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UniProtKB - P45385 (IGA3_HAEIF)

Entry version 105 (07 Apr 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Immunoglobulin A1 protease autotransporter

Gene

iga

Organism
Haemophilus influenzae
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known. EC:3.4.21.72

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei292Curated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processVirulence

Protein family/group databases

MEROPS protease database

More...MEROPSi		S06.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin A1 protease autotransporter (EC:3.4.21.72)
Cleaved into the following 2 chains:
Immunoglobulin A1 protease
Short name:
IGA1 protease
Immunoglobulin A1 protease translocator
Alternative name(s):
Helper peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzae
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri727 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038760126 – 1545Immunoglobulin A1 protease autotransporterAdd BLAST1520
ChainiPRO_000002696426 – 1012Immunoglobulin A1 proteaseAdd BLAST987
ChainiPRO_00000269651013 – 1545Immunoglobulin A1 protease translocatorSequence analysisAdd BLAST533

Keywords - PTMi

Zymogen

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P45385

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 336Peptidase S6PROSITE-ProRule annotationAdd BLAST311
Domaini1293 – 1545AutotransporterPROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P45385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGKFSVG 
        60         70         80         90        100
ATNVEVRDKN NRPLGNVLPN GIPMIDFSVV DVDKRIATLV NPQYVVGVKH 
       110        120        130        140        150
VSNGVSELHF GNLNGNMNNG NAKAHRDVSS EENRYYTVEK NEYPTKLNGK 
       160        170        180        190        200
AVTTEDQAQK RREDYYMPRL DKFVTEVAPI EASTDSSTAG TYNNKDKYPY 
       210        220        230        240        250
FVRLGSGTQF IYENGTRYEL WLGKEGQKSD AGGYNLKLVG NAYTYGIAGT 
       260        270        280        290        300
PYEVNHENDG LIGFGNSNNE YINPKEILSK KPLTNYAVLG DSGSPLFVYD 
       310        320        330        340        350
REKGKWLFLG SYDYWAGYNK KSWQEWNIYK PEFAEKIYEQ YSAGSLIGSK 
       360        370        380        390        400
TDYSWSSNGK TSTITGGEKS LNVDLADGKD KPNHGKSVTF EGSGTLTLNN 
       410        420        430        440        450
NIDQGAGGLF FEGDYEVKGT SDNTTWKGAG VSVAEGKTVT WKVHNPQYDR 
       460        470        480        490        500
LAKIGKGTLI VEGTGDNKGS LKVGDGTVIL KQQTNGSGQH AFASVGIVSG 
       510        520        530        540        550
RSTLVLNDDK QVDPNSIYFG FRGGRLDLNG NSLTFDHIRN IDEGARLVNH 
       560        570        580        590        600
STSKHSTVTI TGDNLITDPN NVSIYYVKPL EDDNPYAIRQ IKYGYQLYFN 
       610        620        630        640        650
EENRTYYALK KDASIRSEFP QNRGESNNSW LYMGTEKADA QKNAMNHINN 
       660        670        680        690        700
ERMNGFNGYF GEEEGKNNGN LNVTFKGKSE QNRFLLTGGT NLNGDLNVQQ 
       710        720        730        740        750
GTLFLSGRPT PHARDIAGIS STKKDSHFSE NNEVVVEDDW INRNFKATNI 
       760        770        780        790        800
NVTNNATLYS GRNVESITSN ITASNNAKVH IGYKAGDTVC VRSDYTGYVT 
       810        820        830        840        850
CTTDKLSDKA LNSFNPTNLR GNVNLTESAN FVLGKANLFG TIQSRGNSQV 
       860        870        880        890        900
RLTENSHWHL TGNSDVHQLD LANGHIHLNS ADNSNNVTKY NTLTVNSLSG 
       910        920        930        940        950
NGSFYYLTDL SNKQGDKVVV TKSATGNFTL QVADKTGEPN HNELTLFDAS 
       960        970        980        990       1000
KAQRDHLNVS LVGNTVDLGA WKYKLRNVNG RYDLYNPEVE KRNQTVDTTN 
      1010       1020       1030       1040       1050
ITTPNNIQAD VPSVPSNNEE IARVDEAPVP PPAPATPSET TETVAENSKQ 
      1060       1070       1080       1090       1100
ESKTVEKNEQ DATETTAQNR EVAKEAKSNV KANTQTNEVA QSGSETKETQ 
      1110       1120       1130       1140       1150
TTETKETATV EKEEKAKVET EKTQEVPKVT SQVSPKQEQS ETVQPQAEPA 
      1160       1170       1180       1190       1200
RENDPTVNIK EPQSQTNTTA DTEQPAKETS SNVEQPVTES TTVNTGNSVV 
      1210       1220       1230       1240       1250
ENPENTTPAT TQPTVNSESS NKPKNRHRRS VRSVPHNVEP ATTSSNDRST 
      1260       1270       1280       1290       1300
VALCDLTSTN TNAVLSDARA KAQFVALNVG KAVSQHISQL EMNNEGQYNV 
      1310       1320       1330       1340       1350
WVSNTSMNKN YSSSQYRRFS SKSTQTQLGW DQTISNNVQL GGVFTYVRNS 
      1360       1370       1380       1390       1400
NNFDKATSKN TLAQVNFYSK YYADNHWYLG IDLGYGKFQS KLQTNHNAKF 
      1410       1420       1430       1440       1450
ARHTAQFGLT AGKAFNLGNF GITPIVGVRY SYLSNADFAL DQARIKVNPI 
      1460       1470       1480       1490       1500
SVKTAFAQVD LSYTYHLGEF SVTPILSARY DANQGSGKIN VNGYDFAYNV 
      1510       1520       1530       1540 
ENQQQYNAGL KLKYHNVKLS LIGGLTKAKQ AEKQKTAELK LSFSF
Length:1,545
Mass (Da):170,627
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EDD753988F6D478
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M87490 Genomic DNA Translation: AAA24967.1

Protein sequence database of the Protein Information Resource

More...PIRi		B41859

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87490 Genomic DNA Translation: AAA24967.1
PIRiB41859

3D structure databases

SMRiP45385
ModBaseiSearch...

Protein family/group databases

MEROPSiS06.007

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central
PfamiView protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGA3_HAEIF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45385
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 7, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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