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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1264-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Ordered Locus Names:HI_1233
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001622451 – 886Pyruvate dehydrogenase E1 componentAdd BLAST886

Proteomic databases

PRIDEiP45119

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi71421.HI1233

Structurei

3D structure databases

ProteinModelPortaliP45119
SMRiP45119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA
KOiK00163
OMAiREPWFPG
PhylomeDBiP45119

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR004660 2-oxoA_DH_E1
IPR035807 PDC_E1_N
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

Sequencei

Sequence statusi: Complete.

P45119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEILKNDVD PIETQDWLQS LDSLIREEGV ERAQYIVEQV IGQARTSGVS
60 70 80 90 100
LPTGVTTDYV NTIPVAEQPA YPGDHAIERR IRSAVRWNAI AMVLRSQKKD
110 120 130 140 150
LDLGGHISTF QSAATMYEVC YNHFFKAATE KNGGDLIFFQ GHAAPGMYAR
160 170 180 190 200
AFLEGRLTEE QMDNFRQEAF TDGLSSYPHP KLMPEFWQFS TVSMGLGPVN
210 220 230 240 250
AIYQARFLKY LDNRGLKDTK DQKVYAFLGD GEMDEIESKG ALTFAAREHL
260 270 280 290 300
DNLIFTISCN LQRLDGPVNG NGKIVQELEG LFTGAGWEVI KVLWGSDWDK
310 320 330 340 350
LFAKDTSGKL TQLMMEVVDG DYLTFKSKDG AYIREHFFGR YPETAALVAD
360 370 380 390 400
MTDDEIWALR RGAHDSEKLY AAYAKAQNAT KPVVILAHQV KGYKIPEAES
410 420 430 440 450
KNTAHQSKKM SYESLKGFRD FFELPLTDEQ VEKLEYIKFA EGTPEYEYLH
460 470 480 490 500
GHRKALNGYV PARRTKFDVE YKVPALEEFK ALLEEQPRGI STTMAFTRAL
510 520 530 540 550
NILLKDKNIG KTIVPMIADE ARTFGMEGLF RQVGIYNPHG QNYIPSDRDL
560 570 580 590 600
VAYYREAKDG QVLQEGINEL GATASWLAAA NSYSVNNQPM IPFFIYYSMF
610 620 630 640 650
GFQRVGDMMW AAGDQLARGF MVGGTSGRTT LNGEGLQHED GHSHIQAGII
660 670 680 690 700
PNCITYDPSF AFEVAVIMQD GINRMYGEKQ EDVFYYMTTL NEVMDQPAMP
710 720 730 740 750
AGAEEGIRKG LYKFETVEGK KGKGHVQLLG SGAIMRHVRE AAQILANDYG
760 770 780 790 800
VTSDVFSAPS FNELAREGHD AARWNLLHPT ETQRVPYVAQ VLADLPTVAS
810 820 830 840 850
TDYVKGYADQ IRAFVPSKHY HVLGTDGFGR SDSRANLREH FEVDARYVVV
860 870 880
AALSQLAKEG TVSNQVVADA IAKFGLNVDR INPLYA
Length:886
Mass (Da):99,131
Last modified:November 1, 1995 - v1
Checksum:i1B936A75DD69E71D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22886.1
PIRiA64112
RefSeqiNP_439389.1, NC_000907.1
WP_005694293.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22886; AAC22886; HI_1233
GeneIDi950116
KEGGihin:HI1233
PATRICifig|71421.8.peg.1285

Similar proteinsi

Entry informationi

Entry nameiODP1_HAEIN
AccessioniPrimary (citable) accession number: P45119
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names

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