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Entry version 163 (13 Nov 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Troponin T, fast skeletal muscle

Gene

TNNT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P45378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Troponin T, fast skeletal muscle
Short name:
TnTf
Alternative name(s):
Beta-TnTF
Fast skeletal muscle troponin T
Short name:
fTnT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNNT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11950 TNNT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600692 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P45378

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Arthrogryposis, distal, 2B2 (DA2B2)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B2 inheritance is autosomal dominant.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08228074R → C in DA2B2. 1 Publication1
Natural variantiVAR_02645374R → H in DA2B2. 3 PublicationsCorresponds to variant dbSNP:rs121434638Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7140

MalaCards human disease database

More...
MalaCardsi
TNNT3
MIMi618435 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000130595

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36639

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P45378

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831282

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNNT3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33518637

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861782 – 269Troponin T, fast skeletal muscleAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P45378

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P45378

PeptideAtlas

More...
PeptideAtlasi
P45378

PRoteomics IDEntifications database

More...
PRIDEi
P45378

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55658 [P45378-1]
55659 [P45378-2]
55660 [P45378-3]
55661 [P45378-4]
55662 [P45378-5]
55663 [P45378-6]
55664 [P45378-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P45378

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P45378

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130595 Expressed in 89 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P45378 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P45378 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002451
HPA037810
HPA056909

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112994, 18 interactors

Protein interaction database and analysis system

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IntActi
P45378, 9 interactors

Molecular INTeraction database

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MINTi
P45378

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278317

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P45378

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3634 Eukaryota
ENOG410XS6A LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158477

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P45378

KEGG Orthology (KO)

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KOi
K12046

Identification of Orthologs from Complete Genome Data

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OMAi
VDKECEG

Database of Orthologous Groups

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OrthoDBi
1013139at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P45378

TreeFam database of animal gene trees

More...
TreeFami
TF313321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027707 TNNT
IPR027708 Tnnt3
IPR001978 Troponin
IPR038077 Troponin_sf

The PANTHER Classification System

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PANTHERi
PTHR11521 PTHR11521, 1 hit
PTHR11521:SF4 PTHR11521:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00992 Troponin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90250 SSF90250, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P45378-1) [UniParc]FASTAAdd to basket
Also known as: Tnt1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP
60 70 80 90 100
RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL
110 120 130 140 150
VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED
160 170 180 190 200
DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID
210 220 230 240 250
HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ
260
KHSKKAGTPA KGKVGGRWK
Length:269
Mass (Da):31,825
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87B25AF8773D742F
GO
Isoform 2 (identifier: P45378-2) [UniParc]FASTAAdd to basket
Also known as: Tnt3

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.

Show »
Length:258
Mass (Da):30,596
Checksum:iF42BF2526BDC5ED9
GO
Isoform 3 (identifier: P45378-3) [UniParc]FASTAAdd to basket
Also known as: Tnt1f

The sequence of this isoform differs from the canonical sequence as follows:
     39-46: Missing.

Show »
Length:261
Mass (Da):30,964
Checksum:i6D7AF5AF58952CD1
GO
Isoform 4 (identifier: P45378-4) [UniParc]FASTAAdd to basket
Also known as: Tnt3f

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.
     39-46: Missing.
     240-252: TTLRSRIDQAQKH → MNVRARVQMLAKF

Show »
Length:250
Mass (Da):29,746
Checksum:i3E60707FDA580499
GO
Isoform 5 (identifier: P45378-5) [UniParc]FASTAAdd to basket
Also known as: Tnt3f*

The sequence of this isoform differs from the canonical sequence as follows:
     23-46: Missing.

Note: Minor isoform detected in approximately 1% of cDNA clones.
Show »
Length:245
Mass (Da):29,121
Checksum:i320B367968566805
GO
Isoform 6 (identifier: P45378-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-46: Missing.

Show »
Length:256
Mass (Da):30,349
Checksum:i9522A0CA453CB492
GO
Isoform 7 (identifier: P45378-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-33: Missing.
     39-46: Missing.

