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Entry version 113 (07 Apr 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Adhesion and penetration protein autotransporter

Gene

hap

Organism
Haemophilus influenzae
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable protease; promotes adherence and invasion by directly binding to a host cell structure.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei243By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCell adhesion

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S06.006

Transport Classification Database

More...
TCDBi
1.B.12.3.2, the autotransporter-1 (at-1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion and penetration protein autotransporter (EC:3.4.21.-)
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hap
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzae
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri727 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038759626 – 1394Adhesion and penetration protein autotransporterAdd BLAST1369
ChainiPRO_000002695626 – ?Adhesion and penetration protein
ChainiPRO_0000026957? – 1394Adhesion and penetration protein translocatorSequence analysis

Keywords - PTMi

Zymogen

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P45387
With#Exp.IntAct
itself2EBI-7074441,EBI-7074441

GO - Molecular functioni

Protein-protein interaction databases

Molecular INTeraction database

More...
MINTi
P45387

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P45387

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 286Peptidase S6PROSITE-ProRule annotationAdd BLAST261
Domaini1140 – 1394AutotransporterPROSITE-ProRule annotationAdd BLAST255

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central
IPR033116, TRYPSIN_SER

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02395, Peptidase_S6, 2 hits
PF03212, Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01414, autotrans_barl, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P45387-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKTVFRLNF LTACISLGIV SQAWAGHTYF GIDYQYYRDF AENKGKFTVG
60 70 80 90 100
AQNIKVYNKQ GQLVGTSMTK APMIDFSVVS RNGVAALVEN QYIVSVAHNV
110 120 130 140 150
GYTDVDFGAE GNNPDQHRFT YKIVKRNNYK KDNLHPYEDD YHNPRLHKFV
160 170 180 190 200
TEAAPIDMTS NMNGSTYSDR TKYPERVRIG SGRQFWRNDQ DKGDQVAGAY
210 220 230 240 250
HYLTAGNTHN QRGAGNGYSY LGGDVRKAGE YGPLPIAGSK GDSGSPMFIY
260 270 280 290 300
DAEKQKWLIN GILREGNPFE GKENGFQLVR KSYFDEIFER DLHTSLYTRA
310 320 330 340 350
GNGVYTISGN DNGQGSITQK SGIPSEIKIT LANMSLPLKE KDKVHNPRYD
360 370 380 390 400
GPNIYSPRLN NGETLYFMDQ KQGSLIFASD INQGAGGLYF EGNFTVSPNS
410 420 430 440 450
NQTWQGAGIH VSENSTVTWK VNGVEHDRLS KIGKGTLHVQ AKGENKGSIS
460 470 480 490 500
VGDGKVILEQ QADDQGNKQA FSEIGLVSGR GTVQLNDDKQ FDTDKFYFGF
510 520 530 540 550
RGGRLDLNGH SLTFKRIQNT DEGAMIVNHN TTQAANVTIT GNESIVLPNG
560 570 580 590 600
NNINKLDYRK EIAYNGWFGE TDKNKHNGRL NLIYKPTTED RTLLLSGGTN
610 620 630 640 650
LKGDITQTKG KLFFSGRPTP HAYNHLNKRW SEMEGIPQGE IVWDHDWINR
660 670 680 690 700
TFKAENFQIK GGSAVVSRNV SSIEGNWTVS NNANATFGVV PNQQNTICTR
710 720 730 740 750
SDWTGLTTCQ KVDLTDTKVI NSIPKTQING SINLTDNATA NVKGLAKLNG
760 770 780 790 800
NVTLTNHSQF TLSNNATQIG NIRLSDNSTA TVDNANLNGN VHLTDSAQFS
810 820 830 840 850
LKNSHFSHQI QGDKGTTVTL ENATWTMPSD TTLQNLTLNN STITLNSAYS
860 870 880 890 900
ASSNNTPRRR SLETETTPTS AEHRFNTLTV NGKLSGQGTF QFTSSLFGYK
910 920 930 940 950
SDKLKLSNDA EGDYILSVRN TGKEPETLEQ LTLVESKDNQ PLSDKLKFTL
960 970 980 990 1000
ENDHVDAGAL RYKLVKNDGE FRLHNPIKEQ ELHNDLVRAE QAERTLEAKQ
1010 1020 1030 1040 1050
VEPTAKTQTG EPKVRSRRAA RAAFPDTLPD QSLLNALEAK QAELTAETQK
1060 1070 1080 1090 1100
SKAKTKKVRS KRAVFSDPLL DQSLFALEAA LEVIDAPQQS EKDRLAQEEA
1110 1120 1130 1140 1150
EKQRKQKDLI SRYSNSALSE LSATVNSMLS VQDELDRLFV DQAQSAVWTN
1160 1170 1180 1190 1200
IAQDKRRYDS DAFRAYQQQK TNLRQIGVQK ALANGRIGAV FSHSRSDNTF
1210 1220 1230 1240 1250
DEQVKNHATL TMMSGFAQYQ WGDLQFGVNV GTGISASKMA EEQSRKIHRK
1260 1270 1280 1290 1300
AINYGVNASY QFRLGQLGIQ PYFGVNRYFI ERENYQSEEV RVKTPSLAFN
1310 1320 1330 1340 1350
RYNAGIRVDY TFTPTDNISV KPYFFVNYVD VSNANVQTTV NLTVLQQPFG
1360 1370 1380 1390
RYWQKEVGLK AEILHFQISA FISKSQGSQL GKQQNVGVKL GYRW
Length:1,394
Mass (Da):155,441
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5BF28660103F60F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1167Missing in AAB03707 (PubMed:7830568).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U11024 Genomic DNA Translation: AAB03707.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S60762

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11024 Genomic DNA Translation: AAB03707.1
PIRiS60762

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SYJX-ray2.20A26-1036[»]
SMRiP45387
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

MINTiP45387

Protein family/group databases

MEROPSiS06.006
TCDBi1.B.12.3.2, the autotransporter-1 (at-1) family

Family and domain databases

Gene3Di2.160.20.20, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR006315, OM_autotransptr_brl
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central
IPR033116, TRYPSIN_SER
PfamiView protein in Pfam
PF02395, Peptidase_S6, 2 hits
PF03212, Pertactin, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit
TIGRFAMsiTIGR01414, autotrans_barl, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAP2_HAEIF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45387
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 7, 2021
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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