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Entry version 192 (05 Jun 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Troponin T, cardiac muscle

Gene

TNNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-390522 Striated Muscle Contraction

SIGNOR Signaling Network Open Resource

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SIGNORi
P45379

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Troponin T, cardiac muscle
Short name:
TnTc
Alternative name(s):
Cardiac muscle troponin T
Short name:
cTnT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNNT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11949 TNNT2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
191045 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P45379

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, familial hypertrophic 2 (CMH2)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06725938A → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs200754249EnsemblClinVar.1
Natural variantiVAR_01987780F → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs886039053Ensembl.1
Natural variantiVAR_00760589I → N in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964855Ensembl.1
Natural variantiVAR_016195102R → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964856Ensembl.1
Natural variantiVAR_007606102R → Q in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964856Ensembl.1
Natural variantiVAR_016196102R → W in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516456EnsemblClinVar.1
Natural variantiVAR_009194104R → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516457Ensembl.1
Natural variantiVAR_016197114A → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs727504245Ensembl.1
Natural variantiVAR_007607120F → I in CMH2. 2 PublicationsCorresponds to variant dbSNP:rs121964858Ensembl.1
Natural variantiVAR_019878120F → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964858Ensembl.1
Natural variantiVAR_042747140R → C in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516463Ensembl.1
Natural variantiVAR_007608170Missing in CMH2. 1
Natural variantiVAR_007609173E → K in CMH2. 1 Publication1
Natural variantiVAR_016199189S → F in CMH2. 1 PublicationCorresponds to variant dbSNP:rs727504246Ensembl.1
Natural variantiVAR_007610254E → D in CMH2. 1 PublicationCorresponds to variant dbSNP:rs45466197Ensembl.1
Natural variantiVAR_019879281N → I in CMH2. 1 PublicationCorresponds to variant dbSNP:rs863225119Ensembl.1
Natural variantiVAR_007612288R → C in CMH2. 3 PublicationsCorresponds to variant dbSNP:rs121964857Ensembl.1
Natural variantiVAR_007613288R → P in CMH2. 2 PublicationsCorresponds to variant dbSNP:rs397516484Ensembl.1
Natural variantiVAR_019880296R → C in CMH2. 1 PublicationCorresponds to variant dbSNP:rs367785431Ensembl.1
Cardiomyopathy, dilated 1D (CMD1D)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043983141R → W in CMD1D. 2 PublicationsCorresponds to variant dbSNP:rs74315380Ensembl.1
Natural variantiVAR_016198151R → W in CMD1D. 2 PublicationsCorresponds to variant dbSNP:rs74315379Ensembl.1
Natural variantiVAR_022931210Missing in CMD1D. 1 Publication1
Natural variantiVAR_043984215R → L in CMD1D. 1 PublicationCorresponds to variant dbSNP:rs121964860Ensembl.1
Natural variantiVAR_043985220Missing in CMD1D. 2 Publications1
Cardiomyopathy, familial restrictive 3 (RCM3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Related information in OMIM

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7139

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
TNNT2

MalaCards human disease database

More...
MalaCardsi
TNNT2
MIMi115195 phenotype
601494 phenotype
612422 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000118194

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
75249 Familial isolated restrictive cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36638

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2095202

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TNNT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21264536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861732 – 298Troponin T, cardiac muscleAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by CK2By similarity1
Modified residuei204Phosphothreonine; by PKC/PRKCABy similarity1
Modified residuei208Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei213Phosphothreonine; by PKC/PRKCA and RAF1By similarity1
Modified residuei294Phosphothreonine; by PKC/PRKCABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P45379

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P45379

PeptideAtlas

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PeptideAtlasi
P45379

PRoteomics IDEntifications database

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PRIDEi
P45379

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55665
55666 [P45379-10]
55667 [P45379-11]
55668 [P45379-2]
55669 [P45379-3]
55670 [P45379-4]
55671 [P45379-5]
55672 [P45379-6]
55673 [P45379-7]
55674 [P45379-8]
55675 [P45379-9]

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P45379

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P45379

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P45379

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118194 Expressed in 165 organ(s), highest expression level in cardiac ventricle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P45379 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P45379 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015371
HPA015774
HPA017888

