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Protein

UvrABC system protein B

Gene

uvrB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1277-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
Ordered Locus Names:HI_1247
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001383951 – 679UvrABC system protein BAdd BLAST679

Proteomic databases

PRIDEiP45125

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

Protein-protein interaction databases

STRINGi71421.HI1247

Structurei

3D structure databases

ProteinModelPortaliP45125
SMRiP45125
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 414Helicase ATP-bindingUniRule annotationAdd BLAST384
Domaini436 – 589Helicase C-terminalUniRule annotationAdd BLAST154
Domaini639 – 674UVRUniRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCW Bacteria
COG0556 LUCA
KOiK03702
OMAiRYMHSEI
PhylomeDBiP45125

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

P45125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKINTKPF ILHSDFRPSG DQPQAIEKLA ENLTDGLAHQ TLLGVTGSGK
60 70 80 90 100
TFTIANVIAQ LNRPAMLLAP NKTLAAQLYA EMKAFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTFIEKDASI NDQIEQMRLS ATKSFLERRD TIVVASVSAI
160 170 180 190 200
YGLGDPDSYL QMMLHLQQGA IIDQRQILAK LAELQYTRND QAFQRGTFRV
210 220 230 240 250
RGEIIDIFPA ESDDRAVRIE LFDDEIERLS LFDPLTGSSF GAVPRFTIYP
260 270 280 290 300
KTHYVTPRER ILDAIENIKK ELVSRREYFI KEHKLLEEQR ISQRTQFDIE
310 320 330 340 350
MMNELGYCSG IENYSRYLSG RNEGEPPPTL FDYMPPDAIL IIDESHVTVP
360 370 380 390 400
QIGGMYRGDR SRKETLVEYG FRLPSALDNR PLRFEEFERL APQTIYVSAT
410 420 430 440 450
PGAYELEKSG SEIIDQVVRP TGLLDPLIEI RPVSIQVDDL LSEARQRADK
460 470 480 490 500
NERVLVTTLT KKMAEDLTDY LDEHGIRVRY LHSDIDTVER VEIIRDLRLG
510 520 530 540 550
EFDVLVGINL LREGLDIPEV SLVAILDADK EGFLRSERSL IQTIGRAARN
560 570 580 590 600
LNGKAILYAD SITKSMEKAI TETNRRREKQ TKYNEEHGIV PQALNKKVGE
610 620 630 640 650
LLDIGQGANQ KAKANKQRGK MAAEPTALYN APKNAKEYQQ QIKKLEQQMY
660 670
KFAQDLEFEK AAAIRDQLHQ LREQFVFDN
Length:679
Mass (Da):77,526
Last modified:November 1, 1995 - v1
Checksum:i926DF16C1B21A0C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22897.1
PIRiG64112
RefSeqiNP_439403.1, NC_000907.1
WP_005694308.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22897; AAC22897; HI_1247
GeneIDi950196
KEGGihin:HI1247
PATRICifig|71421.8.peg.1299

Similar proteinsi

Entry informationi

Entry nameiUVRB_HAEIN
AccessioniPrimary (citable) accession number: P45125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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