Show »
Length:250
Mass (Da):29,735
Checksum:i9A9651EBDF220547
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KVA2H9KVA2_HUMAN
Troponin T, fast skeletal muscle
TNNT3
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JCA5C9JCA5_HUMAN
Troponin T, fast skeletal muscle
TNNT3
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZN9C9JZN9_HUMAN
Troponin T, fast skeletal muscle
TNNT3
239Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WA37F8WA37_HUMAN
Troponin T, fast skeletal muscle
TNNT3
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YFB1A0A286YFB1_HUMAN
Troponin T, fast skeletal muscle
TNNT3
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50446 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti149E → G in CAE45814 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08228074R → C in DA2B2. 1 Publication1
Natural variantiVAR_02645374R → H in DA2B2. 3 PublicationsCorresponds to variant dbSNP:rs121434638Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00912123 – 46Missing in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_00791423 – 33Missing in isoform 2, isoform 4 and isoform 7. 5 PublicationsAdd BLAST11
Alternative sequenceiVSP_03496434 – 46Missing in isoform 6. 4 PublicationsAdd BLAST13
Alternative sequenceiVSP_00791539 – 46Missing in isoform 3, isoform 4 and isoform 7. 4 Publications8
Alternative sequenceiVSP_007916240 – 252TTLRS…QAQKH → MNVRARVQMLAKF in isoform 4. 2 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M21984 mRNA Translation: AAA36777.1
AF026276 Genomic DNA Translation: AAF21629.1
AK056968 mRNA Translation: BAG51835.1
DQ778624 mRNA Translation: ABG77458.1
BX640689 mRNA Translation: CAE45814.1
BT019997 mRNA Translation: AAV38800.1
CR541927 mRNA Translation: CAG46725.1
AC051649 Genomic DNA No translation available.
BC050446 mRNA Translation: AAH50446.1 Different initiation.
BC117327 mRNA Translation: AAI17328.1
BC171727 mRNA Translation: AAI71727.1
BC143537 mRNA Translation: AAI43538.1
U14641 mRNA Translation: AAA50359.1
U14642 mRNA Translation: AAA50360.1
U14643 mRNA Translation: AAA50361.1
U14644 mRNA Translation: AAA50362.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41594.1 [P45378-6]
CCDS41595.1 [P45378-4]
CCDS41596.1 [P45378-7]
CCDS7727.1 [P45378-2]
CCDS86164.1 [P45378-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I53021
S48660
S74259
S74260
S74261

NCBI Reference Sequences

More...
RefSeqi
NP_001036245.1, NM_001042780.2 [P45378-4]
NP_001036246.1, NM_001042781.2 [P45378-6]
NP_001036247.1, NM_001042782.2 [P45378-7]
NP_001284575.1, NM_001297646.1 [P45378-7]
NP_006748.1, NM_006757.3 [P45378-2]
XP_006718353.1, XM_006718290.3
XP_006718356.1, XM_006718293.2
XP_006718363.1, XM_006718300.3 [P45378-5]
XP_011518645.1, XM_011520343.2 [P45378-1]
XP_016873695.1, XM_017018206.1 [P45378-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000278317; ENSP00000278317; ENSG00000130595 [P45378-2]
ENST00000344578; ENSP00000344870; ENSG00000130595 [P45378-5]
ENST00000381558; ENSP00000370970; ENSG00000130595 [P45378-7]
ENST00000381563; ENSP00000370975; ENSG00000130595 [P45378-3]
ENST00000381579; ENSP00000370991; ENSG00000130595 [P45378-4]
ENST00000381589; ENSP00000371001; ENSG00000130595 [P45378-6]
ENST00000397301; ENSP00000380468; ENSG00000130595 [P45378-1]
ENST00000641119; ENSP00000492914; ENSG00000130595 [P45378-6]
ENST00000641787; ENSP00000493331; ENSG00000130595 [P45378-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7140

