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Entry version 129 (16 Oct 2019)
Sequence version 2 (15 Jul 1998)
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Protein

ATP-dependent RNA helicase HrpA homolog

Gene

hrpA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi106 – 113ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA processing Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase HrpA homolog (EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hrpA
Ordered Locus Names:HI_1070
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri71421 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000579 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551791 – 1304ATP-dependent RNA helicase HrpA homologAdd BLAST1304

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P45018

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
71421.HI_1070

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P45018

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 257Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST165
Domaini281 – 448Helicase C-terminalPROSITE-ProRule annotationAdd BLAST168

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi203 – 206DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CQ7 Bacteria
COG1643 LUCA

KEGG Orthology (KO)

More...
KOi
K03578

Identification of Orthologs from Complete Genome Data

More...
OMAi
YIKLMTD

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR024590 HrpA_C
IPR027417 P-loop_NTPase
IPR010222 RNA_helicase_HrpA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF11898 DUF3418, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 1 hit
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01967 DEAH_box_HrpA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P45018-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNSSVKHTL TPLQQSLFSQ LNDIMLVDQR RLSARIHGIG KIKSQEAQQA
60 70 80 90 100
VAAEIQQQIE QARLRVEQRK SAVQNPIVFP ESLPVSQRKV EIQKLISEHQ
110 120 130 140 150
VIVVAGETGS GKTTQLPKMC LELGFGNLGM IGHTQPRRIA ARSVAARIAE
160 170 180 190 200
ELETELGGLV GYKVRFNDQI SDNTQIKLMT DGILLAEIQN DRFLNQYSCL
210 220 230 240 250
IIDEAHERSL NNDFILGYLK QLLPRRRRDL KLIITSATID VERFSKHFNN
260 270 280 290 300
APIIEVSGRT YPVEVRYRPV VEEDDQDQLQ GILNAVDELQ AEGRGDILIF
310 320 330 340 350
MNGEREIRDT AEALQKQNLK HTEILPLFAR LSAQEQNKIF HPSGLNRIVL
360 370 380 390 400
ATNVAETSLT VPSIKYVIDP GTARISRYSY RTKVQRLPIE PISQASANQR
410 420 430 440 450
KGRCGRVSEG ICIRLYSEED FNSRPEFTDP EILRTNLASV ILQMTALGLD
460 470 480 490 500
DIEAFPFVDA PDERHIQDGV KLLEELGAFE TVQTKSGEKR LLTRVGRQLA
510 520 530 540 550
QLPVDPRLAK MILSAVNFGC VYEMMIIVSA LSIQDPRERP QEKQQASDEK
560 570 580 590 600
HRRFADKKSD FLAFLNLWRY LQEQQKESSK NQFRRQCQKD FLNYLRIREW
610 620 630 640 650
QDIYHQIRLT VREMSLPINS EKAEYQQIHT ALLSGLLSHI GLKEAEKQQY
660 670 680 690 700
LGARNAHFAI FPNSVLFKKQ PKWVMAAELV ETSKLWGRMV AEIEPEWIEP
710 720 730 740 750
LAEHLIKKSY SVPLWSKSRG AVIADEKVTL YGVPIVAVRP VNYGAIDPTV
760 770 780 790 800
SREIFIQSAL VEGGWNTKHK FFKENQRLVR EVEELEHKSR RRDILVDDRT
810 820 830 840 850
LFEFYDQRIG TEVVSQKHFD TWWKKAQQKD PELLNFEHSF LINDDAEQVS
860 870 880 890 900
KLDFPNFWHQ GNLKLKLTYQ FEPGTDADGV TVHIPLPLLN QVEMTGFDWQ
910 920 930 940 950
IPGLREELVI ALIKSLPKSY RRNFVPAPNY AQAFLSRAVP LEKPLLDTLI
960 970 980 990 1000
YELRRMTGVT VEAEHWNWEQ IPSHLKMTFR VVDENGKKIA ESMNLDELKF
1010 1020 1030 1040 1050
NLKDRVQESI SAVADDGIEQ SGLHIWSFAD LPQCYEQKQR GFSVKAFPAI
1060 1070 1080 1090 1100
VDEKDAVGIK LFETEFEQSV AMQQGLRRLL LLNVPSPIKY LHEKLPNKAK
1110 1120 1130 1140 1150
LGLYFTPFGR VLDLIDDCIA CAVDKLIADF GGFVWDEAGF EKLRDFVREN
1160 1170 1180 1190 1200
LNEVTVDIAQ KVEQILTLTY QLNQRLKGKM DFTMAFALSD IKSQLAGLVY
1210 1220 1230 1240 1250
QGFVQKSGYD RLPDLQRYLQ AVDKRIDKLA QDVNRDRAAM LRVEQVQQAY
1260 1270 1280 1290 1300
QQLLAKLPKS KPISDEVAEI RYMIEELRVS LFAQQLGTKY QISDKRIGNI

ISQY
Length:1,304
Mass (Da):149,626
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i179B59B57FBA5867
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22728.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G64165
I64019

NCBI Reference Sequences

More...
RefSeqi
NP_439228.2, NC_000907.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC22728; AAC22728; HI_1070

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
950050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hin:HI1070

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|71421.8.peg.1114

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22728.1
PIRiG64165
I64019
RefSeqiNP_439228.2, NC_000907.1

3D structure databases

SMRiP45018
ModBaseiSearch...

Protein-protein interaction databases

STRINGi71421.HI_1070

Proteomic databases

PRIDEiP45018

Genome annotation databases

EnsemblBacteriaiAAC22728; AAC22728; HI_1070
GeneIDi950050
KEGGihin:HI1070
PATRICifig|71421.8.peg.1114

Phylogenomic databases

eggNOGiENOG4105CQ7 Bacteria
COG1643 LUCA
KOiK03578
OMAiYIKLMTD

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR024590 HrpA_C
IPR027417 P-loop_NTPase
IPR010222 RNA_helicase_HrpA
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF11898 DUF3418, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01967 DEAH_box_HrpA, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRPA_HAEIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P45018
Secondary accession number(s): P44108, P44109, P71368
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: October 16, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
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