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MORF4L2Q150143EBI-8485957,EBI-399257

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112993, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3280 Cardiac Troponin complex

Protein interaction database and analysis system

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IntActi
P45379, 9 interactors

Molecular INTeraction database

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MINTi
P45379

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000236918

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P45379

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P45379

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3634 Eukaryota
ENOG410XS6A LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154709

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231049

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P45379

KEGG Orthology (KO)

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KOi
K12045

Identification of Orthologs from Complete Genome Data

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OMAi
EVHFESR

Database of Orthologous Groups

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OrthoDBi
614199at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P45379

TreeFam database of animal gene trees

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TreeFami
TF313321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.350, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11521 PTHR11521, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00992 Troponin, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (12+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.

This entry has 12 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P45379-1) [UniParc]FASTAAdd to basket
Also known as: TNT1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDIEEVVEE YEEEEQEEAA VEEEEDWRED EDEQEEAAEE DAEAEAETEE
60 70 80 90 100
TRAEEDEEEE EAKEAEDGPM EESKPKPRSF MPNLVPPKIP DGERVDFDDI
110 120 130 140 150
HRKRMEKDLN ELQALIEAHF ENRKKEEEEL VSLKDRIERR RAERAEQQRI
160 170 180 190 200
RNEREKERQN RLAEERARRE EEENRRKAED EARKKKALSN MMHFGGYIQK
210 220 230 240 250
QAQTERKSGK RQTEREKKKK ILAERRKVLA IDHLNEDQLR EKAKELWQSI
260 270 280 290
YNLEAEKFDL QEKFKQQKYE INVLRNRIND NQKVSKTRGK AKVTGRWK
Length:298
Mass (Da):35,924
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69974F2200CD5BEF
GO
Isoform 2 (identifier: P45379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.

Show »
Length:297
Mass (Da):35,794
Checksum:i7A88F02291D9BFFB
GO
Isoform 3 (identifier: P45379-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Missing.

Show »
Length:297
Mass (Da):35,794
Checksum:iD2B458D8909A0404
GO
Isoform 4 (identifier: P45379-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-23: Missing.
     54-54: Missing.

Show »
Length:296
Mass (Da):35,665
Checksum:iED0B5849847E101A
GO
Isoform 5 (identifier: P45379-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.

Show »
Length:297
Mass (Da):35,795
Checksum:iA19DAF593FFCC93C
GO
Isoform 6 (identifier: P45379-6) [UniParc]FASTAAdd to basket
Also known as: TNT3

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: Missing.

Show »
Length:288
Mass (Da):34,590
Checksum:iF7956C33F94255B0
GO
Isoform 7 (identifier: P45379-7) [UniParc]FASTAAdd to basket
Also known as: TNT4

The sequence of this isoform differs from the canonical sequence as follows:
     18-32: Missing.

Show »
Length:283
Mass (Da):34,091
Checksum:iE70D862729679EF5
GO
Isoform 8 (identifier: P45379-8) [UniParc]FASTAAdd to basket
Also known as: TNT2

The sequence of this isoform differs from the canonical sequence as follows:
     18-22: Missing.

Show »
Length:293
Mass (Da):35,424
Checksum:iD2E545EC0C3034DE
GO
Isoform 9 (identifier: P45379-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-137: Missing.

Show »
Length:259
Mass (Da):31,137
Checksum:iA0B999CC0E2005AB
GO
Isoform 10 (identifier: P45379-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-203: Missing.

Show »
Length:295
Mass (Da):35,596
Checksum:i51ADF1E637A72DDC
GO
Isoform 11 (identifier: P45379-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-32: Missing.
     201-203: Missing.

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):34,263
Checksum:iF0547EE868527B3D
GO
Isoform 12 (identifier: P45379-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Missing.
     99-137: Missing.
     201-203: Missing.

