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Entry version 105 (07 Apr 2021)
Sequence version 1 (01 Nov 1995)
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Protein

Immunoglobulin A1 protease autotransporter

Gene

iga

Organism
Haemophilus influenzae
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known. EC:3.4.21.72

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei292Curated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processVirulence

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S06.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin A1 protease autotransporter (EC:3.4.21.72)
Cleaved into the following 2 chains:
Immunoglobulin A1 protease
Short name:
IGA1 protease
Alternative name(s):
Helper peptide
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:iga
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzae
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri727 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell outer membrane, Membrane, Periplasm, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000038760126 – 1545Immunoglobulin A1 protease autotransporterAdd BLAST1520
ChainiPRO_000002696426 – 1012Immunoglobulin A1 proteaseAdd BLAST987
ChainiPRO_00000269651013 – 1545Immunoglobulin A1 protease translocatorSequence analysisAdd BLAST533

Keywords - PTMi

Zymogen

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P45385

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 336Peptidase S6PROSITE-ProRule annotationAdd BLAST311
Domaini1293 – 1545AutotransporterPROSITE-ProRule annotationAdd BLAST253

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P45385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGKFSVG
60 70 80 90 100
ATNVEVRDKN NRPLGNVLPN GIPMIDFSVV DVDKRIATLV NPQYVVGVKH
110 120 130 140 150
VSNGVSELHF GNLNGNMNNG NAKAHRDVSS EENRYYTVEK NEYPTKLNGK
160 170 180 190 200
AVTTEDQAQK RREDYYMPRL DKFVTEVAPI EASTDSSTAG TYNNKDKYPY
210 220 230 240 250
FVRLGSGTQF IYENGTRYEL WLGKEGQKSD AGGYNLKLVG NAYTYGIAGT
260 270 280 290 300
PYEVNHENDG LIGFGNSNNE YINPKEILSK KPLTNYAVLG DSGSPLFVYD
310 320 330 340 350
REKGKWLFLG SYDYWAGYNK KSWQEWNIYK PEFAEKIYEQ YSAGSLIGSK
360 370 380 390 400
TDYSWSSNGK TSTITGGEKS LNVDLADGKD KPNHGKSVTF EGSGTLTLNN
410 420 430 440 450
NIDQGAGGLF FEGDYEVKGT SDNTTWKGAG VSVAEGKTVT WKVHNPQYDR
460 470 480 490 500
LAKIGKGTLI VEGTGDNKGS LKVGDGTVIL KQQTNGSGQH AFASVGIVSG
510 520 530 540 550
RSTLVLNDDK QVDPNSIYFG FRGGRLDLNG NSLTFDHIRN IDEGARLVNH
560 570 580 590 600
STSKHSTVTI TGDNLITDPN NVSIYYVKPL EDDNPYAIRQ IKYGYQLYFN
610 620 630 640 650
EENRTYYALK KDASIRSEFP QNRGESNNSW LYMGTEKADA QKNAMNHINN
660 670 680 690 700
ERMNGFNGYF GEEEGKNNGN LNVTFKGKSE QNRFLLTGGT NLNGDLNVQQ
710 720 730 740 750
GTLFLSGRPT PHARDIAGIS STKKDSHFSE NNEVVVEDDW INRNFKATNI
760 770 780 790 800
NVTNNATLYS GRNVESITSN ITASNNAKVH IGYKAGDTVC VRSDYTGYVT
810 820 830 840 850
CTTDKLSDKA LNSFNPTNLR GNVNLTESAN FVLGKANLFG TIQSRGNSQV
860 870 880 890 900
RLTENSHWHL TGNSDVHQLD LANGHIHLNS ADNSNNVTKY NTLTVNSLSG
910 920 930 940 950
NGSFYYLTDL SNKQGDKVVV TKSATGNFTL QVADKTGEPN HNELTLFDAS
960 970 980 990 1000
KAQRDHLNVS LVGNTVDLGA WKYKLRNVNG RYDLYNPEVE KRNQTVDTTN
1010 1020 1030 1040 1050
ITTPNNIQAD VPSVPSNNEE IARVDEAPVP PPAPATPSET TETVAENSKQ
1060 1070 1080 1090 1100
ESKTVEKNEQ DATETTAQNR EVAKEAKSNV KANTQTNEVA QSGSETKETQ
1110 1120 1130 1140 1150
TTETKETATV EKEEKAKVET EKTQEVPKVT SQVSPKQEQS ETVQPQAEPA
1160 1170 1180 1190 1200
RENDPTVNIK EPQSQTNTTA DTEQPAKETS SNVEQPVTES TTVNTGNSVV
1210 1220 1230 1240 1250
ENPENTTPAT TQPTVNSESS NKPKNRHRRS VRSVPHNVEP ATTSSNDRST
1260 1270 1280 1290 1300
VALCDLTSTN TNAVLSDARA KAQFVALNVG KAVSQHISQL EMNNEGQYNV
1310 1320 1330 1340 1350
WVSNTSMNKN YSSSQYRRFS SKSTQTQLGW DQTISNNVQL GGVFTYVRNS
1360 1370 1380 1390 1400
NNFDKATSKN TLAQVNFYSK YYADNHWYLG IDLGYGKFQS KLQTNHNAKF
1410 1420 1430 1440 1450
ARHTAQFGLT AGKAFNLGNF GITPIVGVRY SYLSNADFAL DQARIKVNPI
1460 1470 1480 1490 1500
SVKTAFAQVD LSYTYHLGEF SVTPILSARY DANQGSGKIN VNGYDFAYNV
1510 1520 1530 1540
ENQQQYNAGL KLKYHNVKLS LIGGLTKAKQ AEKQKTAELK LSFSF
Length:1,545
Mass (Da):170,627
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EDD753988F6D478
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M87490 Genomic DNA Translation: AAA24967.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B41859

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87490 Genomic DNA Translation: AAA24967.1
PIRiB41859

3D structure databases

SMRiP45385
ModBaseiSearch...

Protein family/group databases

MEROPSiS06.007

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central
PfamiView protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGA3_HAEIF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45385
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 7, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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