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Protein

Troponin T, fast skeletal muscle

Gene

TNNT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB
  • troponin C binding Source: UniProtKB
  • troponin I binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP45378

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, fast skeletal muscle
Short name:
TnTf
Alternative name(s):
Beta-TnTF
Fast skeletal muscle troponin T
Short name:
fTnT
Gene namesi
Name:TNNT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000130595.16
HGNCiHGNC:11950 TNNT3
MIMi600692 gene
neXtProtiNX_P45378

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Arthrogryposis, distal, 2B (DA2B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.
See also OMIM:601680
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02645374R → H in DA2B. 1 PublicationCorresponds to variant dbSNP:rs121434638Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi7140
MalaCardsiTNNT3
MIMi601680 phenotype
OpenTargetsiENSG00000130595
Orphaneti1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
PharmGKBiPA36639

Chemistry databases

ChEMBLiCHEMBL3831282

Polymorphism and mutation databases

BioMutaiTNNT3
DMDMi33518637

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861782 – 269Troponin T, fast skeletal muscleAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP45378
PeptideAtlasiP45378
PRIDEiP45378
ProteomicsDBi55658
55659 [P45378-2]
55660 [P45378-3]
55661 [P45378-4]
55662 [P45378-5]
55663 [P45378-6]
55664 [P45378-7]

PTM databases

iPTMnetiP45378
PhosphoSitePlusiP45378

Expressioni

Tissue specificityi

In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle.

Gene expression databases

BgeeiENSG00000130595 Expressed in 89 organ(s), highest expression level in muscle of leg
ExpressionAtlasiP45378 baseline and differential
GenevisibleiP45378 HS

Organism-specific databases

HPAiCAB002451
HPA037810
HPA056909

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112994, 18 interactors
IntActiP45378, 7 interactors
MINTiP45378
STRINGi9606.ENSP00000278317

Structurei

3D structure databases

ProteinModelPortaliP45378
SMRiP45378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00390000013611
HOVERGENiHBG052790
InParanoidiP45378
KOiK12046
OMAiGRHPPKV
OrthoDBiEOG091G0U67
PhylomeDBiP45378
TreeFamiTF313321

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR027708 Tnnt3
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PTHR11521:SF4 PTHR11521:SF4, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P45378-1) [UniParc]FASTAAdd to basket
Also known as: Tnt1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP
60 70 80 90 100
RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL
110 120 130 140 150
VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED
160 170 180 190 200
DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID
210 220 230 240 250
HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ
260
KHSKKAGTPA KGKVGGRWK
Length:269
Mass (Da):31,825
Last modified:January 23, 2007 - v3
Checksum:i87B25AF8773D742F
GO
Isoform 2 (identifier: P45378-2) [UniParc]FASTAAdd to basket
Also known as: Tnt3

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.

Show »
Length:258
Mass (Da):30,596
Checksum:iF42BF2526BDC5ED9
GO
Isoform 3 (identifier: P45378-3) [UniParc]FASTAAdd to basket
Also known as: Tnt1f

The sequence of this isoform differs from the canonical sequence as follows:
     39-46: Missing.

Show »
Length:261
Mass (Da):30,964
Checksum:i6D7AF5AF58952CD1
GO
Isoform 4 (identifier: P45378-4) [UniParc]FASTAAdd to basket
Also known as: Tnt3f

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.
     39-46: Missing.
     240-252: TTLRSRIDQAQKH → MNVRARVQMLAKF

Show »
Length:250
Mass (Da):29,746
Checksum:i3E60707FDA580499
GO
Isoform 5 (identifier: P45378-5) [UniParc]FASTAAdd to basket
Also known as: Tnt3f*

The sequence of this isoform differs from the canonical sequence as follows:
     23-46: Missing.

Note: Minor isoform detected in approximately 1% of cDNA clones.
Show »
Length:245
Mass (Da):29,121
Checksum:i320B367968566805
GO
Isoform 6 (identifier: P45378-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-46: Missing.

Show »
Length:256
Mass (Da):30,349
Checksum:i9522A0CA453CB492
GO
Isoform 7 (identifier: P45378-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.
     39-46: Missing.