Show »
Length:255
Mass (Da):30,681
Checksum:iD20694B11931D87A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7Z554Q7Z554_HUMAN
Troponin T cardiac isoform
TNNT2 HNTN1, hCG_1641227
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRJ5A0A0A0MRJ5_HUMAN
Troponin T, cardiac muscle
TNNT2
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPN8E7EPN8_HUMAN
Troponin T, cardiac muscle
TNNT2
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDF8C9JDF8_HUMAN
Troponin T, cardiac muscle
TNNT2
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRJ4A0A0A0MRJ4_HUMAN
Troponin T, cardiac muscle
TNNT2
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JM61C9JM61_HUMAN
Troponin T, cardiac muscle
TNNT2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPW4E7EPW4_HUMAN
Troponin T, cardiac muscle
TNNT2
281Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242K → E in CAA70840 (PubMed:9689598).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06725938A → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs200754249EnsemblClinVar.1
Natural variantiVAR_01987780F → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs886039053Ensembl.1
Natural variantiVAR_00760589I → N in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964855Ensembl.1
Natural variantiVAR_016195102R → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964856Ensembl.1
Natural variantiVAR_007606102R → Q in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964856Ensembl.1
Natural variantiVAR_016196102R → W in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516456EnsemblClinVar.1
Natural variantiVAR_009194104R → L in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516457Ensembl.1
Natural variantiVAR_016197114A → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs727504245Ensembl.1
Natural variantiVAR_007607120F → I in CMH2. 2 PublicationsCorresponds to variant dbSNP:rs121964858Ensembl.1
Natural variantiVAR_019878120F → V in CMH2. 1 PublicationCorresponds to variant dbSNP:rs121964858Ensembl.1
Natural variantiVAR_013021139R → K. Corresponds to variant dbSNP:rs2996496Ensembl.1
Natural variantiVAR_042747140R → C in CMH2. 1 PublicationCorresponds to variant dbSNP:rs397516463Ensembl.1
Natural variantiVAR_029450140R → K. Corresponds to variant dbSNP:rs2996496Ensembl.1
Natural variantiVAR_043983141R → W in CMD1D. 2 PublicationsCorresponds to variant dbSNP:rs74315380Ensembl.1
Natural variantiVAR_016198151R → W in CMD1D. 2 PublicationsCorresponds to variant dbSNP:rs74315379Ensembl.1
Natural variantiVAR_007608170Missing in CMH2. 1
Natural variantiVAR_007609173E → K in CMH2. 1 Publication1
Natural variantiVAR_016199189S → F in CMH2. 1 PublicationCorresponds to variant dbSNP:rs727504246Ensembl.1
Natural variantiVAR_022931210Missing in CMD1D. 1 Publication1
Natural variantiVAR_043984215R → L in CMD1D. 1 PublicationCorresponds to variant dbSNP:rs121964860Ensembl.1
Natural variantiVAR_043985220Missing in CMD1D. 2 Publications1
Natural variantiVAR_042748221I → T. Corresponds to variant dbSNP:rs45520032EnsemblClinVar.1
Natural variantiVAR_057310231I → T. Corresponds to variant dbSNP:rs45520032EnsemblClinVar.1
Natural variantiVAR_013022249S → T. Corresponds to variant dbSNP:rs2996495Ensembl.1
Natural variantiVAR_007610254E → D in CMH2. 1 PublicationCorresponds to variant dbSNP:rs45466197Ensembl.1
Natural variantiVAR_007611263K → R1 PublicationCorresponds to variant dbSNP:rs3730238Ensembl.1
Natural variantiVAR_029451279N → Y. Corresponds to variant dbSNP:rs4523540Ensembl.1
Natural variantiVAR_019879281N → I in CMH2. 1 PublicationCorresponds to variant dbSNP:rs863225119Ensembl.1
Natural variantiVAR_007612288R → C in CMH2. 3 PublicationsCorresponds to variant dbSNP:rs121964857Ensembl.1
Natural variantiVAR_007613288R → P in CMH2. 2 PublicationsCorresponds to variant dbSNP:rs397516484Ensembl.1
Natural variantiVAR_019880296R → C in CMH2. 1 PublicationCorresponds to variant dbSNP:rs367785431Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00664218 – 32Missing in isoform 7. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_00664118 – 22Missing in isoform 8. 1 Publication5
Alternative sequenceiVSP_00664323 – 32Missing in isoform 6 and isoform 11. 6 Publications10
Alternative sequenceiVSP_00664423Missing in isoform 2 and isoform 4. 1 Publication1
Alternative sequenceiVSP_00664554Missing in isoform 3, isoform 4 and isoform 12. 2 Publications1
Alternative sequenceiVSP_00664699 – 137Missing in isoform 9 and isoform 12. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_006648201 – 203Missing in isoform 10, isoform 11 and isoform 12. 3 Publications3
Alternative sequenceiVSP_006647201Missing in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S64668 mRNA Translation: AAB27731.1 Sequence problems.
X74819 mRNA Translation: CAA52818.1
L40162 mRNA Translation: AAA67422.1
X79855 mRNA Translation: CAA56235.1
X79856 mRNA Translation: CAA56236.1
X79857 mRNA Translation: CAA56237.1
X79858 mRNA Translation: CAA56238.1
AF004422
, AF004409, AF004410, AF004411, AF004412, AF004413, AF004414, AF004415, AF004416, AF004417, AF004418, AF004419, AF004420, AF004421 Genomic DNA Translation: AAC39590.1
AY044273 Genomic DNA Translation: AAK92231.1
AK290621 mRNA Translation: BAF83310.1
EF179183 Genomic DNA Translation: ABN05286.1
AC119427 Genomic DNA No translation available.
BC002653 mRNA Translation: AAH02653.1
Y09626 Genomic DNA Translation: CAA70839.1
Y09627 Genomic DNA Translation: CAA70840.1
Y09628 Genomic DNA Translation: CAA70841.1
S71126 mRNA Translation: AAB30956.1
S71127, S71128 Genomic DNA Translation: AAB30957.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30968.1 [P45379-11]
CCDS30969.1 [P45379-6]
CCDS60390.1 [P45379-12]
CCDS73003.1 [P45379-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54671 TPHUTC