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7140

UCSC genome browser

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UCSCi
uc001luo.5 human [P45378-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21984 mRNA Translation: AAA36777.1
AF026276 Genomic DNA Translation: AAF21629.1
AK056968 mRNA Translation: BAG51835.1
DQ778624 mRNA Translation: ABG77458.1
BX640689 mRNA Translation: CAE45814.1
BT019997 mRNA Translation: AAV38800.1
CR541927 mRNA Translation: CAG46725.1
AC051649 Genomic DNA No translation available.
BC050446 mRNA Translation: AAH50446.1 Different initiation.
BC117327 mRNA Translation: AAI17328.1
BC171727 mRNA Translation: AAI71727.1
BC143537 mRNA Translation: AAI43538.1
U14641 mRNA Translation: AAA50359.1
U14642 mRNA Translation: AAA50360.1
U14643 mRNA Translation: AAA50361.1
U14644 mRNA Translation: AAA50362.1
CCDSiCCDS41594.1 [P45378-6]
CCDS41595.1 [P45378-4]
CCDS41596.1 [P45378-7]
CCDS7727.1 [P45378-2]
CCDS86164.1 [P45378-3]
PIRiI53021
S48660
S74259
S74260
S74261
RefSeqiNP_001036245.1, NM_001042780.2 [P45378-4]
NP_001036246.1, NM_001042781.2 [P45378-6]
NP_001036247.1, NM_001042782.2 [P45378-7]
NP_001284575.1, NM_001297646.1 [P45378-7]
NP_006748.1, NM_006757.3 [P45378-2]
XP_006718353.1, XM_006718290.3
XP_006718356.1, XM_006718293.2
XP_006718363.1, XM_006718300.3 [P45378-5]
XP_011518645.1, XM_011520343.2 [P45378-1]
XP_016873695.1, XM_017018206.1 [P45378-1]

3D structure databases

SMRiP45378
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112994, 18 interactors
IntActiP45378, 9 interactors
MINTiP45378
STRINGi9606.ENSP00000278317

Chemistry databases

ChEMBLiCHEMBL3831282

PTM databases

iPTMnetiP45378
PhosphoSitePlusiP45378

Polymorphism and mutation databases

BioMutaiTNNT3
DMDMi33518637

Proteomic databases

MassIVEiP45378
PaxDbiP45378
PeptideAtlasiP45378
PRIDEiP45378
ProteomicsDBi55658 [P45378-1]
55659 [P45378-2]
55660 [P45378-3]
55661 [P45378-4]
55662 [P45378-5]
55663 [P45378-6]
55664 [P45378-7]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7140

Genome annotation databases

EnsembliENST00000278317; ENSP00000278317; ENSG00000130595 [P45378-2]
ENST00000344578; ENSP00000344870; ENSG00000130595 [P45378-5]
ENST00000381558; ENSP00000370970; ENSG00000130595 [P45378-7]
ENST00000381563; ENSP00000370975; ENSG00000130595 [P45378-3]
ENST00000381579; ENSP00000370991; ENSG00000130595 [P45378-4]
ENST00000381589; ENSP00000371001; ENSG00000130595 [P45378-6]
ENST00000397301; ENSP00000380468; ENSG00000130595 [P45378-1]
ENST00000641119; ENSP00000492914; ENSG00000130595 [P45378-6]
ENST00000641787; ENSP00000493331; ENSG00000130595 [P45378-7]
GeneIDi7140
KEGGihsa:7140
UCSCiuc001luo.5 human [P45378-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7140
DisGeNETi7140

GeneCards: human genes, protein and diseases

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GeneCardsi
TNNT3
HGNCiHGNC:11950 TNNT3
HPAiCAB002451
HPA037810
HPA056909
MalaCardsiTNNT3
MIMi600692 gene
618435 phenotype
neXtProtiNX_P45378
OpenTargetsiENSG00000130595
Orphaneti1146 Digitotalar dysmorphism
1147 Sheldon-Hall syndrome
PharmGKBiPA36639

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3634 Eukaryota
ENOG410XS6A LUCA
GeneTreeiENSGT00940000158477
InParanoidiP45378
KOiK12046
OMAiVDKECEG
OrthoDBi1013139at2759
PhylomeDBiP45378
TreeFamiTF313321

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP45378

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNNT3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNNT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7140
PharosiP45378

Protein Ontology

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PROi
PR:P45378

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130595 Expressed in 89 organ(s), highest expression level in muscle of leg
ExpressionAtlasiP45378 baseline and differential
GenevisibleiP45378 HS

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR027707 TNNT
IPR027708 Tnnt3
IPR001978 Troponin
IPR038077 Troponin_sf
PANTHERiPTHR11521 PTHR11521, 1 hit
PTHR11521:SF4 PTHR11521:SF4, 1 hit
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
SUPFAMiSSF90250 SSF90250, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNNT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45378
Secondary accession number(s): A8MQ76
, A8MSW1, B3KPX3, B7WP64, B7ZL26, B7ZVV9, Q12975, Q12976, Q12977, Q12978, Q17RG9, Q6FH29, Q6N056, Q86TH6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 13, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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