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Protein

Aldose reductase-related protein 2

Gene

Akr1b8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton donor1
Sitei78Lowers pKa of active site TyrBy similarity1
Binding sitei111Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 273NADP1 PublicationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-193144 Estrogen biosynthesis
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase-related protein 2 (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Fibroblast growth factor-regulated protein
Protein FR-1
Gene namesi
Name:Akr1b8
Synonyms:Fgfrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107673 Akr1b8

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246311 – 316Aldose reductase-related protein 2Add BLAST316

Proteomic databases

EPDiP45377
MaxQBiP45377
PaxDbiP45377
PeptideAtlasiP45377
PRIDEiP45377

2D gel databases

REPRODUCTION-2DPAGEiIPI00273096
P45377

PTM databases

iPTMnetiP45377
PhosphoSitePlusiP45377
SwissPalmiP45377

Expressioni

Inductioni

By FGF-1.

Gene expression databases

BgeeiENSMUSG00000029762 Expressed in 237 organ(s), highest expression level in embryo
GenevisibleiP45377 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiP45377, 1 interactor
MINTiP45377
STRINGi10090.ENSMUSP00000040244

Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP45377
SMRiP45377
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP45377

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
GeneTreeiENSGT00760000119041
HOGENOMiHOG000250272
HOVERGENiHBG000020
InParanoidiP45377
KOiK00011
OMAiWLVHWPP
OrthoDBiEOG091G0D69
PhylomeDBiP45377
TreeFamiTF106492

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P45377-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATFVELSTK AKMPIVGLGT WKSPPNQVKE AVKAAIDAGY RHIDCAYAYC
60 70 80 90 100
NENEVGEAIQ EKIKEKAVQR EDLFIVSKLW PTCFEKKLLK EAFQKTLTDL
110 120 130 140 150
KLDYLDLYLI HWPQGLQPGK ELFPKDDQGR ILTSKTTFLE AWEGMEELVD
160 170 180 190 200
QGLVKALGVS NFNHFQIERL LNKPGLKHKP VTNQVECHPY LTQEKLIQYC
210 220 230 240 250
HSKGISVTAY SPLGSPDRPS AKPEDPSLLE DPKIKEIAAK HEKTSAQVLI
260 270 280 290 300
RFHIQRNVVV IPKSVTPSRI QENIQVFDFQ LSDEEMATIL SFNRNWRACL
310
LPETVNMEEY PYDAEY
Length:316
Mass (Da):36,121
Last modified:January 23, 2007 - v2
Checksum:i0C6F0A7BA806497C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242E → K in AAH05789 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04204 mRNA Translation: AAA16953.1
BC005789 mRNA Translation: AAH05789.1
CCDSiCCDS19991.1
PIRiA53440
RefSeqiNP_032038.1, NM_008012.1
UniGeneiMm.5378

Genome annotation databases

EnsembliENSMUST00000038406; ENSMUSP00000040244; ENSMUSG00000029762
GeneIDi14187
KEGGimmu:14187
UCSCiuc009bgz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiALD2_MOUSE
AccessioniPrimary (citable) accession number: P45377
Secondary accession number(s): Q99JN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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