NCBI Reference Sequences

More...
RefSeqi
NP_000355.2, NM_000364.3 [P45379-10]
NP_001001430.1, NM_001001430.2 [P45379-6]
NP_001001431.1, NM_001001431.2 [P45379-11]
NP_001001432.1, NM_001001432.2
NP_001263274.1, NM_001276345.1 [P45379-1]
NP_001263275.1, NM_001276346.1 [P45379-12]
NP_001263276.1, NM_001276347.1 [P45379-6]
XP_006711571.1, XM_006711508.3 [P45379-6]
XP_011508240.1, XM_011509938.2 [P45379-1]
XP_011508241.1, XM_011509939.1 [P45379-3]
XP_011508242.1, XM_011509940.2 [P45379-5]
XP_011508244.1, XM_011509942.2 [P45379-7]
XP_011508245.1, XM_011509943.2 [P45379-7]
XP_016857706.1, XM_017002217.1 [P45379-11]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000236918; ENSP00000236918; ENSG00000118194 [P45379-1]
ENST00000360372; ENSP00000353535; ENSG00000118194 [P45379-12]
ENST00000367318; ENSP00000356287; ENSG00000118194 [P45379-6]
ENST00000367320; ENSP00000356289; ENSG00000118194 [P45379-12]
ENST00000412633; ENSP00000408731; ENSG00000118194 [P45379-11]
ENST00000509001; ENSP00000422031; ENSG00000118194 [P45379-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7139

