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Protein

Dihydroxy-acid dehydratase

Gene

ilvD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase large subunit (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-valine from pyruvate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Acetolactate synthase small subunit (ilvH), Acetolactate synthase large subunit (ilvI)
  2. Ketol-acid reductoisomerase (NADP(+)) (ilvC)
  3. Dihydroxy-acid dehydratase (ilvD)
  4. Branched-chain-amino-acid aminotransferase (ilvE)
This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi195Iron-sulfur (4Fe-4S)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-776-MONOMER
UniPathwayiUPA00047; UER00057
UPA00049; UER00061

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroxy-acid dehydrataseUniRule annotation (EC:4.2.1.9UniRule annotation)
Short name:
DADUniRule annotation
Gene namesi
Name:ilvDUniRule annotation
Ordered Locus Names:HI_0738
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001034691 – 612Dihydroxy-acid dehydrataseAdd BLAST612

Proteomic databases

PRIDEiP44851

Interactioni

Protein-protein interaction databases

STRINGi71421.HI0738

Structurei

3D structure databases

SMRiP44851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IlvD/Edd family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C01 Bacteria
COG0129 LUCA
KOiK01687
OMAiIPGHVHL
PhylomeDBiP44851

Family and domain databases

HAMAPiMF_00012 IlvD, 1 hit
InterProiView protein in InterPro
IPR004404 DihydroxyA_deHydtase
IPR000581 DiOHA_6PGluconate_deHydtase
IPR020558 DiOHA_6PGluconate_deHydtase_CS
IPR037237 IlvD/EDD_N
PfamiView protein in Pfam
PF00920 ILVD_EDD, 1 hit
SUPFAMiSSF143975 SSF143975, 1 hit
TIGRFAMsiTIGR00110 ilvD, 1 hit
PROSITEiView protein in PROSITE
PS00886 ILVD_EDD_1, 1 hit
PS00887 ILVD_EDD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P44851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLRSATST QGRNMAGARA LWRATGMKEN DFGKPIIAVV NSFTQFVPGH
60 70 80 90 100
VHLKDMGQLV AAEIEKAGGV AKEFNTIAVD DGIAMGHGGM LYSLPSRDLI
110 120 130 140 150
ADSVEYMVNA HCADAMVCIS NCDKITPGML MAAMRLNIPT IFVSGGPMEA
160 170 180 190 200
GKTKLSDQLI RLDLVDAMIE AADPNVSDER IDAIERSACP TCGSCSGMFT
210 220 230 240 250
ANSMNCLTEA LGLSLPGNGS MLATHADRKE LFLKAGRQIV ELCKRYYEQD
260 270 280 290 300
DASVLPRSIG TFDAFENAMS LDIAMGGSSN TVLHLLAAAQ EAGVDFKMED
310 320 330 340 350
IDRLSRKVPC LSKIAPNTNK YHMEDVHRAG GIMGLLGELD RAGLIHKNTH
360 370 380 390 400
TVLGMSMGEQ LDQYDIIRNQ DEELHKFFRA GPAGIRTTQA FSQDCRWDTV
410 420 430 440 450
DNDRVNGCIR NKENAISQEG GLAVLFGNLA EDGCIVKTAG VDESIWKFTG
460 470 480 490 500
TAIVFESQED AVAGILGGKV KEGHVVVIRY EGPKGGPGMQ EMLYPTSYLK
510 520 530 540 550
SMGLGKKCAL LTDGRFSGGT SGLSIGHVSP EAASGGAIGL VRNGDIINID
560 570 580 590 600
IPNRAINLEI SNEELATRRA EQDQKGWQPA NREREVSFAL KVFGHFATSA
610
DKGAVRDKTL LK
Length:612
Mass (Da):65,823
Last modified:November 1, 1995 - v1
Checksum:i42CE1C8F7E0A09A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC22397.1
PIRiG64089
RefSeqiNP_438897.1, NC_000907.1
WP_005693142.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC22397; AAC22397; HI_0738
GeneIDi949825
KEGGihin:HI0738
PATRICifig|71421.8.peg.774

Similar proteinsi

Entry informationi

Entry nameiILVD_HAEIN
AccessioniPrimary (citable) accession number: P44851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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