UniProtKB - P45385 (IGA3_HAEIF)
Protein
Immunoglobulin A1 protease autotransporter
Gene
iga
Organism
Haemophilus influenzae
Status
Functioni
Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.
Catalytic activityi
- Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known. EC:3.4.21.72
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 292 | Curated | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
GO - Biological processi
- pathogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Virulence |
Protein family/group databases
MEROPSi | S06.007 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin A1 protease autotransporter (EC:3.4.21.72)Cleaved into the following 2 chains: Alternative name(s): Helper peptide |
Gene namesi | Name:iga |
Organismi | Haemophilus influenzae |
Taxonomic identifieri | 727 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus |
Subcellular locationi
Other locations
- Periplasm By similarity
Extracellular region or secreted
Other locations
Other locations
- Cell outer membrane By similarity; Multi-pass membrane protein By similarity
Note: The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- cell outer membrane Source: UniProtKB-SubCell
- cell surface Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell outer membrane, Membrane, Periplasm, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000387601 | 26 – 1545 | Immunoglobulin A1 protease autotransporterAdd BLAST | 1520 | |
ChainiPRO_0000026964 | 26 – 1012 | Immunoglobulin A1 proteaseAdd BLAST | 987 | |
ChainiPRO_0000026965 | 1013 – 1545 | Immunoglobulin A1 protease translocatorSequence analysisAdd BLAST | 533 |
Keywords - PTMi
ZymogenFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 336 | Peptidase S6PROSITE-ProRule annotationAdd BLAST | 311 | |
Domaini | 1293 – 1545 | AutotransporterPROSITE-ProRule annotationAdd BLAST | 253 |
Domaini
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).By similarity
Keywords - Domaini
Signal, Transmembrane, Transmembrane beta strandFamily and domain databases
Gene3Di | 2.160.20.20, 1 hit 2.40.128.130, 1 hit |
InterProi | View protein in InterPro IPR005546, Autotransporte_beta IPR036709, Autotransporte_beta_dom_sf IPR012332, P22_tailspike-like_C_sf IPR011050, Pectin_lyase_fold/virulence IPR000710, Peptidase_S6 IPR030396, Peptidase_S6_dom IPR004899, Pertactin_central |
Pfami | View protein in Pfam PF03797, Autotransporter, 1 hit PF02395, Peptidase_S6, 1 hit PF03212, Pertactin, 1 hit |
PRINTSi | PR00921, IGASERPTASE |
SMARTi | View protein in SMART SM00869, Autotransporter, 1 hit |
SUPFAMi | SSF103515, SSF103515, 1 hit SSF51126, SSF51126, 1 hit |
PROSITEi | View protein in PROSITE PS51208, AUTOTRANSPORTER, 1 hit PS51691, PEPTIDASE_S6, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P45385-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNKKFKLNF IALTVAYALT PYTEAALVRD DVDYQIFRDF AENKGKFSVG
60 70 80 90 100
ATNVEVRDKN NRPLGNVLPN GIPMIDFSVV DVDKRIATLV NPQYVVGVKH
110 120 130 140 150
VSNGVSELHF GNLNGNMNNG NAKAHRDVSS EENRYYTVEK NEYPTKLNGK
160 170 180 190 200
AVTTEDQAQK RREDYYMPRL DKFVTEVAPI EASTDSSTAG TYNNKDKYPY
210 220 230 240 250
FVRLGSGTQF IYENGTRYEL WLGKEGQKSD AGGYNLKLVG NAYTYGIAGT
260 270 280 290 300