Show »
Length:250
Mass (Da):29,735
Checksum:i9A9651EBDF220547
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVA2H9KVA2_HUMAN
Troponin T, fast skeletal muscle
TNNT3
239Annotation score:
C9JZN9C9JZN9_HUMAN
Troponin T, fast skeletal muscle
TNNT3
239Annotation score:
C9JCA5C9JCA5_HUMAN
Troponin T, fast skeletal muscle
TNNT3
208Annotation score:
F8WA37F8WA37_HUMAN
Troponin T, fast skeletal muscle
TNNT3
244Annotation score:
A0A286YFB1A0A286YFB1_HUMAN
Troponin T, fast skeletal muscle
TNNT3
190Annotation score:

Sequence cautioni

The sequence AAH50446 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149E → G in CAE45814 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02645374R → H in DA2B. 1 PublicationCorresponds to variant dbSNP:rs121434638Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00912123 – 46Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_00791423 – 33Missing in isoform 2, isoform 4 and isoform 7. 5 PublicationsAdd BLAST11
Alternative sequenceiVSP_03496434 – 46Missing in isoform 6. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_00791539 – 46Missing in isoform 3, isoform 4 and isoform 7. 4 Publications8
Alternative sequenceiVSP_007916240 – 252TTLRS…QAQKH → MNVRARVQMLAKF in isoform 4. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21984 mRNA Translation: AAA36777.1
AF026276 Genomic DNA Translation: AAF21629.1
AK056968 mRNA Translation: BAG51835.1
DQ778624 mRNA Translation: ABG77458.1
BX640689 mRNA Translation: CAE45814.1
BT019997 mRNA Translation: AAV38800.1
CR541927 mRNA Translation: CAG46725.1
AC051649 Genomic DNA No translation available.
BC050446 mRNA Translation: AAH50446.1 Different initiation.
BC117327 mRNA Translation: AAI17328.1
BC171727 mRNA Translation: AAI71727.1
BC143537 mRNA Translation: AAI43538.1
U14641 mRNA Translation: AAA50359.1
U14642 mRNA Translation: AAA50360.1
U14643 mRNA Translation: AAA50361.1
U14644 mRNA Translation: AAA50362.1
CCDSiCCDS41594.1 [P45378-6]
CCDS41595.1 [P45378-4]
CCDS41596.1 [P45378-7]
CCDS7727.1 [P45378-2]
CCDS86164.1 [P45378-3]
PIRiI53021
S48660
S74259
S74260
S74261
RefSeqiNP_001036245.1, NM_001042780.2 [P45378-4]
NP_001036246.1, NM_001042781.2 [P45378-6]
NP_001036247.1, NM_001042782.2 [P45378-7]
NP_001284575.1, NM_001297646.1 [P45378-7]
NP_006748.1, NM_006757.3 [P45378-2]
XP_006718353.1, XM_006718290.3 [P45378-1]
XP_006718356.1, XM_006718293.2 [P45378-3]
XP_006718363.1, XM_006718300.3 [P45378-5]
XP_011518645.1, XM_011520343.2 [P45378-1]
XP_016873695.1, XM_017018206.1 [P45378-1]
UniGeneiHs.73454

Genome annotation databases

EnsembliENST00000278317; ENSP00000278317; ENSG00000130595 [P45378-2]
ENST00000344578; ENSP00000344870; ENSG00000130595 [P45378-5]
ENST00000381558; ENSP00000370970; ENSG00000130595 [P45378-7]
ENST00000381563; ENSP00000370975; ENSG00000130595 [P45378-3]
ENST00000381579; ENSP00000370991; ENSG00000130595 [P45378-4]
ENST00000381589; ENSP00000371001; ENSG00000130595 [P45378-6]
ENST00000397301; ENSP00000380468; ENSG00000130595 [P45378-1]
ENST00000641119; ENSP00000492914; ENSG00000130595 [P45378-6]
ENST00000641787; ENSP00000493331; ENSG00000130595 [P45378-7]
GeneIDi7140
KEGGihsa:7140
UCSCiuc001luo.5 human [P45378-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT3_HUMAN
AccessioniPrimary (citable) accession number: P45378
Secondary accession number(s): A8MQ76
, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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