UCSC genome browser

More...
UCSCi
uc001gwg.5 human [P45379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64668 mRNA Translation: AAB27731.1 Sequence problems.
X74819 mRNA Translation: CAA52818.1
L40162 mRNA Translation: AAA67422.1
X79855 mRNA Translation: CAA56235.1
X79856 mRNA Translation: CAA56236.1
X79857 mRNA Translation: CAA56237.1
X79858 mRNA Translation: CAA56238.1
AF004422
, AF004409, AF004410, AF004411, AF004412, AF004413, AF004414, AF004415, AF004416, AF004417, AF004418, AF004419, AF004420, AF004421 Genomic DNA Translation: AAC39590.1
AY044273 Genomic DNA Translation: AAK92231.1
AK290621 mRNA Translation: BAF83310.1
EF179183 Genomic DNA Translation: ABN05286.1
AC119427 Genomic DNA No translation available.
BC002653 mRNA Translation: AAH02653.1
Y09626 Genomic DNA Translation: CAA70839.1
Y09627 Genomic DNA Translation: CAA70840.1
Y09628 Genomic DNA Translation: CAA70841.1
S71126 mRNA Translation: AAB30956.1
S71127, S71128 Genomic DNA Translation: AAB30957.1
CCDSiCCDS30968.1 [P45379-11]
CCDS30969.1 [P45379-6]
CCDS60390.1 [P45379-12]
CCDS73003.1 [P45379-1]
PIRiA54671 TPHUTC
RefSeqiNP_000355.2, NM_000364.3 [P45379-10]
NP_001001430.1, NM_001001430.2 [P45379-6]
NP_001001431.1, NM_001001431.2 [P45379-11]
NP_001001432.1, NM_001001432.2
NP_001263274.1, NM_001276345.1 [P45379-1]
NP_001263275.1, NM_001276346.1 [P45379-12]
NP_001263276.1, NM_001276347.1 [P45379-6]
XP_006711571.1, XM_006711508.3 [P45379-6]
XP_011508240.1, XM_011509938.2 [P45379-1]
XP_011508241.1, XM_011509939.1 [P45379-3]
XP_011508242.1, XM_011509940.2 [P45379-5]
XP_011508244.1, XM_011509942.2 [P45379-7]
XP_011508245.1, XM_011509943.2 [P45379-7]
XP_016857706.1, XM_017002217.1 [P45379-11]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61B/E193-298[»]
1J1EX-ray3.30B/E193-298[»]
4Y99X-ray2.00B193-298[»]
SMRiP45379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112993, 9 interactors
ComplexPortaliCPX-3280 Cardiac Troponin complex
IntActiP45379, 9 interactors
MINTiP45379
STRINGi9606.ENSP00000236918

Chemistry databases

ChEMBLiCHEMBL2095202

PTM databases

iPTMnetiP45379
PhosphoSitePlusiP45379

Polymorphism and mutation databases

BioMutaiTNNT2
DMDMi21264536

2D gel databases

UCD-2DPAGEiP45379

Proteomic databases

EPDiP45379
PaxDbiP45379
PeptideAtlasiP45379
PRIDEiP45379
ProteomicsDBi55665
55666 [P45379-10]
55667 [P45379-11]
55668 [P45379-2]
55669 [P45379-3]
55670 [P45379-4]
55671 [P45379-5]
55672 [P45379-6]
55673 [P45379-7]
55674 [P45379-8]
55675 [P45379-9]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7139
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236918; ENSP00000236918; ENSG00000118194 [P45379-1]
ENST00000360372; ENSP00000353535; ENSG00000118194 [P45379-12]
ENST00000367318; ENSP00000356287; ENSG00000118194 [P45379-6]
ENST00000367320; ENSP00000356289; ENSG00000118194 [P45379-12]
ENST00000412633; ENSP00000408731; ENSG00000118194 [P45379-11]
ENST00000509001; ENSP00000422031; ENSG00000118194 [P45379-6]
GeneIDi7139
KEGGihsa:7139
UCSCiuc001gwg.5 human [P45379-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7139
DisGeNETi7139

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNNT2
GeneReviewsiTNNT2
HGNCiHGNC:11949 TNNT2
HPAiCAB015371
HPA015774
HPA017888
MalaCardsiTNNT2
MIMi115195 phenotype
191045 gene
601494 phenotype
612422 phenotype
neXtProtiNX_P45379
OpenTargetsiENSG00000118194
Orphaneti154 Familial isolated dilated cardiomyopathy
75249 Familial isolated restrictive cardiomyopathy
54260 Left ventricular noncompaction
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA36638

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00940000154709
HOGENOMiHOG000231049
InParanoidiP45379
KOiK12045
OMAiEVHFESR
OrthoDBi614199at2759
PhylomeDBiP45379
TreeFamiTF313321

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP45379

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNNT2 human
EvolutionaryTraceiP45379

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TNNT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7139

Protein Ontology

More...
PROi
PR:P45379

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000118194 Expressed in 165 organ(s), highest expression level in cardiac ventricle
ExpressionAtlasiP45379 baseline and differential
GenevisibleiP45379 HS

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNNT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45379
Secondary accession number(s): A2TDB9
, A8K3K6, O60214, Q99596, Q99597, Q9BUF6, Q9UM96
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: June 5, 2019
This is version 192 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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