assayⁱ
DNA-binding transcription factor activity Source: UniProtKB
double-stranded DNA binding Source: MGI
nuclear receptor activity Source: MGI
phospholipid binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 12456679
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12456679
sequence-specific DNA binding Source: MGI
steroid hormone receptor activity Source: InterPro
transcription regulatory region DNA binding Source: MGI
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid metabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15014077
calcineurin-mediated signaling Source: MGI
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
cholesterol homeostasis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15014077
endocrine pancreas development Source: Reactome
epithelial cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 25063451
hormone-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
pancreas morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 25063451
positive regulation of transcription, DNA-templated Source: MGI
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12456679
positive regulation of viral genome replication Source: MGI
regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 15684064
regulation of transcription, DNA-templated Source: UniProtKB
tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-4090294 SUMOylation of intracellular receptors R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 5 group A member 2 Alternative name(s): Liver receptor homolog 1 Short name: LRH-1
Gene namesⁱ	Name:Nr5a2 Synonyms:Lrh1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1346834 Nr5a2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053736	1 – 560	Nuclear receptor subfamily 5 group A member 2Add BLAST		560

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	289	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationⁱ

Sumoylated by SUMO1 at Lys-289 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P45448
PaxDbⁱ	P45448
PRIDEⁱ	P45448

PTM databases

iPTMnetⁱ	P45448
PhosphoSitePlusⁱ	P45448

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026398 Expressed in 174 organ(s), highest expression level in female gonad
CleanExⁱ	MM_NR5A2
ExpressionAtlasⁱ	P45448 baseline and differential
Genevisibleⁱ	P45448 MM

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2 (PubMed:12820970, PubMed:15976031). Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (By similarity).By similarity2 Publications

Protein-protein interaction databases

BioGridⁱ	204976, 3 interactors
STRINGⁱ	10090.ENSMUSP00000027649

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	322 – 329	Combined sources	8
Helixⁱ	334 – 351	Combined sources	18
Beta strandⁱ	354 – 356	Combined sources	3
Helixⁱ	361 – 381	Combined sources	21
Helixⁱ	385 – 387	Combined sources	3
Helixⁱ	390 – 416	Combined sources	27
Beta strandⁱ	419 – 423	Combined sources	5
Beta strandⁱ	429 – 431	Combined sources	3
Helixⁱ	432 – 437	Combined sources	6
Helixⁱ	441 – 459	Combined sources	19
Helixⁱ	464 – 475	Combined sources	12
Helixⁱ	486 – 507	Combined sources	22
Helixⁱ	514 – 519	Combined sources	6
Helixⁱ	522 – 541	Combined sources	20
Helixⁱ	549 – 555	Combined sources	7
Turnⁱ	556 – 558	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P45448
SMRⁱ	P45448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P45448

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	319 – 558	NR LBDPROSITE-ProRule annotationAdd BLAST		240

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	176 – 205	FTZ-F1 boxAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR5 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	107 – 127	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	143 – 167	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000063718
HOVERGENⁱ	HBG106677
InParanoidⁱ	P45448
KEGG Orthology (KO) More...KOⁱ	K08027
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06RK
PhylomeDBⁱ	P45448
TreeFamⁱ	TF350737

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P45448-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSASLDTGDF QEFLKHGLTA IASAPGSETR HSPKREEQLR EKRAGLPDRH 
        60         70         80         90        100
RRPIPARSRL VMLPKVETEA PGLVRSHGEQ GQMPENMQVS QFKMVNYSYD 
       110        120        130        140        150
EDLEELCPVC GDKVSGYHYG LLTCESCKGF FKRTVQNQKR YTCIENQNCQ 
       160        170        180        190        200
IDKTQRKRCP YCRFKKCIDV GMKLEAVRAD RMRGGRNKFG PMYKRDRALK 
       210        220        230        240        250
QQKKALIRAN GLKLEAMSQV IQAMPSDLTS AIQNIHSASK GLPLSHVALP 
       260        270        280        290        300
PTDYDRSPFV TSPISMTMPP HSSLHGYQPY GHFPSRAIKS EYPDPYSSSP 
       310        320        330        340        350
ESMMGYSYMD GYQTNSPASI PHLILELLKC EPDEPQVQAK IMAYLQQEQS 
       360        370        380        390        400
NRNRQEKLSA FGLLCKMADQ TLFSIVEWAR SSIFFRELKV DDQMKLLQNC 
       410        420        430        440        450
WSELLILDHI YRQVAHGKEG TIFLVTGEHV DYSTIISHTE VAFNNLLSLA 
       460        470        480        490        500
QELVVRLRSL QFDQREFVCL KFLVLFSSDV KNLENLQLVE GVQEQVNAAL 
       510        520        530        540        550
LDYTVCNYPQ QTEKFGQLLL RLPEIRAISK QAEDYLYYKH VNGDVPYNNL 
       560
LIEMLHAKRA

Length:560

Mass (Da):64,020

Last modified:May 30, 2000 - v3

Checksum:ⁱ186F8C4025934643

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A6YY04	A0A0A6YY04_MOUSE	Nuclear receptor subfamily 5 group ... Nuclear receptor subfamily 5 group A member 2	Nr5a2	539	Annotation score:
Q1WLP7	Q1WLP7_MOUSE	Liver receptor-like protein 1 varia... Liver receptor-like protein 1 variant 2 (Nuclear receptor subfamily 5 group A member 2)	Nr5a2	499	Annotation score:
A0A0A6YWQ4	A0A0A6YWQ4_MOUSE	Nuclear receptor subfamily 5 group ... Nuclear receptor subfamily 5 group A member 2	Nr5a2	136	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81385 mRNA Translation: AAA39447.1 BC137845 mRNA Translation: AAI37846.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15328.1
PIRⁱ	S27874
NCBI Reference Sequences More...RefSeqⁱ	NP_109601.1, NM_030676.3
UniGeneⁱ	Mm.16794

Genome annotation databases

Ensemblⁱ	ENSMUST00000027649; ENSMUSP00000027649; ENSMUSG00000026398
GeneIDⁱ	26424
KEGGⁱ	mmu:26424
UCSC genome browser More...UCSCⁱ	uc007cva.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P45448	Nuclear receptor subfamily 5 group A member 2 (Fragment)		MOUSE		136	UniRef100_P45448
Liver receptor-like protein 1 variant 2		MOUSE		499
Orphan nuclear receptor FTF (Fragment)		MOUSE		21
UPI000057675A		MOUSE		243

Protein	Similar proteins		Species	Score	Length	Source
P45448	Nuclear receptor subfamily 5 group A member 2		RAT		560	UniRef90_P45448
Nuclear receptor subfamily 5 group A member 2 (Fragment)		MOUSE		136
UPI000A30A17D		MUSPA		560
UPI000A315F5E		MUSCR		560
Liver receptor-like protein 1 variant 2		MOUSE		499
+10

Protein	Similar proteins		Species	Score	Length	Source
P45448	Nuclear receptor subfamily 5 group A member 2	)	HUMAN		541	UniRef50_O00482
Nuclear receptor subfamily 5 group A member 2		CHICK		501
Nuclear receptor subfamily 5 group A member 2		RAT		560
NR5A2 isoform 1		PANTR		541
NR5A2 isoform 1		PONAB		541
+392

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81385 mRNA Translation: AAA39447.1 BC137845 mRNA Translation: AAI37846.1
CCDSⁱ	CCDS15328.1
PIRⁱ	S27874
RefSeqⁱ	NP_109601.1, NM_030676.3
UniGeneⁱ	Mm.16794

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PK5	X-ray	2.40	A/B	313-560	[»]
	1ZH7	X-ray	2.50	A/B	318-560	[»]
	3F5C	X-ray	3.00	A	313-560	[»]
ProteinModelPortalⁱ	P45448
SMRⁱ	P45448
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204976, 3 interactors
STRINGⁱ	10090.ENSMUSP00000027649

PTM databases

iPTMnetⁱ	P45448
PhosphoSitePlusⁱ	P45448

Proteomic databases

MaxQBⁱ	P45448
PaxDbⁱ	P45448
PRIDEⁱ	P45448

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027649; ENSMUSP00000027649; ENSMUSG00000026398
GeneIDⁱ	26424
KEGGⁱ	mmu:26424
UCSCⁱ	uc007cva.2 mouse

Organism-specific databases

CTDⁱ	2494
MGIⁱ	MGI:1346834 Nr5a2

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000063718
HOVERGENⁱ	HBG106677
InParanoidⁱ	P45448
KOⁱ	K08027
OrthoDBⁱ	EOG091G06RK
PhylomeDBⁱ	P45448
TreeFamⁱ	TF350737

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-4090294 SUMOylation of intracellular receptors R-MMU-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-4090294 SUMOylation of intracellular receptors
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

EvolutionaryTraceⁱ	P45448
Protein Ontology More...PROⁱ	PR:P45448
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026398 Expressed in 174 organ(s), highest expression level in female gonad
CleanExⁱ	MM_NR5A2
ExpressionAtlasⁱ	P45448 baseline and differential
Genevisibleⁱ	P45448 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PIRSFⁱ	PIRSF002530 Nuc_orph_FTZ-F1, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR5A2_MOUSE
Accessionⁱ	P45448Primary (citable) accession number: P45448 Secondary accession number(s): B9EHF9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	May 30, 2000
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P45448 (NR5A2_MOUSE)

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Nuclear receptor subfamily 5 group A member 2

Nr5a2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