UniProtKB - P45446 (RORB_RAT)
Nuclear receptor ROR-beta
Rorb
Functioni
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity.
2 PublicationsCritical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 18 – 93 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 21 – 41 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 57 – 81 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- melatonin receptor activity Source: RGD
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
- zinc ion binding Source: InterPro
GO - Biological processi
- amacrine cell differentiation Source: UniProtKB
- brain development Source: RGD
- cellular response to retinoic acid Source: UniProtKB
- circadian rhythm Source: RGD
- eye photoreceptor cell development Source: UniProtKB
- negative regulation of osteoblast differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of circadian rhythm Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to hormone Source: RGD
- retina development in camera-type eye Source: UniProtKB
- retinal cone cell development Source: UniProtKB
- retinal rod cell development Source: UniProtKB
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Receptor |
Biological process | Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor ROR-betaAlternative name(s): Nuclear receptor RZR-beta Nuclear receptor subfamily 1 group F member 2 Retinoid-related orphan receptor-beta |
Gene namesi | Name:Rorb Synonyms:Nr1f2, Rzrb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1306778, Rorb |
Subcellular locationi
Nucleus
- nucleoplasm By similarity
Nucleus
- nucleoplasm Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 280 | A → F, V or S: Inhibits transactivation activity. 1 Publication | 1 | |
Mutagenesisi | 280 | A → G: No effect on transactivation activity. 1 Publication | 1 | |
Mutagenesisi | 457 | Y → A: Inhibits transactivation activity. 1 Publication | 1 | |
Mutagenesisi | 459 | E → A: Inhibits transactivation activity. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL4105721 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053516 | 1 – 470 | Nuclear receptor ROR-betaAdd BLAST | 470 |
Proteomic databases
PaxDbi | P45446 |
PTM databases
PhosphoSitePlusi | P45446 |
Expressioni
Tissue specificityi
Inductioni
Interactioni
Subunit structurei
Monomer.
Interacts with CRX.
3 PublicationsProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018137 |
Chemistry databases
BindingDBi | P45446 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P45446 |
SMRi | P45446 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P45446 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 222 – 460 | NR LBDPROSITE-ProRule annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 104 – 127 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 456 – 461 | AF-2 | 6 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 21 – 41 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 57 – 81 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4216, Eukaryota |
InParanoidi | P45446 |
PhylomeDBi | P45446 |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50142 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCENQLKTKA DGTAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ
60 70 80 90 100
NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ
110 120 130 140 150
RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNTETGG
160 170 180 190 200
TYANGHVIDL PKSEGYYNID SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV
210 220 230 240 250
HNLFTYSSFN NGQLAPGITM SEIDRIAQNI IKSHLETCQY TMEELHQLAW
260 270 280 290 300
QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN
310 320 330 340 350
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV
360 370 380 390 400
NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLLEPR KVQKLQEKIY
410 420 430 440 450
FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPDIVN
460 470
TLFPPLYKEL FNPDCAAVCK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1LQ88 | F1LQ88_RAT | Nuclear receptor ROR-beta | Rorb | 470 | Annotation score: | ||
A0A0G2JX88 | A0A0G2JX88_RAT | Nuclear receptor ROR-beta | Rorb | 459 | Annotation score: | ||
A0A8I5ZY30 | A0A8I5ZY30_RAT | Nuclear receptor ROR-beta | Rorb | 461 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022577 | 1 – 13 | MCENQ…KADGT → MR in isoform 1. CuratedAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14610 Genomic DNA Translation: AAA42095.1 Different initiation. |
PIRi | I65219 |
Genome annotation databases
UCSCi | RGD:1306778, rat [P45446-2] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14610 Genomic DNA Translation: AAA42095.1 Different initiation. |
PIRi | I65219 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K4W | X-ray | 1.90 | A | 212-463 | [»] | |
1N4H | X-ray | 2.10 | A | 212-470 | [»] | |
1NQ7 | X-ray | 1.50 | A | 219-462 | [»] | |
AlphaFoldDBi | P45446 | |||||
SMRi | P45446 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000018137 |
Chemistry databases
BindingDBi | P45446 |
ChEMBLi | CHEMBL4105721 |
PTM databases
PhosphoSitePlusi | P45446 |
Proteomic databases
PaxDbi | P45446 |
Genome annotation databases
UCSCi | RGD:1306778, rat [P45446-2] |
Organism-specific databases
RGDi | 1306778, Rorb |
Phylogenomic databases
eggNOGi | KOG4216, Eukaryota |
InParanoidi | P45446 |
PhylomeDBi | P45446 |
Enzyme and pathway databases
Reactomei | R-RNO-383280, Nuclear Receptor transcription pathway |
Miscellaneous databases
EvolutionaryTracei | P45446 |
PROi | PR:P45446 |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
IDEALi | IID50142 |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RORB_RAT | |
Accessioni | P45446Primary (citable) accession number: P45446 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families