PYEVNHENDG LIGFGNSNNE YINPKEILSK KPLTNYAVLG DSGSPLFVYD
310 320 330 340 350
REKGKWLFLG SYDYWAGYNK KSWQEWNIYK PEFAEKIYEQ YSAGSLIGSK
360 370 380 390 400
TDYSWSSNGK TSTITGGEKS LNVDLADGKD KPNHGKSVTF EGSGTLTLNN
410 420 430 440 450
NIDQGAGGLF FEGDYEVKGT SDNTTWKGAG VSVAEGKTVT WKVHNPQYDR
460 470 480 490 500
LAKIGKGTLI VEGTGDNKGS LKVGDGTVIL KQQTNGSGQH AFASVGIVSG
510 520 530 540 550
RSTLVLNDDK QVDPNSIYFG FRGGRLDLNG NSLTFDHIRN IDEGARLVNH
560 570 580 590 600
STSKHSTVTI TGDNLITDPN NVSIYYVKPL EDDNPYAIRQ IKYGYQLYFN
610 620 630 640 650
EENRTYYALK KDASIRSEFP QNRGESNNSW LYMGTEKADA QKNAMNHINN
660 670 680 690 700
ERMNGFNGYF GEEEGKNNGN LNVTFKGKSE QNRFLLTGGT NLNGDLNVQQ
710 720 730 740 750
GTLFLSGRPT PHARDIAGIS STKKDSHFSE NNEVVVEDDW INRNFKATNI
760 770 780 790 800
NVTNNATLYS GRNVESITSN ITASNNAKVH IGYKAGDTVC VRSDYTGYVT
810 820 830 840 850
CTTDKLSDKA LNSFNPTNLR GNVNLTESAN FVLGKANLFG TIQSRGNSQV
860 870 880 890 900
RLTENSHWHL TGNSDVHQLD LANGHIHLNS ADNSNNVTKY NTLTVNSLSG
910 920 930 940 950
NGSFYYLTDL SNKQGDKVVV TKSATGNFTL QVADKTGEPN HNELTLFDAS
960 970 980 990 1000
KAQRDHLNVS LVGNTVDLGA WKYKLRNVNG RYDLYNPEVE KRNQTVDTTN
1010 1020 1030 1040 1050
ITTPNNIQAD VPSVPSNNEE IARVDEAPVP PPAPATPSET TETVAENSKQ
1060 1070 1080 1090 1100
ESKTVEKNEQ DATETTAQNR EVAKEAKSNV KANTQTNEVA QSGSETKETQ
1110 1120 1130 1140 1150
TTETKETATV EKEEKAKVET EKTQEVPKVT SQVSPKQEQS ETVQPQAEPA
1160 1170 1180 1190 1200
RENDPTVNIK EPQSQTNTTA DTEQPAKETS SNVEQPVTES TTVNTGNSVV
1210 1220 1230 1240 1250
ENPENTTPAT TQPTVNSESS NKPKNRHRRS VRSVPHNVEP ATTSSNDRST
1260 1270 1280 1290 1300
VALCDLTSTN TNAVLSDARA KAQFVALNVG KAVSQHISQL EMNNEGQYNV
1310 1320 1330 1340 1350
WVSNTSMNKN YSSSQYRRFS SKSTQTQLGW DQTISNNVQL GGVFTYVRNS
1360 1370 1380 1390 1400
NNFDKATSKN TLAQVNFYSK YYADNHWYLG IDLGYGKFQS KLQTNHNAKF
1410 1420 1430 1440 1450
ARHTAQFGLT AGKAFNLGNF GITPIVGVRY SYLSNADFAL DQARIKVNPI
1460 1470 1480 1490 1500
SVKTAFAQVD LSYTYHLGEF SVTPILSARY DANQGSGKIN VNGYDFAYNV
1510 1520 1530 1540
ENQQQYNAGL KLKYHNVKLS LIGGLTKAKQ AEKQKTAELK LSFSF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87490 Genomic DNA Translation: AAA24967.1 |
PIRi | B41859 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87490 Genomic DNA Translation: AAA24967.1 |
PIRi | B41859 |
3D structure databases
SMRi | P45385 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S06.007 |
Family and domain databases
Gene3Di | 2.160.20.20, 1 hit 2.40.128.130, 1 hit |
InterProi | View protein in InterPro IPR005546, Autotransporte_beta IPR036709, Autotransporte_beta_dom_sf IPR012332, P22_tailspike-like_C_sf IPR011050, Pectin_lyase_fold/virulence IPR000710, Peptidase_S6 IPR030396, Peptidase_S6_dom IPR004899, Pertactin_central |
Pfami | View protein in Pfam PF03797, Autotransporter, 1 hit PF02395, Peptidase_S6, 1 hit PF03212, Pertactin, 1 hit |
PRINTSi | PR00921, IGASERPTASE |
SMARTi | View protein in SMART SM00869, Autotransporter, 1 hit |
SUPFAMi | SSF103515, SSF103515, 1 hit SSF51126, SSF51126, 1 hit |
PROSITEi | View protein in PROSITE PS51208, AUTOTRANSPORTER, 1 hit PS51691, PEPTIDASE_S6, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGA3_HAEIF | |
Accessioni | P45385Primary (citable) accession number: P45385 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |